• Food Science and Preservation
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• v.16 no.6
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• pp.959-964
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• 2009

The resveratrol contents in grapes showed a great variation according to the cultivars. In spite of it, a high resveratrol content in fruit was found generally in cultivars of Shigyoku, Pione, Muscat of Alexandria (black colored cultivars) and Muscatel Ruso, Gold Finger, Niunai (green colored cultivars). But in case included fruit stem and rachis, some cultivars, i.e. Shigyoku, Muscat of Alexandria and Baby Finger, showed relatively higher resveratrol content, and these cultivars could be advantageous for cultivation without chemical fungicide, because resveratrol was known as a phytoalexin. While resveratrol was not detected in fruit flesh, fruit stem and rachis contained considerably high content of resveratrol; that shows resveratrol may be synthesized in these parts.

• Bulletin of the Korean Space Science Society
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• 2003.10a
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• pp.74-74
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• 2003

로켓엔진의 연소실에서는 고온의 연소가스로부터 다량의 열이 발생하기 때문에 이로부터 연소실을 보호하기 위한 방법이 필수적으로 요구된다. 한국 최초의 액체 로켓인 KSR-III 로켓의 주엔진인 KL-3 엔진에서는, 연소실을 보호하기 위한 방법으로 실리카/페놀(Silica/Phenolic) 내열재를 이용하는 용융냉각 방식을 채택하였다 용융냉각 방식은 내열재와 고온의 연소가스와의 물리ㆍ화학적 상호작용에 의해 삭마가 발생하게 되는데, 이러한 삭마는 연소실에서도 가장 고온부인 노즐목에 집중적으로 발생하는 경향이 있다. 그러나 노즐목에서 삭마의 진행은 노즐목의 크기를 증가시키고 연소압 및 추력을 감소시키는 부작용을 초래하게 된다. 본 연구에서는 이러한 열적 삭마에 의한 노즐목 크기의 증가량을 알아내기 위해 KL-3 엔진 노즐목의 형상을 측정하고자 시도하였으며, 노즐목의 삭마에 영향을 미치는 주요 인자를 확인하고 진행과정을 고찰하였다. 노즐목의 형상 측정을 위해서는 기존에 사용하던 3차원 변위 측정기를 이용한 방식의 접근이 곤란함에 따라 영상처리 기법을 도입한 측정 방식을 고안하여 사용하였으며, 이 장비는 만족스런 성능을 보여주었다. 시험결과를 통해서 삭마에 영향을 주는 주요 인자로 분무형태, 연소시간, 연소 온도를 제시하였고 이 중에서 분무형태는 삭마 형상에, 연소 시간 및 연소온도는 삭마량에 주로 영향을 끼친다는 것을 알 수 있었다. 또한 시간에 따른 삭마의 진행이 3개의 구간으로 나누어 설명할 수 있음을 밝혔는데, 노즐목이 원형을 그대로 유지하며 삭마진행이 미미한 구간, 원형에서 벗어나 요철형상이 발달하면서 삭마진행이 가속되는 구간, 요철형상이 이미 정착되어서 요철의 깊이만 증가하되 삭마량은 미미한 구간이다. 결과적으로 60초 연소 후 노즐목 면적 증가율은 +5.82% 정도이며, 이에 따른 연소압 및 추력의 감소 또한 1% 미만으로 미비하였다. 따라서 본 KL-3 엔진에 사용된 내열재의 내열 성능은 임무를 수행하기에 적절하다고 판단하였다.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.467-481
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• 2006

In the era of the Internet and ubiquitous computing, IS users are still facing a variety of threats. Therefore, a need of more tightened information security service increases unprecedentedly. In this sense, this study is aimed at proposing a new research model in which IT assets (i.e., network, system, and information influence) and Information Security Service (i.e., confidentiality, integrity, nonrepudiation, authentication) affect information security qualty positively, leading to users' satisfaction eventually To prove the validity of the proposed research model, PLS analysis is applied with valid 177 questionnaires. Results reveal that both IT assets and Information Security Service influence informations security quality positively, and user satisfaction as well. From the results, it can be concluded that Korean government's recent orchestrated efforts to boost the IT assets and Information Security Service helped great improve the information security quality and user satisfaction.

