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Flavonoid Biosynthesis: Biochemistry and Metabolic Engineering (Flavonoid 생합성:생화학과 대사공학적 응용)

  • Park, Jong-Sug;Kim, Jong-Bum;Kim, Kyung-Hwan;Ha, Sun-Hwa;Han, Bum-Soo;Kim, Yong-Hwan
    • Journal of Plant Biotechnology
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    • v.29 no.4
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    • pp.265-275
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    • 2002
  • Flavonoid biosynthesis is one of the most extensively studied areas in the secondary metabolism. Due to the study of flavonoid metabolism in diverse plant system, the pathways become the best characterized secondary metabolites and can be excellent targets for metabolic engineering. These flavonoid-derived secondary metabolites have been considerably divergent functional roles: floral pigment, anticancer, antiviral, antitoxin, and hepatoprotective. Three species have been significant for elucidating the flavonoid metabolism and isolating the genes controlling the flavonoid genes: maize (Zea mays), snapdragon (Antirrhinum majus) and petunia (Prtunia hybrida). Recently, many genes involved in biosynthesis of flavonoid have been isolated and characterized using mutation and recombinant DNA technologies including transposon tagging and T-DNA tagging which are novel approaches for the discovery of uncharacterized genes. Metabolic engineering of flavonoid biosynthesis was approached by sense or antisense manipulation of the genes related with flavonoid pathway, or by modified expression of regulatory genes. So, the use of a variety of experimental tools and metabolic engineering facilitated the characterization of the flavonoid metabolism. Here we review recent progresses in flavonoid metabolism: confirmation of genes, metabolic engineering, and applications in the industrial use.

A Field Research on Multi-Language Sign System in Hospital at the Point of View in Convergent Study - Focused on General Hospital in Busan and South Gyeongsang Province - (융합적 관점에서 본 병원 사인시스템 다중언어 표기 현황 조사 - 부산 및 경남지역 의료기관을 중심으로 -)

  • Park, Han Na;Paik, Jin Kyung
    • Korea Science and Art Forum
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    • v.37 no.1
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    • pp.87-97
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    • 2019
  • The study began in recent years with the aim of grasping the nation's medical status following the fast-growing trend of international medical tourism and attracting foreign patients, among other things, Busan, which ranks second in attracting foreign patients after the nation's capital, Seoul, has been highly active in the past eight years, with foreign patients rising by about 426 percent, and Russian patients entering the sea. In addition, Gimhae and Changwon, the Busan-based Gyeongsangnam-do region, ranked first and second in number of foreign residents, and are inhabited by a variety of foreign workers. Medical institutions, such as hospitals, should be able to find directions within hospitals. It is also a space where information in various languages, including Korean, English, Chinese, or Russian, must be delivered in a single medium. Based on this research, the purpose of this research is to provide converged information that helps foreigners who are not familiar with Korean language easily understand the proposed recognition system when visiting hospitals. Therefore, this paper is applied to a multi-language survey of six medical institutions (A, B, C, D, E, F) at the university hospital in Busan, and 10 medical institutions (R, J) in Gimhae, South Gyeongsang Province with high foreign residents. Research results and contents are as follows. First, the results of analyzing the design of the sinusoidal system show that the font uses colorless Gothic fonts, arrows, and pictograms to introduce the design of a typical hospital sign system. Second, the results of the multi-lingual situation were found to have only two languages in the system, such as Korean and English, and to have four languages, including Korean, English, Chinese, and Russian, according to their geographical location. However, it was judged that most medical institutions currently have only two languages (Korean, English) that may cause some discomfort in terms of language for foreign patients in non-English speaking countries. Based on these findings, it is necessary to propose designs that are considered by Koreans as well as foreign users in the use of multilingual hospital sign systems.

