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http://dx.doi.org/10.15204/jkobgy.2015.28.1.058

Effects of Fermented Soybean on Body Weight, Body Fat and Serum Lipid in Obese Women  

Nam, Eun-Young (Dept. of Korean Gynecology, College of Korean Medicine Se-Myung University)
Kim, Dong-Il (Dept. of Korean Gynecology, College of Korean Medicine Dong-Guk University)
Choi, Min-Sun (Dept. of Korean Gynecology, College of Korean Medicine Dong-Guk University)
Kim, Hyung-Jun (Dept. of Korean Gynecology, College of Korean Medicine Se-Myung University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.28, no.1, 2015 , pp. 58-72 More about this Journal
Abstract
Objectives: The purpose of this study was to examine the effects of fermented soybean on body weight, body fat, serum lipid profiles in obese women, especially specific to menopausal woman. Methods: Sixty healthy obese volunteers who visited ${\bigcirc}{\bigcirc}$ University Oriental Hospital from May 20th, 2014 to September 25th, 2014 took part in clinical trial. They divided into 2 groups, 30 volunteers allocated to fermented soybean and other 30 to placebo group. Body weight, BMI, waist and hip ratio, serum lipid were measured 3 times, and fat percentage, leptin, adiponectin were evaluated 2 times. Results: All 60 volunteers completed 12-week trial. 5 men were excluded, and 2 women against the clinical decision rule were excluded. In the end, 53 women were studied as clinical subjects. After 12 weeks intervention, there was no effects in comparison of group by time interaction. Without considering time interaction, there was a significant difference in triglyceride level between soybean group and placebo group (p=0.044). Treatment group were dividing by age 40, a group in age 40 or over 40, and other group aged below 40. There was a significant difference in group by time interaction of total cholesterol level, and without considering time interaction, there was a significant change in waist-hip ratio between groups. Conclusions: There were no effects on weight and body fat decrease in 12-week trial using fermented soybean as a supplement. But there were significant differences in triglyceride change between the treatment and placebo groups, also cholesterol and waist and hip ratio in soybean group divided by age 40. It seems that fermented soybean is effected on improving serum lipid profiles.
Keywords
Obesity; Women; Fermented Soybean; Cheonggukjang; Serum lipid;
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1 Kim HS, et al. Isolation and identification of a bacillus sp. producing α-glucosidase Inhibitor 1-deoxynojirimycin. J Microbiol Biotechnol. 2011;39(1):49-55.
2 Lee SM, et al. 1-deoxynojirimycin isolated from a bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes. J Microbiol Biotechnol. 2013;23(5):637-43.   DOI   ScienceOn
3 Maesta N, et al. Effects of soy protein and resistance exercise on body composition and blood lipids in postmenopausal women. Maturitas. 2007;56(4):350-8.   DOI   ScienceOn
4 Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995;333(5):276-82.   DOI   ScienceOn
5 Jo SH, et al. The relationship between body fat mass measured by DEXA and BMI in postmenopausal women. J Korean Soc Menopause. 2003;9(2):156-62.   DOI
6 Kim JS, et al. Comparison of DEXA and CT for truncal obesity in adult women related to metabolic complications. J Korean Acad Fam Med. 2007;28(9):675-81.
7 Hersh AL, Stefanick ML, Stafford RS. National use of postmenopausal hormone therapy: annual trends and response to recent evidence. JAMA. 2004;291(1):47-53.   DOI   ScienceOn
8 Svendsen OL, Hassager C, Christiansen C. Age-and menopause-associated variations in body composition and fat distribution in healthy women as measured by dual-energy X-ray absorptiometry. Metabolism. 1995;44(3):369-73.   DOI   ScienceOn
9 Rexrode KM, et al. Abdominal adiposity and coronary heart disease in women. JAMA. 1998;280(21):1843-8.   DOI   ScienceOn
10 Tremolliers FA, Pouilles JM, Ribot CA. Relative influence of age and menopause on total and regional body composition change in postmenopausal women. Am J Obstet Gynecol. 1996;175(6):1594-600.   DOI   ScienceOn
11 Clarkson TB, Anthody MS, Williams JK. The potential of soybean phytoestrogens for postmenopausal hormone replacement therapy. Exp Biol Med. 1998;217(3):365-8.   DOI
12 Messina M, Nagata C, Wu AH. Estimated Asian adult soy protein and isoflavone intakes. Nutr Cancer. 2006;55(1):1-12.   DOI   ScienceOn
13 Potter SM, et al. Soy protein and isoflavones; Their effects on blood lipids and bone density in post-menopausal women. Am J Clin Nutr. 1998;68(6):1375-9.
