• The Korean Journal of Nuclear Medicine
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• v.7 no.2
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• pp.43-46
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• 1973

이 논문(論文)은 1969년(年) 9월(月) 부터 시작된 IAEA, Internal Society of Hematology 후원(後援)인 ICSH(International Committee for Standardization of Haematology 주최로 열린 제5차 ICSH Panel에서 거론된 Ferrokinetics에 관한 몇 가지 문제점을 초록한 것이다. 1973년 11월 19일 IAEA/ICSH는 Ferrokinetics의 수기(手技)상의 문제점에 관한 토론이 있었다. 즉 혈청철(血淸鐵)이나 총철결합능(總鐵詰合能)을 검사용 혈액 채취시마다 매번 측정해야 되는지에 관한 문제, 환자(患者)의 총철결합능(總鐵詰合能)이 낮을 때 $^{59}Fe$를 주사(注射)하기전 직업적 공혈자(供血者)의 혈장(血漿)과 미리 incubation한 후 주어야 하는지의 문제, 검사용 혈액채취시 그 혈액양, 주입하는 방사성동위원소의 양(量), 항응고제(抗凝固劑)로 Heparin 대신 ACD를 사용할 수 있는지 여부, 통상(通常)의 주사기(注射器)를 사용할 때 그 오차를 줄이는 방법에 관한 문제 방사능(放射能) 계측시(計測時) 혈장(血漿) 대신 전혈(全血)을 사용채도 좋은가에 관한 문제점등이 토론되었다. 여기서 대체로 의견이 일치된 점으로는 주입(注入)하는 $^{59}Fe$는 비방사능(比放射能)이 $5{\mu}Ci/{\mu}g$이상일 것, 이의 양(量)은 체중당(體重當) 얼마로 표시할 것, 방사능계측(放射能計測)에 사용되는 혈액(血液)은 반드시 혈장(血漿)으로 통일할 것, 혈청철(血淸鐵)의 측정(測定)에는 첫번째 및 네번째의 검사용 혈액(血液)을 사용할 것, 혈액(血液)채취후 즉시 혈장(血漿)을 분리(分離)하여 보관할 것, 등(等)에 의견을 모았으며 앞으로 이에 관한 상보(詳報)를 마련하기로 하였다.各) 검사(檢査)에서 계산(計算)된 측정치(測定値)에 차이(差異)가 있어 그 결과(結果)의 해석(解釋) 및 비교(比較) 검토(檢討)에 적지않은 난점(難點)이 생겨 표준화(標準化)된 공통적(共通的)인 방법(方法)의 사용(使用)이 중요(重要)하다는 사실(事實)이 인식(認識)되게 되었다. 1966년(年) 호주(濠洲)의 Sydney에서 개최(開催)되었든 제11차(第11次) 국제혈액학회(國際血學會)때 열린 제4차(第4次) International Committee for Standardization in Haematology(ICSH)에서 Diagnostic Applications of Radioisotopes in Haematology에 관(關)한 expert panel을 갖을것을 의결(議決)하여 다음과 같은 12명(名)의 위원(委員)이 결정(決定)되었으며 위원회(委員會)의 의장(議長)에 Dr. Szur, 총무(總務)에 Dr. Glass가 각각(各各) 선임(選任)되었다. 그간(間) 1967년(年) 영경(英京) London에서 첫 회합(會合)이 있은후(後) New York, Vienna(IAEA후원(後援)) Brthesda(NIH후원(後援))에서 전문위원회(專門委員會)를 갖고 적혈구수명측정법(赤血球壽命測定法)에 관(關)한 의견(意見)의 일치(一致)를 보았다. ICSH와 국제혈액학회(國際血學會)에서는 이번에 결정(決定)된 적혈구수명측정법(赤血球壽命測定法)을 널리 소개(紹介)하며, 측정법(測定法)과 얻어진 결과(結果)의 해석(解釋)에 표준화(標準化)를 기(期)할 목적(目的)으로 이에 연관성(聯關性)있는 전문지(專門誌)에 게재(揭載)할 것을 요청(要請) 받었기에 이에 전문(全文)을 소개(紹介)하는 바이다. 이들은 방사성(放射性) chromium 법(法)의 모든 세부적(細部的)인 면(面)을 표준화(標準化)하고 있으며 그간(間) 가장 논란(論難)의 대상(對象)이 되었던,

