• Proceedings of the Mineralogical Society of Korea Conference
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• 2003.05a
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• pp.53-53
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• 2003

남한에 분포하는 현생 화강암류는 트라이아스기-쥬라기의 소위 대보화강암과 백악기-제3기의 불국사화강암으로 분류되어 왔다. 대보조산운동은 대동누층군의 퇴적이후에 일어난 조구조운동을 지칭하므로 트라이아스기의 화강암을 포함하는 대보화강암이라는 명칭은 그와 사실상 직접적인 관계는 없다. 트라이아스기-쥬라기의 화강암은 영덕, 청송 암체 외에는 경상분지 밖에 위치하고 백악기-제3기의 화강암은 속리산, 월악산 암체 외에는 경상분지 안쪽에 주로 분포한다. 트라이아스기-쥬라기의 화강암 중 영광-대전-청주-충주-원주-강릉 방면에 걸쳐 북동-남서 방향으로 분포하는 화강암질 저반은 남한에서 가장 넓은 면적을 차지하는 화강암체지만 신뢰할만한 연대측정 자료가 매우 부족한 실정이다. 이 화강암질 저반에 대해서는 Rb-Sr, K-Ar법이 해답을 주기 어렵다. 예를 들어 청주-음성-증평 지역의 화강암류에 대한 Rb-Sr 전암 자료는 분산이 심하며 약 380 Ma에 해당되는 초시선을 보여 기원물질의 불균질성 내지 불완전한 혼합 효과를 반영하고 있다. 옥천대와 영남육괴에 분포하는 일부 화강암체에 대해 잘못 보고된 Rb-Sr 전암연대 역시 모두 중광물의 U-Pb 연대보다 오래된 값을 보이는 것으로 보아 이들은 생성 당시부터 일정한 $^{87}$ Sr/$^{86}$Sr 초기치를 가지지 않고 Rb/Sr 비에 따른 양(+)의 기울기를 가졌음이 확실하다. 과잉의 방사기원 Ar을 가지거나 폐쇄온도가 낮은 광물들을 대상으로 한 K-Ar 자료 역시 화강암체의 관입편대를 정확하게 지시할 수는 없다. 우리는 이에 대한 연구의 일환으로 충청남도 청원군의 물류센터에서 채취한 중립질의 흑운모화강암 한 시료에 대한 U-Pb 스핀연대측정 결과를 다음과 같이 보고한다. $^{206}$ Pb$^{*}$ /$^{238}$ U age = 174.6$\pm$2.7 Ma $^{207}$ Pb$^{*}$ /$^{235}$ U age = 170.3$\pm$14.6 Ma $^{207}$ Pb$^{*}$ /$^{206}$ Pb sup */ age = 111$\pm$187 Ma 위에서 볼 수 있듯이 청주화강암의 스핀에 대해 콘코던트(concordant)한 연대가 얻어졌으며 자료의 오차, 스핀의 U-Pb계에 대한 폐쇄온도 및 화강암의 솔리더스(solidus)를 고려할 때 $^{206}$ Pb$^{*}$ /$^{238}$ U 연대인 174.6$\pm$2.7 Ma를 관입정치시기로 해석한다. 동일 시료의 흑운모에 대해서는 145 Ma의 Rb-Sr 연대가 얻어졌으며 따라서 관입이후 약 35$0^{\circ}C$까지 대략 1$0^{\circ}C$/Ma의 냉각속도를 구할 수 있었다. 청주화강암의 쥬라기 중기 연대는 영광-대전-청주-충주-원주-강릉 지역의 화강암질 저반이 대동누층군 퇴적 이후에 일어난 지구조 사건과 연관되었을 가능성을 지시하지만 이를 확인하기 위해서는 더 많은 자료가 요구된다. 우리는 현재 충주, 괴산 지역의 화강암체에 대해서도 스핀 연대측정을 수행중에 있으며 이들 자료를 암상을 구분하여 해석한다면 우리나라 중생대 지구조운동에 대한 새로운 사실이 밝혀질 수 있을 것으로 믿는다.

