• Korean Journal of Psychosomatic Medicine
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• v.7 no.2
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• pp.203-212
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• 1999

Objectives : "Alexithymia" mean literally "no word for mood(or emotion)". It is not only a marked constriction in emotional functioning but a deficit in their cognitive processing. We designed this study to investigate the level of alexithymia, psychopathology and personality factors of patients with somatoform disorder and with diabetes mellitus. Methods : The subjects were consisted of patients with somatoform disorder(N=20), patients with diabetes mellitus(N=20), and normal control(N=20). The level of alexithymia, psychopathology and personality factors were assessed by the Toronto Alexithymia Scale(TAS), the Symptom Checklist 90-Revision(SCL 90-R), and the Sixteen Personality Factor Questionnaire(16-PF). And we compared demographic characteristics, psychopathology and personality factors among three groups, and assessed the relationship between alexithymia and psychopathology, and between alexithymia and personality factors. Results : The results were as follows. 1) Patients with somatoform disorder showed significantly higher TAS scores compared to patients with diabetes mellitus and the normal control group. 2) Patients With somatoform disorder showed significantly higher scores of somatization, anxiety scales than patients with diabetes mellitus and the normal control group, and showed significantly higher scores of obsessive-compulsive, depression, phobic anxiety, psychoticism scales than the normal control group by the SCL-90-R. 3) The normal control group showed high intelligence scores only as compared to patients with somatoform disorder by the 16-PF. 4) A significant relationship was found between TAS scores and psychopathology in patients with somatoform disorder. 5) All three groups did not shown any correlation between TAS and 16-PF. Conclusion : Patients with somatoform disorder showed higher TAS scores and more multiple psychopathology than patients with diabetes mellitus and the normal controls. A significant relationship was found between TAS scores and psychopathology in patients with somatoform disorder. We suggest that the therapeutic approach to patients with somatoform disorder to express emotions and manage psychopathology, and that the treatment methods of patients with diabetes mellitus aims to improve firstly physical conditions are more helpful.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.7
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• pp.1573-1582
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• 2011

Risk of lung cancer among lung-related diseases has gradually increased during last decades. The chest digital radiography is the primary diagnosis method for lung cancer. Diagnosing lung cancer using this method requires doctors of ripe experience. Despite their experience there are often wrong diagnoses, which decrease early diagnosis and survival rates of patients. The aim of this study was intended to establish the base on the Computer Aided Diagnosis (CAD) by analyzing Image Recognition Algorithm using Principle component Analysis (PCA) and diagnosing patient's chest X-ray image. The database obtained through this approach enables a doctor to significantly reduce misdiagnosis during the early diagnosis stage, if he or she utilizes it as the preliminary reading step. Case studies were carried out using normal organ, and organs suffering from bronchogenic carcinoma and granuloma. A normal image and unique disease images were extracted after PCA analysis, and their cross-recognition efficiency were compared each other. The result revealed that the recognition rate was much high between normal and disease images, but relatively low between two disease images. In order to increase the recognition efficiency among chest diseases the related algorithms have to be developed continuously in the future study, and such effort will establish the resolute base for CAD.

• The korean journal of orthodontics
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• v.41 no.1
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• pp.42-50
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• 2011

Objective: The purposes of this study were to establish cephalometric norms of Mongolian adults, which have not previously been reported in orthodontic journals, and to compare them with cephalometric norms of Korean adults. Methods: Lateral cephalometric radiographs of 74 Mongolian adults (35 men, 39 women) and 95 Korean adults (52 men, 43 women) with normal occlusions and well-balanced lateral profiles were obtained. The subjects were chosen by orthodontists of the same ethnic background. Forty craniofacial variables were measured, and groups were compared by analysis of covariance. Results: The cephalometric norms for male and female Mongolian and Korean adults with normal occlusions and well-balanced lateral profiles were established. Sexual dimorphism was found in linear skeletal measurements and vertical skeletal relationships. Compared with Korean adults, Mongolian adults had shorter anterior facial height, more prominent chins, and more upright upper incisors. There were few differences in soft tissue measurements. The differences were statistically significant, but their clinical importance may be limited. Conclusions: Cephalometric differences can be considered, but little difference may exist in the orthodontic diagnosis and treatment planning of Mongolian and Korean adults.

