• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.1
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• pp.147-154
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• 2018

Objectives: This study aims to examine the improvement against facial wrinkles after needle-embedding therapy. Methods: The study participants were 10 women treated with needle-embedding therapy in the Korean Medical Clinic from September, 2011 to August, 2014. The subjects were treated every ten days for twenty days, totally three times, and the result of treatment was evaluated five times, such as pre-treatment, after each treatments, one month and two months later of the last treatment with ARAMO-SG. Results: 1. Depth and range of facial wrinkles, facial skin pore test, and sensitivity test were visibly improved after needle-embedding therapy and follow-up compared pre-treatment (p<0.05). 2. The significant improvements in facial skin texture test was not observed and sustained until the follow-up measurement at 2 months. 3. Any adverse reaction related to needle-embedding therapy did not happen. Conclusions: This study suggests that needle-embedding therapy can improve facial wrinkles. The positive results of this study support the requirement for additional research investigating the efficacy of needle-embedding therapy in women.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.1
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• pp.99-121
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• 2018

Objectives: Genital herpes is common disease in gynecological field. Although various treatment options such as herbal medicine, acupuncture, moxibustion are used in genital herpes, there is not enough evidence about the treatment options. This study is to prove the efficacy of oriental medicine on genital herpes by investigating papers and suggest direction of future research. Method: We searched for papers which had both genital herpes and oriental medicine from Cochrane, Pubmed, Scopus, CNKI, Oasis, Korean traditional knowledge portal, Journal of Korean Obstetrics & Gynecology up to November 2017. After searching papers, we classified according to the study design and analyzed selected studies. Results: Sixteen papers were finally selected. Four papers are laboratory studies with Hartley guinea pig with recurrent genital herpes. Twelve papers are clinical trials which includes one single group trial, one controlled trial, ten randomized controlled trials. All of the studies have shown that herbal medicine is effective in improving the symptom of genital herpes and decreasing the recurrent rate of genital herpes and also has immunoregulatory effect. Conclusions: This study shows that herbal medicine could be a good treatment option for genital herpes. However, more well-designed clinical studies and laboratory studies will be needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.169-180
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• 2005

Objective : Spatholobus Suberectus Dunn stems, Chinese vine plants, have been used for the relief of menstrual disorders and rheumatic arthralgia. In this study, we investigated the antitumor effect of Spatholobus Suberectus Dunn on cervical cancer in vitro. Methods : HeLA cervical cancer cell lines were used as targets. We examined the effect of water extract from Spatholobus Suberectus Dunn on cell proliferation, cell cycle regulation and cell cycle-regulating gene expression. Further, we investigated the apoptotic effects of Spatholobus Suberectus Dunn on cervical cancer cell lines. Results : Spatholobus Suberectus Dunn significantly inhibited the proliferation of cervical cancer cell lines in a dose-dependent and time dependent manner. Fluorescence activated cell sorter (FACS) analysis indicated that Spatholobus Suberectus Dunn induced G1 cell cycle arrest. Spatholobus Suberectus Dunn enhanced the expression of $p21^{waf1}$ and $p27^{kip1}$ with cell cycle arrest. Further, Spatholobus Suberectus Dunn stimulated apoptosis via caspase3 pathway. Conclusions : These findings suggest that Spatholobus Suberectus Dunn is a candidate agent for the treatment of cervical cancer. p21waf1 and $p21^{waf1}$ and $p27^{kip1}$ may play an important role in Spatholobus Suberectus Dunn-induced cell cycle arrest and cell growth inhibition.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.156-168
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• 2005

Objective : The purpose of this study is to identify the clinical effects of Chiljehyangbuhwan in the treatment of dysmenorrhea patients. Methods : We studied fifty patients who visited Kyung Hee University Oriental Medical Center from July, 2004 to August, 2004. Women with organic disease such as ut. myoma, ov. cyst and pelvic inflammatory disease were excluded from this study. We treated them with Chiljehyangbuhwan for one menstrual cycle. The severity of dysmenorrhea were measured by MVRS (Multidimensional Verbal Rating scale), VRS (Verbal Rating scale) and VAS (Visual Analog Scale). Results : Chiljehyangbuhwan significantly decreased the severity of dysmenorrhea. Furthermore Chiljehyangbuhwan had an effect on dysmenorrhea for next menstrual cycle without taking. Chiljehyangbuhwan did not show hepatic and renal virulence. Conclusion : This study shows that Chiljehyangbuhwan has remarkable effects on dysmenorrhea patients and that effects continue to next menstrual cycle without taking medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.242-252
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• 2005

Purpose : This study carried out to develop the questionnaires that can measure objectively menstrual quantity and determine quantity index. Method : First, we made questionnaires to measure menstrual quantity by six question. Then we investigated 1309 women's questionnaires who has the menses. Conclusion : 1. the questionnaires that can measure objectively menstrual quantity and determine quantity index was high a correlation coefficient therefore those were used Method of Menstrual Quantity(here after MMQ) calculation. Those were added and averaged. 2. We examined correlation of calculated MMQ and women's questionnaires who has the menses therefore we got 0.30~0.47 correlation. 3. MMQ 1~3(hypomenorrhea) was 39 persons 3.19%, MMQ 4~6(normal menorrhea) was 1050 persons 85.85% and MMQ 7~10(hypermenorrhea) was 134 persons 10.96%. MMQ 4 tended to be little and MMQ 6 tended to be much. 4. MMQ confidence was high as 82% comparatively so we thought MMQ was appropriate as the measured method of menstrual quantity.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.192-206
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• 2005

