• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.1
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• pp.11-19
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• 2012

Purpose: The purpose of this study is to evaluate the synergic efficacy of oriental herb medicine for osteoporosis patients by examining whether there is any change in BMD. Osteoporosis patients are classified into a group having taken Fosamax and the other group having taken Fasamax and Samgieumgamibang in this study. Methods: Mean BMD and T-score are measured in all patients before and 3 months after treatment. Results: 1. The group having taken Fosamax showed no statistically significant mean BMD change before and after treatment. 2. The group having taken Fosamax showed no statistically significant T-score change before and after treatment. 3. The group having taken both Fosamax and Samgieumgamibang showed increase in mean BMD, which does not bear statistically significant change. 4. The group having taken both Fosamax and Samgieumgamibang showed statistically significant T-score change before and after treatment(p<0.05). Conclusions: After treatment, BMD in patients having taken Fosamx did not change significantly, but in patients having taken both Fosamax and Samgieumgamibang increased, which proves the efficacy of oriental herb medicine for osteoporosis patients.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.46-55
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• 2012

Objectives: It is well known that genetic factors and environmental factors play major role in aging skin. In general, son and daughter take after their parents in appearance. But comparability of skin properties in Korean family has not been well estimated. So we evaluated the correlation of skin properties in Korean mother-daughter pairs. Methods: 10 couples of mother and daughter pair(n=20) participate in this study. Mothers and daughters were aged $50.6{\pm}2.459$ and $23.8{\pm}2.15$ years, respectively. Skin moisture, sebum, skin color and elasticity is measured using non-invasive method : Corneometer CM825, Sebumeter(MPA580), Mexameter MX18, Cutometer MPA580. Statistical analysis program we used is Minitab 14 Korea. Results: The Skin moisture of mother group was significantly higher than daughter group. And skin elasticity(R2) of the daughter group was significantly higher than mother group. In the results of correlation analysis between mother and daughter pairs, skin elasticity(R2) had high positive correlation(r=0.729, p=0.026). But skin moisture, sebum, melanin index, erythema index and skin elasticity(R5) did not be confirmed a significant correlation. Conclusions: Skin elasticity(R2) is the only factor that showed high positive correlation significantly in mother and daughter pairs. Mother and daughter share the genetic factors and environmental factors that influence skin aging. So, mother's aging pattern will be a good guide for anti-aging of daughters.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.1
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• pp.1-10
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• 2012

Purpose: This study was conducted to evaluate the inhibitory effect of Achyranthis Radix extract(ARE) loaded hydrogel on osteoclast differentiation. Methods: MTT-assay was performed to estimate cytotoxicity of ARE, Achyranthis Radix-alginate hydrogel disk(ARHD) in bone marrow macrophages stimulated(BMMs) with human receptor activator of nuclear factor-${\kappa}B$ ligand(RANKL), human macrophage-colony stimulating factor(M-CSF). Tartrate resistant acid phosphatase staining and RT-PCR were performed to know the inhibitory effect on osteoclast differentiation. Reactive oxygen species and actin ring formation were analysed to observe the effect of ARHD. Results: ARE has no cytotoxicity at the concentration of 0.1 $mg/m{\ell}$ or lower. ARE decreased the number of TRAP positive cells in RANKL, M-CSF stimulated BMMs and the gene expression. ARHD has no cytotoxicity at the concentration of 10 ${\mu}g/m{\ell}$ (24, 48hours), 50 ${\mu}g/m{\ell}$ (24 hours). ARHD restrained the synthesis of reactive oxygen species and the formation of actin ring. Conclusions: Achyranthis Radix has the inhibitory effect of osteoclast differentiation and bone resorption. Further studies are needed to treat osteoporosis by Achyranthis Radix.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.38-45
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• 2012

