• Proceedings of the KIEE Conference
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• 2008.04a
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• pp.125-126
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• 2008

현재, 우리나라 당뇨병의 유병률은 빠른 속도로 증가하고 있으며 당뇨병의 유병기간이 길수록 각종 합병증이 발생하며 더욱 심각한 증세를 나타내기도 한다. 그 중, 비만 및 고혈당, 당대사장애로 인한 당뇨병성 혈관 합병증과 말초 혈관 경화증이 많이 발병하고 있는 실정이다. 본 연구에서는 광혈류량 측정법(Photoplethysmograaphy)으로 손가락에서 얻어진 맥파의 2차 미분 분석을 통해 당뇨병으로 확진된 36명의 당뇨병 환자에 대해 말초혈관 경화도를 연령별로 비교하고자 하였다. 이때 사용한 PPG 파형의 2차 미분 분석 평가 인자는 a와 d이고, d/a는 혈관의 경화도를 의미하며 경화도가 클수록 d/a의 값은 감소하게 되고, 연령이 증가할수록 경화도는 증가하게 된다. 50대 미만의 당뇨병 환자의 d/a값은 $-0.32{\pm}0.12$, 50대는 $-0.48{\pm}0.13$, 60대는 $-0.55{\pm}0.16$, 70대 이상에서는 $-0.59{\pm}0.19$로 연령이 높아질수록 d/a값이 감소하는 것을 확인하였다. 또한, SPSS 13.0 for Windows(SPSS Inc, USA)의 Oneway ANOVA 분석 결과, 연령과 경화도는 통계적으로 유의한 차이를 보였다(p<0.05). 하지만 70대 이상의 당뇨병 환자 그룹에서는 유의한 차이를 확인할 수 없었다. 본 연구에서는 PPG 파형의 2차 미분 분석을 통하여 연령별 당뇨병 환자의 말초혈판 경화도를 비교하였으며, 향후 보완 연구를 통해 비침습적이고 간단한 방법으로 당뇨병 환자의 말초혈관 경화도를 객관적으로 평가하고 진단할 수 있는 시스템 개발로 당뇨병 환자들의 심혈관계질환 사전예방과 치료효과 판정에 도움을 줄 것으로 기대한다.

• Journal of Korea Association of Health Promotion
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• v.4 no.1
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• pp.12-27
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• 2006

"본 논문은 대한내과학회지 2006년 제70권 제3호에 실렸던 논문으로 대한내과학회 편집위원회의 승인을 득하고 본 협회지에 게재함. Background : Diabetes mellitus is a major independent risk factor for atherosclerosis. In recent years non-invasive high resolution B-mode ultrasound methods have been developed to measure the intima-media thickness(IMT) of the carotid artery as an indicator for early atherosclerosis. Itis known that obesity plays a role in the development of type 2 diabetes and cardiovascular disease, and it has also been reported that not only the amount but also the distribution of body fat is important. This study investigated the relationship between obesity and the development of carotid atherosclerosis in type 2 diabetic patients. Methods: Carotid IMT was measured by ultrasound B-mode imaging in 144 patients with type 2diabetes mellitus. All subjects underwent assessment for the degree and distribution of obesity, the presence of coronary artery disease risk factors, and the presence of diabetic complications. Resuts: Carotid IMT was increased in the abdominal obese group defined by waist circurference. However, there was no significant difference in carotid TMT between the non-obese group and obese group as defined by body mass index, waist to hip ratio, and total body fat percent measured by bio electrical impedance analysis. There were positive correlations between carotid IMT and age, duration of diabetes, systolic blood pressure, and waist circumference. Multiple linear regression analysis revealed the variable that interacted independently with carotid IMT was age in type 2 diabetic patients. Carotid IMT was significantly increased in type 2 diabetic patients with macrovascular complications and microvascvlar complications .Conclusion: This study suggested that abdominal obesity rather than general obesity was associated with carotid atherosclerosis reflected by increment of carotid IMT in type 2 diabetic subjects.

