• Korean Journal of Biological Psychiatry
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• v.6 no.2
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• pp.153-160
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• 1999

Animal models can provide a useful tool for the study of some aspects of psychiatric disorders and their treatment. The four criteria for the evaluation of animal models of psychiatric disorders are as following : 1) similarity of inducing conditions 2) similarity of behavioral state 3) common underlying neurobiological mechanisms 4) reversal by clinically effective treatment techniques. Several animal models have been proposed for schizophrenia : phenylethylamine model, L-dopa model, hallucinogen model, cocaine model, amphetamine model, phencyclidine model, noradrenergic reward system lesion model, reticular stimulation model, social isolation model, conditioned avoidance reaction, catalepsy test, paw test, self-stimulation paradigms, latent inhibition paradigms, blocking paradigms, prepulse inhibition of the startle reflex, rodent interaction, social behavior in monkeys, hippocampal damage, high ambient pressure, and models using selective breeding. Among them, animals with bilateral lesion of the hippocampus may provide an adequate animal model for several symptoms of schizophrenia, and ketamine model can reproduce negative symptoms and cognitive deficits as well as positive symptoms of schizophrenia. In conclusion, no model of schizophrenia is entirely representative of the disease, and findings gleaned from model systems must be cautiously interpreted. Furthermore, the process of developing and validating animal models must work in concert with the process to identify reliable measures of human phenomenology.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.30 no.3
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• pp.64-76
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• 2002

기존의 이론적 연구와 실험적 연구를 바탕으로 충돌 제트의 수치 모델을 개발하였다. 본 모델은 like-doublet 충돌제트로부터 생성되는 액적의 모든 특성을 액막이 분열되는 시점에서 결정한다. 액적 특성을 결정하기 위해 이론적 연구로부터 얻어진 액막 두께, 액주의 직경, 액적 크기와 실험적 연구로부터 얻어진 액막/액적 속도, 액막 분열 거리, 분열 주파수, 액적 질량 유량 분포를 이용하였다. 액적의 질량 유량 분포는 Laplace 분포로부터 표준 편차를 이용하여 모사하였다. 또한 실험 결과를 이용하여 액막 분열 거리, 분열 주기, 표준 편차에 대한 경험식을 유도하였다. 개발된 모델은 정성적인 분무 패턴뿐만 아니라 정량적인 SMD 및 질량 유량 분포에서 실험 결과와 잘 일치한다.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.12
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• pp.1489-1495
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• 2013

High-pressure flows are ubiquitous in many industrial fields. A representative application is fuel injection using a common-rail control system in diesel engines, where the injection pressure in the injector exceeds 1000 bar. In high-speed injection, the fluid injected through the nozzle undergoes breakup owing to the interaction with the ambient gas. The breakup process influences mixture formation, which in turn influences combustion in diesel engines. Therefore, it is very important to analyze the breakup process of fuel spray. The Reitz and Diwakar model and cascade atomization and breakup (CAB) model were used in this study as sub-models for the numerical analysis of the breakup process of fuel spray. This study aims to precisely analyze the breakup process of spray and to investigate the breakup frequency of the injected fuel. Consequently, it proposes a suitable sub-model for analyzing the breakup process of a diesel spray by using CFX, a commercial CFD program.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.6
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• pp.447-454
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• 2017

A three-dimensional two-phase large eddy simulation(LES) has been conducted to investigate the breakup and atomization of liquid jets such as a diesel jet in parallel flow and water jet in cross flow. Gas-liquid two-phase flow was solved by a combined model of Eulerian for gas flow and Lagrangian for a liquid jet. Two stochastic breakup models were implemented to simulate the liquid column and droplet breakup process. The penetration depth and SMD(Sauter Mean Diameter) were analyzed, which was comparable with the experimental data.