• Radiation Oncology Journal
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• v.12 no.1
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• pp.9-16
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• 1994

Hypothesis that hypoxic tumors should be more responsive to the addition of preferential hypoxic cell cytotoxin SR 4233 (tirapazamine) to fractionated irradiation was tested in the mouse SCCVll carcinoma and RIF-1 sarcoma, Model of hypoxic tumor was established using the tumor bed effect: tumors growing in the preirradiated tissue (preirradiated tumors) were more hypoxic than tumors growing in the unirradiated tissue (unirradiated tumors). When the tumors reached a mean volume of 100 $mm^{3}$, both unirradiated and preirradiated tumors were treated with a fractionated course of 6${\times}$2 Gy in 3 days or 8${\times}$2.5 Gy in 4 days with SR 4233 (0.08 mmol/kg/injection) given 30 minutes before each irradiation or without SR 4233. Compared to the unirradiated tumors, hypoxic preirradiated tumors were approximately 5 times more resistant to fractionated irradiation alone but were approximately 5 times more responsive to SR 4233. Addition of SR 4233 Potentiated the effect of fractionated irradiation in both unirradiated and preirradiated tumors. Potentiation in the preirradiated tumors was morequal to or greater than that in the unirradiated tumors and seemed to be higher for more fractionated treatment. We confirm the hypothesis in a transplantable mouse tumor. Present results suggest that radioresistance of some hypoxic tumors can be overcome with hypoxic cytotoxin.

• The Korean Journal of Food And Nutrition
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• v.11 no.2
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• pp.192-199
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• 1998

1. 조사 대상자들의 평균 키와 체중은 각각 161.00$\pm$4.15cm, 50.45$\pm$8.15kg이었으며 BMI는 19.81$\pm$3.98, 체지방율은 26.12$\pm$4.12, skinfold thickness는 40.40$\pm$12.56mm로 나타났다. 2. 조사 대상자들의 혈액성상은 적혈구 수, 헤모글로빈, 헤마토크리트치, albumin, globulin, 총 콜레스테롤, LDL-콜레스테롤, HDL-콜레스테롤, 총 중성지방을 측정하였으며 헤마토크리트치를 제외한 나머지 성상들은 모두 정상 범위에 속하였다. 헤마토크리트치는 정상범주에 미달되는 것으로 나타나 이로 말미암아 철분 결핍성 빈형에 노출될 확률이 아주 많음을 보였다. 3. 용돈별로 체지방율을 분류하여 분석한 결과 한달 용돈이 평균 20~30만원을 쓰는 group의 체지방율이 22.00%로서 정상 수준 이었으며, 30만원 이상 사용하는 group은 비만으로 나타났다.(p<0.05) 한편, 그 외의 group들은 체내 체지방율 수준도 정상 수준인 20~25%를 넘어 체중으로 나타났다. 또한 30만원 이상 사용하는 group은 다른 group보다 RBC(million/㎣), Hb(g/이), Hct(%) 모두가 낮게 나타났으며, 빈혈로 판정될 수 있는 수준이었다. 4. 다이어트 빈도별 각 요인들간의 상관관계를 살펴보면 다이어트 시도를 자주 한다고 답변한 group이 거의 실시하지 않는다., 실시해 본 적이 없다라고 대답한 group보다 체중과 BMI가 유의적으로 낮았다.(p<0.05) 그러나 skinfold thickness(mm)와 체지방율은 유의차가 나타나지 않았다. 따라서 비록 다이어트 실시를 자주할 경우 절대적인 체중감량은 감소되지만 체내 지방량이 감소되는 것은 아니라고 판단된다. 5. 다이어트 실시기간에 따라 혈액 성상을 분석한 결과, 4개월 미만 다이어트를 실시하였으나, 1개월 전부터 현재(설문지에 응답한 시점)까지 기간 중에는 다이어트를 실시한 적이 없다고 대답한 group의 Alb(g/dl)과 Glo(g/dl)의 수치가 다이어트를 실시한 적이 없다고 대답한 group에 비해 유의적으로 높게 나타났다.(p<0.05) 6. 체중은 BMI와 양의 상관관계를 나타내었으며, BMI는 견갑골과도 높은 양의 상관관계를 가졌다. 상완부는 견갑골, skinfold thickness(mm), 체지방율과 높은 양의 상관관계를 보였으며, 반면 Hb(g/dl), Hct(%)와는 음의 상관관계를 나타내었다. 견갑골은 BMI 뿐 아니라 skinfold thickness(mm), 체지방율과 양의 상관관계를 나타내었으며, skinfold thickness(mm)는 체지방율과 유의적인 양의 상관관계가 있음이 나타났다. 7. RBC(million/㎣)는 Hb(g/dl) 및 Hct(%)와 유의적인 양의 상관관계를 나타내었으며, Hb(g/dl)도 Hct(%)와 유의적인 양의 상관관계를 나타내었다. Alb(g/dl)은 Glo(g/dl) 및 TCH(mg/dl), HDL(mg/dl)과도 양의 상관관계를 가졌다. Glo(g/dl)은 TCH(mg/dl)과 양의 상관관계를 보였으며, TCH(mg/dl)은 Alb(g/dl), Glo(g/dl)이에도 TTG(mg/dl), LDL-cho(mg/dl) HDL-cho과도 양의 상관관계를 나타내었다. TTG(mg/dl)은 LDL-cho(mg/dl)과는 양의 상관관계를 HDL-cho(mg/dl)과는 음의 상관관계를 나타내었다.