• The Korean Journal of Pancreas and Biliary Tract
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• v.22 no.4
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• pp.165-171
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• 2017

Background/Aim: There is little data on whether plastic stents with a larger diameter are patent for longer than small stents in patients with bile duct cancer. The aim of this study was to compare the stent survival between 7-French (Fr) and 10-Fr plastic stents and evaluate the factors affecting stent survival. Methods: Patients with biliary obstruction due to biliary tract cancer were enrolled at Yonsei University Wonju College of Medicine from January 2010 to October 2014. Results: A total of 215 patients (7-Fr:10-Fr = 89:126 patients) were retrospectively enrolled. The primary tumor sites were common bile duct (n = 111), hilar (n = 45), and ampulla of Vater (n = 59). Rates of stent migration and stent obstruction were not different between the two groups. The median duration of stent survival was 3.3 months in the 7-Fr group and 5.9 months in the 10-Fr group (p = 0.543). The diameter of the stent did not have an effect on stent survival (hazard ratio 1.11, 95% confidence interval 0.71-1.73, p = 0.649). Conclusions: 7-Fr and 10-Fr stents have similar rates of stent migration and stent obstruction. The stent survival of 7-Fr was not inferior to 10-Fr stents in the management of biliary tract cancer.

• The Journal of Korean Academy of Prosthodontics
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• v.57 no.4
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• pp.356-363
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• 2019

A patient who went through maxillectomy can have soft palate defects including oronasal fistulas and suffer from dysphagia and dysarthria due to velopharyngeal insufficiency. This defect causes the food to enter nasal cavity and creates hypernasal sound which debilitates a quality of life. An obturator can rehabilitate the substantial oral tissue defects. The maxillary obturator separates the nasopharynx from the oropharynx during speech and deglutition by closing of the defect. For edentulous obturator patient, it is difficult to obtain proper retention due to reduced peripheral sealing. Therefore, the contours of the defects must be used to maximize the retention, stability, and support. Hollow type obturator can improve physiologic function by reducing weight than the traditional obturator. This case report describes a patient with hemi-maxillectomy who recovers mastication, speech, deglutition, and appearance with a maxillary obturator using physiological border molding of the velopharyngeal area and double-processing method.

• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.291-300
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• 2018

Background: The use of a functionally closed system for the glycerolization and deglycerolization of red blood cells (RBCs) allows for prolonged post-thaw storage for more than 24 hours. The aim of this study was to assess glycerolization and deglycerolization processing for RBCs using a high glycerol method in the automated, closed system provided by Haemonetics ACP 215. Methods: Thirty-five packed RBCs were glycerolized using the ACP 215 to a final concentration of 40% (wt/vol). The units were either frozen as such (n=30) or excess glycerol was removed (n=5) before freezing. After storage at $-80^{\circ}C$, the units were thawed, deglycerolized and resuspended in SAG-M. The frozen-thawed RBCs were stored at $4^{\circ}C$, and analyzed for their stability and in vitro quality. Results: No prefreeze excess glycerol removal units showed significantly less potassium leakage during post-thaw storage compared to the prefreeze excess glycerol removal units. All measurements of the stability and in vitro quality of thawed RBCs prepared from frozen RBCs without the prefreeze removal of excess glycerol during post-thaw storage at $4^{\circ}C$ for 7 days were acceptable to the American Blood Bank Association's standards and European standards. Conclusion: RBCs frozen without prefreeze removal of excess glycerol and the ACP 215 simplifies cryopreservation procedure and increases the stability of frozen-thawed RBCs. This increases the practical applicability of cryopreserved RBCs in blood transfusion practice.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.1
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• pp.9-18
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• 2019

Modular system can be divided into two types based on the methods of resisting load. The one is the open-sided modular system composed of beams and columns. The other is the enclosed modular system composed of panels and studs. Of the Modular systems, the use of open-sided modular system is limited because it consists of closed member sections. In order to solve this problem, Choi et al.(2017) proposed a composite modular system with folded steel members filled with concrete. However, it was assumed in the previous study that the connections between modules are composed of rigid joint. Therefore it didn't identify the effect of connection behavior in structure. This study used finite element analysis to calculate stiffness of the connections in the proposed modular system. The linearization method presented in FEMA 440 is used for seismic performance assessment of structures, considering the connection stiffness computed in this study. The result of analysis shows that the capacity and story drift ratio obtained in the model considering stiffness of connection are less than those in the model not considering connection stiffness. Based on this observation, it is concluded that the stiffness of connection has a considerable effect on structural behavior.

