Radiation Oncology Journal
- Volume 12 Issue 1
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- Pages.9-16
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- 1994
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
Hypoxic Tumor Can be More Responsive to Fractionated Irradiation Combined with SR 4233 (Tirapazamine)
분할방사선조사와 SR 4233 병용에 의한 저산소분압 종양의 반응증강
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Kim, Il-Han
(Department of Therapeutic Radiology, Seoul National University College of Medicine) ;
- J.-Martin-Brown (Department of Radiation Oncology, Stanford University School of Medicine)
- Published : 1994.02.01
Abstract
Hypothesis that hypoxic tumors should be more responsive to the addition of preferential hypoxic cell cytotoxin SR 4233 (tirapazamine) to fractionated irradiation was tested in the mouse SCCVll carcinoma and RIF-1 sarcoma, Model of hypoxic tumor was established using the tumor bed effect: tumors growing in the preirradiated tissue (preirradiated tumors) were more hypoxic than tumors growing in the unirradiated tissue (unirradiated tumors). When the tumors reached a mean volume of 100
마우스 종양인 SCCVll과 RIF-1에서 선택적 저산소세포 치사제인 SR 4233 (tirapazamine)과 분할 방사선조사를 병용하면 저산소분획이 큰 종양에서 방사선 감수성이 더욱 증강될 것인가를 확인하기 위하여 본 연구를 실시하였다. 종양세포 이식이전에 방사선조사를 받은 정상조직에서 성장한 종양의 저산소세포 분획이 크다는 사실을 이용하여 저산소세포분획이 큰 종양 모델을 수립 사용하였다. 일정 용적의(100