• Title/Summary/Keyword: 분화율

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Effects of Adjuvant Radiation Therapy and Chemotherapy Following Curative Surgery in Locally Advanced Rectal Cancer (국소 진행된 직장암에서 근치적 절제술 후 방사선치료와 항암화학요법과의 병용치료에 대한 효과)

  • Kang, Ki-Mun;Choi, Ihl-Bohng;Kim, In-Ah;Jang, Jee-Young;Shin, Kyung-Sub;Jang, Suck-Kyun;Lee, Jae-Hak;Kim, Young-Ha;Won, Chong-Man;Choi, Dong-Hwan;Kim, Jin-Seung;Park, Shinn-Hee
    • Radiation Oncology Journal
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    • v.15 no.2
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    • pp.121-128
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    • 1997
  • Purpose : To evaluate the effect of postoperative adjuvant radiation therapy and chemotherapy on the survival, pattern of failure and complication for locally advanced rectal carcinoma Materials and Methods : From October 1992 to September 1995, twenty eight patients with rectal carcinoma were treated by postoperative adjuvant radiation therapy and chemotherapy Radiation therapy was delivered with 6MV and 15MV linear accelerator, 180c0y fractions 5 day per week. Total radiation doses were 5040cGy in $B_{2+3}$ and 5580cGy in $C_{2+3}$. Within 4 weeks after radical surgery. 5-FU$(400mg/m^2/day)\;and\;Leucovorin(20mg/m^2/day)$ were administered by intravenous injection for 4 days during the first and fifth week of radiation therapy. The median follow up was 19 months with a range 2 to 47 months. Results : The 2 year overall survival and disease free survival rates were $78.6\%\;and\;70.8\%$, respectively. The 2 year overall survival was $93.0\%\;in\;B_{2+3}$ and $76.2\%\;in\;C_{2+3}$(p=0.11) The 2 year disease free survival was $79.4\%\;in\;B_{2+3}\;and\;69.2\%\;in\;C_{2+3}(p=0.13)$. The overall failure rate was $21.42\%$(6/28) including $10.72\%$(3/28) locoregional recurrence, $3.62\%$(1/28) distant metastasis and $7.12\%$(2/28) locoregional recurrence with distant metastasis. The overall locoregional recurrence rate was $17.92\%$(5/28). The 2 year locoregional recurrence rates were $13.32\%(2/15)\;and\;23.12\%$(3/13) for respectively for $B_{2+3}\;and\;C_{2+3}$ The difference between the locoregional recurrence of $B_{2+3}\;and\;C_{2+3}$ patients was not significant(p=0.07). Complications developed in 13 patients$(46.42\%)$, including 8 dermatitis, 7 loose stool, 6 leukopenia, 4 tenesmus, 2 diarrhea. In Univariate analysis, there was no statistically significant factor except for tumor grade in locoregional recurrence, disease free survival and overall survival rate(p=0.04, 0.05, 0.04). Conclusion : This study sugges1s that postoperative adjuvant radiation therapy and chemotherapy is effective in patients with locally advanced rectal cancer. Therefore these results need to be confirmed with a long term follow-up and larger number of patients with the further clinical trials including prospective controlled studies.

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Growth Characteristics and Grain Yield of F$_1$ Hybrids, Their Restorers and Maintainers in Rice (벼 1대 잡종 품종들의 생장특성과 수량)

  • 김창국;이변우
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.39 no.3
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    • pp.262-269
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    • 1994
  • This study was conducted to clarify high yielding factors of F$_1$ hybrids in terms of the growth characteristics, canopy structure, nitrogen content and nitrogen profile in the canopy. Varieties used in this study were four hybrid rices showing different heterosis in grain yield and their parents. Varieties of Japonica were Reimei (maintainer), TP 681 and TP 1278(restorers), and F$_1$ (Reimei ms ${\times}$ TP 681, Reimei ms ${\times}$ TP 1278) hybrid rices. Those of Indica type were 1378 (maintainer), Milyang 46 and Suweon 287(restorers), and F$_1$ (1378 ms ${\times}$ Milyang 46, 1378 ms ${\times}$ Suweon 287) hybrid rices. High heterosis in F$_1$ hybrid rices were shown in panicles per hill and spikelets per panicle, being greatest in spikelets per panicle. Spikelets per square meter expressed even greater heterosis than those two yield components because of multiplicative effect of them. Heterosisof ripened concentration of leaf nitrogen and steeper gradient of leaf nitrogen in canopy strata but also better productive structure in favor of light interception seemed to have led to higher canopy photosynthesis of F$_1$ hybrids and subsequent higher partition of assimilates for leaf area expantion especially during vegetative growth stage. Higher dry matter production, resulting from these factors, during vegetative stage would have contributed to the production of greater number of spikelets per square meter, and consequently to higher grain yield in F$_1$ hybrids.