14 Merz-Demlow BE, et al. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr. 2000;71(6):1462-9.
15 Kokubo Y, et al. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations The Japan public health center-based (JPHC) study cohort I. Circulation. 2007;116(22):2553-62.   DOI   ScienceOn
16 Fukutake M, et al. Quantification of genistein and genistin in soybeans and soybean products. Food Chem Toxicol. 1996;34(5):457-61.   DOI   ScienceOn
17 Wing RR, et al. Weight gain at the time of menopause. Arch Intern Med. 1991; 151(1):97-102.   DOI   ScienceOn
18 Kang KD, et al. Identification of the genes involved in 1-deoxynojirimycin synthesis in bacillus subtilis MORI 3K-85. J Microbiol. 2011;49(3):431-40.   DOI
19 Nam YY, et al. Anti-hyperlipidemic effect of soybean extract fermented by bacillus subtilis MORI in db/db mice. Laboratory Animal Research. 2012;28(2):123-9.   DOI
20 Korean society of obstetrics and gynecology. Gynecology 4th rev. ed. Seoul:Korean Medical Book. 2007:563-4.
21 World Health Organization, 2011. Obesity and overweight. Fact sheet No. 311, updated August 2014. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/
22 Kim S, Jin SH, Kim TH. A study on etiological factors, symptoms of a disease, and treatments of obesity based on Dong-Yi Bo Gam. J Korean Oriental Med. 1998;19(2):125-36.
23 The society of Korean medicine obstetrics and gynecology. Korean medicine obstetrics and gynecology. Seoul: Uiseongdang. 2012:295-311.
24 Jung H. Postmenopausal hormone therapy and weight change. J Korean Soc Menopause. 2004;10(4):227-35.
25 Ahn YS, Kim YS, Shin DH. Isolation, identification, and fermentation characteristics of bacillus sp. with high protease activity from traditional cheonggukjang. Korean J Food SCI Technol. 2006;38(1):82-7.
26 Kaneki M, et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition. 2001;17(4):315-21.   DOI   ScienceOn
27 Ley CJ, Lees B, Stevenson JC. Sex-and menopause-associated changes in body-fat distribution. Am J Clin Nutr. 1992;55(5):950-4.
28 Setchell KD. Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr. 1998;68(6):1333S-46S.
29 Professors of herbalogy, Colleges of Korean medicine in Korea. Herbalogy. Seoul: Younglimsa. 2010:194-5.
30 Takatsuka N, et al. Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women. Prev Med. 2000;31(4):308-14.   DOI   ScienceOn
31 Allison DB, et al. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur J Clin Nutr. 2003;57(4):514-22.   DOI   ScienceOn
32 Anderson JW, et al. Soy compared to casein meal replacement shakes with energy-restricted diets for obese women: randomized controlled trial. Metabolism. 2007;56(2):280-8.   DOI   ScienceOn
33 Brown EC, et al. Soy versus whey protein bars: effects on exercise training impact on lean body mass and antioxidant status. J Nutr. 2004;3(1):22.   DOI
34 Deibert P, et al. Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet. Int J Obesity. 2004;28(10):1349-52.   DOI   ScienceOn
35 St-Onge MP, et al. Supplementation with soy-protein? rich foods does not enhance weight loss. J Acad Nutr Diet. 2007;107(3):500-5.
36 Kataoka S. Functional effects of Japanese style fermented soy sauce(shoyu) and its components. J Biosci Bioeng. 2005; 100(3):227-34.   DOI   ScienceOn
37 Soh JR, et al. Effect of Cheonggukjang supplementation upon hepatic acyl-CoA synthase, carnitine palmitoyl transferase I, acyl-CoA oxidase and uncoupling protein 2 mRNA levels in C57BL/6J mice fed with high fat diet. Genes Nutr. 2008;2(4):365-9.   DOI
38 Markovits J, et al. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res. 1989;49(18):5111-7.
39 Fotsis T, et al. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci. 1993;90(7):2690-4.   DOI   ScienceOn