• Journal of Chest Surgery
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• v.30 no.7
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• pp.701-707
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• 1997

Although many reseraches have been persued to detect the molecular tumor marker to define the cancer, ideal tumor marker which speak for the characteristics of malignancy and has high sensitivity and specificity is not known. One of the characteristics of the malignant cells is indefinite proliferative potential, in other word, immortality. The expression of telomerase and stabilization of te10meres are con omitant with the attaiunent of immortality in tumor cells; thus the measurement of telomerase activity in clinically obtained tumor samples may provide important information which would be useful as a diagnostic marker to detect immortal cancer cells. Telomerase activity was analyzed in 12 non-small cell . lung cancer cell lines and 41 primary non-small cell lung cancers with the use of a PCR-based assay. All the cell lines and the majority of tumors displayed telomerase activity, but telomerase was not detectable in most of the corresponding pathologically-normal tissues. Telomere length was not correlated with telomerase activity. The present study indicate that measurement of telomerase activity may be useful as a molecular tumor marker in non-small cell lung cancer.

• The korean journal of orthodontics
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• v.28 no.2 s.67
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• pp.189-201
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• 1998

The purpose of this study was to evaluate the characteristics of craniofacial skeleton on orthognathic surgical cases with skeletal Class III malocclusion. For this study, 74 students at the dental college of Chosun University volunteered as a normal occlusion group. They had well-balanced faces and good occlusions with acceptable Class I molar relationship. They had not received orthodontic treatment and had no signs or symptoms of temporomandibular joint dysfunction. 45 malocclusion patients enrolled for orthognathic surgical treatment with skeletal Class III malocclusion at the Department of Orthodontics, College of Dentistry, Chosun University. On the basis of this study. the results of this study were as follows: 1. Skeletal Class III malocclusion was largely due to the overgrowth of mandible in man and the undergrowth of maxilla in woman. 2. The mandible was antero-inferiorly overgrown by large MP-HP angle and large genial angle in orthognathic surgical cases with skeletal Class III malocclusion. And also, upper incisors were severely labioversioned, but on the other hand lower incisors were linguoversioned. 3. In female, lower-third facial height was characteristically shortened in comparison with middle-third facial height and also, lower facial throat angle was small in male.

• The korean journal of orthodontics
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• v.28 no.2 s.67
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• pp.203-217
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• 1998

Sella turcica contains pituitary gland that has influence on craniofacial growth. So, if the volume of sella turcica correlate to the function of Pituitary gland, we can assume that the volume of sella turcica in skeletal Class III patients has some difference to that of normal occlusion group. The purpose of this study was to evaluate the difference of shape and volume of sella turcica between normal occlusion group and Class III patients. The shape of sella turcica was Classified by Inaba method and the volume of sella turcica was measured in lateral and P-A cephalograms by Di Chiro method. To find out the possibility of the volume of sella turcica as diagnostic aid to predict Class III growth pattern, the correlation coefficients between the volume of sella and cephalometric variables were calculated. The results were as follows. 1. The volume of sella turcica in Class III patients is larger than that of normal occlusion groups 2. The volume of sella turcica in female was larger than that of male in Class III patients 3. The volume of sella turcica has close correlation with APDI, ANB, SNA, SNB, ODI, gonial angle, post. cranial base length 4. Sella Index (volume of sella / ant. cranial base length) can be a more accurate indicator that represent Class III growth pattern than volume of sella itself. 5. The morphologic pattern of sella turcica had no significant difference between two groups.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.13 no.6
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• pp.115-121
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• 2013

This paper related with the DSE-MMA (Dithered Sign-Error MMA) that is the simplification of computational arithmetic number in blind equalization algorithm in order to compensates the intersymbol interference which occurs the passing the nonlinear communication channel in the presence of the band limit and phase distortion. The SE-MMA algorithm has a merit of H/W implementation for the possible to reduction of computational arithmetic number using the 1 bit quantizer in stead of multiplication in the updating the equalizer tap weight. But it degradates the overall blind equalization algorithm performance by the information loss at the quantization process compare to the MMA. The DSE-MMA which implements the dithered signed-error concepts by using the dither signal before qualtization are added to MMA, then the improved SNR performance which represents the roburstness of equalization algorithm are obtained. It has a concurrently compensation capability of the amplitude and phase distortion due to intersymbol interference like as the SE-MMA and MMA algorithm. The paper uses the equalizer output signal, residual isi, MD, MSE learning curve and SER curve for the performance index of blind equalization algorithm, and the computer simulation were performed in order to compare the SE-MMA and DSE-MMA applying the same performance index. As a result of simulation, the DSE-MMA can improving the roburstness and the value of every performance index after steady state than the SE-MMA, and confirmed that the DSE-MMA has slow convergence speed which meaning the reaching the seady state from initial state of adaptive equalization filter.

• Tuberculosis and Respiratory Diseases
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• v.41 no.5
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• pp.489-493
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• 1994

Background: Nicotinamide adenine dinucleotide glycohydrolase(NADase) is located on the surface of the cells. It is bound by glycosylphosphatidylinositol(GPI)-linkage, which can be cleaved by bacterial PI-specific phospholipase C(PI-PLC). Recently, it was studied that NADase was increased in infected tuberculosis animal, but absolute NADase is uncertainly increased because of high NADase in Mycobacterium tuberculosis. Therefore, we studied pure NADase activity in red blood cells of normal person and patients of tuberculosis. Method: We evaluated the 19 healthy adults and 16 tuberculosis infected patients, and then, the latter cases were evaluated after 3 months antituberculosis therapy. NADase activity was calculated by scintillated counting of cleaved radioactive [carbonyl-$^3H$] nicotinamide Result: NADase activity was $2021.1{\pm}824.0\;pmol/min/10^6$ erythrocytes in healthy adults vs. $3339.0{\pm}1568.0$ in tuberculosis infected patients, and was $3339.0{\pm}1568.0$ in pretreated patients vs. $2238.6{\pm}1013.1$ in same 3 months treated patients. Conclusion: NADase activity of erythrocytes is elevated in tuberculosis infection, and normalized afer antituberculosis therapy. Therefore, we suggested NADase activity as the new diagnostic and therapeutic indicator.