Purpose: The purpose of this study is to find the factors that can affect the assessment on severity of cold hypersensitivity on hands and feet by comparing the temperature distribution among the seasons, the scan time and the laboratory temperature. Methods: We compared the temperature distribution of the arms and legs, according to the season and scan time on the basis of the results of Digital Infrared Thermal Imaging(DITI) conducted on 178 women who visited the hospital in summer and winter. We evaluated the correlation between the laboratory temperature and temperature distribution of the arms and legs. Results: The temperature distribution of the arms and legs was significantly different between summer and winter. The temperature distribution of the arms and legs was not significantly different according to the scan time. There was no significant correlation between laboratory temperature and the temperature distribution of the arms and legs in summer and winter. Conclusions: The diagnostic criteria to assess the severity of cold hypersensitivity on hands and feet need to be changed according to the season. The scan time and the small variation($24^{\circ}C{\sim}27^{\circ}C$) of the laboratory temperature doesn't affect the assessment of severity of cold hypersensitivity.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.12-26
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• 2012

Objectives: The purpose of this study is to examine the effects of Sagunjatang-Gami(SGJT) on uterine and ovarian function in the ovariectomized rat postmenopause model. Methods: SGJT was administered in ovariectomized Wister albino female rats for three month. After that, uterine weight, uterine index, serum estradiol-$17{\beta}$ levels and phosphorylation of ERK or AKT, and histological analysis of uterus were measured to assess the impact on uterine and ovarian function in ovariectomized rats. In addition, phosphorylation of $ER{\alpha}$, ERK, AKT by SGJT in MDA-MB-231 cells were measured. To identify safety of SGJT, the cell cytoxicity in MDA-MB-231 cells and serum GOT, GPT levels were measured in ovariectomized rats. Results: The results were as follows. 1. SGJT decreased the viability of MDA-MB-231 cells in a dose-dependent manner. 2. The level of serum GOT, GPT in SGJT-treated group showed significant decrease in comparison with control group. 3. Phosphorylation of $ER{\alpha}$, ERK, AKT by SGJT in MDA-MB-231 cells were increased. 4. Uterus index in SGJT-treated group showed significant increase in comparison with control group. The level of serum estradiol-$17{\beta}$ in SGJT-treated group showed significant increase in comparison with control group. Phosphorylation of ERK or AKT by SGJT in the uterus of ovariectomized rats was increased significantly. 5. Uterus index and the level of serum estradiol-$17{\beta}$ in SGJT-treated group increased at higher rates in comparison with estrogen-treated group. Conclusions: Taken together, we suggest that SGJT has been shown to be effective in preventing postmenopausal uterine and ovarian degeneration and curing postmenopausal low estrogen related symptoms.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.27-37
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• 2012

Purpose: Dysmenorrhea is mostly depending on the causative factor, which usually falls under the categories of Cold and Heat pattern in traditional Oriental medical theories and diagnosis. Thus, we investigated menstruation symptom and sign related to dysmenorrhea and verified the validity of Cold and Heat pattern identification. Methods: We investigated menstruation symptom and sign related to dysmenorrhea in total 14 gynecology-medical books including ${\ll}$Exemplar Of Korean Medicine (Dongui Bogam)${\gg}$ and whole body symptom and sign identifying Cold and Heat pattern at the same time. A survey based on this investigation was carried out targeting women of childbearing age. Results: According to 14 gynecology-medical books, polymenorrhea is relevant to Heat pattern, oligomenorrhea to Cold pattern and darkness of menstrual blood is relevant to Heat pattern. Among the total of 343 womens, 196 subjects suffered from dysmenorrhea. The number of dysmenorrhea with polymenorrhea(Heat pattern) was 6 person, with oligomenorrhea(Cold pattern) was 27 person. And the number of dysmenorrhea with darkness of menstrual blood(Heat pattern) was 39 person. As the result of checking correlations of menstrual symptom scores and whole body symptom scores, there was no significance of Cold and Heat pattern between menstrual symptoms and whole body symptoms. Conclusions: The results suggest that the period of menstrual cycle and the color of menstrual blood provides some informations of Cold and Heat pattern identification. But considering with other whole body symptom and sign is needed for more precise result.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.1
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• pp.78-91
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• 2016

