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http://dx.doi.org/10.15204/jkobgy.2015.28.1.046

Effects of Trogopterorum Faeces on the Apoptostic Cell Death in Breast Cancer Cells  

Song, Yu-Rim (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University)
Kim, Ji-Eun (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University)
Yang, Seung-Jeong (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University)
Park, Kyung-Mi (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University)
Jung, Su-Jung (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University)
Cho, Seong-Hee (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Dong-Shin University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.28, no.1, 2015 , pp. 46-57 More about this Journal
Abstract
Objectives: This study was designed to investigate the effects of Trogopterorum Faeces on the apoptostic cell death in breast cancer cells. Methods: In the experiment, the effects of Trogopterorum Faeces on proliferation rates and type of cell death were investigated using MCF-7 cells in vitro. The effects on expression levels of caspase 3 and caspase 9 were also investigated. Results: The effects on expression levels of caspase 3 and caspase 9 were also investigated. In the present results, treatment with Trogopterorum Faeces decreased proliferation rates in a dose dependent manner. $ID_{50}$ (50 % inhibitory dosage) was $177.2{\mu}g/ml$. In addition, treatment with Trogopterorum Faeces increased percentage of apoptotic cells. Finally the expression level of caspase 3 and caspase 9 were elevated by treatment with Trogopterorum Faeces respectively. Conclusions: This study suggests that Trogopterorum Faeces can trigger caspase dependent apoptosis in MCF-7 cells.
Keywords
Trogopterorum Faeces; Apoptostic Cell Death; Breast Cancer Cells;
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Times Cited By KSCI : 6  (Citation Analysis)
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