• Journal of the Korea Convergence Society
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• v.9 no.8
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• pp.71-76
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• 2018

The aim of this study was to evaluate the association between obesity and periodontal diseases in Korea adults. The date from the 2015 Korean National Health and Nutrition Survey were used, and 4,827 subjects over 19 years were included in the analysis. Periodontal disease was assessed using the Community Periodontal Index. Obesity was measured according to body mass index. Odd ratios (ORs) were estimated using binary logistic regression analysis model. The stratification variables were smoking and diabetes, and also adjusted for sex, age, and education level. The adjusting variables included sex, age, and education level. The ORs of obesity for periodontal disease were 0.78 (95% CI = 0.51-1.22) for the category of <18.5 of BMI and 1.29 (95% CI = 1.11-1.49) for the ${\geq}25$ BMI category (both compared to the 18.5 to 24.9 category). In a subgroup analysis, the OR of BMI among those who were both non-smoking and no diabetes was 1.20 (95% CI = 1.02-1.48) for those with BMI levels ${\geq}25$. This study implies that obesity intolerance may be an independent risk factor for periodontal diseases. Obesity should also be considered when managing periodontal disease to improve oral health.

• Journal of Korean Medical classics
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• v.24 no.6
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• pp.131-133
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• 2011

비단은 비만을 기초로 한 당뇨병의 초기상태이며, 당내량 손상(IGT)은 당대사가 정상과 당뇨병 사이에 있는 아건강 상태를 말한다. 비단의 병인병기와 임상특징은 당내량 손상과 기본적으로 일치한다. 당내량 손상은 비만환자가 비단을 거쳐 당뇨병으로 발병되는 자연발전과정으로 비단과 당내량 손상의 공통적인 발병인소는 비만이며, 그 병리중심은 비위(脾胃)기능실조로 인한 당내량 이상으로 중의(中醫) 증형(證型)에 있어 허실(虛實)변화가 있다. 비단과 비만형 IGT 증후, 병리방면에서의 발생과 발전의 작용을 탐구하여 조기에 중약(中藥)을 사용하면 체중을 감소시키고 더 나아가 당뇨병을 예방하는데 중요한 임상의의가 있다.

• Journal of Nutrition and Health
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• v.41 no.8
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• pp.767-775
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• 2008

Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis at brown adipose tissues and has been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of A-3826G polymorphism in 117 Korean prepubertal children aged 8-11 years olds. Anthropometry by bioelectrical impedance analysis method, plasma lipid profiles by auto-biochemical analyzer and UCP-1 genotyping by PCR-RFLP were done. The frequencies of UCP-1 genotypes were AA; 17.7%, AG; 57.8%, GG; 26.6%. The frequencies of each G allele (55.5%) was similar to Japanese's (49%) and higher than Caucacian's (25%). No correlation UCP-1 polymorphism and BMI (kg/$m^2$) or the degree of obesity described by the relative percentiles of the standard weight according to height in prepubertal children. However, plasma total- and LDL-cholesterol were significantly increased in G allele when sex, age and weight were adjusted. Our results suggested that G allele of UCP-1 gene was stronger risk factors in hyperLDLcholesterolemia than A allele. This impact might be progressed as the precaution against the revalence of obesity based-metabolic disease.

• Development and Reproduction
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• v.16 no.2
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• pp.113-120
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• 2012

We examined the distribution of uterine mast cells in cycling mice of different ages between 7 weeks and 38 weeks by toluidine blue staining. Mast cell density increased gradually depending on the age and culminated at 30 weeks after birth. Of the estrous stages, uteruses at metestrus showed markedly higher density of mast cells than those at the other stages in cycling mice of all ages analysed in this study and the majority of the mast cells were found in myometrium. We also discriminated types of the uterine mast cells in cycling mice at 10 weeks old by Alcian blue-safranin double staining. Mucosal type was most abundant among three types, including connective-tissue types and mixed types, through the entire estrous cycles. The portion of mixed types increased slightly after estrous. The abundance of uterine collagen protein determined by Masson trichrome staining was exactly consistent with the density distribution of the uterine mast cells during estrous cycles. Taken together, these results may imply that uterine mucosal mast cells, together with collagen proteins, are heavily involved in tissue remodeling of cycling mouse uterus.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.219-221
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• 2009