• Journal of agriculture & life science
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• v.50 no.3
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• pp.129-139
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• 2016

Curcumin plays a protective role in brain injury through its anti-oxidant and anti-inflammatory activities. Moreover, peroxiredoxin-5 exerts a protective effect against oxidative stress. The aim of this study was to investigate whether curcumin modulated the peroxiredoxin-5 expression in focal cerebral ischemic animal model. Middle cerebral artery occlusion(MCAO) was performed to induce cerebral ischemic injury in rats. Adult male rats were injected intraperitoneally with vehicle or curcumin(50mg/kg B.W.) 1 h after MCAO and cerebral cortex tissues were collected 24 h after MCAO. Photographs of hematoxylin and eosin staining showed that MCAO induced necrotic changes with scalloped shrunken form and apoptotic changes with nuclear chromatin condensations. However, curcumin treatment attenuated MCAO-induced histopathological changes. Moreover, this study clearly showed that peroxiredoxin-5 expression was decreased in MCAO operated animal with vehicle using a proteomics approach. However, this decrease in peroxiredoxin-5 expression was attenuated by curcumin treatment. Reverse-transcription PCR and Western blot analyses confirmed that curcumin treatment alleviated the MCAO injury-induced decrease in peroxiredoxin-5 expression(p<0.05). These results demonstrated that curcumin regulates peroxiredoxin-5 expression in MCAO animal model. In conclusion, our findings suggest that curcumin exerts a neuroprotective effect in cerebral ischemia by attenuating the MCAO-induced decrease in peroxiredoxin-5 expression.

• Proceedings of KOSOMES biannual meeting
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• 2006.05a
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• pp.129-135
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• 2006

This study was performed to characterize the seasonal variation of water quality and sediment environment from May, 2004 to February, 2006 in 21 stations of Gwangyang bay. Gawngyang bay is located in the middle of south coast of Korea and semi-dosed with Yeosu peninsula, Gwangyang-city and Namhea-do. Water quality at the west coast of Myo-do were highly deteriorated than other stations. At summer season(July 2005), the concentration of the most analytical items were highly detected than other seasons and the lowest concentration was at the winter season(January 2005, February 2006). Especially, DIP and TP were highly detected around the coast of Yeosu industrial complex. N/P ratio were higher than 16 of Redfield ratio in the spring(May 2005) and winter(February 2006) at the surface layer. While at other seasons and most stations were lower than 16 of Redfield ratio. In the survey of sediment environment, ignition loss(IL), chemical oxygen demand(COD) and acid volatile sulfide(AVS) were in the range of $2.51\sim22.10%,\;2.65\sim48.41mg/g-dry\;and\;0.01\sim8.95mg/g-dry$, respectively. COD in surface sediment was highest at summer season AVS was highest at autumn. In sediment, the corelationship coefficients between COD and IL, COD and AVS were 0.65 and 0.44, respectively.

• Sleep Medicine and Psychophysiology
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• v.9 no.1
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• pp.24-33
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• 2002