• Proceedings of the KIEE Conference
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• 2000.07d
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• pp.2696-2698
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• 2000

본 연구에서는 실수형 염색체들로 구성된 개체에 대해 감수분열을 적용하여 개체를 만들고, 이 생식체들의 랜덤한 선택과 교배에 의해 세대가 진화함에 따라 탐색을 수행하는 감수분열 유전알고리즘을 이용하여 퍼지모델의 최적 구조와 파라미터를 탐색하고 Gradient Descent 알고리즘으로 파라미터를 정밀 조정하는 방안을 제안한다. 제안된 방안을 적용하여 Box-Jenkins의 가스로 데이터에 대한 퍼지모델을 구성하고 그 적용 가능성을 보인다.

• Journal of the Korean Society of Propulsion Engineers
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• v.14 no.2
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• pp.1-9
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• 2010

LES(Large eddy simulation) of breakup and droplet atomization of a liquid jet into cross turbulent flow was performed. Two phase flow of gas and liquid phases were modeled by the mixed numerical scheme of both Eulerian and Lagrangian methods for gas and liquid droplet respectively. The breakup process of a liquid column and droplets was observed by implementing the blob-KH wave breakup model. The penetration depth into cross flow was comparable with experimental data for several variants of the liquid-gas momentum flux ratio by varying liquid injection velocity. SMD(Sauter Mean Diameter) distribution downstream of jet was analyzed.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.11a
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• pp.131-134
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• 2007

This numerical analysis was performed in order to validate adoption of the sheet breakup model in high-pressure environment, which were used for prediction of spray characteristics in atmosphere environment. In experiments the higher environment pressure the shorter breakup length; the results of new sheet breakup model predicted the breakup length in good agreement with experimental results qualitatively and quantitatively. Also the shape of spray calculated by numerical analysis were agreed well with experiments quantitatively.

• Journal of the Korean Geotechnical Society
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• v.20 no.9
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• pp.47-56
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• 2004

A new fragmentation model, called the GRS (the generation model of weathered residual soils) model, was proposed in this study, This model could identify the formation of a residual soil. This model is based on the phenomena that as the soil was weathered more highly, soil particles were smaller and pores were more expanded simultaneously. The possibility of fragmentation, $P_F,$ which was based on the fractal theory, was introduced in this model. There were some fundamental notions in the GRS model that soil particles were generated as the rock is fragmented, and the fragmentation of the rock was performed step by step. The $P_F,$ of the rock was not constant at each fragmentation steps. As a result of application on the GRS model, there were more residue where $P_{Fi}s$ were small at any particle size. There was a S-shape of PSD curve at the concave shape of $P_{Fi},$ and the PSD curve goes to a gaped graded curve at the convex shape of $P_{Fi}.$ The shape of PSD curve was concave in the case of small $P_{Fi}s.$ The value of $P_{Fi}$ increased with the coefficient of uniformity $(C_u)$ and the fragmentation fractal dimension $(D_r),$ but had no relation with the coefficient of gradation $(C_C)$.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.05a
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• pp.156-160
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• 2006

This study investigated the characteristics of spray generated by a liquid-liquid co-axial swirl injector used in a combustor of the liquid rocket engine. The linear stability analysis[1] was introduced In liquid sheet breakup and Post[2]'s collision model which considers shattering was adopted on the collision model after breakup. Every model was implemented to KIVA[3], which was adopted as solve. To validate the implemented models the cases of high and low injection velocity were calculated respectively and each result agreed well with test results.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.56-56
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• 1993

새로운 cell cycle 특이적 억제제의 스크리닝 방법의 확립과 이를 이용하여 cell cycle 억제제의 검색 및 세포분열 및 성장을 억제하는 작용의 분석과 이들의 항암작용 및 세포성장 및 분열 억제 작용의 signal transduction mechanism을 규명한다. 이상의 연구를 수행하기 위해 흰쥐 재생간 조직 및 흰쥐 일차 배양 간세포를 연구 모델로 하여 스크리닝 방법을 확립하고, 세포 분열 및 성장 억제제의 연구 대상 약물로는 기존의 천연물 및 미생물의 2차 대사 산물을 분리 정제한 물질등을 사용하여 그 작용 효능을 연구한다. 1) 흰쥐 부분 간 절제 수술 26시간 후 핵 단백질을 분리 2) MPF activity 측정 3) MPF 활성 저해제 생산 균주의 1차 탐색