• The Journal of the Korea Contents Association
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• v.20 no.3
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• pp.671-677
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• 2020

The number one female cancer in Korea is breast cancer, and the incidence rate continues to increase. There are many opinions that this is due to the impact of increased sedentary life along with economic growth. In this study, the international standard exercise status questionnaire was administered to patients and normal group who visited to the specialized cancer hospital in Korea, and to standardized scores of the exercise status (MET score) obtained from questionnaire were used to compare the impaction on breast cancer risk and difference of the MET score between the patients and control group. The ages of the study subjects were selected as subjects without statistical differences between the patients group and the normal group. also done with survey the family history, BMI, the menarche, age at birth of first child, the degree of education to exclude impaction on breast cancer risk depending on physical activity. In general, the breast cancer patients showed lower MET scores than the normal group, and the effect of activity on breast cancer was greater in post-menopausal women than in pre-menopausal women. Also BMI was similar to breast cancer risk. Maintaining proper weight through exercise can reduce the accumulation of carcinogens in breast cancer in the body, thereby reducing the incidence of breast cancer.

• Journal of Applied Biological Chemistry
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• v.52 no.3
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• pp.103-108
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• 2009

Little is known about roles of adipose tissue, although obesity is one of the potential risk factors in causing breast cancer and adipose tissue surrounding breast ductal cells is the largest organ. To identify the genes that are regulated by factors secreted from adipocytes in breast cancer cells, MDA-MB-231 cells were treated with the culture medium of adipocytes. In present study glucocorticoid-induced TNF receptor-related protein ligand (GITRL) gene was studied among the induced genes. It was found that GITRL was significantly increased by the culture medium of adipocytes. Proteinase K-treated adipocyte culture supernatants failed to induce GITRL expression. These findings indicate that unknown protein factors are responsible for the induction of GITRL expression. The expression of GITRL did not affect the invasive ability of MDA-MB-231 cells, but coculture with NK92 expressing GITR suppressed the invasiveness of MDA-MB-231 cells.

• The Korean Journal of Rheology
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• v.11 no.1
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• pp.1-8
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• 1999

This paper experimentally investigates the steady shear behaviors of electro-rheological(ER) fluids under flow mode at high pressure level. As for the ER fluid to be tested, two types of ER fluids are employed; water-based ER fluids (ERF 1, ERF 2) and water-free ER fluid(ERF 3). The water-based ER fluids are composed inhousingly, and the concentrations of dispersed particles are 20 wt% and 30 wt% for ERF 1 and ERF 2, respectively. To generate the flow mode at high pressure, an experimental apparatus operated by two-way hydraulic cylinder is constructed and utilized. The pressure difference is measured by the pressure sensor, while the flow rate is calculated using the measured data of the displacement sensor(LVDT). Consequently, the shear stress and shear rate are distilled by incorporating the measured data; the pressure difference and the flow rate.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.1
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• pp.62-68
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• 2015

Supernumerary teeth (SNTs) refer to extra teeth over normal numbers. SNTs can influence adjacent teeth and structure. Therefore, it is important to find SNTs before they cause problems and to decide when to extract them. Etiology of SNTs has not exactly been found, but it has been proposed that genetic and environmental factors are associated. SNT appears as a single unit in most cases and multiple SNTs usually occur as a part of a syndrome. Non-syndromic multiple SNTs are rarely seen. This report is to document the occurrence of multiple supernumerary premolars in a father and his three sons. Heritage is an important factor in SNT development so familial history is important for early detection of SNT.

• Journal of Veterinary Clinics
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• v.29 no.5
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• pp.400-403
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• 2012

A 10-year-old, intact male, toy poodle was presented with abdominal distension, truncal alopecia, hepatomegaly, and sustained elevation of alkaline phosphatase. Vacuolar hepatopathy and glycogen deposition in hepatocytes were confirmed by liver biopsy and ultrasound-guided fine-needle aspiration with periodic acid-Schiff (PAS) staining of mass lesion respectively. Cortisol and some sex hormones associated with adrenal gland were analyzed at IDEXX Reference Laboratories before and 1 hour after ACTH stimulation. The results of analysis confirmed elevation of some sex hormones including androstenedione, progesterone and 17 hydroxyprogesterone, not cortisol concentration, before and 1 hour after ACTH stimulation. The dog was diagnosed as atypical form of hyperadrenocorticism associated with sex steroids excess. The treatment was initiated with trilostane (0.5 mg/kg, PO, q12hr) that is an adrenal steroid synthesis inhibitor. Trilostane was administered for 8 weeks and the clinical sign including truncal alopecia was improved.