Exhibition Hall Lighting Design that Fulfill High CRI Based on Natural Light Characteristics - Focusing on CRI Ra, R9, R12 (자연광 특성 기반 고연색성 실현 전시관 조명 설계 - CRI Ra, R9, R12를 중심으로)

  • Ji-Young Lee;Seung-Teak Oh;Jae-Hyun Lim
    • Journal of Internet Computing and Services
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    • v.25 no.4
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    • pp.65-72
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    • 2024
  • To faithfully represent the intention of the work in the exhibition space, lighting that provides high color reproduction like natural light is required. Thus, many lighting technologies have been introduced to improve CRI, but most of them only evaluated the general color rendering index (CRI Ra), which considers eight pastel colors. Natural light provides excellent color rendering performance for all colors, including red and blue, expressed by color rendering index of R9 and R12, but most artificial lighting has the problem that color rendering performance such as R9 and R12 is significantly lower than that of natural light. Recently, lighting technology that provides CRI at the level of natural light is required to realistically express the colors of works including primary colors but related research is very insufficient. Therefore this paper proposes exhibition hall lighting that fulfills CRI with a focus on CRI Ra, R9, and R12 based on the characteristics of natural light. First reinforcement wavelength bands for improving R9 and R12 are selected through analysis of the actual measurement SPD of natural and artificial lighting. Afterward virtual SPDs with a peak wavelength within the reinforcement wavelength band are created and then SPD combination conditions that satisfy CRI Ra≥95, R9, and R12≥90 are derived through combination simulation with a commercial LED light source. Through this, after specifying two types of light sources with 405,630nm peak wavelength that had the greatest impact on the improvement of R9 and R12, the exhibition hall lighting applied with two W/C White LEDs is designed and a control Index DB of the lighting is constructed. Afterward experiments with the proposed method showed that it was possible to achieve high CRI at the level of natural light with average CRI Ra 96.5, R9 96.2, and R12 94.0 under the conditions of illuminance (300-1,000 Lux) and color temperature (3,000-5,000K).

Designing a Writing Support System Based on Narrative Comprehension of Readers (독자의 내러티브 이해를 반영한 창작 지원 시스템 설계)

  • Kwon, Hochang;Kwon, Hyuk Tae;Yoon, Wan Chul
    • Journal of the HCI Society of Korea
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    • v.9 no.2
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    • pp.23-31
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    • 2014
  • A variety of writing support systems focus on the information management or the feature analysis of the commercially successful narrative texts. In these approaches, the reader's role in the narrative creating process is overlooked. During a writing work, an author anticipates the reader's response or expectation to the narrative and he/she organizes the narrative either along or against the prediction about readers. Assessing and controlling the reader's comprehension in the development of events influences the aesthetic quality of the narrative. In this paper, we suggest a writing support system to visualize and adjust the characteristics of a narrative text related to the reader's comprehension, which is theoretically based on the narrative structure model and the event-indexing situation model. Under the development of the support system, we designed an interactive framework to create events as the basic units of story and arrange them onto both story- and discourse-time axes. Using this framework, we analyzed the organization of events about an actual film narrative. We also proposed both the continuity of the situational dimensions and the cognitive complexity as the characteristics to affect the reader's comprehension, hence we devised a method to visualize and evaluate them. This method was applied to the actual film narrative and the result was discussed in the aspect of the features of the narrative and wiring support strategies.

Efficient Object Localization using Color Correlation Back-projection (칼라 상관관계 역투영법을 적용한 효율적인 객체 지역화 기법)

  • Lee, Yong-Hwan;Cho, Han-Jin;Lee, June-Hwan
    • Journal of Digital Convergence
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    • v.14 no.5
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    • pp.263-271
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    • 2016
  • Localizing an object in image is a common task in the field of computer vision. As the existing methods provide a detection for the single object in an image, they have an utilization limit for the use of the application, due to similar objects are in the actual picture. This paper proposes an efficient method of object localization for image recognition. The new proposed method uses color correlation back-projection in the YCbCr chromaticity color space to deal with the object localization problem. Using the proposed algorithm enables users to detect and locate primary location of object within the image, as well as candidate regions can be detected accurately without any information about object counts. To evaluate performance of the proposed algorithm, we estimate success rate of locating object with common used image database. Experimental results reveal that improvement of 21% success ratio was observed. This study builds on spatially localized color features and correlation-based localization, and the main contribution of this paper is that a different way of using correlogram is applied in object localization.

