• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.1
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• pp.102-115
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• 2016

Objectives: The purpose of this study is to find out the characteristics of dysmenorrhea patients with the Inbody test results by Sasang constitutions. Methods: The data from the 541 participants were collected using a structured measurement of menstrual pain. Based on the survey responses, we had 329 women with dysmenorrhea as the test group and 212 women without dysmenorrhea as the control group. The clinical trials subjects were asked to respond to another questionnaire for identifying their constitutional types and undergo Inbody test. Results: The result of a comparison of the test and control groups showed that the DSOM test showed that the scores of blood deficiency, qi stagnation, blood stasis and phlegm were significantly higher in dysmenorrhea. The result of the taeumin's test groups showed that the DSOM test showed that the scores of heat were significantly higher. For the Sasang constitution, there is a difference on the cause of the outbreak. Taeumin from blood deficiency, blood stasis, dampness, heart, kidney, phlegm and lung is associated with dysmenorrhea. Soeumin from blood deficiency, qi stagnation, blood stasis, liver, heart, spleen and phlegm is associated with dysmenorrhea. The ratio of overweight of taeumin was low in blood deficiency and yin deficiency. The ratio of lowweight of soeumin was high in heat. Conclusions: The DSOM test showed that the scores of blood deficiency, qi stagnation, blood stasis and phlegm were significantly higher in dysmenorrhea.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.3
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• pp.30-39
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• 2015

Objectives This study aims to analyze Heart Rate Variability (HRV) in women after missed abortion compared with healthy women Methods We studied 35 women who visited Kang-Nam Kyung-Hee Korean Hospital after missed abortion from 01 January 2012 to 28 February 2015 (missed abortion group) and 35 normal women visiting medical examination center from 1 January 2014 to 31 December 2014 (Normal Group). We measured HRV of each women and investigated the difference of HRV between two groups. Results The standard deviation of NN intervals (SDNN) in Missed abortion group is lower than normal group. The square root of the mean square difference of successive NNs (RMSSD) in Missed abortion group is lower than normal group. However there was no significant difference. Total Power (TP) and Low frequency power (LF) is significantly lower in Missed abortion group compared with normal group. High frequency power (HF), Very low frequency power (VLF) and LF/HF ratio in missed abortion group is lower than normal group. but There was no significant difference. Conclusions Missed abortion group is lower in function of overall autonomic nervous system, especially sympathetic nerve.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.1
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• pp.127-134
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• 2016

Objectives Arrhythmia can occur frequently when state of pregnancy or after carriage, but it is rare that the symptom continues. We have a case of arrhythmia, which occurred after stillbirth and has lasted for about 4 months, treated by Korean medicine treatment, so we report a case on arrhythmia occurred after stillbirth.Methods Patient, who suffered from arrhythmia after stillbirth, was enrolled in this study. She received Korean medicine therapies such as herbal medicine, acupuncture and negative cupping.Results Discomfort and frequency of arrhythmia was reduced by Korean medicine therapiesConclusions The present study suggests that Korean medicine therapies have a effect on arrhythmia caused by stillbirth.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.113-127
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• 2015

Objectives: This study was performed to analyze the trend of acne-related experimental studies in Korean medicine. Methods: We searched 17 articles related with experimental study of acne, published Korean medical journals from 2005 to 2014. We classified all articles according to the journal and checked on the kind of herbs. All articles were categorized into two types: cell experimental study and animal experimental study. Results: 1. Total 17 papers were searched; 7 articles (41.2%) were published in the Journal of Korean Medical Ophthalmology, Otolaryngology, Dermatology, 4 articles (23.5%) were published in the Journal of Korean Institute of Pharmacopuncture, 3 articles (17.6%) were published in Korean Journal of Oriental Physiology and Pathology, 2 articles (11.8%) were published in Korean Journal of Herbology, and 1 article (5.9%) was published in the Journal of Korean Medicine. 2. Total 17 kind of herbs were used in the studies; 10 articles (58.8%) used single herb, 7 articles (41.2%) used complex herbs. 3. Total 17 articles were categorized 2 types; 16 cell experimental studies (94.1%), 1 animal experimental study (5.9%). 4. Experimental researches were mainly investigated using Raw 264.7 cell line and P. acnes. The levels of NO, iNOS, $TNF-{\alpha}$, PGE, COX-2, $IL-1{\beta}$, IL-6, NF-kB were analyzed to confirm of herbs' antibacterial, anti-inflammatory, antioxidant activity. Conclusions: Searching for natural antibiotics, it is needed to do experimental studies continuously, and also needed to diversify the kind herbs and experimental bacteria.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.102-112
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• 2015

Objectives: This study was performed to obtain reference data of traditional Korean medicine diagnostic methods for the practical usage in women infertility. Methods: The study involved 38 female patients of age 20-38 years that had diagnosed of infertility. All the subjects answered to pattern identification questionnaire and Questionnaire for the Sasang Constitution Classification (QSCC II). Pattern identification scores and constitution types have been analyzed with variables of infertility factors and age. Statistical analysis was performed by adopting descriptive and inferential tests. Results: In pattern identification questionnaire analysis, the patterns were observed in order of frequency: liver stasis; blood deficiency; kidney-yang deficiency; kidney-yin deficiency; damp-heat; blood stasis; and phlegm. The group, less than 35 years old, had the higher average score of liver stasis (p<0.05). Also, the group with tubal and peritoneal factors, had the higher average score of blood deficiency (p<0.05). In QSCC II analysis, So-yang type had the higher average score of liver stasis, kidney-yang deficiency, and kidney-yin deficiency. So-eum type had the higher average score of liver stasis, kidney-yang deficiency, kidney-yin deficiency, and blood deficiency. While, Tae-um type had the higher average score of liver stasis and phlegm. Conclusions: We would accumulate the clinical data for the practical usage of traditional Korean medicine diagnostic methods in women infertility.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.85-91
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• 2015