Objective : To know about ovarian hyperstimulation syndrome pathophysiology, risk factors and clinical features and to research the trend of the study related to OHSS. Methods : We referred a PubMed site by using searching word of "ovarian hyperstimulation syndrome"(Limits: 1 Year, only items with abstracts, Human). Results : 28 journals with 49 papers were searched. Conclusion 1. The study of OHSS subjects on pathophysiology, prevention and medical treatment. 2. As OHSS is an exaggerated response to ovulation induction therapy, it's emphasized that aspect of prevention OHSS. 3. Preventing OHSS are the following. The first is to give a GnRH agonist or antagonist in substitute for hCG. The second is to screen out prevalence of thrombophilia. The third is to monitor $E_2$ levels. The forth is to aspirate of Mediculous follicle. The fifth is cryopreservation of all embryos. The sixth is that administration of albumin for treatment of OHSS. But, it's not useful to administration of albumin for prevention of OHSS. 4. There's no therapy of OHSS. But, there's only symptomatic treatment of OHSS.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.2
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• pp.200-206
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• 2012

Objectives: The purpose of this study is to report the effect of combination of herbal medicine and conventional treatment on preterm labor patient at high risk for preterm delivery. Methods: The patient in this case was 33-year-old female with gravid 3, para 2, abortus 1. She experienced 1 preterm birth 5 years ago. She visited our clinic with lower abdominal pain at 14th gestational week. We treated her by herbal medicine. She also take vaginal progesterone from 19th gestational week to 34th gestational week. Results: She maintained her pregnancy until giving a birth by cesarean section at 38th gestational week. No adverse effects were not observed among mother or infant. Conclusions: Combination of herbal medicine and conventional treatment is effective on preterm labor patient at high risk for preterm delivery.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.2
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• pp.33-51
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• 2011

Objectives: This study was performed to assess the protective effect of Saengmaek-san (SM) on UVB-induced HaCaT cell damage. Methods: The protective effects of Saengmaek-san(SM) were determined by UVB-induced HaCaT assay. We assessed protective effects of Saengmaek-san (SM) on LDH release and nitrite release from HaCaT. And COX-2, Bcl-2, Bax, $TNF{\alpha}$, c-jun, c-fos, NF-kB, iNOS, Bcl-xL gene expression were determined in HaCaT using real-time PCR method. Results: 1. SM inhibited LDH-release, nitrite production in UVB-exposed HaCaT. 2. SM suppressed the gene expression of COX-2, $TNF{\alpha}$ in UVB-exposed HaCaT. 3. SM increased the gene expression of Bcl-2, Bax, Bcl-xL family protein in UVB-exposed HaCaT. 4. SM suppressed the gene expression of c-jun, c-fos, NF-kB in UVB-exposed HaCaT. Conclusions: The study showed SM inhibited the cell damage in UVB-exposed HaCaT.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.2
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• pp.185-199
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• 2012

Objectives: This study aimed to review the effects and treatment of Korean, Oriental, Chinese medicine for premenstrual syndrome(PMS) as preceding research in order to further research the effective Korean Medicine treatment for PMS. Methods: Databases from Jan., 2002 through Feb., 2012 were searched through Pubmed for international journals; Korean studies information service system(KISS), National Discovery for Science Leaders(NDSL), Journal of Korean Acumoxa, J of Oriental Obstetrics and Gynecology, J of Meridian and Acupoint, and J of Korean Oriental Medicine for Korean journals were searched for national journals. The following search terms were used: acupuncture premenstrual syndrome, alternative medicine premenstrual syndrome, traditional Chinese medicine(TCM), premenstrual syndrome for Pubmed, premenstrual syndrome(in Korean and English) for the remaining search. Results: Twenty four studies were included in this review. Conclusions: Alternative medicinal intervention such as acupuncture and herb medicine may be effective treatment method in controlling premenstrual syndrome and premenstrual dysphoric disorder(PMDD).

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.2
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• pp.112-119
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• 2011

Objectives: This study is to report the effect of oriental medicine on a cervical incompetence patient. Methods: The effectiveness of surgical cerclage in the cervical incompetence have had prolonged controversy. Herbal medicine was given to a cervical incompetence patient whom was suggested surgical cerclage. The patient was a 40-year-old female and treated with Dojeukgangki-tang gagambang. Results: After oriental herbal treatment, the clinical symptom of a cervical incompetence was improved and maintained, the patient was delivered in 38 weeks through cesarian section. Conclusions: Oriental herbal medicine and treatment have possibility to be a useful alternative to the surgical cerclage on cervical incompetence on the basis of more persistent study.