• Korean Journal of Medicinal Crop Science
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• v.18 no.4
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• pp.224-230
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• 2010

This study was conducted to investigate anti-oxidative and inflammatory inhibition effects of green tea and dietary fiber mixture on liver of high fat diet-induced obese rats. 21 male rats were divided into 3 dietary groups and control group (A), high fat diet-induced group (B), and high fat (HF) diet-induced + EQ diet-$S^{(R)}$ diet group (C). Immunoblotting and RT-PCR analysis revealed protein expression, and anti-oxidant analysis revealed MDA (malondialdehyde), GSH (glutathione), and free DPPH radical. As a results, Body weight and food consumption were not significantly different between groups. The levels of MDA and GSH were lower in HF + $EQS^{(R)}$ group than in HF group. Also, the $EQS^{(R)}$ demonstrated to be more effective than HF group for a DPPH radicals scavenging activities. In addition, protein and mRNA level of TNF-$\alpha$ in HF + $EQS^{(R)}$ group showed relatively more potent pro-inflammatory activity inhibition compared to HF group. These results suggest that green tea mixture (EQ diet-$S^{(R)}$) provide positive effects on anti-oxidative and inflammatory inhibition effects on obese animal model or obesity related diseases.

• Korean Journal of Pharmacognosy
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• v.45 no.1
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• pp.69-76
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• 2014

The purpose of this study was to investigate anti-obesity and anti-hyperlipidemic effects of extracts from Geranium thunbergii (GT) in high-fat-diet-induced obese rats. Animals were randomly divided into four groups [normal diet, high fat diet, MeOH extract of GT (GTM), and BuOH fraction of GT (GTB)] and GT samples were treated with dose of 100 mg/kg for 8 weeks. It was observed that GTB-treated group significantly reduced body weight gain, food intake, epididymal fat weight, and triglyceride level in serum and liver compared to control group. The rats fed GTB also decreased contents of thiobarbituric acid-reactive substances (TBARS), hydroxyl radical, and xanthin oxidase (XO) increased by high fat diet. Furthermore, the anti-oxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase were increased by GTB treatment. The experimental results indicate that GTB has anti-obesity and anti-hyperlipidemic effects, as well as radical scavenging activity.

• Herbal Formula Science
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• v.25 no.2
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• pp.167-177
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• 2017

Objectives : This study aimed to evaluate inhibitory effects of GHJ on allergic inflammatory response in human mast cells (HMC-1). Methods : To investigate the inhibitory effect of GHJ (62.5, 125, 250, 500, $1000{\mu}g/mL$), HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI). Enzyme-linked immunosorbent assays (ELISAs), RT-PCR and Western blot analysis were investigated using GHJ extract. Results : GHJ inhibited levels of $TNF-{\alpha}$ and IL-6 of $1000{\mu}g/mL$ concentration in ELISA and mRNA expression. GHJ had inhibitory effects in level of MAPKs, $p-I{\kappa}B-{\alpha}$ and p-NF-kB also. GHJ attenuated Compound 48/80-stimulated histamine release. In addition, GHJ inhibited PCA reaction in vivo. Conclusion : This study indicated that GHJ extract can inhibit allergic responses in HMC-1 cell.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.2
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• pp.215-219
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• 2014

In Korean Cosmetic Act, four uses of functional cosmetics are recognized: skin whitening, anti-wrinkle, UV protection or suntan. Cosmeceuticals, one of the functional cosmetics, have been specifically developed for medical and cosmetic benefits. However, the uses of cosmeceuticals in patent applications are not limited to those of functional cosmetics, and the number is increasing with variety of medical use claims such as anti-inflammatory, prevention of hair loss, or obesity in cosmeceutical patent applications. Since some of the cosmeceutical use claims are not clearly distinguished from medical use claims in pharmaceuticals, there has been a controversy over the extent of granting patents regarding the medical use of cosmeceuticals. In this article, we have investigated the range of medical uses in patented claims of functional cosmetics, summarized examiners' views and discussed the examination practice of cosmetic-related inventions in the United States, Europe, and Japan.

• Journal of The Korean Society of Integrative Medicine
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• v.8 no.1
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• pp.125-135
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• 2020

Purpose : Obesity indices are major predictive markers for coronary artery stenosis, but there are few studies about the relationship between obesity indices and coronary artery stenosis in the Korean population. Therefore, we analyzed the association between obesity indices and coronary artery stenosis among health-screen examinees. Methods : This study included 99 males and females who visited a health-examination center. The obesity indices included body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT), visceral adipose tissue/subcutaneous adipose tissue ratio (V/S ratio). All subjects had their degree of coronary artery stenosis measured using coronary computed tomography angiography (CCTA). A multiple logistic regression test was conducted to analyze the association between obesity indices and coronary artery stenosis. Results : This study was taken by multiple logistic regression test adjusted by age, sex, smoking status, frequency of alcohol drinking/week and frequency of exercise/week. The adjusted odds ratio for the presence of coronary artery stenosis for subjects with abdominal obesity (abdominal obesity defined as a waist circumference ≥ 90 cm in males; ≥ 85 cm in females) was 6.263 (95 % confidence interval (CI) 1.974-19.869), for subjects with visceral obesity by visceral adipose tissue (visceral obesity defined as a visceral adipose tissue ≥ 100) was 11.430 (95 % CI 3.044-42.928). Conclusion : In this study of adults, WC and VAT were independent predictors of coronary artery stenosis. These results suggest that WC and VAT may be useful markers of coronary artery stenosis.

