The Human gene testing act (GenDG) in Germany starts from the characteristic features of gene testing, i.e. dualisting structure consisted of anlaysis on the one side and the interpretation on the other side. The linguistic distincion of 'testing', 'anlaysis' and 'judgment' in the act is a fine example. Another important basis of the regulation is the ideological purpose of the law, that is information autonomy. The normative texts as such and the founding principle are the basis of the classification of testing types. Especially in the case of gene testing for medical purpose is classified into testing for diagnostic purpose and predictive purpose. However, those two types are not always clearly differentiated because the predictive value of testing is common in both types. In the legal regulation of gene testing it is therefore important to manage the uncertainty and subjectivity which are inherent in the gene-analysis and the judgment. In GenDG the system ensuring the quality of analysis is set up and GEKO(Commity for gene tisting) based on the section 23 of GenDG concretes the criterium of validity through guidelines. It is also very important in the case of gene testing for medical purpose to set up the system for ensurement of procedural rationality of the interpretation. The interpretation of the results of analysis has a wide spectrum because of the consistent development of technology on the one side and different understandings of different subjects who performs gene testings. Therefore the process should include the communication process for patients in oder that he or she could understand the meaning of gene testing and make plans of life. In GenDG the process of genetic counselling and GEKO concretes the regulation very precisely. The regulation as such in GenDG seems to be very suggestive to Korean legal polic concerning the gene testing.
Due to the exhaustion of resources and increasing concerns about the environment, reverse logistics has become a critical issue in recent years. We discuss the conventional logistics operations and the reverse logistics operations in the automotive industry. The traditional supply chain (TSC) and the reverse supply chain (RSC) models are developed to compare performance between two systems. In addition, results of the simulation models are discussed in respect to total costs, inventory levels and stock-outs to analyze the effects of introducing of reverse logistics system.
Journal of the Computational Structural Engineering Institute of Korea
/
v.23
no.2
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pp.217-225
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2010
Most of the steel bridges in Korea are being currently designed by the allowable stress design method that uses the conventional deterministic factors of safety. However the limit state design based on the concept of probability, statistics and reliability engineering is becoming very popular as a global standard deign method, leading the rational and economic bridge design. As part of the fundamental research to establish the load and resistance factor design(LRFD) of steel bridges considering domestic environmental conditions and regional characteristics, an experimental design is conducted by applying AASHTO-LRFD specification especially to a steel closed-box girder, which occupies relatively a large portion of steel bridges in Korea. Throughout the experimental design according to various sectional changes, some of the issues to be considered in the LRFD design of a composite steel closed-box girder bridge are examined. In this process, an Excel-based design verification program is developed for easy computation and prevention of errors. Quantitative reliability levels of the bridge sections designed by LRFD are also estimated using a reliability analysis method, and compared with the target reliability indexes applied in the LRFD design to verify the validity of the procedure and methodology used in this study.
Recent market environment shows a new relationship between customer and company, which you could not observe in the past. Customers now are used to various benefits through the participation of marketing process. It is no wonder that customers visit company web site, gather a lot of information about the product on the website, and express their satisfaction and opinions about the product. Furthermore, these activities are being made ubiquitously. Despite the fact there are a lot of customer participation in the Internet environment, Customers Participation has been given little attention in the academic literature. This study explores the effect of the properties of Internet infra on customers participation. The implications of this study are as follows. First, by reviewing the literature on the performance and process of customers participation in the marketing activities, this study identifies why customers did not participate in the marketing activities under non-Internet environment. Second, this study identifies the properties of Internet infra influencing customers informative participation. Third, we suggest some managerial strategies for enhancing the performance of a company by customer participation. Consequently, we suggest managerial implications for completely different marketing strategies in response to customers participation in the marketing activities under the digital environment.
