• Journal of Life Science
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• v.18 no.4
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• pp.580-584
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• 2008

$O^6-methylguanine-DNA$ methyltransferase (MGMT) is a DNA repair protein that protects cells against the carcinogenic effects of alkylating agents. The loss of MGMT expression was commonly known due to hypermethylation of CpG islands in its promoter region. We evaluated the expression of MGMT by immunohistochemistry in order to examine the relationship between loss of MGMT expression and clinicopathological characteristics in 74 Korean patients with non-small cell lung cancers. Loss of MGMT was detected in 25 (33.8%) of 74 cases. The loss of MGMT expression was frequently seen in the adenocarcinoma than in the squamous cell carcinoma (p=0.021). However, there was no significant differences between loss of MGMT expression and other clinicopathological characteristics, including age, gender, smoking status, tumor size, tumor T stage, and lymph node metastasis (p>0.05). In conclusion, loss of MGMT expression was related with the histologic type of lung cancer. Further methylation study of MGMT promoter is needed to evaluate the relationships with immunohistochemical expression of MGMT and to clarify the role of MGMT in lung cancer.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.3
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• pp.247-254
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• 2021

Acne vulgaris is a chronic inflammatory skin disease related to pilosebaceous unit. In acne lesions, hyperseborrhea, dysseborrhea, inflammatory event, and an imbalance in skin microflora, particularly an increase in Cutibacterium acnes (C. acnes) colonization comparing to other bacteria, have been observed. The objective of this study was to evaluate anti-acne effects of Artemisia annua extract (AAE) on antibacterial activity related to preservation of the balance in skin microbiome, inhibition of inflammation, and reduction of excessive sebum production. When C. acnes and Staphylococcus epidermidis (S. epidermidis) were co-cultured in the presence of AAE, the reduction of C. acnes growth by AAE was greater than that of S. epidermidis. In addition, when C. acnes was cultured in a medium containing AAE (C. acnes AAE), levels of cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-6 and toll-like receptors-2 activity were decreased in comparison with C. acnes cultured in a medium without AAE (C. acnes CM). Moreover, AAE significantly inhibited excessive sebum production induced by palmitic acid. These results suggest that AAE, as a natural extract with various targets, can inhibit selective growth of C. acnes and inflammatory reactions derived from C. acnes, which are the main causes of acne, and consequently can be used as a substance to alleviate acne by reducing excessive sebum formation.

• Korean Journal of Family Social Work
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• no.58
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• pp.67-96
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• 2017

The purpose of this study is to examine psychological difficulties that elderly women experience in each divorce decision making stage and they are shown by counselling cases made with elderly women who got divorced in their early stage of elderly life. For this purpose, total 18 counseling cases were collected from November 2012 to March 2013 and a qualitative analysis was made accordingly. The result of this study was made by analyzing meaningful subjects emerged in individual testimonies during a counseling process and it shows that the decision to divorce goes through stages such as , , , , , and . In addition, psychological difficulties experienced in a divorce decision process appear to be, , , , , , and . It is meaningful that this study provides counseling strategies for psychosocial support of the elderly women who go through difficulties in their divorce decision making process.

• The Korean Journal of Applied Statistics
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• v.32 no.2
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• pp.213-227
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• 2019

In this paper, we propose an end-to-end deep learning model combining Bayesian neural network with Korean speech recognition. In the past, Korean speech recognition was a complicated task due to the excessive parameters of many intermediate steps and needs for Korean expertise knowledge. Fortunately, Korean speech recognition becomes manageable with the aid of recent breakthroughs in "End-to-end" model. The end-to-end model decodes mel-frequency cepstral coefficients directly as text without any intermediate processes. Especially, Connectionist Temporal Classification loss and Attention based model are a kind of the end-to-end. In addition, we combine Bayesian neural network to implement the end-to-end model and obtain Monte Carlo estimates. Finally, we carry out our experiments on the "WorimalSam" online dictionary dataset. We obtain 4.58% Word Error Rate showing improved results compared to Google and Naver API.