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Usefulness of Tc-99m MIBI Scan in the Postoperative Follow Up Of Well-Differentiated Thyroid Cancer (분화된 갑상선암의 수술후 경과 관찰에서 Tc-99m MIBI 스캔과 다른 추적 지표들의 유용성 비교)

  • You, Kye-Hwa;Song, Jae-Soon;Shinn, Joon-Jae;Lee, Hyun-Kyung;Cha, Wang-Ki;Kim, Do-Min;Kim, Eun-Sil;Kim, Chong-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.31 no.3
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    • pp.356-364
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    • 1997
  • To evaluate the clinical utility of Tc-99m MIBI scan in the detection of residual thyroid tissue or metastatic lesion in postoperative thyroid cancer patients, we compared Tc-99m MIBI scan with I-131 diagnostic and therapeutic scan in 30 postoperative well-differentiated thyroid cancer patients. Thyroglobulin levels of both on and off thyroid hormone medication and antithyroglobulin antibody were tested [Tg(on), Tg(off)]. Positive rates for I-131 diagnostic and Tc-99m MIBI scan were 81% and 68% respectively. Concordance between I-131 diagnostic and Tc-99m MIBI scan was observed in 15 cases; 12 positive and 3 negative respectively. Among the 6 cases with negative I-131 diagnostic scan and positive Tc-99m MIBI scan, 4 were Positive in the therapeutic I-131 scan We concluded that Tc-99m MIBI scan maybe a useful complementary modality to the currently established method of I-131 scan and serum thyroglobulin level in the detection of recurrent or metastatic thyroid cancer, especially in the case of negative I-131 diagnostic scan.

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In Vitro Tissue Culture Frequency and Transformation of Various Cultivars of Soybean (Glycine max (L.) Merr.) (다양한 콩 자원들의 기내 조직배양 효율 및 형질전환)

  • Seo, Mi-Suk;Cho, Chuloh;Jeong, Namhee;Sung, Soon-Kee;Choi, Man-Soo;Jin, Mina;Kim, Dool-Yi
    • Korean Journal of Plant Resources
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    • v.34 no.4
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    • pp.278-286
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    • 2021
  • Efficient in vitro regeneration system is essential for the successful crop breeding of soybean (Glycine max (L.) Merr.) using the new biotechnology. The genotype of donor plants strongly influences the establishment of tissue culture system. Therefore, the screening of genotypes with excellent tissue culture ability is very important for soybean genetic improvement. In this study, we report the tissue culture efficiency of 21 soybean cultivars belong to Korean soybean core-collection and two foreign cultivars (Jack and Maverick). The Kwangan, Anpyeong and Seonam are share close genetic relationship in 21 cultivars and these three cultivars were observed the high frequency of germination and regeneration. Furthermore, the high tissue culture abilities were also observed in the Williams 82 used in reference genome sequencing and the two foreign cultivars. The transformation of pBAtc:tRNA with bar gene was performed by Agrobacterium tumefaciens in the cultivars with high tissue culture ability. Transformation of the bar gene was identified by PCR analysis in Kwangan, Pungwon, Seonam, and Maverick. Our results provide useful information for the breeding of various soybean cultivars by plant biotechnology such as, genome editing.