• Proceedings of the Korean Information Science Society Conference
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• 2001.10a
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• pp.763-765
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• 2001

최근 휴대폰 보급의 활성화에 따라 무선인터넷 사용 및 무선 환경에서의 전자 상거래가 빠르게 증가 하고 있다. 유선 환경상에서와 마찬가지로 무선 환경상에서의 전자상거래 역시 소비자와 판매자가 서로를 신뢰할 수 있는 시스템이나 기법이 필요하다. 무선환경에서의 보안을 위해 WML 전자서명과 WPKI 등 여러 가지 방법들이 활발히 연구중이나 단말기 성능 제한과 WAP 게이트웨이에서 데이터 변환으로 인한 보안문제 등과 같이 현실적으로 많은 문계점을 가지고 있다. 본 논문에서는 보다 놓은 신뢰도를 얻을 수 있도록 유선환경과 무선환경을 접목시킨 신뢰성 있는 전자영수증 발급시스템을 제안한다. 시스템에서는 전자 서명을 이용한 전자영수증을 발급함으로써 판매자 및 소비자의 신원을 보장하고 판매자의 부인봉쇄효과를 갖는다. 또 무선 단말기의 단점을 보완하고자 신뢰할 수 있는 검증 서버를 설 치하여 영수증 검증 및 보관기능을 제공한다.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.4
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• pp.141-162
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• 2018

Objectives The purpose of this study is to provide evidence of traditional Korean medicine treatment in children and adolescents by reviewing previous studies published in the journal of pediatrics of Korean medicine. Methods We have reviewed clinical studies of children and adolescents in the journal of pediatrics of Korean medicine from 2008 to 2017. Results Eighty-seven clinical studies of children and adolescents were reviewed. Total number of patients were 1644 in the studies. Among these, top 5 most commonly reported diseases in children and adolescents were atopic dermatitis, growth, autism, juvenile idiopathic arthritis and obesity. The most common intervention to treat those was taking herbal medicine. Most of the clinical studies showed effectiveness of this approach in treating children and adolescents. Conclusions More double-blinded randomized controlled clinical trials of Korean medicine interventions treating children and adolescents are needed to establish evidence-based treatment.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.4
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• pp.18-44
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• 2017

Purpose: The object of this study was to observe the anti-climacterium activity of Gagamguibiondam-tang (GGOT) on ovariectomized (OVX) rats, a well-documented rodent models resembles with women postmenopausal climacterium symptoms, as including cardiovascular diseases, obesity, hyperlipidemia, osteoporosis, organ steatosis and mental disorders. Methods: In this study, anti-climacteric effects were evaluated separated into three categories; 1) anti-obese, 2) anti-uterine atrophy and 3) anti-osteoporotic effects. Five groups were used (8 rats in each group); sham control, OVX control, GGOT 500, 250 and 125 mg/kg administered groups. Twenty-eight days after bilateral OVX surgery, GGOT were orally administered, once a day for 84 days, and then the changes on the body weight and gain during experimental periods, serum estradiol levels, abdominal fat pad and uterus weights with histopathology of abdominal fat pads (total thickness and mean adipocyte diameters) and uterus (total, epithelial and mucosal thickness, percentages of uterine gland regions) for anti-obese and estrogenic effects. In addition, femur, tibia and fourth or fifth lumbar vertebrae (L4 or L5) wet, dry and ash weights, mineral density (BMD), bone strength (failure load), serum osteocalcin and bone specific alkaline phosphatase (bALP) contents, histological and histomorphometrical analyses - bone mass and structure with bone resorption, were monitored for anti-osteoporosis activity. Results: As a result of OVX, noticeable increases of body weight and gains, food and water consumption, weights of abdominal fat pad deposited in dorsal abdominal cavity, serum osteocalcin levels were demonstrated in this experiment with decrease of uterus, femur, tibia and L5 weights, serum bALP and estradiol levels. In addition, marked hypertrophic changes of adipocytes located in deposited abdominal fat pads, uterine disused atrophic changes, decreases of bone mass and structures of femur, tibia and L4 were also observed in OVX control rats with dramatic increases of bone resorption markers, the Ocn and OS/BS at histopathological and histomorphometrical analysis in this study as compared with sham-operated control rats, suggesting the estrogen-deficient climacterium symptoms - obese and osteoporosis were induced by OVX, respectively. However, these estrogen-deficient climacterium symptoms induced by bilateral OVX in rats were significantly inhibited by 84 days of continuous oral treatment of GGOT 500, 250 and 125 mg/kg, respectively. Especially, GGOT 500, 250 and 125 mg/kg showed clear dose-dependent inhibitory activities on the OVX-induced climacterium signs. Conclusion: The results suggest that oral administration of GGOT 500, 250 and 125 mg/kg has clear dose-dependent favorable anti-climacterium effects - estrogenic, anti-obese and anti-osteoporotic activities in OVX rats in this experiment.