As the wireless mobile communication is being widespread, mobile technologies will have important roles in the communication with the explosive growth of demanding for wireless portable devices. Among the mobile technologies, a great deal of interest has been taken in mobile ad hoc network (MANET), which is a collection of wireless mobile nodes forming a temporary network without the aid of stationary infrastructure in recent. Furthermore, considering characteristic of ad hoc networks, the design of efficient routing protocols is an important issue. In recent years, on-demand protocols among routing protocols have noticed because of the low routing overhead. However, on-demand protocols suffer from production of the enormous query Packets by broadcasting in order to setup routes, that is, a flooding scheme. The flooding scheme is very costly and results in serious problem, which we refer as the broadcast storm problem. In this paper, we propose a Dynamic Adaptation Query flooding Using Neighbor Topology (NT-DAQ) scheme, in order to resolve the broadcast storm Problem. When a route discovery is in progress, each mobile node decides on the basis of neighbor topology information whether discovery process participates or not. Therefore, our proposed scheme enables to improve network performance in which minimize the number of query rackets. We evaluate the efficiency of our proposed scheme through simulation.
The purpose of this research is to develop system and to establish methodology for managing spatial Database in Land Management Information System(LMIS). Spatial Database which is used by a various public department such as parcel survey and registry, land use planning and Land value appraisal in local government, is composed of parcel map, topographic map and zoning map. Spatial data has been constructed and managed by various department and then hard to maintain accuracy and coinsistency. So, it is important to establish the basic data management concept that source data(ex : parcel map, topographic map, zoning map, etc.) should be managed by responsible department. at the same time, application data for bussiness (ex : individual parcel price map) must be recomposed from base map by it's own objects. This is, Spatial data management system (SDMS) should be designed, developed according to this concept for managing consistency among data, reducing construction and management cost of database. Our SDMS was developed based on Open LMIS middleware architecture using OpenGIS CORBA specification for standard interface, RUP(Rational Unified Process) for development methodology, UML(Unified Modeling Language) for system design and VisiBroker, C++, CAD system for system implementation.
Ha, Tae-Jin;Kim, Yeong-Mi;Ryu, Je-Ha;Woo, Woon-Tack
Journal of the Institute of Electronics Engineers of Korea CI
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v.44
no.2
s.314
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pp.37-46
/
2007
In this paper, we propose technologies for enhancing the immersive realization of virtual objects in AR-based product design. Generally, multimodal senses such as visual/auditory/tactile feedback are well known as a method for enhancing the immersion in case of interaction with virtual objects. By adapting tangible objects we can provide touch sensation to users. A 3D model of the same scale overlays the whole area of the tangible object so the marker area is invisible. This contributes to enhancing immersion. Also, the hand occlusion problem when the virtual objects overlay the user's hands is partially solved, providing more immersive and natural images to users. Finally, multimodal feedback also creates better immersion. In our work, both vibrotactile feedback through page motors, pneumatic tactile feedback, and sound feedback are considered. In our scenario, a game-phone model is selected, by way of proposed augmented vibrotactile feedback, hands occlusion-reduced visual effects and sound feedback are provided to users. These proposed methodologies will contribute to a better immersive realization of the conventional AR system.
Background : Uvulopalatopharyngoplasty(UPPP) has become the most common surgical treatment for obstructive sleep apnea syndrome(OSAS). However, the results of this therapeutic modality have been quite variable with successful results by several authors and poor results by others. Until recently, in Korea, there is only a few reports about the clinical efficacy of UPPP. A prospective study was undertaken to evaluate the effectiveness and complications of UPPP. Method : Twenty-six OSAS patients who had undergone UPPP with preoperative and postoperative polysomnographic studies were included in this study. Two definitions of surgical success were used. The responder was defined, using a conventional criteria, as a 50% or more reduction in apnea index(AI) or apneahypopnea index(AHI) after UPPP, or a postoperative AI of <10 or AHI of <20. The initial cure was defined, using our own criteria, as a postoperative AI of <5 or AHI of <10. Complications were categorized in two groups : early(disorders during the first 10 postoperative days) and late. Results : Eighteen patients(69.2%) were responders, and ten patients(38.5%) were considered as initial cure. On the other hand, in five patients (19.2%), postoperative polysomnographic data demonstrated deterioration compared with preoperative data. Reduction rate of AI or AHI following UPPP was not significantly related to the preoperative body mass index, AI or AHI. There was no significant change of sleep architecture before and after UPPP in responder and initial cure groups. Early complications such as pain, dyspnea, bleeding, nasal reflux, dysphagia or wound disruption were observed in all patients. Late complications such as nasal reflux, voice change, dysphagia, loss of taste, pharyngeal dryness or foreign body sensation were discovered in 22 patients (84.6%). However, all early and late complications were of minor importance. Conclusion : The response to UPPP was favorable in approximately 70% of OSAS patient. However, the initial Cure rate of UPPP was relatively low. We suggest that selection of more appropriate surgical candidates and adequate surgical protocol is necessary to obtain a more successful result with UPPP.