• Journal of radiological science and technology
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• v.44 no.2
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• pp.117-122
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• 2021

This study is desinged to examine for radiation protection effect of Protaetia Brevitarsis Larvae extracts on the blood and prostate of male rat as a natural radiation protection agent. 5 groups were classified using 90 male rat as experimental animals. Each group was clssified as normal control group (NC Group), the group administered protaetia brevitarsis larvae extracts (PBE Group), irradiated group (IR Group), irradiated group after administration of protaetia brevitarsis larvae extracts (PBE+IR Group), the group administered protaetia brevitarsis larvae extracts after irradiaton (IR+PBE Group). In IR Group, 7 Gy/h of Co-60 gamma ray was irradiated to SD rats. In PBE+IR Group, protaetia brevitarsis larvae extacts wewe injected at 200 mg/kg/day for 14 days before irradiation, In IR+PBE Group, protaetia brevitarsis larvae extract was injeted after irradiation. On the 1, 7 and 21 days after irradiation, the experimental animals were sacrificed to evaluate the changes in blood cell component, superoxide dismutase (SOD) activity, histopathological evaluation of the liver and prostate gland. As a result, the PBE+IR Group and IR+PBE Group showed a significantly recovery of white blood cell (p<0.01, p<0.01), platelet (p<0.01, p<0.01) than the IR Group. It was also confirmed that SOD activity of PBE+IR Group (p<0.01) and IR+PBE Group (p<0.01) was significantly increased than the IR Group. Also PBE+IR Group and IR+PBE Group showed less inflammatory reactions of cystoplasm in the prostate gland than the IR Group. In conclusion, the protaetia brevitarsis larvae have radioprotection effect against blood and prostate gland. It is expected to be useful for research of radiation protection agent.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.2
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• pp.90-98
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• 2011

This study aims to discuss the characteristics of garden architecture in Italian Renaissance Villa Lante that was constructed by the cardinal in Bagnaia at 16th century through actual survey and analysis of the garden's elements. To do this, it was studied in two ways: Analysis of the present conditions and review historical documents. The results are as follows. First, the buildings, the gardens and the surrounding landscapes are visually connected each other in relations between the topography and the surrounding landscapes. Second, the spatial composition accepted Neoplatonic law of multiple proportions and was influenced by ancient myth and "Liber ruralium commodorum" of Pietro de Crescenzi(1305). Third, the garden's elements consist of plants, buildings and items. In plants, the upper plants are fir tree, cypress and pine tree and the lower plants are english holly, box tree and sweet oleander. The buildings are casino, loggia and terrace. The items are pot, sundial, chair, viewing platform and fountain. The result of this study, the political and social, technical phenomena which constitute construction pattern affected the locational property and the spatial organization of the neighbor on Villa Lante.

• FLOWER RESEARCH JOURNAL
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• v.26 no.4
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• pp.209-215
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• 2018

The survey conducted with 120 florists in Korean domestic flower shops to investigate the use and awareness of floral preservatives in Korea. As a result, only 19.8% of the domestic florists use floral preservatives frequently in their shops, whereas 45.5% do not use them at all, suggesting very low use frequency. Korean domestic florists considered the use of floral preservatives mostly for storing cut flowers to preventing bacteria growth. For the reasons not to use floral preservatives, 51.4% of the Korean domestic florists did not value its usefulness, showing a lack of awareness of floral preservatives. However, 44.2% of the florists who had the experience with floral preservatives satisfied with the effect of floral preservatives, and 49.5% of the respondents positively answered to recommend floral preservatives to others. General awareness on floral preservatives among Korean domestic florists was positive. 50.5% of the florists with the experience with the floral preservative had the high intention to re-purchase the flower preservatives. The low use frequency and lack of recognition of floral preservatives in Korea were likely due to very few floral preservative brands and little advertising. However, the high satisfaction level and repurchase intention rate shown by the florists indicates that increasing advertising and education for the floral preservatives would improve the accessibility and awareness of the products and their effects increasing the opportunity to use floral preservatives among Korean domestic florists, further enhancing consumers' satisfaction by improving the cut flower quality and its vase life.