Pot Cultivation Method of Veronica rotunda Nakai (둥근산꼬리풀의 포트 재배 방법)

  • Yeon, Soo Ho;Lee, Seung Yeon;Lee, Cheol Hee
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2019.04a
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    • pp.88-88
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    • 2019
  • 현삼과(Scrophulariaceae)의 둥근산꼬리풀(Veronica rotunda Nakai)은 흰색의 꽃이 총상화서로 피며, 관상용으로 쓰인다. 또한, 접선골도라 하여, 전초를 약용하고 활혈, 지혈, 청폐열, 화간위에 효능이 있는 자생식물이다. 본 연구는 둥근산꼬리풀의 포트 재배방법 확립을 위하여 2018년 5월 15일에 파종하여 생산된 유묘를 7월 16일에 정식하여 10월 15일까지 약 14주 동안 수행하였다. 식재용기 실험은 비닐포트[3치($7{\times}7cm$), 4치($9{\times}8.5cm$)]와 플라스틱 화분[8호($7{\times}7cm$), 10호($9{\times}9cm$), 12호($10.5{\times}10.5cm$)]를 이용하였고, 토양 종류[중화 피트모스:펄라이트(3:1, 4:1), 마사토:중화 피트모스(2:1, 3:1)], 묘의 소질[파종 립수(1, 2, 4, 6립), 파종 용기(162, 200, 288구 트레이)] 등의 연구를 진행하였다. 대조구는 플라스틱 화분 10호에 원예상토를 충진하고 200구 트레이에 4립씩 파종하여 생산된 1셀을 정식하였다. 연구의 결과, 식재용기에 따른 둥근산꼬리풀의 생육은 플라스틱 12호 화분에서 가장 양호하였으며, 토양의 양이 많을수록 전반적인 생육이 증가하였다. 토양 종류별로는 원예상토에서 재배한 처리구에서 양호한 생육을 보였다. 중화 피트모스와 펄라이트 3:1 혼용토의 경우, 원예상토와 전반적인 생육에 큰 차이가 없어 이용가치가 있을 것으로 판단된다. 한편, 피트모스의 비율이 높은 4:1 혼용토에서는 비교적 생육이 억제되었으며, 잎이 황화되었다. 마사토와 중화 피트모스의 혼용토는 원예상토에 비해 왜화되는 결과를 보였으며, 측지수, 마디수, 엽수에는 큰 영향을 주지 않았다. 그러나 개화율을 감소시키는 결과를 보였다. 셀당 파종한 종자의 양을 달리하여 생산된 유묘를 정식하여 재배한 결과, 전반적인 생육은 1립 파종구에서 양호하였다. 한편, 파종량이 많을수록 초장, 절간장이 감소하며, 포트당 마디수, 측지수 및 개화율이 증가하여, 본 연구의 목표인 관상적 이용에 적합한 것으로 판단된다. 파종용기별 생산된 유묘이식 결과, 초기생육이 왕성할수록 후기생육도 우수하였다. 162구 생산묘 정식구는 다른 처리구보다 전반적으로 생육이 왕성하였으며, 다음으로 200구 순이었다. 파종용기에 따른 묘의 크기는 정식 후의 개화율에 유의적인 차이가 없었다. 따라서, 둥근산꼬리풀의 재배는 플라스틱 화분 12호에 원예상토를 충진하여 162구 트레이에 셀당 6립 파종하여 생산된 유묘를 정식하는 것이 분화용 재배에 효과적인 것으로 생각된다. 한편, 재배에 이용되는 토양의 종류에 따른 비율 및 개화촉진 등의 추가적인 연구가 필요하다.

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Radiotherapy Results of Malignant Astrocytoma and Glioblastoma Multiforme (악성 성상세포종과 교아세포종의 방사선 치료성적)

  • Choi, Doo-Ho;Lee, Hae-Kyung;Hong, Seong-Eon
    • Radiation Oncology Journal
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    • v.10 no.2
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    • pp.163-169
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    • 1992
  • A retrospective analysis was performed on 53 patients with brain malignant astrocytoma and glioblastoma multiforme treated with surgical resection and postoperative radiotherapy in the period between January 1980 and June 1991. There were 13 patients with malignant astrocytoma, 40 patients with glioblastoma multiforme. Survival rates were analyzed according to histologic grade, age, performance status, extent of surgical resection, tumor location, symptom duration, total radiation dose and addition of chemo­therapy after radiation therapy. 5 year actuarial survival rate for malignant astrocytoma was $29.4\%$, for glioblastoma multiforme was $2.8\%$. Histologic grade, age, performance status, total radiation dose were statistitically significant prognostic factors.