A Study of Gamma-ray Irradiation Effects on Commercially Available Single-mode Optical Fiber (국내외 상용 단일모드 광섬유의 감마선 영향 분석 연구)

  • Kim, Jong-Yeol;Lee, Nam-Ho
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2012.05a
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    • pp.564-567
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    • 2012
  • Optical fibers are going to be used for telecommunication, image fibers, sensors under irradiation in nuclear power plants and various irradiation facilities. Especially, Temperature detection sensors using Raman light scattering, temperature or strain sensors using fiber gratings, magnet-optical sensors using photo-magnetic effect, are already commercialized. However, When fibers are exposed to ionizing radiation, color centers are formed in fibers which reduces their light transmission, and it is limited in applying under radiation environments. In this study, $Co^{60}$ gamma-ray induced optical attenuation on Ge-doped single mode(SM) fiber has been measured. Gamma-ray is irradiated for 4hours at the dose rate of 0.5kGy/hr, 2kGy/hr, 8kGy/hr. Consequently, gamma-ray induced loss based on radiation effects in Ge-doped SM fiber occur precisely. Furthermore, dose rate effect that the higher dose rate in the same total dose, the more increase loss of optical fiber and annealing effect that the higher the loss after irradiation, the more increase the recovery rate of the loss are observed in the fiber. This results plan to make use of bases in the study of the radiation-hardened optical fiber.

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Experimental Proof for Symmetric Ramsey Numbers (대칭 램지 수의 실험적 증명)

  • Lee, Sang-Un
    • Journal of the Korea Society of Computer and Information
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    • v.20 no.3
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    • pp.69-74
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    • 2015
  • This paper offers solutions to unresolved $43{\leq}R(5,5){\leq}49$ and $102{\leq}R(6,6){\leq}165$ problems of Ramsey's number. The Ramsey's number R(s,t) of a complete graph $k_n$ dictates that n-1 number of incidental edges of a arbitrary vertex ${\upsilon}$ is dichotomized into two colors: (n-1)/2=R and (n-1)/2=B. Therefore, if one introduces the concept of distance to the vertex ${\upsilon}$, one may construct a partite graph $K_n=K_L+{\upsilon}+K_R$, to satisfy (n-1)/2=R of {$K_L,{\upsilon}$} and (n-1)/2=B of {${\upsilon},K_R$}. Subsequently, given that $K_L$ forms the color R of $K_{s-1)$, $K_S$ is attainable. Likewise, given that $K_R$ forms the color B of $K_{t-1}$, $K_t$ is obtained. By following the above-mentioned steps, $R(s,t)=K_n$ was obtained, satisfying necessary and sufficient conditions where, for $K_L$ and $K_R$, the maximum distance should be even and incidental edges of all vertices should be equal are satisfied. This paper accordingly proves R(5,5)=43 and R(6,6)=91.

A Study on the Recognition Algorithm of Paprika in the Images using the Deep Neural Networks (심층 신경망을 이용한 영상 내 파프리카 인식 알고리즘 연구)