• The Journal of the Korea Contents Association
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• v.15 no.6
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• pp.337-345
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• 2015

Korea worker is well known for its long work and amongst employees and to change un-healthy lifestyle. This study aims to investigate the association between health behaviors and sleep problems in employees. It employed data from the Third Korean Working Conditions Survey (KWCS). The total number of individuals included in the analysis was 34,788 employees, from the 2011 survey. The outcome was sleep problems, which had a prevalence rate of 2.5% in men and 2.3% in women. An adjusted odds ratios were as follows: 2.26(1.75-2.91) for hypertension, 2.21(1.60-3.06) for obesity, 26.82(21.51-33.45) for depression and 2.02(1.64-2.49) for high level of job stress. We need to invest to identify relevant and various health service promotion for sleep problem that un-healthy workers want will use.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.1
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• pp.89.1-89.1
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• 2014

빛공해란, 불필요하거나 필요 이상의 인공빛이 야생 동식물들과 우리 인간들에게 악영향을 미치는 현상을 말하며, 실생활에서 인공빛 에너지를 목적에 맞지 않게 사용하는 것이 이 현상의 주요 원인이라고 할 수 있다. 빛공해 현상은 야생 동식물들에게 악영향을 주어 개체수를 감소시킬뿐만 아니라 멸종에까지 이르게 할 수 있으며, 지구 자전의 영향으로 하루 24시간 주기로 설정되어 있는 우리 인간의 생체리듬을 교란시켜 암, 비만, 당뇨병, 그리고 우울증 등과 같은 인간의 목숨을 위협할 수 있는 질병들을 일으키기도 한다. 하지만 인공빛을 목적에 맞게 올바르게 사용한다면 그로 인해 절약된 에너지와 그 비용을 다른 필요한 분야에 대체하여 사용할 수 있을 것이다. 우리는 과거의 빛공해 관련 논문과 보고서의 설문조사 결과를 통하여 빛공해로 인한 피해와 에너지 낭비 문제가 빛공해에 대한 일반 시민들의 무관심으로부터 발생하고 있다는 사실을 확인할 수 있었다. 따라서 우리는 빛공해에 대한 일반 시민들의 인식 변화를 알아보기 위하여 기존에 진행된 설문조사와 같은 문답내용의 설문조사를 올해 다시 실시하였다. 그 설문조사의 결과를 통하여 우리는 과거보다 빛공해에 대한 인식이 많이 확산되어 있다는 사실을 알 수 있었으며, 그 이유로는 최근 빛공해와 관련된 많은 뉴스 기사들과 함께 웹상의 소셜네트워크와 같은 다양한 경로의 정보매체들을 통하여 빛공해에 대한 정보를 보다 빠르고 쉽게 접할 수 있는 환경이 조성되었기 때문이라고 분석하였다. 빛공해 인식 확산에 더욱 더 기여하기 위하여 최근에 우리는 국제 어두운 밤하늘 협회 한국 지부 (Korean Chapter, International Dark-Sky Association) 인가를 받아 그 단체 이름으로 빛공해 방지 홍보 사업을 온라인과 오프라인을 통하여 보다 더 활발히 진행하기 위하여 많은 노력을 하고 있다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.2
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• pp.117-123
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• 2009

Magnolia extract, prepared from the Chinese herb Magnolia officinalis, is known for its potent anti-oxidative and anti-inflammatory effects. In this report, we showed that Magnolia extract inhibits adipocyte differentiation, as evidenced by reduced triglyceride (TG) accumulation. Also, Magnolia extract increased hormone sensitive lipase (HSL) protein level, and decreased the adipogenic transcription factor peroxisome proliferator activated receptor (PPAR)-${\gamma}$ protein and their corresponding mRNA. Our results suggest a potential apllication of Magnolia extract as anti-obesity agents inhibits adipocyte differentiation through the down-regulation of adipogenic transcription factors and other adipocyte-specific genes.