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.3
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• pp.18-32
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• 2013

Objectives: In this research, the effect of Gyogam-dan (GGD) on depression and immunity were assessed in ovariectomized rats subjected to repetitive stress. GGD is the prescription consisting of Poria cocos and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After GGD (100 or 400 mg/kg) were orally administered, Elevated Plus Maze (EPM) and forced swimming test (FST) were performed to evaluate depressive and anxiety response. As well, the change of corticosterone (CORT) and the change of interleukin-$1{\beta}$ (IL-$1{\beta}$) and interleukin-4 (IL-4) in blood serum and in brain were mesured. Results: 1. In the EPM, there were no statistically significant differences among the groups. 2. In the FST, immobility time significantly decreased in rats of each experiment group compared with the control group (p<0.01). 3. Serum CORT level were decreased in 400 mg GGD group (p<0.05). 4. On IL-$1{\beta}$ and IL-4 measurement in the serum and brain, there were not significant increase or decrease compared with the control group. Conclusions: These results suggest that GGD is effective to reduce depression-behavior in ovariectomized rats. However, GGD do not has significant efficacy to reduce anxiety-behavior in EPM test. Measurement of serum CORT level reveals significant decrease and it shows anti-depressant like effect. Results on immunity are not significant.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.3
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• pp.117-131
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• 2012

Objectives: This study was designed to observe the effect of chuna manupulation in alleviating the symptoms of postpartum patients with low back pain and pelvic girdle pain. Methods: Targeted by outpatient 30 postpartum patients, A group was patients who were treated with acupuncture, traditional Korean medicine, physical therapy, B group was patients who were treated with acupuncture, traditional Korean medicine, physical therapy, and chuna manupulation. After 2-months, the progress of symptoms was evaluated by visual analogue scale(VAS) and Oswestry Disability Index(ODI) and Pain drawing. Results: 1. Group A and B were analyzed for general characteristics, with an average age of both groups, average weeks at admission after delivery, parity and method of delivery, weight gain and BMI during pregnancy were no significant differences in. 2. VNRS improvement in the rate of group A was $2.84{\pm}4.73$, VNRS improvement in the rate of group B was $4.85{\pm}1.49$. Between the two groups was statistically significant. 3. ODI improvement rate in group A was $10.14{\pm}4,39$, ODI improvement rate in Group B was $15.16{\pm}3.41$. Between the two groups was statistically significant. 4. Patients who received acupuncture, traditional Korean medicine, physical therapy, and chuna manupulation. in group B compared pubis, thighs, buttocks showing more effective in pain relief than group A, who received only acupuncture, traditional Korean medicine, physical therapy. Conclusions: In case of postpartum patients with low back pain and pelvic girdle pain, it is more effective to treat with Integrated traditional Korean therapy and chuna manupulation than to treat with only integrated traditional Korean therapy.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.3
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• pp.1-15
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• 2012

