• Environmental and Resource Economics Review
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• v.8 no.2
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• pp.175-206
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• 1999

본 연구는 2부문 개방거시경제모형을 이용하여 환경규제정책이 거시경제실적-국내자본 축적, 경상수지상태, 소비수준-에 미치는 영향을 동태적으로 분석하려고 한다. 정부가 환경규제를 강화할 경우, 즉 최대 허용가능한 오염배출량을 감소할 경우, 투자활동이 감소하게 되어 장기 정상상태에서 자본축적량이 감소하게 된다. 반면에, 환경규제가 강화될 경우 경제주체들은 국제채권의 구입을 늘리게 되어 새로운 정상균형상태에서 국제채권의 보유는 증가하게 된다(경상수지는 개선된다). 그러나 환경규제의 강화가 자산의 잠재가치와 두 재화의 소비에 미치는 효과는 불분명하다. 만약, 자본축적량과 최대 허용가능한 오염배출량의 변화에 따른 제조업부문의 산출고의 변화가 비제조업부문 산출고의 변화를 능가한다면, 환경규제 강화정책은 두 재화의 소비를 감소시킬 것이다. 본 연구에서는 환경규제정책의 변화를 예상한 경우와 예상하지 못한 경우, 그리고 예상하지 못한 경우에도 정책의 변화가 영구적 또는 일시적인 경우에 따라 환경규제 강화가 자본 한 단위의 시장가치 자본축적량 및 국제채권 보유에 미치는 영향을 단기 전환적 동태분석하고자 한다. 환경규제정책의 변화가 사전에 발표되어 민간 경제주체들이 정책의 변화를 예상할 수 있는 경우에는, 민간경제주체들이 정책의 변화 전에 자신들의 행동을 조정하므로 실제 정책 실시 후에는 정책이 각 경제변수에 미치는 효과는 정책을 예상하지 못한 경우보다 훨씬 줄어들게 된다. 정책 변화를 예상하지 못한 경우보다 정책 변화가 발표됨으로써 사전에 정책 변화를 예상한 경우에 환경규제 강화에 따른 자본축적량의 장기적인 감소효과가 훨씬 작게 되고, 따라서 국제채권 보유를 증가시키는(경상수지 상태를 개선시키는) 효과도 줄어들게 된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.201-208
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• 2020

This study examined the anti-obesity effect of krill oil (KO) by regulating adipokines in a high-fat diet (HFD)-induced obese mouse model. The mice were fed a 60 kcal% HFD for 16 weeks, and KO was then administered at an oral dose of 100, 200, and 500 mg/kg/day for four weeks before the end of the experiment. The administration of KO at concentrations of 200 and 500 mg/kg/day decreased body weight gain significantly compared with the HFD-fed control group. In addition, the HFD-fed control group showed the abnormal release of adipokines by an increase in leptin and decrease in adiponectin, compared to the normal diet-fed normal group. On the other hand, KO (500 mg/kg/day)-administered group attenuated the abnormal release of adipokines by the down-regulation of leptin and the up-regulation of adiponectin. Therefore, KO could be a promising therapeutic agent for obesity by the regulation of adipokines.

• Journal of Chest Surgery
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• v.37 no.10
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• pp.817-826
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• 2004

Background: Several studies have demonstrated that conventional hypothermic cardiopulmonary bypass (CPB) causes cellular injury, abnormal responses in peripheral vascular beds and increased postoperative bleeding, whereas normothermic CPB provides protection of the hypothermic-induced effects and better cardiac recovery. The present study was prospectively performed to compare the effects of normothermic CPB to those of hypothermic CPB on the inflammatory and hematologic responses during cardiac surgery. Material and Method: Thirty-four adult patients scheduled for elective cardiac surgery were randomly assigned to hypothermic CPB (nasopharyngeal temperature $26～28^{\circ}C,$ n=17) or normothermic CPB (nasopharyngeal $temperature>35.5^{\circ}C,$ n=17) group. In both groups, cold $(4^{\circ}C)$ crystalloid cardioplegia was applied for myocardial protection. Blood samples were drawn from radial artery before (Pre-CPB), 10 minutes after starting (CPB-10) and immediately after ending (CPB-OFF) CPB. Total leukocyte and platelet counts, interleukin-6 (IL-6) level(expressed as percent to the baseline of Pre-CPB), D-dimer level, protein C and protein S activity were measured with the blood samples. The amount of bleeding for postoperative 24 hours and blood transfusion after operation were also assessed. All parameters were compared between the two groups. Result: The total leukocyte counts $(10,032\pm65/mm^3)$ and the increased ratio of IL-6 $(353\pm7.0%)$ at CPB-OFF in the normothermic group were higher than that $(7,254\pm48/mm^3$ and $298\pm7.3%)$ of the hypothermic group(p=0.02 and p=0.03). In the normothermic group, protein C activity $(32\pm3.8%)$ and protein S activity $(35\pm4.1%)$ at CPB-OFF were significantly lower than that $(45\pm4.3%$ and $51\pm3.8%)$ of the hypothermic group (p=0.04 and p=0.009). However, there were no differences in platelet counts and D-dimer concentration. In the normothermic group, the amount of bleeding for postoperative 24 hours $(850\pm23.2$ mL) and requirements for blood transfusion after operation such as packed cell $(1,402\pm20.5$ mL), fresh frozen plasma $(970\pm20.8$ mL) and platelet $(252\pm6.4$ mL) were higher than that $(530\pm21.5$ mL, $696\pm15.7$ mL, $603\pm18.2$ mL and $50\pm0.0$ mL) of the hypothermic group. Conclusion: These results indicate that normothermic CPB with cold crystalloid cardioplegia was associated with higher increase in inflammatory response, hemostatic abnormalities and postoperative bleeding problem than moderate hypothermic CPB.