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Radiotherapy Results of Brain Astrocytoma and Glioblastoma Multiforme (성상세포종과 교아세포종의 방사선치료성적)

  • Choi Doo Ho;Kim Il Han;Ha Sung Hwan;Chi Je Geun
    • Radiation Oncology Journal
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    • v.6 no.2
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    • pp.163-168
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    • 1988
  • A retrospective analysis was performed on 49 patients with astrocytoma or gliobiastoma multiforme of brain who received postoperative radiotherapy in the period between February 1979 and December 1985 Fourteen patients had grade 1 astrocytoma, 11 patients grade II, 14 patients grade III, and 10 patients glioblastoma multiforme. Three year actuarial survival rates were $85.7\%,\;44.0\%\;and\;23.1\%$ for grade I, II, and III astrocytomas, respectively. One and 2 year actuarial survival rates for patients with glioblastoma multiforme were $54.5\%\;and\;27.3\%$, respectively. Histologic grade, age, extent of operation and tumor location were revealed to be prognosticators.

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Isozymes and Karyotypes of Bufo Species (두꺼비 종류의 아이소자임과 염색체)

  • Yung J. Kim;Yang I, Sunwoo;Kang S. Rhee
    • The Korean Journal of Zoology
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    • v.19 no.3
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    • pp.123-138
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    • 1976
  • Isozymes and chromosomes of Bufo bufo and B. kangii were studied by starch gel electrohporesis and bone marrow air-drying method. Twently-three enzymes and nonenzymatic proteins in Bufo species collected in Korea provided a basis for the estimating the proportion of polymorphic loci in the genum. Of 23 loci controlling the proteins examined, 26% and 17$% were polymorphic in B. bufo and B. kangii, respectively. In B. bufo, 4 loci had 3 alleles and no loci had more than 2 alleles in B. kangii. Both species had same karyotypes with 22 chromosomes except one pair of chromosome which had sat-chromosomes in B. bufo karyotypes. The genetic similarity was approximately 0.5.

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Birth Cohort and Educational Differences in the Marital and Fertility Life Course in South Korea (한국의 혼인과 출산 생애과정: 출생코호트별 및 교육수준별 차이를 중심으로)

  • Woo, Hae-Bong
    • Korea journal of population studies
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    • v.35 no.1
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    • pp.151-179
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    • 2012
  • This study investigates birth cohort and educational differences in the marital and fertility life course using the Hernes model. First, lifetime marriage rates remain high across birth cohorts but men in the youngest birth cohort(1965-74) experience a somewhat significant reduction in ever-marriage rates. Second, this study also finds educational differences in lifetime marriage rates across birth cohorts. The likelihood of being never married is particularly high for poorly educated men in the youngest birth cohort but women show the opposite pattern. Third, quantum changes in the fertility transition are more likely to be the changes in higher-order births, while the changes in first and second births are mainly tempo changes. Fourth, the negative association between education and fertility is significantly larger for higher-order births. Finally, marriage and fertility show the opposite pattern in their association with education. Overall, educational differences in lifetime marriage rates become stronger across birth cohorts but the association between education and higher-order births shows the opposite pattern.

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Plantlet Formation and Somatic Embryogenesis from the penduncle explants of wild Corydalis remota for. peatinata (야생 현호색 (Corydalis remota for. peatinata)의 꽃자루로부터 체세포배 발생과 소식물체형성)

  • 천우재;이대원
    • Korean Journal of Plant Tissue Culture
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    • v.26 no.1
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    • pp.15-19
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    • 1999
  • For the induction of somatic embryogenic callus, the penduncle explants of Corydalis remota for peatinata were cultured on MS basal media supplemented with 2,4-D, kinetin and zeatin. The highest embryogenic callus formation was observed on the media containing 2.0 mg/L of 2,4-D and 2.0 mg/L of zeatin. The somatic embryogenesis on the media with 0.5 mg/L of cytokinin (zeatin or kinetin) were excellent under light condition, however somatic embryos abnormally developed into plantlets. Normal dicotyledonary plantlets were found on MS medium supplemented with 1.0 mg/L of zeatin. When MS medium with 2,4-D plus cytokinin and with BAP were used, the secondary somatic embryogenesis took place in root explants of the regenerants derived from in vitro somatic embryogenic callus.

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