• 대한한방부인과학회지
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• 제19권1호
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• pp.166-177
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• 2006

Purpose : This investigation was undertaken to evaluate the antiproliferation, atoptosis of Sam-nueng(Sparganii Rhizoma) extract using MCF-7 human breast cancer cells. Methods : MCF-7 cells were cultured in Dulbecco's modified Eagle's medium/F12(DMEM/F12) supplemented with 10 % fetal bovine serum(FBS; Gibco) and antibiotics. At varying times after extract treatment, cells were harvested with scraper and processed for analysis of protein expression, proliferation, cytotoxicity and apoptosis. Results : Our results show that the extract of Sam-nueng(Sparganii Rhizoma) strongly inhibits the proliferation of MCF-7 cells in a dose and time-dependent manner. Sulforhodamine B showed that the addition of Sam-nueng(Sparganii Rhizoma) extract reduced the viability of MCF-7 cells in a dose-dependent manner. Poly[ADP(ribose)] polymerase(PARP) which serves as a marker of cells undergoing apoptosis, a major substrate for caspase-3 was extensively cleaved in the Sam-nueng(Sparganii Rhizoma)-treated cells. Conclusion : So, we can conclude that Sam-nueng(Sparganii Rhizoma) can have an inhibitive effect on MCF-7 human breast cancer cells by variable mechanisms.

• 대한한방부인과학회지
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• 제31권2호
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• pp.18-30
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• 2018

Objective: This study was designed to investigate the anti-cancer effects of AAH on ovarian cancer in vitro and by using allograft model in vivo. Methods: In this experiment, the effects of AAH on proliferation rates, cell morphology, cell death type, cell cycle, caspase activities and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in A2780, human ovarian cell line. Results: AAH inhibited proliferation of A2780 cells in a dose dependent manner. In addition, AAH induced apoptosis but did not affect cell cycle of A2780 cells. AAH also effectively inhibited caspase 3 and caspase 9 activities respectively. In allograft tumor model, AAH reduced tumor volume and expanded life span in a dose dependent manner. Conclusion: It can be inferred that AAH can induce apoptosis in ovarian cancer cells and has possibility as an anticancer agent for ovarian cancer.

• 대한한방부인과학회지
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• 제29권4호
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• pp.57-68
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• 2016

Objectives: This paper aims to report the effects of Korean medical treatment on a patient who underwent abdominal surgery with hyperthermic intraperitoneal chemotherapy for ovarian cancer. Methods: An ovarian cancer patient underwent abdominal surgery and got Korean medical treatment during 7-day hospitalization. About 2 years later, with metastasis to the lymph nodes detected, she had abdominal surgery with hyperthermic intraperitoneal chemotherapy and got Korean medical treatment during 10-day hospitalization. The treatment included herbal medicine and acupuncture. Numerical Rating Scale (NRS) of symptoms was measured every morning. Results: After the treatment, sequela following surgery decreased, and general conditions improved. During 1st and 2nd hospitalization, NRS of general weakness, heartburn and dorsal chill significantly decreased (10 to 5, 10 to 5 and 10 to 2, respectively) while edema in both legs remained the same. Conclusions: This case shows that Korean medical treatment is effective for a patient who underwent abdominal surgery with hyperthermic intraperitoneal chemotherapy for ovarian cancer.

• 대한한방부인과학회지
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• 제27권3호
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• pp.124-134
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• 2014

Objectives: We designed this study to evaluate the effect of Korean medical treatment on complications of chemotherapy after curative resection in patient with ovarian carcinoma IV. Methods: The patient got total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAHBSO) on 9/4 and received chemotherapy on 10/7, 10/28, 11/18. During this period, the patient suffered from anorexia, dyspepsia, nausea, weight loss and insomnia. We treated the patient with herbal medicine and acupuncture. The efficacy of treatment was evaluated with visual analog scale (Vas), weight and 36-item short form health survey instrument (SF-36). Results: After treatment, although the scale values went ups and downs according to chemotherapy schedule, abdominal pain Vas changed 7 to 0, weight changed 46 kg to 51 kg. Also, SF-36 scores increased. Conclusions: This case report shows that the Korean medical treatment is useful in the treatment of complications of chemotherapy after curative resection in patient with ovarian carcinoma IV.