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.4 no.2
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• pp.179-186
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• 2006

Chemical wastes are generated from nuclear facilities and R&D laboratories, but the uranium concentration in the final dried cake is evaluated into 11.2 Bq/g, which exceeds the exemption level of 10 Bq/g for each U isotopes, so the cake is categorized into a radioactive waste. Acid dissolution was applied to extract uranium from the waste sludge, and uranium adsorption on the dissolved solution was experimented by using IRN-77 and Diphosil bead. A large amount of resin was required to get above 80% of uranium removal, which was found to be due to a large amount of metal ions simultaneously dissolved from the precipitates with uranium. As an alternative method, acid dissolution is applied to the dewatered wet cake of the sludge, and the natural evaporation method is adopted for the dissolved solution. The uranium concentration of the dissolved solution was estimated to be 6.97E-01 Bq/ml, and the specific activity of the final waste sheets is evaluated to be 4.3 Bq/g. These results lead to the suggestion that the application of acid dissolution to the wet cake and the natural evaporation for the dissolved solution is an effective treatment method for chemical wastes containing uranium.

• Progress in Medical Physics
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• v.12 no.1
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• pp.19-29
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• 2001

In dose modeling, the shape of actual source and sealed capsule are important parameter to determine the physical dose computation. The author investigated the effect of filter of source self-absorption and sealed capsule to designed the high dose rate Ir-192 source for Ralstron(Japan) unit. The size of source designed to 1.5 mm $\Phi$ x 1.5mm length of actual source sealed with stainless steel which is 3.0mm $\Phi$ x 12.0mm length connected to driving cable. The dose attenuation was derived 66.3 % from 2655 segmented source at reference point of 10mm lateral distance of source. The output dose rate factor in tissue for designed source showed 0.0013511 cGy/mCi-sec in reference point at 1cm lateral distance of source center. The dose distribution at inferior of source showed the 52% of that of source tip region, however, the filtering effect was small as 4% at 45degrees of source axis. The dose attenuation within 20 degrees of source axis at near source-cable connector showed large filtering effect as 40% over, but the small effect was revealed isotropic dose distribution at large angle.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.3 no.4
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• pp.175-182
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• 1998

Recently it is reported that anomalously low saline surface waters (salinity < 32) occurred at the Ulleung Basin in the East Sea-Japan Sea, during early September to November 1996. Apparent source of such a low saline watermass seems remotely linked to the Changjiang Dilute Water (CDW), which expands to the vicinity of Cheju Island during a flood season. Based on the assumption that waters passing through the Western Channel of the Korea Strait are formed by a mixing of Kuroshio Water and CDW, simplified two end-member mixing model using $^{228}Ra/^{226}Ra$ as a conservative tracer is applied to calculate the contribution of each end member for the formation of low saline surface seawater. Model calculations show CDW contributes $58{\pm}3%$ in September 1996 (S=32.17) and $10{\pm}3%$ in February 1997 (S=34.53) in the formation of surface water flowing into the Western Channel of the Korea Strait. Although results arc deduced from a simplified model with limited data, this study demonstrates that Changjiang discharge is clearly traceable to the interior of the East Sea-Japan Sea in fall season. Undergoing Three Valley Dam construction in the Changjiang River would invoke inevitable changes in the nature and discharge of CDW and its impacts on the marine environment might be significant in the northern East China Sea and even in the Ulleng Basin for coming decades.

• Korean Journal of Weed Science
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• v.10 no.2
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• pp.109-113
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• 1990

In order to determine selective mode of action of naproanilide between rice and paddy weeds, absorption and translocation of $^{14}C$-naproanilide in rice, Echinochloa crus galli, Cyperus serotinus, and Sagittaria pygmaea were studied, Rice plant and Echinochloa crus-galli absorbed less amount of $^{14}C$-naproanilide than Sagittaria pygmaeo and Cyperus serotinus. Less amount of $^{14}C$-naproanilide was translocated into shoots and translocation rate was slower in rice and Ecl:inochloa crzis-galli than that of Sagittaria pygmaea and Cyperars serotinus. Also, 30-40% of $^{14}C$-naproanilide was distributed at tubers of Sagittaria pygmaea and Cyperus serotinus, which explained that higher amount of $^{14}C$-naproanilide was absorbed from tubers. $^{14}C$-naproanilide was gradually decreased in all plant species and finally more radioactivity was determined in Sagittaria pygmaea and Cyperus serotinus than in Echinochloa cars-galli and rice plant after $^{14}C$-naproanilide treated plants were transferred to Kasugai solution.

