• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2003.05a
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• pp.30-32
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• 2003

지난 수 세기 동안 많은 연구자들이 천연자원으로부터 의약품 등의 기능성 생리 활성 물질을 개발하고자 하는 노력이 시도되어 왔지만 그 대상은 주로 인류가 오래 전부터 민간약으로 사용한 육상 식물 자원에 치중되어 왔다. 하지만 최근에는 채집 기술, 양식 기술 및 분석 기술의 발달과 더불어 관련 분야 학문의 진보에 힘입어 그 동안 미개척 분야인 해양 생물 자원에 눈을 돌리게 되었다. (중략)

• Proceedings of the EASDL Conference
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• 2003.04a
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• pp.80-80
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• 2003

전통적으로 오랜 세월동안 콩이나 콩 발효 식품을 이용해온 동양인에게는 구미의 여러나라에 비해 유방암과 대장암의 발생율이 훨씬 낮다는 것은 잘 알려진 사실이다. 그 이유는 콩을 발효시킴으로써 새로운 기능성 성분의 생성으로 인한 생리활성 효과를 기대할 수 있기 때문인 것으로 파악되고 있다. 이러한 생리활성 효과를 검토하기 위해 본 연구에서는 증자된 콩에 메주로부터 분리한 Bacillus sp.와 Aspergillus sp.를 이용하여 혼합 발효시킨 후, 동결 건조하여 분쇄 후 분말화 하였다.(중략)

• The Korean Journal of Food And Nutrition
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• v.25 no.3
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• pp.413-418
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• 2012

The purpose of this study is to determine the possibility of using Crataegi fructus as a natural food source. To accomplish this purpose, the contents of general and biological activities were measured. The contents of carbohydrate, crude protein, crude lipid and ash are 85.6%, 2.4%, 1.9% and 0.4%, respeectively. Further, the calories of Crataegi fructus was 369.1 kcal. The contents of essential and non-essential amino acids were 852.26 mg and 1,178.29 mg, respeectively. The K was the largest mineral followed by Ca, P, Mg, which means Crataegi fructus is an alkali material. Crataegi fructus extracts slightly(17.6~32.8) inhibited ${\alpha}$-glucosidase activity. However, there is no inhibitory activity against ${\alpha}$-amylase. In terms of proteslytic activity, Crataegi fructus extracts showed a strong activity than pancreatin(used as a positive control). These results indicate that Crataegi fructus can be used as a natural resource for material aiding digestion.

• Journal of the Korean Applied Science and Technology
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• v.39 no.1
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• pp.108-114
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• 2022

In this study, the antioxidant effect of black sea ginseng containing a large amount of eicosapentaenoic acid, a natural physiologically active substance, was investigated, and its superiority as a functional cosmetic raw material was presented. The ability of the sea cucumber extract to remove active oxygen was evaluated for the inhibitory effect on intracellular nitric oxide (NO) production. The physiologically active substances of sea cucumber have an antioxidant effect that removes free radicals, and as a result of evaluation, it was confirmed that excellent NO production was suppressed. Studies have shown that bioactive substances are involved in antioxidant effects, immune and inflammatory response regulation by showing high antioxidant efficacy even at low concentrations. It is thought that the antioxidant removal ability of sea cucumber greatly contributes to the antioxidant efficacy of phenolic components containing EPA (eicosapentaenoic acid) of the sea cucumber extract. It was found to be similar to the report that the antioxidant component of sea cucumber works. In addition, it is excellent for wound healing with the eicosapentaenoic acid (EPA) component contained in a large amount of sea cucumber extract, which has been proven to be involved in the inhibitory effect of inflammatory activity. As a result of this study, it was confirmed that the effect of the phenol component contained in the sea cucumber extract had a close causal relationship with the antioxidant activity.