  • Hwa, Ji Ho;Lee, Bong Ki;Lee, Dae Weon
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2017.04a
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    • pp.142-142
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    • 2017
  • 본 연구에서는 파프리카를 자동 수확하기 위한 시스템 개발의 일환으로 파프리카 재배환경에서 획득한 영상 내에 존재하는 파프리카 영역과 비 파프리카 영역의 RGB 정보를 입력으로 하는 인공신경망을 설계하고 학습을 수행하고자 하였다. 학습된 신경망을 이용하여 영상 내 파프리카 영역과 비 파프리카 영역의 구분이 가능 할 것으로 사료된다. 심층 신경망을 설계하기 위하여 MS Visual studio 2015의 C++, MFC와 Python 및 TensorFlow를 사용하였다. 먼저, 심층 신경망은 입력층과 출력층, 그리고 은닉층 8개를 가지는 형태로 입력 뉴런 3개, 출력 뉴런 4개, 각 은닉층의 뉴런은 5개로 설계하였다. 일반적으로 심층 신경망에서는 은닉층이 깊을수록 적은 입력으로 좋은 학습 결과를 기대 할 수 있지만 소요되는 시간이 길고 오버 피팅이 일어날 가능성이 높아진다. 따라서 본 연구에서는 소요시간을 줄이기 위하여 Xavier 초기화를 사용하였으며, 오버 피팅을 줄이기 위하여 ReLU 함수를 활성화 함수로 사용하였다. 파프리카 재배환경에서 획득한 영상에서 파프리카 영역과 비 파프리카 영역의 RGB 정보를 추출하여 학습의 입력으로 하고 기대 출력으로 붉은색 파프리카의 경우 [0 0 1], 노란색 파프리카의 경우 [0 1 0], 비 파프리카 영역의 경우 [1 0 0]으로 하는 형태로 3538개의 학습 셋을 만들었다. 학습 후 학습 결과를 평가하기 위하여 30개의 테스트 셋을 사용하였다. 학습 셋을 이용하여 학습을 수행하기 위해 학습률을 변경하면서 학습 결과를 확인하였다. 학습률을 0.01 이상으로 설정한 경우 학습이 이루어지지 않았다. 이는 학습률에 의해 결정되는 가중치의 변화량이 너무 커서 비용 함수의 결과가 0에 수렴하지 않고 발산하는 경향에 의한 것으로 사료된다. 학습률을 0.005, 0.001로 설정 한 경우 학습에 성공하였다. 학습률 0.005의 경우 학습 횟수 3146회, 소요시간 20.48초, 학습 정확도 99.77%, 테스트 정확도 100%였으며, 학습률 0.001의 경우 학습 횟수 38931회, 소요시간 181.39초, 학습 정확도 99.95%, 테스트 정확도 100%였다. 학습률이 작을수록 더욱 정확한 학습이 가능하지만 소요되는 시간이 크고 국부 최소점에 빠질 확률이 높았다. 학습률이 큰 경우 학습 소요 시간이 줄어드는 반면 학습 과정에서 비용이 발산하여 학습이 이루어지지 않는 경우가 많음을 확인 하였다.

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GIS-based Water Pollution Analysis (GIS기반의 오폐수 분석에 관한 연구)