Objectives: The purpose of this study was to investigate the effects of Chaenomelis Fructus Herba Water Extract(CF) on the production of inflammatory mediators in RAW 264.7 cell mouse macrophages stimulated with LPS. Methods: We have not examined effect of CF on the cell viability of RAW 264.7 cell until we investigated effects of CF on LPS-induced productions of NO, Ca and various cytokines in RAW 264.7 cell. And when p-value is below 0.05, it is judged to have the significant difference statistically(P<0.05). Results: 1. CF increased the cell viability in the RAW 264.7 cell at the density of 25, 50, 100 and 200 ${\mu}g/ml$. 2. CF inhibited significantly increasing the production of NO in LPS-induced RAW 264.7 cell at the density of 25, 50, 100 and 200 ${\mu}g/ml$. 3. CF inhibited significantly increasing the production of Intracellular Ca in LPS-induced RAW 264.7 cell at the density of 25, 50, 100 and 200 ${\mu}g/ml$. 4. CF inhibited significantly the IL-2, IL-10, IL-12p70, TNF-${\alpha}$, GM-CSF, M-CSF, LIF and VEGF of the RAW 264.7 cell induced by LPS at the density of 25, 50, 100 and 200 ${\mu}g/ml$. 5. CF inhibited significantly the IL-4 at the density of 25, 50 ${\mu}g/ml$, the IL-5, IL-15 and MIG at the density of 25, 50 and 200 ${\mu}g/ml$ and IFN-${\gamma}$ at the density of 25, 100 ${\mu}g/ml$ respectively in the RAW 264.7 cell increased by LPS. Conclusions: CF inhibited significantly increasing IL-2, IL-10, IL-12p70, TNF-${\alpha}$, GM-CSF, M-CSF, LIF, VEGF, NO and Ca in LPS-induced RAW 264.7 cell at the density of more than 25 ${\mu}g/ml$ without causing the toxicity. These results signify that CF has antiinflammatory effect on controlling the over inflammatory reaction by the RAW 264.7 cell.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.3
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• pp.40-60
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• 2012

Objectives: The object of this study was to observe antitumor, anticachexia and immunomodulatory effects of Shipyeukmiyeugi-eum(SYM) on human breast cancer cell, MCF-7, xenograft Balb/c nu-nu nude mice. Methods: Three different dosages of SYM-125, 250 and 500 mg/kg were orally administered once a day for 28 days from 11 days after tumor cell inoculation, and the changes on the body weights, tumor volume and weights, weights of spleen and popliteal lymph node and epididymal fat, serum IL-6 and IFN-${\gamma}$ levels, NK cell and peritoneal macrophage activities, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents were observed. In addition, histopathological observations of apoptotic cell, spleen, popliteal lymph node and cervical brown adipose were also detected. The results were compared with a potent cytotoxic estrogen receptor antagonist, Tamoxifen 20 mg/kg treated mice. Results: Tumor volumes and weights were decreased without cytotoxic effects on the both MCF-7 and MCF-10A cells as results of all three different dosages of SYM treatment. And weights of body, spleen, popliteal lymph node, epididymal fat, serum IFN-${\gamma}$, NK cell, peritoneal macrophage activities, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents were increased with decrease of serum IL-6. At histopathological observations, apoptotic tumor cells, spleen, popliteal lymph node and cervical brown adipose tissue were increased. That means tumor-related immunosuppress and cachexia were markedly inhibited by SYM treatment as compared with tumor-bearing mice. On the other hand, Tamoxifen showed marked cytotoxic effects against MCF-7 and MCF-10A, decreases of tumor volume and weights, and increases of apoptotic tumor cells and related decreases of tumor cell volumes, but tamoxifen markedly deteriorated the tumor-related immune-suppress and cachexia. Conclusions: The results obtained in this study suggest that SYM showed favorable anticancer effects and anticachexic effects on the MCF-7 cell xenograft through immunomodulatory effects. SYM did not induce any cytotoxic effects against both normal and cancer cells.