• Journal of radiological science and technology
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• v.46 no.1
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• pp.1-8
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• 2023

As the demand for bone mineral density testing increases in Korea, which is close to an aging society, it is necessary to evaluate the repeatability of equipment such as femur phantom other than l-spine for more accurate diagnosis. However, in clinical practice, it is often not possible to proceed such evaluation due to insufficient quality control conditions. Therefore, this study is to evaluate the usefulness of the femur phantom after fabricating the same using 3D printing technology. The femur phantom was output using GlowFill filament and FDM 3D printing type. Each phantom was repeatedly scaned 20 times to compare whether the existing l-spine phantom and the fabricated femur phantom were suitable as a phantom for quality control. Each time the seven researchers took three times, the location of the femur phantom was readjusted, and then scanned to confirm the error between the researchers. As a result of conducting repeatability evaluation using femur phantom, the coefficient of variation rate was 2%, which was within the minimum precision tolerance of 2.5%. The reproducibility between the researcher was also found to be suitable as the average coefficient of variation was 0.031 and the coefficient of variation rate was 3.1%, which was within the minimum precision error range of 5%. In conclusion, it is considered that the prospective attitude and usefulness of the femur phantom fabricated by 3D printing in clinical practice will be sufficient.

• Journal of the Korean Society of Radiology
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• v.17 no.6
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• pp.843-849
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• 2023

This study attempted to determine the optimal algorithm after quantitatively analyzing noise, SNR, and CNR measurements by reconstructing four algorithms (Standard, Soft, Bone, and Detail) from head and neck CT images of patients who underwent implant surgery. As an analysis method, pixel values were calculated through the region of interest in the reconstructed image using the Image J program. For noise, SNR, and CNR, the region of interest was measured at the location of the pharynx, masseter muscle, and parotid gland in the image, and the mean and SD values were obtained. The values of SNR and CNR were calculated based on the given formula. As a result, the standard algorithm showed the lowest noise and the highest SNR. CNR was highest in the Soft algorithm, but showed no significant difference from the Standard algorithm. Therefore, it is believed that the Standard algorithm is the optimal algorithm for examining patients wearing intraoral implants in head and neck CT examinations. We hope that the data from this study will be used as basic data for image evaluation in head and neck CT examinations, and that the quality of images will be further improved through various algorithm changes. It is believed that this will be an opportunity to do so.

• Progress in Medical Physics
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• v.25 no.3
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• pp.167-175
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• 2014

The purpose of this study is to evaluate the variation of the dose which is delivered to the patients with glottis cancer under IMRT (intensity modulated radiation therapy) by using the 3D registration with CBCT (cone beam CT) images and the DIR (deformable image registration) techniques. The CBCT images which were obtained at a one-week interval were reconstructed by using B-spline algorithm in DIR system, and doses were recalculated based on the newly obtained CBCT images. The dose distributions to the tumor and the critical organs were compared with reference. For the change of volume depending on weight at 3 to 5 weeks, there was increased of 1.38~2.04 kg on average. For the body surface depending on weight, there was decreased of 2.1 mm. The dose with transmitted to the carotid since three weeks was increased compared be more than 8.76% planned, and the thyroid gland was decreased to 26.4%. For the physical evaluation factors of the tumor, PITV, TCI, rDHI, mDHI, and CN were decreased to 4.32%, 5.78%, 44.54%, 12.32%, and 7.11%, respectively. Moreover, $D_{max}$, $D_{mean}$, $V_{67.50}$, and $D_{95}$ for PTV were increased or decreased to 2.99%, 1.52%, 5.78%, and 11.94%, respectively. Although there was no change of volume depending on weight, the change of body types occurred, and IMRT with the narrow composure margin sensitively responded to such a changing. For the glottis IMRT, the patient's weight changes should be observed and recorded to evaluate the actual dose distribution by using the DIR techniques, and more the adaptive treatment planning during the treatment course is needed to deliver the accurate dose to the patients.