Clean Development Mechanism(CDM) projects under the Kyoto Protocol have two objectives. One is to assist the Parties included in Annex I in achieving compliance with their quantified emission limitation and reduction commitments in cost-effective ways by allowing them to implement emission reduction projects in Non-Annex I countries and receive CERs, which will offset their reduction commitments. The other is to assist Parties not included in Annex I in achieving sustainable development and technology transfers through investments by Annex I countries. However, in reality, it is said that the former objective is achievable but the latter is not. In this light, this article suggests sustainability appraisal criteria applicable for Korea. Among various methodologies, we used the 'multi-attributes utility theory(MAUT)'; one of the 'multi-criteria analysis (MCA)' methodologies judged to be the most practical and relevant. Based on the guidelines of the MAUT methodology, we identified sustainability criteria that meet the guidelines. We took two tracks, the first to find the preferences of Korean experts, and the other to check foreign cases. In all, 37 preliminary criteria were suggested to Korean experts and each criterion was scored, from between 1 and 3, in terms of relevance, possibility of real improvement, easiness of data collection, and preferences. We combined foreign cases and the results of a survey conducted in Korea and selected 12 core criteria and 10 additional criteria. After that, all the criteria were converted into indicators. The indicators were applied to a CDM project for case study. We chose the "Sihwa Tidal Power Project", which is currently the biggest tidal power plant in the world. Twelve core indicators and 3 additional indicators were applied. In order to weight each indicator, the 'analytical hierarchy process (AHP)' was used. A total of 30 experts were asked to suggest weights and 21 answered. Among them, only 14 respondents were proven to meet the consistency ratio. We analyzed the 14 responses through Expert Choice and the CDM project was scored (+)53.082. In addition, sensitivity analysis was undertaken with the result of (+)44.667 to (+)65.522. As a result of this study, it was proven that this project would contribute to the sustainable development of Korea.
Recently some report has been published on the classification of Sasang constitution by analysis of genetic polymorphism. In this study, to present the ideas in the study on the classification of Sasang constitution based on the genetic variation of individuals, we reviewed the previous studies dealing with relationship between genetic polymorphism and Sasang constitution and suggested new molecular biological methodologies applicable to the classification of Sasang constitution. The results were as follow; 1. In the studies on the classification of constitution by analysis of genetic polymorphism, the special genes were desirable as subjects rather than the non-functional part of genome such as inter-gene and intron. Since microsatellite is usually located in inter-gene or intron, representation of constitutions may not associated with the polymorphism of certain microsatellite. 2. It may possible that polymorphism patterns of the genes related to the expression of individuality is associated with the types of Sasang constitutions. Therefore, angiotensin converting enzyme (ACE) which known have some role in the determination the human performance is one of the candidate genes can use for the classification of Sasang constitutions. 3. It is well known that HLA types are very variable in human and closely associated with the determination of susceptibility for certain disease. The studies on the polymorphism of HLA types may applicable to the classification of Sasang constitutions. 4. DNA chip technique which developed recently for the analysis of the expression of human genes may powerful tools in the study of Sasang medicine.
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