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http://dx.doi.org/10.15204/jkobgy.2018.31.2.018

Effects of Artemisiae Annuae Herba (AAH) on Cell Death of Ovarian Cancer in Vivo and in Vitro Study  

Seo, Kook-Jang (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University)
Cho, Seong-Hee (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University)
Yang, Seung-Jung (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University)
Park, Kyung-Mi (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.31, no.2, 2018 , pp. 18-30 More about this Journal
Abstract
Objective: This study was designed to investigate the anti-cancer effects of AAH on ovarian cancer in vitro and by using allograft model in vivo. Methods: In this experiment, the effects of AAH on proliferation rates, cell morphology, cell death type, cell cycle, caspase activities and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in A2780, human ovarian cell line. Results: AAH inhibited proliferation of A2780 cells in a dose dependent manner. In addition, AAH induced apoptosis but did not affect cell cycle of A2780 cells. AAH also effectively inhibited caspase 3 and caspase 9 activities respectively. In allograft tumor model, AAH reduced tumor volume and expanded life span in a dose dependent manner. Conclusion: It can be inferred that AAH can induce apoptosis in ovarian cancer cells and has possibility as an anticancer agent for ovarian cancer.
Keywords
Artemisiae Annuae Herba; Ovarian Cancer; Apoptosis; p38 MAPK; Caspase 3; Caspase 6;
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Times Cited By KSCI : 6  (Citation Analysis)
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