Objectives: Postmenopausal symptoms are subject to many factors. Recently, obesity has been suggested as a factor of hot flush. So this study aims to report the relationship between body composition and Menopause Rating Scale (MRS), The Menopause-specific Quality of Life Questionnaire (MENQOL) of postmenopausal women. Methods: We studied 42 climacteric women who had visited Kyung Hee University Hospital at Gangdong from April 2011 to July 2014. 42 women had filled out MRS, MENQOL, and they had taken body composition tests. Pearson correlation tests were conducted. (Correlation was statistically significant at the 0.05 level) Results: Correlation between psychological subscale of MENQOL and Waist-Hip Ratio (WHR) was statistically significant (pearson correlation coefficient=0.385; p-value=0.012). But other subscales of MRS and MENQOL were not statistically related with body composition. Conclusions: WHR could be an important factor of psychological health of menopausal women. So, abdominal fat reduction must be considered when curing menopausal symptoms. In connection with climacteric depression, well-designed studies would be necessary.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.58-72
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• 2015

Objectives: The purpose of this study was to examine the effects of fermented soybean on body weight, body fat, serum lipid profiles in obese women, especially specific to menopausal woman. Methods: Sixty healthy obese volunteers who visited ${\bigcirc}{\bigcirc}$ University Oriental Hospital from May 20th, 2014 to September 25th, 2014 took part in clinical trial. They divided into 2 groups, 30 volunteers allocated to fermented soybean and other 30 to placebo group. Body weight, BMI, waist and hip ratio, serum lipid were measured 3 times, and fat percentage, leptin, adiponectin were evaluated 2 times. Results: All 60 volunteers completed 12-week trial. 5 men were excluded, and 2 women against the clinical decision rule were excluded. In the end, 53 women were studied as clinical subjects. After 12 weeks intervention, there was no effects in comparison of group by time interaction. Without considering time interaction, there was a significant difference in triglyceride level between soybean group and placebo group (p=0.044). Treatment group were dividing by age 40, a group in age 40 or over 40, and other group aged below 40. There was a significant difference in group by time interaction of total cholesterol level, and without considering time interaction, there was a significant change in waist-hip ratio between groups. Conclusions: There were no effects on weight and body fat decrease in 12-week trial using fermented soybean as a supplement. But there were significant differences in triglyceride change between the treatment and placebo groups, also cholesterol and waist and hip ratio in soybean group divided by age 40. It seems that fermented soybean is effected on improving serum lipid profiles.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.3
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• pp.97-106
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• 2015

Objectives The purpose of this study is to report the effect of Gamihachul-tang-gagam-bang on two patients with Chemotherapy Induced Nausea and Vomiting (CINV) and Radiotherapy Induced Nausea and Vomiting (RINV). respectively. Methods Two patients with CINV and RINV who admitted KyungHee University Hospital at Gangdong were treated by oriental medical treatments such as acupuncture, moxibustion, cupping treatment and herbal medicine ( Gamihachul-tang-gagam-bang ). Results After treatments, patients' nausea and vomiting improved and patients' amount of intake also increased. Conclusions According to this case report, Gamihachul-tang-gagam-bang is effective for treating CINV and RINV.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.46-57
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• 2015

Objectives: This study was designed to investigate the effects of Trogopterorum Faeces on the apoptostic cell death in breast cancer cells. Methods: In the experiment, the effects of Trogopterorum Faeces on proliferation rates and type of cell death were investigated using MCF-7 cells in vitro. The effects on expression levels of caspase 3 and caspase 9 were also investigated. Results: The effects on expression levels of caspase 3 and caspase 9 were also investigated. In the present results, treatment with Trogopterorum Faeces decreased proliferation rates in a dose dependent manner. $ID_{50}$ (50 % inhibitory dosage) was $177.2{\mu}g/ml$. In addition, treatment with Trogopterorum Faeces increased percentage of apoptotic cells. Finally the expression level of caspase 3 and caspase 9 were elevated by treatment with Trogopterorum Faeces respectively. Conclusions: This study suggests that Trogopterorum Faeces can trigger caspase dependent apoptosis in MCF-7 cells.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.3
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• pp.74-86
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• 2015

Objectives To identify whether Sovereign-Minister-Assistant-Courier (君臣佐使) Theory and Meridian Tropism (歸經) Theory of oral herbal medicine can be applied to trans-dermal medicine and whether pharmaceutical efficacy can be delivered to skin by Courier herb (使藥). Methods We reviewed previous studies related to Sovereign-Minister-Assistant-Courier Theory. And we examined whether prescription compositions based on Sovereign-Minister-Assistant-Courier Theory correspond with efficacy results of trans-dermal medicine experimentally identified. Results When Sovereign-Minister-Assistant-Courier Theory is applied to trans-dermal medicine, Courier herb act as delivering the effective components to the lesion penetrating skin barrier. And we identified that medicine absorbed through the digestive processes may not correspond with Courier herb applied topically. Conclusions We identified that Courier herb act as delivering the effective components to the lesion. But to strength evidences, additional studies on this action will be needed.