• Journal of Radiation Protection and Research
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• v.33 no.1
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• pp.21-26
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• 2008

When the calibration on Liquid Scintillation Counter using the Solid $^3H$ Standard Source of 200,000DPM is executed, the uncertainty due to activity and geometry difference, exists. Therefore, this paper intends to evaluate environmental samples comparatively accurately as decreasing this uncertainty existing in the process of calibration. For this, measurements on samples manufactured by $^3H$ Standard Source and sensitivity study were performed. Also, this paper verified calibration results using Radioactivity-Error-Analysis Method, and evaluated quantitatively the effect by geometry and activity difference based on verification result. According to the result of sensitivity study, in case of using the exposure time of 75 sec and Repeat method, the measuring accuracy and precision of about $1{\sim}3%$ were increased in comparison with the existing method. By analysis result, the effect by activity difference did not appear, and a plastic cell existing into Teflon vial made a role as reflector. The less the effect of plastic cells are decreased, the more activity is high, and the effect of those can be neglected at the activity of 200,000 DPM.

• The Korean Journal of Nuclear Medicine
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• v.34 no.3
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• pp.234-242
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• 2000

Purpose: Tc-99m MIBI scintimammography has been validated as an useful non-invasive diagnostic tool for the primary breast cancer. But most studies have included small population of patients. We have experienced a large study population and investigated the diagnostic usefulness of Tc-99m MIBI scintimammography in detection of primary breast cancer and axillary lymph node metastasis. Materials and Methods: This study included 305 patients who underwent scintimammogtaphy for palpable breast masses or abnormal radiologic findings. Tc-99m MIBI scintimammography was performed 10 minutes after intravenous injection of 925 MBq of Tc-99m MIBI. If the early image revealed abnormal finding, 3 hour delayed image was also acquired. We calculated early and delayed lesion to non-lesion ratios (L/N). The pathologic diagnosis was obtained from surgical operation or FNAB and compared with the results of Tc-99m MIBI scintimammography. Results: Malignant breast diseases were 155 and benign ones were 150. Tc-99m MIBI scintimammography revealed 132 true positive, 23 false negative, 10 false positive, and 140 true negative cases. The sensitivity, specificity, positive predictive value and negative predictive value for the primary breast cancer detection were 85.2%, 93.4%, 92.9%, and 85.9%, respectively. The sensitivity, specificity, positive predictive and negative predictive values of Tc-99m MIBI scintimammography in detecting metastatic axillary lymph node involvement were 22%, 90.4%, 61.9% and 62.3%, respectively. Early L/N of malignant breast disease was significantly higher than that of benign one ($2.44{\pm}0.97\;vs\;1.94{\pm}0.78$, p=0.01). Delayed L/N had no significant difference between malignant and benign breast diseases ($1.94{\pm}0.52\;vs\;1.91{\pm}0.73$, p=0.43). Conclusion: Our study revealed that Tc-99m MIBI scintimammography was an useful diagnostic tool for the diagnosis of breast cancer. And early L/N ratio might provide complementary role in the detection of breast cancer. But the Tc-99m MIBI scintimammography had limited value in the detection of small breast cancer (less than 1 cm) and axillary lymph node metastasis.

• The Korean Journal of Nuclear Medicine
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• v.36 no.3
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• pp.195-202
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• 2002