• Microbiology and Biotechnology Letters
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• v.28 no.2
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• pp.97-104
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• 2000

Screening of Biologically Active Essential Oils from Ligusticum tenuissimum. Kim, Min-Hae, Young-Gil Kim, Jin-Ha Lee, Keo-Pyo Hong, Jung-Ki Hong, Young-Joon Kong, and Hyeon-Yong Lee*. Division of Food and Biotechnology, Kangwon National University, Chunchon 200-701, Korea, 1 Regional Crop Development Station, Kangwon Agricultural Research & Extension Services, Chunchon 200-150, Korea-The biological activities of the crude essential oils from Ligusticum tenuissimum and the control(phthalic anhydride) were compared. About 60% of the growth of MCF7, A549, and Rep3B cells were inhibited by adding 1.0 mg/ml of the crude essential oils and below 40% was observed by the control. Cytotoxicity on human normal lung cell(IMR90) was scored as 34.4% for the crude oil and 26.4% for control, respectively. It was found that the crude essential oils were more effective than the control in anti mutagenecity tested by both Rec-assay and CRG V79 cells. The growth of human T-cell(Jurkat) was enhanced up to 1.21 times by adding the crude essential oil compared with the control. 50% of a-glucosidase activity was inhibited by both the crude essential oil and the control. ACE activities were inhibited 80.1 % and 65.3% by adding 1.0 mg/ml of the crude oil and the control, respectively. The higher enhancement of glutathione-S-transferase activity was observed in the crude oil than those in the control: 301 % v.s 234% at 1.0 mg/ml of the treatment. Thrombolytic activity was measured as 42.9% and 28.6% for the crude oil and the standard, respectively. The effect of the oil on the nerve cells PCI2, was observed as follows: the neurite of PCl2 cells was lengthened up to 255 /-lm longer than 205 /-lm of control. The number of neurite-bearing cells were about two times higher than control. The survival ratio of the crude essential oil was also increased up to 56.4% which was about two fold higher than in control.

• Journal of Mushroom
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• v.18 no.4
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• pp.403-409
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• 2020

This study was carried out to investigate the changes in the biological activity and nutritional content of Flammulina velutipes, Grifola frondosa, and Sparassis crispa extracts after roasting treatment. Regarding biological activities, the DPPH radical scavenging activity was the highest in the extracts of air-dried G. frondosa, while the nitrite scavenging activity was significantly higher in the extracts of roasted S. crispa (p<0.05). The total polyphenol contents of F. velutipes and S. crispa were significantly increased by the roasting treatment compared with those in fresh samples (p<0.05). Regarding the amino acid composition of edible mushrooms, the content of sweet-taste amino acids, including serine (Ser) and alanine (Ala), increased in G. frondosa after roasting, whereas bitter amino acids, including decreased in roasted versus samples. Moreover, the contents of essential amino acids such as leucine (Leu), isoleucine (Ile), methionine (Met), valine (Val), and histidine (His) in F. velutipes and S. crispa were increased due to the roasting treatment (versus fresh samples). Thus, it was confirmed that the r method is effective in improving the nutritional content of edible mushrooms.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2019.10a
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• pp.86-86
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• 2019

• Food preservation and processing industry
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• v.8 no.1
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• pp.8-9
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• 2009

• Korean Journal of Food Science and Technology
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• v.52 no.1
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• pp.75-80
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• 2020

This study was conducted to compare the functional component content, antioxidant activity, and nitric oxide (NO) inhibition effect of non-enzyme treated, enzyme-treated, and commercial noni juice samples. Enzyme-treated noni juice samples were prepared by cellulase (0.1%) and pectinase (0.1%) treatment of unripe fruits (EUN) and ripe fruits (ERN). Total polyphenol content of the noni juice samples ranged between 0.36 and 1.61 mg/mL. The EUN had the highest total polyphenol content (1.61 mg/mL), while the ERN had the highest scopoletin content (123.88 ㎍/mL) and the highest antioxidant activity. Nitric oxide levels in ERN and NJ5 were lower (55.95 and 60.14%, respectively) than those in other samples. Based on these observations, it was confirmed that enzyme treatment could improve the functional component content and physiological activity of noni juice. In particular, EUN prepared using the ripened noni fruit is expected to have greater utilization value due to its enhanced functionality.