• Journal of Chest Surgery
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• v.34 no.11
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• pp.831-842
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• 2001

Background: Patients with cardiac diseases who have structural defects in their heart bring about metabolic insult such as preoperative acid-base imbalance. Cardiac operation requires many nonphysiologic procedures such as extracorporeal circulation, hypothermia, and hemodilution. We studied the acid-base status of surgical heart diseases pre-operatively, during extracorporeal circulation, and post-operatively and researched the treatment indications of acid-base disturbances. Material and Method: From January 1997 to May 1999, fifty two cases of open heart surgery were carried out under extracorporeal circulation, which divided into a set of pediatric and adult groups, congenital and acquired groups, non-cyanotic and cyanotic groups, The $\alpha$ -stat arterial blood gas analysis was done in each group during the preoperative period, during the operation with extracorporeal circulation, and during the postoperative period. Result: Before surgery, all patients present metabolic acidosis, PaO2 was low in adult group and acquired group and compensatory respiratory alkalosis was noted in cyanotic group. During extracorporeal circulation, adult group revealed alkalosis and normal in acquired group. Pediatric group presents low Pa$CO_2$, metabolic acidosis and respiratory alkalosis. Congenital group and non-cyanotic group showed non-compensatory alkalosis trend and non-compensatory respiratory acidosis were observed in cyanotic group during extracorporeal circulation. Postoperative acid-base status of adult group was recovered to normal and the standard bicarbonate was increased in the acquired group. All of the pediatric, congenital non-cyanotic, and cyanotic groups revealed the lack of buffer base.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.12
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• pp.6246-6256
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• 2013

The aim of this study was to determine the factors affecting the Bone Mineral Density (BMD) on Premenopausal Women. This study made use of the data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011). The results are as follows. The factors with an effect on the bone mineral density (BMD) were the body mass index, age, and walking exercise. These factors explain 11.7% of the variance in the BMD. In addition, the bone density of people in their 20s was lower than those in their 50s. Walking exercise for less than 3 days showed that the BMD had decreased significantly. In conclusion, to maintain a normal BMD on premenopausal women, it is important to avoid an excessive diet and recognize the correct body image. These results suggest that education programs including the appropriate diet and lifestyle should be developed for women in their 20's.

• The Journal of Engineering Geology
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• v.3 no.2
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• pp.149-165
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• 1993

Nowadays, the field hydraulic test is still an only method to evaluate groundwater characteristics in subsurface. The results of hydraulic test are very important for the concept model of fracture hydrogeology as well as the geometric pattern of fractures. The hydraulic tests performed in Korea are generally analysed under such assumption as steady radial flow in homogeneous aquifer or along simple geometry of fractures. Also the transmissivity measured in a fixed interval length is equivalent to a sum of individual fracture transmissivities in test legth. The boundary effects of weH hydraulics and the geometry of flow paths are hardly obtained from the test results analysed by a steady flow method. To circumvent this problem, the flow dimensional analysis was attempted from the results of constant pressure injection test carried out in a fractured granite area. A comparison of the hydraulic conductivity values from the transient and steady analysis shows that the latter is about a factor of 2~3 higher than the former. However, it was possible to analyse a flow dimension of each test interval from flow rate variation with time. The upper part of the bedrock(<10m deep) indicates an open boundary and the flow dimension shows nearly steady states, while the lower part of the bedrock(>25m deep) is characterized as sublinear flow dimension with a dosed boundary. In one of the test sections(15m deep), the flow dimension was changed from linear flow to spherical flow. From the experience of this study, one of the immediate problems to be solved is to enhance the field testing equipments, i.e., an accurate flowmeter with autorecording and a pressure detecting device to be able to install in the test section.