Purpose: For clinical application of beta-emitter labeled antibody, high specific activity is imporiant. Carrier-free $^{188}Re$ from $^{188}W/^{188}Re$ generator is an ideal radionuclide for this purpose. However, low stability of $^{188}Re$ labeled antibody, especially in high specific activity, due to radiolytic decomposition by high energy (2.1 MeV) beta ray was problem. We studied the stability of $^{188}Re$ labeled antibody, and stabilizing effect of several stabilizers. Materials and Methods: Pre-reduced monoclonal antibody (CEA79.4) was labeled with $^{188}Re$ by incubating with generator-eluted $^{188}Re-perrhenate$ in the presence of stannous tartrate for 2 hr at room temperature. Radiochemical purity of each preparation was determined by chromatography. Human serum albumin was added to the labeled antibodies (2%). Stability of $^{188}Re-CEA79.4$ was investigated in the presence of ascorbic acid, ethanol, of Tween 80 as stabilizing agents. Results: Labeling efficiencies were $88{\pm}4%\;(n=12)$. Specific activities of $1.25{\sim}4.77MBq/{\mu}g$ were obtained. If stored after purging with $N_2$, all the preparations were stable for 10 hr. However, stability decreased in the presence of air. Perrhenate and $^{188}Re-tartrate$ was major impurity in declined preparation. colloid-formation was not a significant problem in all cases. Addition of ascorbic acid stabilized the labeled antibodies either under $N_2$ or under air by reducing the formation of perrhenate. Conclusion: High specific activity $^{188}Re$ labeled antibody is unstable, especially, in the presence of oxygen. Addition of ascorbic acid increased the stability.

• Journal of the Korean Society for Marine Environment & Energy
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• v.12 no.3
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• pp.133-142
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• 2009

In order to understand the present environmental condition and future impingement of Changjiang(Yangtze River) outflow upon the adjacent seas after the scheduled completion of the Sanxia (Three Gorges) Dam in 2009, we tried to estimate the mixing ratios among surface waters of three end-members: Changjiang Water (CW), Kuroshio Water (KW), and East China Sea Water (ECSW) using $^{228}Ra/^{226}Ra$ activity ratio and salinity as tracers. Water samples were collected from 32 stations in November 2005 (R/V Tamgu 3), from 20 stations in July 2006 (R/V Ocean 2000) and from 17 stations in August 2006 (R/V Ieodo) in the northern part of the East China Sea. Radium isotopes in ~300 liters of surface seawater were extracted onboard by filtering through manganese impregnated acrylic fibers and following coprecipitation as $Ba(Ra)SO_4$. Activities of radium isotopes were determined by a high purity germanium detector. Results show that the fraction of CW was in the range of 1-23% in the study area, while KW was in the range of 0-30 % and ECSW 58-100 %. The eastward plume of Changjiang outflow, commonly observed in satellite images during summer and also displayed by the eastward-decreasing CW fraction in this study, could be attributed to Ekman transport caused by the SE monsoon prevailing in this region during summer. Results of this study showed that in the drought season, there was a little or no fraction of CW in the study area. Concentration of dissolved inorganic nitrogen (DIN) showed strong positive relationship with the fraction of CW, suggesting Changjiang as the major source of nitrogen. The mixing curve of DIN indicates the removal of nitrate by biological uptake during the mixing of CW with ambient seawater in the study area.

• The Korean Journal of Nuclear Medicine
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• v.34 no.1
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• pp.55-61
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• 2000

Purpose: We performed this study to evaluate the changes of gallbladder ejection fraction (GBEF) in diabetic patients with or without autonomic neuropathy. Materials and Methods: This study included 37 diabetic patients (25 women, 12 men, mean age 51 years) and 24 normal controls (10 women, 14 men, mean age 38 years). After intravenous injection of 185 MBq of $^{99m}Tc$-DISIDA, serial anterior abdominal images were acquired before and after fatty meal. Regions of interest were applied on gallbladder and right hepatic lobe on 60 and 90 minute images to calculate GBEF. Results: GBEF was significantly reduced in diabetes with autonomic neuropathy ($43{\pm}12.3%$) and without autonomic neuropathy ($57.5{\pm}13.2%$) compared with normal controls ($68{\pm}11.6%$, p<0.05). And also, GBEF was significantly reduced in diabetes with autonomic neuropathy compared with diabetes without autonomic neuropathy (p<0.05). Fasting blood glucose level, age, sex, hemoglobin Alc, body mass index, serum lipid level were not different in these two diabetic patient groups (p>0.05). When 50.2% of GBEF was used as the criteria for diabetic autonomic neuropathy, the sensitivity and specificity were 80%, 76.5%, respectively. The area under receiver operating characteristic curve was 0.846. Conclusion: GBEF of diabetic patients with autonomic neuropathy was significantly reduced than that of diabetic patients without autonomic neuropathy.