청소년 비만관리를 좀더 효율적으로 할 수 있는 방안의 하나로 개개인의 비만관리는 물론 건강관리를 위한 Personal Health Record를 제시코자 한다. 연구 참여한 총인원은 267명이었으나 7명의 설문은 응답이 불성실하여 제외한 총 260명의 데이터를 사용하였다. 비만 관리에 PHR을 활용한다는 응답이 남성은 108명으로 가장 높게 응답한 반면, 여성은 PHR을 활용한다는 응답이 28명으로 "보통"이라고 응답한 29보다 낮게 나타났다. PHR 활용을 보통이라고 대답한 그룹은 일반적인 데모그라픽 요인만 분석한 결과 신장과 체중에서 PHR을 사용하지 않거나, 사용하겠다고 답한 그룹보다 체격이 작은 경향을 나타났다. BMI도 PHR활용도가 보통이라고 한 그룹이 평균 21로 사용하지 않겠다는 그룹 평균 22, 사용하겠다는 그룹 22 보다 낮게 나타났다. 충분한 PHR에 관한 사전 인식도 및 의견 조사를 통해 의료서비스 공급자와 소비자 모두의 요구 사항을 수렴하고 각국 현실에 적합한 맞춤형 PHR system을 개발하고 효율적으로 정착시킬 수 있을 것이다.

• Journal of Life Science
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• v.20 no.7
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• pp.1066-1072
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• 2010

The purpose of this study was to investigate the effects of aerobic exercise on adipokines and inflammatory reaction in obesity and type 1 diabetes mellitus (T1DM) children. We studied obese (OG, n=9), type 1 diabetic (DG, n=9), and normal (NG, n=9) children groups. Measurement factors included body weight, % fat, body mass index (BMI), $VO_2max$, lipid profiles and adipokines. The results showed significant differences in body weight, % fat, BMI, and $VO_2max$ (ml/kg/min) among the OG, DG, and NG (p<0.05) groups. There were significant differences in LDL-C and HDL-C between the OG, DG, and NG groups (p<0.05). In addition, adiponectin and retinol binding protein (RBP)-4 were significantly changed in DG and NG after 12 weeks exercise training (p<0.05), and there were also significant differences among the OG, DG, and NG groups (p<0.05). Monocyte chemoattractant protein (MCP)-1 in the OG, DG, and NG groups was significantly increased after 12 weeks exercise training (p<0.05). In conclusion, regulatory aerobic exercise does not change body composition in obese children with T1DM, but exercise and decreased blood inflammatory factors in T1DM may protect obese children from metabolic syndrome.

• Bulletin of Food Technology
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• v.24 no.2
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• pp.245-254
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• 2011

• Journal of Sasang Constitutional Medicine
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• v.10 no.2
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• pp.533-564
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• 1998

In order to know the effect of proliferation and differentiation on edipocyte 3T3-L1 by prescriptions and herbs, Taeyangin(太陽人)'s Okapijangcheok-tang(五加皮壯脊湯) Mihudeungsikjangtang Acanthopanacis Cortex(五加皮) Phragmitis Rhizoma(蘆根) and Taeumin(太陰人)'s Taeumjowi-tang(太陰調胃湯) Cheongsimyonja-tang(淸心蓮子湯) Cheongpaesagan-tang(淸肺瀉肝湯) Galkeunbupyong-tang(葛根浮萍湯) Coicis Semen(薏苡仁) Rhei Undulati Rhizoma(大黃) Mori Cortex(桑白皮) Ulmi Cortex(楡根白皮) Holotrichia Vermiculus Kalopanaxii Cortex(海桐皮) Ephedrae Herba(麻黃) Imperatae Rhizoma(白茅根), were used and had some effects. 1. The proliferation effect of edipocyte 1) At the Taeyangin(太陽人)'s prescriptions and herbs, Okapijangcheok-tang(五加皮壯脊湯) Mihudeungsikjang-tang Acanthopanacis Cortex(五加皮) have a control effect at the boiling water-extract and ethyl alcohol-extract. Phragmitis Rhizoma(蘆根) have a control effect at the ethyl alcohol-extract. 2) At the Taeyangin(太陽人)'s prescriptions and herbs, Taeumjowi-tang(太陰調胃湯) Cheongsimyonja-tang(淸心蓮子湯) Cheongpaesagan-tang(淸肺瀉肝湯) Galkeunbupyong-tang(葛根浮萍湯) have a control effect at the boiling water-extract and ethyl alcohol-extract. Coicis Semen(薏苡仁) Rhei Undulati Rhizoma(大黃) Morl Cortex(桑白皮) Ulmi Cortex(楡根白皮) Kalopanaxii Cortex(海桐皮) · Ephedrae Herba(麻黃) of the boiling water-extract, Holotrichia Vermiculus Kalopanaxii Cortex(海桐皮) of ethyl alcohol-extract have a control effect on edipocytes. Rhei Undulati Rhizoma(大黃) Ulmi Cortex(楡根白皮) Ephedrae Herba(麻黃) of high-density have a cyto-toxicity. 2. The differentiation effect of edipocyte 1) At the Taeyangin(太陽人)'s prescriptions and herbs during the natural differentiation, Phragmitis Rhizoma(蘆根) of the boiling water-extract, Okapijangchek-tang(五加皮壯脊湯) Acanthopanacis Cortex(五加皮) of the ethyl alcohol-extract have a cyto-toxicity on the first-differentiation. 2) At the Taeumin(太陰人)'s prescriptions and herbs during the natural differentiation, Ulmi Cortex (楡根白皮) Kalopanaxii Cortex(海桐皮) of the boiling water-extract have a cyto-toxicity on the first-differentiation. Cheongsimyonja-tang(淸心蓮子湯) Ephedrae Herba(麻黃) of ethyl alcohol-extract have a control effect on the redifferentiation. 3) At the Taeyangin(太陽人)'s prescriptions and herbs on the first-differentiation during the induced differentiation, Acanthopanacis Cortex(五加皮) of ethyl alcohol-extract has a control effect. Okapijangchek-tang(五加皮壯脊湯) Acanthopanacis Cortex(五加皮) Phragmitis Rhizoma(蘆根) of the boiling water-extract have a cyto-toxicity. 4) At the Taeumin(太陰人)'s prescriptions and herbs on the first-differentiation during the induced differentiation, Coicis Semen(薏苡仁) Ephedrae Herba(麻黃) Imperatae Rhizoma(白茅根) of the boiling water-extract and Ephedrae Herba(麻黃) of the ethyl alcohol-extract have a control effect. Kalopanaxii Cortex(海桐皮) of the boiling water-extract and the ethyl alcohol-extract has a cyto-toxicity. Considering this result, the Taeyangin(太陽人) Taeumin(太陰人)'s prescriptions and herbs have a control effect on edipocytes during the proliferation. Acanthopanacis Cortex(五加皮), Coicis Semen(薏苡仁) Ephedrae Herba(麻黃) Imperatae Rhizoma(白茅根) have a control effect on edipocytes during the induced differentiation. In the future, for treating a obesity need a vivo assay and hope this study to help to know the mechanisms of obesity.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.04a
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• pp.96-96
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• 2018