• Journal of Sericultural and Entomological Science
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• v.41 no.S2
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• pp.21-42
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• 1999

뽕잎의 지금까지 박ㄹ혀진 생리활성은 중금속 흡착과 해독효과, 황산화 효과, 혈중지질 억제효과 및 혈당강하 효과를 들 수 있는데, 요약하면 다음과 같다. 1) 뽕잎이 Cd과 Pb같은 중금속에 대한 흡착 및 해독작용에 미치는 영향을 조사해 본 결과, 납중독으로 인하여 감소된 Hb와 Haematocritcl가 뽕잎 투여로 증가되었고 특히 gpa합성에 관여하는 DALAD효소 활성을 증가시켰다. 또한 뇨로의 Pb의 배설 효과가 뽕잎 투여로 증진되었으며 각 조직으로의 Pb축적을 감소시켰다. Cdwndehr으로 중독시킨 흰쥐에서도 감소된 Hd와 Haematocritcl가 뽕잎투여로 증가되었고, 특히 간조직 중의 Cd축적을 61%로 감소시켜 유의성있게 감소시켰다. 또한 뽕잎투여로 인하여 변으로의 Cd의 배설효과는 38%였고 이는 녹차투여 효솨보다는 낮은 수준이었다. 2)뽕잎의 향산화 효과는 녹차와 거의 비슷하였고 특히 혐기 처리함으로써 그 활성이 증가하였다. 또한 뽕잎중의 황산화 활성 성분은 10여종 flavonoidfb 이었고 그 중 quercetin이 가장 높은 황산화 활성을 나타냈다. 특히 dlavonidfb 화합물 중 kaempferol계열의 화합뭉이 황산화 효과가 높음을 알수 있었다. 3) 뽕잎의 고지혈 억제작용에 미치는 영향을 알아본 결과 뽕잎은 혈중 총 콜레스테롤이 차지하는 비율을 보였고 특히 혈중 중성지질 함량을 감소시킴으로써 정상의 80%수준까지 회복시켰다. 또한 콜레스테롤 생합성에 관여하는 효소활성을 뽕잎의 메탄올 추출물 중 물분획뭉이 59.9%수준으로 억제시켰고 지방분해효소 활성은 유의적인 수준은 아니었지만 16% 증가시켰다. 4) 뽕잎의 혈당강하 효과는 뽕잎을 질소가스를 이용하여 혐기처리하는 경우 유의적으로 그 효과가 증강되었다. 또한 뽕잎은 대조약물인 acarbose의 10배 용량에서 대조약물보다 23% 이상의 혈당강하 효과를 나타냈다. 이들의 혈당강하 효과는 같은 농도에서 인슐린 함량을 27%회복시켰으며 특히 surcrose와 maltose와 같은 이당류를 부하시켰을 때 혈당 강하 효과는 유의적이었다. 이는 뽕잎의 혈당강화 효과는 인슐린생합성 증가에 의한 것보다는 glucosidase의 활성을 억제시키는 기전이 더 많이 관여하는 것으로 판단할수 있었다. 또한 뽕잎 중의 혈당강하 성분으로 알려진 1-deoxynojirimycin 함량은 혐기처리로 인하여 그 함량이 5%정도 증가됨을 확인할 수 있었다. 이러한 뽕잎의 생리활성 결과에 기초할 때, 뽕잎은 고지혈증을 포함한 성인병 질환의 예방과 회복에 관련되는 조절기능을 생체에 충분히 발휘할수 있는 기능성 식품의 중요한 자원으로 이용될 수 있으리라 판단된다.