• 대한한방부인과학회지
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• 제35권1호
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• pp.91-104
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• 2022

Objectives: The purpose of this study is to report the effect of combination treatment of Traditional Korean medicine (TKM) and chemotherapy on a ovarian cancer with lung metastasis patient. Methods: One ovarian cancer with lung metastasis patient was treated by TKM in conjunction with Carboplatin/paclitaxel since Feb. 2020. Repeat cycle every 3 weeks for 6 times. The patient has been treated with TKM at the same time. To evaluate the patient, symptoms were measured by Numeric Rating Scale (NRS), Eastern Cooperative Oncology Group (ECOG) and tumor size was measured by scanning with Computed Tomography (CT). Blood tests including cancer biomarker were conducted during treatment. Adverse events were evaluated by the National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), version 5.0. Results: After treatment with Carboplatin/paclitaxel and TKM during 2 months, the size of the ovarian cancer was decreased(Partial Response, PR), size and malignant pleural effusion at right lung disappeared. And no evidence of newly developed metastatic lesions. After 2 months, the tumor response was stable disease while improving the performance and other symptoms. Conclusions: This case provides us conjunctive treatment with Conventional and Eastern medicine may have substantial benefit for patients with end-stage ovarian cancer.

• 대한두경부종양학회지
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• 제10권1호
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• pp.38-45
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• 1994

부인두강(Parapharyngeal space)는 비인두강과 구인두강에 인접하여 위로는 두개저, 아래로는 설골사이에 위치하는 해부학적 잠재공간으로 이곳에 발생하는 종양은 매우 드무나 다양한 병리조직학적 소견을 보이며 인접한 중요장기들로 인한 수술적 어려움으로 두경부 외과의사의 관심이 되어 왔다. 최근 CT나 MRI의 도입으로 이학적 검사가 어려웠던 이부위의 진단에 많은 도움을 얻게 되었고, 발달된 수술방법의 사용으로 크기가 매우 큰 종양도 절제가 가능하게 되었다. 저자들은 1990년 9월부터 1993년 8월까지 한림대학교 이비인후과학교실에서 술전 CT나 MRI를 시행한 후 조직검사로 확진된 부인두강 종물 22례의 후향적 임상분석을 시행하여 다음의 결과를 얻었다. 1) 양성종양이 11례(30.0%), 악성종양이 11례(50.0%)로 빈도에 차이는 없었다. 2) 종양의 조직학적 기원은 타액선종양이 10례(45.5%)로 가장 많았으며 신경종양이 4례(18.2%)였고 기타 종양이 8례(36.4%)로 다양하였다. 3) 방사선학적 진단방법으로는 18례(81.8%)에서 CT를 시행하였고 필요한 경우에 MRI를 5례(22.7%), 혈관조영술을 3례(13.6%)에서 시행하였다. 4) 치료방법으로는 악성종양은 수술 및 방사선치료 또는 항암약물요법을 병리조직검사 결과에 따라 단독 또는 병합하여 시행하였고, 양성종양의 경우에는 모두 수술을 시행하였는데 수술방법은 경이하선 접근법이 가장 많이 사용되었다. 5) 추적조사는 평균 20개월로 양성종양의 경우는 모두 종양의 재발이 없이 치료되었으나 악성종양 중 전이암 1례와 악성 임파종 1례가 사망하였다.

• 한국정보과학회논문지:정보통신
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• 제29권5호
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• pp.482-494
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• 2002

최근 등장한 메일 기반의 계좌이체 시스템은 송금인이 수금인의 계좌번호를 알 필요 없이 메일 주소만 알면 계좌 이체가 가능하도록 하여 사용자에게 많은 편의를 제공한다. 그러나 대부분의 메일기반 계좌이체 시스템은 SSL 기반으로 동작하고 있어 거래 사실에 대한 부인이 가능하고, 영수증 발급이 불가능하다는 문제점이 있다. 이에 따라 이 논문에서는 기밀성, 무결성, 사용자 인증, 부인 봉쇄 둥의 보안 서비스를 제공하고 인증서 기반으로 동작하는 국제 표준 메일 보안 메커니즘인 S/MIME을 적용한 메일 기반의 지불 메커니즘을 제안한다. 이 메커니즘에서는 'Check'라는 수표와 같은 역할을 하는 메시지를 통해 모든 계좌이체 정보가 송금인과 수금인 및 메일 결제 서버 사이에서 전달된다. 이 시스템은 기존의 시스템과 마찬가지로 수금인의 메일 주소만 알면 계좌이체가 가능한 편리성을 제공함과 동시에 S/MIME에 기반한 보안 서비스를 제공함으로서 기존 지불 시스템에서 가장 문제가 되는 송신 부인 문제를 해결하고 영수증 발급도 가능하다.