• Journal of Life Science
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• v.19 no.11
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• pp.1568-1574
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• 2009

The purpose of this study was to investigate whether group III muscle afferents play an important role eliciting abnormal blood pressure response mediated during passive muscle stretch in prehypertensive individuals. Eleven middle-aged prehypertensive men (average BP 133/80 mmHg) and nine middle-aged normotensive men (average BP 119/74 mmHg) participated in this study. After 1 min rest baseline data collection, the subject's foot was flexed (dorsiflexion) by an automated cybex for one minute. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate, stroke volume, cardiac output, and total peripheral resistance were continuously measured on a beat-by-beat basis from a finger via a Finapres device for 1 minute. To evaluate the role of mechanoreflex, a component of exercise pressor reflex, SBP, DBP, and MAP responses over the course of time were examined. The results showed that the pressor response mediated by the muscle mechanoreflex was faster in prehypertensive individuals compared to the normotensive individuals. The substantial pressor response was observed within mean 20 sec of the onset of passive stretch in prehypertension, while mean 45 sec in normotension (p<0.05). It is concluded that excessive pressor response produced during exercise in prehypertension may be due to the dysfunction of the mechano-receptors.

• Journal of Gastric Cancer
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• v.5 no.1
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• pp.29-33
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• 2005

Purpose: To determine the prognostic values of the hematologic parameters checked preoperatively in gastric cancer patients, we evaluated and compared the relationship between hematologic parameters and clinicopathologic factors of gastric cancer patient. Materials and Methods: The medical records of 357 consecutive patients who had undergone surgery for gastric cancer at the Department of Surgery, Hanyang University Hospital, between Dec. 2,000 and Dec. 2003 were reviewed. To exclude any adverse effect of invasive procedures to hematologic parameters, the samples taken immediately at outpatient department was used. The normal range of serum albumin was defined above 3.5 g/dl, serum hemoglobin above 12 g/dl, and serum platelet count under $400\times10^{3}{\mu}l$. Patients were defined as group 1 when any of these parameters was abnormal, and defined as group 2 when all parameters were normal. The relationships between hematologic parameters and survival rate were investigated. Results: The mean values of platelet count increased, but level of serum albumin and serum hemoglobin decreased significantly according to the advancement of the disease stage (P=0.000). The differences of depth of tumor invasion and lymph node metastasis between the group 1 and the group2 was statistically significant (P=0.001). Three-year survival difference between group 1 and group 2 was significant (P=0.037). Conclusion: The hematologic parameters checked preoperatively in patients of gastric cancer are simple and cheap, meanwhile reflect the general condition of the patients. Any presence of anemia, hypoalbuminemia, or thrombocytosis can predict the progression of the disease and poor survival rates.

• Korean Journal of Food Science and Technology
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• v.42 no.2
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• pp.204-209
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• 2010

This study was conducted to investigate the anti-diabetic activity of Kocat-D1, which is widely used in traditional medicine to treat diabetes in Shandong, China. Sprague Dawley rats (8 weeks of age) were separated into 4 groups: a normal control, streptozotocin (STZ)-induced diabetic rat group (DM control), Kocat-D1-1 (diabetic rat treated with 0.25 g/kg/day hot water extract), and Kocat-D1-2 (diabetic rat treated with 1 g/kg/day hot water extract). After eight weeks of treatment, the fasting blood glucose levels of the Kocat-D1-1 ($334.3{\pm}32.9\;mg/dL$) and Kocat-D1-2 group ($259.5{\pm}35.0\;mg/dL$) were significantly lower when compared to the DM control group ($451{\pm}42.6\;mg/dL$). Furthermore, the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), albumin and high-density lipoprotein (HDL) cholesterol in the serum of the Kocat-D1-2 group were significantly normalized when compared to the DM control group. However, significant differences were not observed between the Kocat-D1-1 group and the DM control group. Histochemical staining of the liver of the Kocat-D1-2 group revealed no fat accumulation. The insulin level was significantly upregulated in the Kocat-D1-2 group ($0.13{\pm}0.02\;ng/mL$) when compared to the DM control group ($0.05{\pm}0.04\;ng/mL$). The relative volume of $\beta$-cells in the pancreas of the Kocat-D1-2 group ($49.4{\pm}4.2%$) also increased significantly when compared to the DM control group ($12.9{\pm}7.9%$). These results suggest that Kocat-D1 exerts an anti-hyperglycemic effect through the enhancement of insulin secretion.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.3
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• pp.79-85
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• 2016

In today's fast-paced capitalistic society, a primary concern is whether to invest capital in any way to increase profits. In recent years, many companies have emphasized ethics and practiced corporate social responsibility activities. These activities are not only required to have at the end of the company. Bringing the ultimate goal of profit maximization is one way to contribute to the development of society and the economy. Investors are aware of corporate social responsibility activities and have begun to reflect this in their investments. We studied the behavior of a newly incorporated company's stock price on the KRX SRI Index using a scale that indicates the level of social responsibility for companies in the domestic stock market. Socially responsible investment involves an excellent company that looks out and looks for additional effects on the stock price of imports and improves the reliability of investors through an event study. The results show that the company we examined has a positive impact on the market. This study confirms the hypothesis that additional stock market reaction will occur when superior companies are newly incorporated in the KRX SRI Index and gain investors' trust. The results demonstrate that becoming a newly incorporated corporation in the KRX SRI Index is positive information to investors.