Objectives: Breast cancer patients in Korea need to care about symptoms with complementary medicine including acupuncture. We reviewed the randomized controlled studies using acupuncture in breast cancer patients to establish a basic knowledge of clinical practice guidelines. Methods: We searched the following databases through July 2015: the Cochrane Central Register of Controlled Trials, Ovid-Medline, Ovid-EMBASE, the Allied and Complementary Medicine Databases and OASIS. The articles of RCTs using acupuncture in breast cancer for all symptoms were selected and analyzed. The acupoints, treatment period, inclusion criteria of participants, follow-up period and effectiveness were extracted. Results: Three hundred fifty five records after duplicate were screened, and 14 RCTs were selected. RCTs of Hot flush, pain, fatigue were reviewed. The adverse symptoms using medical treatment in breast cancer patients were targets of acupuncture in RCTs. The acupuncture treatment was decreased the hot flush, pain and fatigue. However, the effect was not confirmed due to various study design. Conclusions: The analysis of the research would be conjugated to establish a basic knowledge of clinical practice guidelines. Well designed studies in Korea are needed to confirm the efficacy and safety of acupuncture in patients with breast cancer.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.3
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• pp.40-53
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• 2015

Objectives The purpose of this study is to report the gynecologic use of Angelicae Gigantis Radix in uterus and gynecology part of Dongeuibogam. Methods I searched prescriptions containing Angelicae Gigantis Radix in uterus and gynecology part of Dongeuibogam and analyzed the selected prescriptions to research the use of Angelicae Gigantis Radix in uterus and gynecology part of Dongeuibogam. Results Prescriptions containing Angelicae Gigantis Radix are utilized for 10 disease patterns in uterus part. The number of prescriptions containing Angelicae Gigantis Radix is 50 in uterus part. Prescriptions containing Angelicae Gigantis Radix are utilized for 29 disease patterns in gynecology part. The number of Prescriptions containing Angelicae Gigantis Radix is 90 in gynecology part. Angelicae Gigantis Radix was taken as a sovereign, minister drug of prescriptions containing Angelicae Gigantis Radix of uterus and gynecology part. In many prescriptions, Angelicae Gigantis Radix is used in the treatment of amenorrhea and dysmenorrhea in uterus part. Prescriptions containing Angelicae Gigantis Radix are used to treat not only female infertility but also male infertility in gynecology part. The Samul-tang is the most useful prescription which contains Angelicae Gigantis Radix. Conclusions Angelicae Gigantis Radix is an effectual medicinal herb for menstrual disease, vaginal discharge, pregnancy disease, postpartum disease. So I consider that it is necessary to study methods which improve convenience and effect of prescriptions containing Angelicae Gigantis Radix.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.3
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• pp.107-118
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• 2015

Objectives Chronic leukorrhea is troublesome symptom to many women. It is well known that Korean medicine is safe and effective on chronic leukorrhea. So this study aims to report the clinical effect of Korean medicine on chronic leukorrhea diagnosed with qi deficiency. Methods The patient received herbal medication, acupuncture, moxibustion, cupping therapy, and Gong-jin therapy during hospitalization (about 17 days). Ikkijeseup-tang (IJST) was applied. Results Chronic leukorrhea, lethargy and loss of appetite was effectively reduced after the treatment. Qi deficiency questionnaire score decreased from 90 to 33. Visual Analogue Scale for chronic leukorrhea decreased from 7 to 0. SF-36 score increased from 268 to 323. Conclusions This case shows that Korean medicine is effective on chronic leukorrhea diagnosed with qi deficiency. Further experimental studies and clinical studies are needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.3
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• pp.11-20
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• 2015

Objectives This study is performed to recognize the relationship between atrophic vaginitis and stress that have an affect on autonomic nervous system. Methods We studied 47 patients who visited Kangnam Kyunghee Korean Hospital Medical Examination Center from November, 2013 to June, 2014. They were devided into two groups, atrophic vaginitis group (AV, n=18) and non-atrophic vaginitis group (NAV, n=29). We compared the result of HRV between the two groups. Results The mean of The standard deviation of NN intervals (SDNN), the square root of the mean squared difference of successive NNs (RMSSD) in AV group was lower than NAV group, but there was no significant difference between the two groups. Total power (TP), low frequency (LF) and very low frequency (VLF) of AV group was significantly lower than NAV group. There was no significant difference in high frequency (HF). Conclusions Women with atrophic vaginitis is expected to have low adaptive capacity against stress.