  • Lee, Chol-Young;Kim, Kye-Hyun;Park, Tae-Og
    • 한국공간정보시스템학회:학술대회논문집
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    • 2007.06a
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    • pp.111-116
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    • 2007
  • 현재 한강수계를 제외한 3대강 수계에서 수질오염총량관리제도가 의무제로써 시행되고 있다. 그러나 과학적 타당성과 외국의 성공사례들로 하여금 한강수계에 대해서도 수질오염총량제도를 의무제화 하려는 시도가 추진되고 있고 있는 실정이다. 이 제도가 한강수계에도 도입된다면, 한강권역에 포함되는 모든 지자체는 해당 유역에서 하천으로 유입되는 배출부하량을 할당받은 할당부하량 이하로 관리하여야만 정해진 유역의 목표수질을 달성할 수 있으며, 배출부하량 관리를 계획한데로 이행하지 못한 지자체는 범칙금 내지는 행정제재를 받게 된다. 따라서 체계적이고 과학적인 모니터링 및 분석 수단이 필요하다. 이 연구는 환경부 고시 한강기술지침에 의거하여 GIS를 이용하여 인천일대의 오폐수 발생부하량 및 배출부하량을 제시하고 과학적인 오염물질 삭감방안을 모색하는 것을 목적으로 진행되었다. 생활계, 산업계, 축산계, 양식계의 4 가지로 분류된 점오염원과 토지 이용 분류에 따른 비점오염원에 대한 각각의 발생부하량을 GIS를 통해 산정하고, 모든 오염원별로 처리경로를 고려하고 처리시설별, 방법별 삭감 효율을 반영하여 배출부하량을 산정하여 GIS상에서 제시하고 분석하였다. 인천일대는 인근지역에 비해 인구밀도가 높고 산업단지가 발달하여 생활계와 산업계 오염원에 의한 발생부하량 및 배출부하량이 많았으며, 특정 오염물에 대해서는 삭감 계획이 필요함을 확인할 수 있었다. 따라서 수질오염총량관리제도에 대비하고 실제 수질 개선을 위하여 본 연구의 결과를 바탕으로 수질관리를 위한 시스템의 보완 및 삭감계획의 수립에 관한 연구가 필요하다.알 수 있었다. 이상의 결과를 토대로 기존 압출추출방법과 초임계 추출 방법을 비교한 결과 $\gamma$-토코페롤의 농도가 1.3${\~}$1.6배 증가함을 확인할 수 있었다.게 상관성이 있어 앞으로 심도 있는 연구가 더욱 필요하다.qrt{F}}}{\pm}e_0$)에서 단정도실수 및 배정도실수의 역수 제곱근 계산에 필요한 평균 곱셈 횟수를 계산한다 이들 평균 곱셈 횟수를 종래 알고리즘과 비교하여 본 논문에서 제안한 알고리즘의 우수성을 증명한다. 본 논문에서 제안한 알고리즘은 오차가 일정한 값보다 작아질 때까지만 반복하므로 역수 제곱근 계산기의 성능을 높일 수 있다. 또한 최적의 근사 역수 제곱근 테이블을 구성할 수 있다. 본 논문의 연구 결과는 디지털 신호처리, 컴퓨터 그라픽스, 멀티미디어, 과학 기술 연산 등 부동소수점 계산기가 사용되는 분야에서 폭 넓게 사용될 수 있다.>16$\%$>0$\%$ 순으로 좋게 평가되었다. 결론적으로 감농축액의 첨가는 당과 탄닌성분을 함유함으로써 인절미의 노화를 지연시키고 저장성을 높이는데 효과가 있는 것으로 생각된다. 또한 인절미를 제조할 때 찹쌀가루에 8$\%$의 감농축액을 첨가하는 것이 감인절미의 색, 향, 단맛, 씹힘성이 적당하고 쓴맛과 떫은맛은 약하게 느끼면서 촉촉한 정도와 부드러운 정도는 강하게 느낄수 있어서 전반적인 기호도에서 가장 적절한 방법으로 사료된다.비위생 점수가 유의적으로 높은 점수를 나타내었다. 조리종사자의 위생지식 점수와 위생관리

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Scalable RDFS Reasoning using Logic Programming Approach in a Single Machine (단일머신 환경에서의 논리적 프로그래밍 방식 기반 대용량 RDFS 추론 기법)

  • Jagvaral, Batselem;Kim, Jemin;Lee, Wan-Gon;Park, Young-Tack
    • Journal of KIISE
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    • v.41 no.10
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    • pp.762-773
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    • 2014
  • As the web of data is increasingly producing large RDFS datasets, it becomes essential in building scalable reasoning engines over large triples. There have been many researches used expensive distributed framework, such as Hadoop, to reason over large RDFS triples. However, in many cases we are required to handle millions of triples. In such cases, it is not necessary to deploy expensive distributed systems because logic program based reasoners in a single machine can produce similar reasoning performances with that of distributed reasoner using Hadoop. In this paper, we propose a scalable RDFS reasoner using logical programming methods in a single machine and compare our empirical results with that of distributed systems. We show that our logic programming based reasoner using a single machine performs as similar as expensive distributed reasoner does up to 200 million RDFS triples. In addition, we designed a meta data structure by decomposing the ontology triples into separate sectors. Instead of loading all the triples into a single model, we selected an appropriate subset of the triples for each ontology reasoning rule. Unification makes it easy to handle conjunctive queries for RDFS schema reasoning, therefore, we have designed and implemented RDFS axioms using logic programming unifications and efficient conjunctive query handling mechanisms. The throughputs of our approach reached to 166K Triples/sec over LUBM1500 with 200 million triples. It is comparable to that of WebPIE, distributed reasoner using Hadoop and Map Reduce, which performs 185K Triples/sec. We show that it is unnecessary to use the distributed system up to 200 million triples and the performance of logic programming based reasoner in a single machine becomes comparable with that of expensive distributed reasoner which employs Hadoop framework.