본 연구는 항비만 기능성을 가지면서 맛과 향이 증진된 분말형 다진양념(다데기)을 개발하기 위해 첨가할 수 있는 약용작물들의 선정 및 그 기능성을 평가하기 위해 실시되었다. 오미자, 진피, 감초, 녹차엽 등을 첨가군으로 선정하여 각각의 시료들을 8시간, $80^{\circ}C$ 증류수에서 추출 후 감압농축하여 추출물을 제조한 뒤 마우스 유래 adipocyte (3T3-L1)에 처리하여 세포내 지방 축적 억제 정도를 실험하였다. 시료 처리 배양 5일 후 오미자, 진피, 감초, 녹차엽 추출물을 처리한 모든 군에서 대조군과 비교시 20% 이상 세포내 중성지방 농도가 감소하였으며 특히 오미자 군에서는 30% 이상 감소를 보였다. C57BL/6 생쥐를 이용하여 고지방식이로 비만을 유도하면서 분말형 다진양념, 오미자, 진피, 감초, 녹차엽 추출물을 경구투여한 뒤 체중증가를 조사한 결과 8주 후 고지방식이와 다데기만을 경구투여한 군은 고지방식이군과 비교하여 체중감소경향만을 보였으나 분말형 다진양념과 추출물을 함께 경구투여한군에서는 유의적으로 체중이 감소하는 결과를 보였다. 이들 추출물을 혼합하여 제조한 분말형 다진양념은 관능검사에서도 고춧가루 특유의 풋내를 감소시켜 향미가 증진되는 것으로 평가되어 오미자, 진피, 감초, 녹차엽을 첨가한 다양한 항비만 기능성 양념 개발이 기대된다.

• Korean Journal of Ichthyology
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• v.22 no.4
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• pp.249-255
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• 2010

Ecological characteristics of landlocked and anadromous populations of Hypomesus nipponensis were investigated from December 2008 to April 2009 in the Soyangho (landlocked population) and Hyangho (anadromous population). Morphological differences between the landlocked and anadromous populations were not found. The spawning season was March in the Soyangho and late February in the Hyangho. Individuals of both populations were sexually mature at sizes over 60 mm total length. Gonadosomatic index of the landlocked population (female: 20.5%, male: 3.7%) was higher than in the anadromous population (female: 17.4%, male: 3.3%). Number of eggs in the ovaries was greater in the anadromous Hyangho (7,325) population and fewer in the Soyangho (4,902) population; this corresponded to the greater total length in the former. Condition factor was 0.6 (0.49~0.74) in the Soyangho population and 0.7 (0.47~0.76) in the Hyangho population. Stomach contents of H. nipponensis consisted mainly of zooplankton and aquatic insects, and the size of prey was larger in the Hyangho population than in the Soyangho population.