• Parasites, Hosts and Diseases
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• v.22 no.2
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• pp.223-228
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• 1984

Seven cases of surgically proven sparganosis were serologically tested by means of microELISA for their specific IgG antibody levels. For that purpose, crude saline extract of spargana from snake, Natrix tigrina lateralis was prepared and used as antigen. The sparganosis sera were also tested with Paragonimus and Cysticercus antigens to observe the cross reactivity. A total of 71 sera from normal control, ectopic and pulmonary paragonimiasis, clonorchiasis, cysticerCOSIS and Taenia saginata cases were also included. Except for one case of old calcified infection, all of 6 human sparganosis showed higher serum levels of specific IgG antibody when the differential point of positive reaction was set at the absorbance value of 0.25 (the sensitivity being 85.7%). In control and other helminthic infections, all except 3 cases of T. saginata infection showed negative reaction to sparganum antigen (the specificity being 90.7%). None of sparganosis cases showed cress reactivity to Paragonimus and Cysticercus antigens. Undiluted cerebrospinal l1uid also showed high levels of antibody when central nervous system was invaded. The serologic diagnosis by means of micro ELISA could be a useful tool in epidemiological study of human sparganosis in susceptible population, as well as in individual diagnosis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.2
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• pp.104-111
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• 2016

This study examined the effects of the biological markers and lifestyle factors on the presence of diabetes in middle-aged adults. A total of 5,363 adults aged 40-64 years were recruited from the 2010-2012 Fifth Korean National Health and Nutrition Examination Survey. The data were analyzed by descriptive statistics, Chi-square test, ANCOVA and logistic regression. The results were as follows. The body mass index was significantly higher in the prediabetes and diabetes group than in the normal group. Hypertension, abdominal obesity, hypercholesterolemia, hypertriglyceridemia, smoking, drinking, and carbohydrate intake were significantly different among three groups. Hypertension, hypercholesterolemia, hypertriglyceridemia, abdominal obesity, body mass index and drinking were the influencing biological markers and lifestyle factors in prediabetes. The significant factors influencing diabetes were hypertension, hypercholesterolemia, hypertriglyceridemia, abdominal obesity, body mass index, and smoking. Overall, the development of intervention programs for effective diabetes prevention in middle-aged adults by lifestyle modification of hypertension, obesity, dyslipidemia, drinking, and smoking is recommended.

• Korean Journal of Food Science and Technology
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• v.46 no.2
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• pp.173-179
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• 2014

The fermentation characteristics of ice wines made from freeze-dried Muscat Bailey A grapes were determined. Muscat Bailey A grapes were concentrated to 34.8 and $40.8^{\circ}Bx$ by freeze drying and were then fermented. The content of reducing sugar was 0.3% in conventional wine after fermentation, but was 21.5 and 23.9% in ice wines at 34 and $40^{\circ}Bx$, respectively. The content of alcohol was 9.6% in conventional wine but was 10.3 and 10.6% in ice wines at 34 and $40^{\circ}Bx$, respectively. It was observed that the red and violet colors of ice wines at 34 and $40^{\circ}Bx$ became dominant compared to the controls. In sensory evaluation studies, ice wines at 34 and $40^{\circ}Bx$ showed higher intensities in color, flavor, and overall preference.

• Journal of Biomedical Engineering Research
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• v.24 no.5
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• pp.381-389
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• 2003

Various adult diseases (cerebral apoplexy, athymiait, etc.) result from hypertension, blood circulation disturbance and increment of HBP. In early diagnosis of these diseases, MRI, X-ray and PET have been used rather aim for treatment than for a prevention of disease. Since. cerebral apoplexy and athymiait could appear to the regular/irregular persons, it is very important to measure HBP which has connection with cerebral blood flow state. HBP has more diagnosis elements than that of BP. So, we can diagnose accurate hypertension by measuring of HBP. But, existing sphygmomanometers and automatic BP monitors can not measure HBP, and can not execute complex function(measuring of BP/HBP, blood flow improvement). Purpose of this paper is to develop a system and algorithm which can measure BP/HBP for accurate diagnosis. Also, we extracted diagnosis factors by correlativity analysis of BP/HBP. Maximum pressure of HBP corresponds to 62% that of BP, Minimum pressure of HBP corresponds to 46% that of BP. Therefore, we developed the multi-function automatic blood pressure monitor which can measure BP/HBP and improve cerebral blood flow state.

• Korean Journal of Ichthyology
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• v.19 no.3
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• pp.185-192
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• 2007

The present experiment was carried out to study the effects of light intensity on growth, survival, caudal fin shape, body composition, skin color and blood component of river puffer, Takifugu obscurus. Four light intensities (0, 500, 1,000, 2,000 lx) were tested in duplicates for 60 days. Specific growth rate (SGR), daily feeding rate (FR) and food coefficient (FC) were reduced following to the decrease of light intensity. However in survival rate there was not significantly different among groups. The damage extent of caudal fin was increased in more strong light intensity. In body composition, moisture and crude protein were only significantly difference according to light intensity. In body color, L and a were the highest in 0 lx. In blood analysis, the content of AST, ALT, GLU significantly increased in more powerful the intensity groups. It is concluded that the supplement of low light intensity (e.g. 0 lx) recommended for the commercial scale aquaculture of river puffer in land-based tank without growth and survival retardation.