• 대한한방부인과학회지
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• 제35권3호
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• pp.1-23
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• 2022

Objectives: The purpose of this study is to evaluate anti-breast cancer and anti-inflammatory effects of Chungganhaewool-tang and Shipyeukmiyeugi-eum. Methods: MDA-MB-231 cells were used to measure cytotoxicity, Reactive oxygen species (ROS) production, protein expression amounts of Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), Cytochrome C Caspase-3, Caspase-7, Caspase-9, Poly ADP-ribose polymerase (PARP), Nuclear factor erythroid-2-related factor 2 (Nrf2), Heme oxygenase-1 (HO-1) and NAD (P) H Quinone Oxidoreductase 1 (NQO1) to evaluate the anti-breast cancer effects of Chungganhaewool-tang (CHT) and Shipyeukmiyeugi-eum (SYE), and THP-1 cells, differentiated into macrophage and induced inflammation with Lipopolysaccharide (LPS), were used to measure production amounts of ROS, Nitric oxide (NO), and protein expression amounts of Inducible nitric oxide synthase (iNOS), Cyclooxygenase (COX-2), Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6) and Tumor necrosis factor-alpha (TNF-α) to evaluate the anti-inflammatory effects of CHT and SYE. Results: CHT and SYE reduced MDA-MB-231 cell counts, increased protein expression of Bax and Cytochrome C, and decreased protein expression of Bcl-2, Bcl-xl. The protein expression amounts of Caspase-3, 7, and 9 decreased, but amounts of the active form, cleaved Caspase-3, 7, and 9, increased. In addition, PARP protein expression decreased, the amount of PARP protein in the cleaved form increased, and the amount of protein expressions of Nrf2 and HO-1 decreased, but NQO1 showed no significant difference. In THP-1 cells CHT and SYE reduced ROS and NO, and reduced protein expressions of iNOS, COX-2, IL-1, and TNF-α, but only SYE groups reduced IL-6. Conclusions: This study suggests that CHT and SYE have potential to be used as treatments for breast cancer.

• 암석학회지
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• 제16권3호
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• pp.162-179
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• 2007

영남(소백산)육괴의 남서부인 지리산지역의 북서부에 선캠브리아 편마암 복합체를 트라이아스기(약 223 Ma)에 관입한 마천층상관입암은 크게 층상계열과 엽상계열의 두 그룹으로 구분되는 고철질-초고철질 암석들로 구성되어 있으며, 마그마혼합의 특성을 잘 보이는 암맥상의 고철질 암이 수반된다. 층상계열은 누적조직의 특성과 주구성 유색광물의 종류에 의해 중앙부의 감람석 반려암대(하부대)와 주변부의 각섬석 반려암대(중 내지 상부대피 두 부분으로 다시 세분된다. 중앙부의 감람석 반려암은 비교적 얇은 우흑질과 우백질의 층들이 규칙적으로 교호된 중립질 반려암질 암과 균질하고 두꺼운 층상구조를 이룬 조립질 반려암질 암들이 서로 협재되어 있으며, 주구성 암종은 우흑질 반려암, 트록토라이트, 우백질 트록토라이트, 사장암질암 등으로 감람석과 사장석이 주구성 광물이다. 엽상계열은 함석영 흑운모휘석 반려암과 보다 분화된 특성의 각섬석 섬록암으로 분류되며 간극상로 산출되는 소량의 석영과 미사장석을 포함하고 있다 주변의 선캠브리아 편마암류와의 접촉대에 냉각대가 발달되어 있어 심부에서 보다 분화된 동원성 마그마가 어느 정도 시간적인 간격을 갖고 좀 더 냉각된 환경에서 관입한 것으로 보인다. 층상계열에 발달된 층상구조는 감람석은 주로 정누적구조 내지 부가누적구조, 사장석은 부가누적 내지 간극누적구조를 보이며, 단사휘석과 각섬석은 간극누적 내지 이형부가누적조직을 이루고 있다. 층상암들에서 마그마작용동안 생성된 습곡구조, 점이층리, 사층리 등이 드물지 않게 산출된다. 마천층상관입암체에 발달된 층상구조와 엽상구조가 주로 중력침전과 제자리 결정작용에 의해 생성되었으며 슬럼핑과 밀도류 흐름작용도 상당한 역할을 하였을 것으로 해석된다.

• 동의생리병리학회지
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• 제28권5호
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• pp.571-575
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• 2014

This study was aimed to obtain epidemiological information of cancer patients treated with Oriental medicine. 58 breast and gynecological cancer patients treated in Cancer Center of Daeguhanny Oriental Hospital from August 2012 to August 2013 were reviewed. Careful investigations were done by categorizing these patients by their origin, stage, treatment, conventional treatment type, chief complaint, etc. In tumor origin, breast cancer showed the largest proportion in total patients(74.1%) and inpatients(81.8%). 63.8% of the patients' tumors were stage III and IV. 48.3% of patients visited Oriental hospital for combination treatment with conventional medicine. 91.4% of the patients have under 5 years of cancer duration. Their cheif complaints are general weakness, postoperative pain and abdominal discomfort in general. This study presented the characteristics of breast and gynecological cancer patients treated by Oriental medical therapies, and thus would be valuable for futher studies of Oriental medical cancer treatments.