Objectives: Nasal continuous positive airway pressure (CPAP) corrected elevated blood pressure (BP) in some studies of obstructive sleep apnea syndrome (OSAS) but not in others. Such inconsistent results in previous studies might be due to differences in factors influencing the effects of CPAP on BP. The factors referred to include BP monitoring techniques, the characteristics of subjects, and method of CPAP application. Therefore, we evaluated the effects of one night CPAP application on BP and heart rate (HR) reactivity using non-invasive beat-to-beat BP measurement in normotensive and hypertensive subjects with OSAS. Methods: Finger arterial BP and oxygen saturation monitoring with nocturnal polysomnography were performed on 10 OSAS patients (mean age $52.2{\pm}12.4\;years$; 9 males, 1 female; respiratory disturbance index (RDI)>5) for one baseline night and another CPAP night. Beat-to-beat measurement of BP and HR was done with finger arterial BP monitor ($Finapres^{(R)}$) and mean arterial oxygen saturation ($SaO_2$) was also measured at 2-second intervals for both nights. We compared the mean values of cardiovascular and respiratory variables between baseline and CPAP nights using Wilcoxon signed ranks test. Delta ($\Delta$) BP, defined as the subtracted value of CPAP night BP from baseline night BP, was correlated with age, body mass index (BMI), baseline night values of BP, BP variability, HR, HR variability, mean $SaO_2$ and respiratory disturbance index (RDI), and CPAP night values of TWT% (total wake time%) and CPAP pressure, using Spearman's correlation. Results: 1) Although increase of mean $SaO_2$ (p<.01) and decrease of RDI (p<.01) were observed on the CPAP night, there were no significant differences in other variables between two nights. 2) However, delta BP tended to increase or decease depending on BP values of the baseline night and age. Delta systolic BP and baseline systolic BP showed a significant positive correlation (p<.01), but delta diastolic BP and baseline diastolic BP did not show a significant correlation except for a positive correlation in wake stage (p<.01). Delta diastolic BP and age showed a significant negative correlation (p<.05) during all stages except for REM stage, but delta systolic BP and age did not. 3) Delta systolic and diastolic BPs did not significantly correlate with other factors, such as BMI, baseline night values of BP variability, HR, HR variability, mean SaO2 and RDI, and CPAP night values of TWT% and CPAP pressure, except for a positive correlation of delta diastolic pressure and TWT% of CPAP night (p<.01). Conclusions: We observed that systolic BP and diastolic BP tended to decrease, increase or remain still in accordance with the systolic BP level of baseline night and aging. We suggest that BP reactivity by CPAP be dealt with as a complex phenomenon rather than a simple undifferentiated BP decrease.

• Journal of Chest Surgery
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• v.30 no.7
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• pp.641-646
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• 1997

Understanding of the surgical anatomy of patients with double outlet right ventricle (DORV) is important in the planning of biventricular repair From May 1995 to September 1996, 7 patients underwent biventricular repair for DORV with remote ventricular septal defect. There were 5 males and 2 (tamales. Age at operation varied from 2 to 9 years(mean 3.4$\pm$ 2.7years). Preoperative diagnostic assessment was made by two-dimensional echocardiography and cardiac catheterization. Ventricular septal defect was perimembranous inlet type in all patients. Associated cardiac anomalies were pulmonary atresia in two, pulmonary stenosis in five and tricuspid chordal attachment to zonal septum in five. The operations were performed intraventricular repair and pulmonary enlargement in two, REV operation in two, and Rastelli operation in three. There was no early postoperative deaths and complications. The follow-up period war from 1 month to 18mon1hs, averaging 10: 6.1 months. In the past, we considered the Fontal operation indicative as primary choice when DORV was associated with abnormal tricuspid chordal attachment to the zonal septum, but now we believe that biventricular repair is feasible for those cases by making conal flap or reattachment method. Biventricular repair has theoretic advantages because it estabilishes normal anatomy and physiology, and it was concluded that the precise preoperative evaluation using both echocardiography and cardiac catheterization was essential to the successful surgery.

• Korean Journal of Cleft Lip And Palate
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• v.6 no.1
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• pp.17-25
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• 2003

Correction of the cleft-lip nasal deformity is a difficult task that requires clear understanding of the associated complex anatomy and function as well as the operation time, the selection of an operation method, On the expectation that it helps enhance understanding the current trend of cleft-rhinoplasty, authors analyzed secondary rhinoplasty between 1999 and 2002, In both the unilateral and bilateral cleft lip rhinoplasty, we reviewed the timing of repair, site of correction and it's major technique, incision or approach method, autogenous cartilage graft method, All patients with a septal deviation did not have a septal surgery, We were active in alar and nasal tip surgery and passive in septal and dorsal deformity correction, And for children, we used a conservative method but for adults, we used radical approach, Most surgeries are focused on esthetic goal and we thought that objective evaluation for nasal obstruction was needed for bener and predictable outcome.