• The Korean Journal of Oral and Maxillofacial Pathology
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• v.42 no.6
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• pp.175-182
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• 2018

Extranodal intraoral Hodgkin lymphoma is not common. We report the case of a 78-year-old male patient with ulcer of the mandibular oral mucosa that was not cured for about 3 weeks. In biopsy and histopathologic examination, it was found to be extranodal intraoral Hodgkin lymphoma. Early diagnosis of oral lesions led to early detection of lesions of the opposite neck lymph node in an additional PET-CT scan. We report this case and review relevant literature.

• The Science & Technology
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• v.30 no.3 s.334
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• pp.80-81
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• 1997

국소성 분절성 신사구체경화증(FSGS)의 형성과정에서 신사구체 비대가 어떤 의미를 갖는가를 집중적으로 연구해 과총에서 수여하는 우수논문상을 수상한 서울대 의대 병리학교실 이현순교수. 이교수는 "병리학은 각종 진단을 내리고 또한 병의 원인을 근원적으로 접근할 수 있다는 점에서 매우 매력적인 학문이라고 생각한다"고 했다.

• The Korean Journal of Oral and Maxillofacial Pathology
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• v.41 no.1
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• pp.9-16
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• 2017

Porphyromonas gingivalis is a gram-negative bacteria of rod shape, and grown in an anerobic condition. It colonizes in subgingival crevice and is known as a major pathogen causing chronic periodontitis. It possesses an invasive property and replicative potential within various cell types, presumably playing an important role in modulating biological behaviors of oral cancer. However, the pathophysiology of P. gingivalis in the malignant transformation of oral cancer has not been fully understood. In this study, we aimed to investigate molecular changes of oral squamous cell carcinoma cells induced by repetitive P. gingivalis infection that clinically resembles chronic periodontitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.5
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• pp.275-281
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• 2019

Polysaccharides produced in microorganisms and plants are known to increase the immune response in the body. We proposed analysis of beta-glucan contents of phellinus linteus fruit body (FB) and mycelium (MC) cultured in cudrania tricuspidata. Also, we examined whether fruit body and mycelium can increase the immune response in cyclophosphamide-induced immunosuppression animal models. We injected cyclophosphamide (50 mg/kg) twice to produce immunosuppression mice. Then, FB (200 mg/kg) and MC (200 mg/kg) were oral administered for 14 days. In order to confirm the immune-enhancing effect of FB and MC, we analyzed spleen weight, the number of immune cells, cytokines, and immunoglobulins levels. Cyclophosphamide decreased the weight of spleen, the number of immune cells. However, FB and MC have significantly increased the weight of spleen, the number of white blood cell, lymphocyte and monocyte. In addition, they have significantly increased immune-related cytokines (IL-2 and IFN-${\gamma}$) and immunoglobulins (IgA, IgG, IgM) levels. As a results, phellinus linteus fruit body (FB) and mycelium (MC) cultured in cudrania tricuspidata can be used as effective natural materials for immune-enhancing.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.1
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• pp.1-8
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• 2023

The purpose of this study is to find terms that can give identity to the major and occupation of clinical laboratory technologist (also known as medical technologist). The term clinical pathology includes all branches of pathology, namely anatomical pathology, chemical pathology, hematology, microbiology, and all respective subspecialties. Unfortunately, several countries exclude anatomical pathology from the term clinical pathology, a problem that gets compounded when the title is translated into languages other than English. Clinical pathology (US, UK) is a medical specialty. Similar terms are laboratory medicine (Germany, Poland), medical/clinical biology (France, Netherlands) or clinical analysis (Spain). Depending on the person questioned, medical technology is defined slightly differently by individuals, companies, and institutions. The definition also depends on the language in which the question is asked. Medical technology can be translated to define clinical laboratory technology, allied health sciences, medical equipment, biomedical engineering, and health technology. The terms 'clinical pathology technology and pathological technology' are not used in allied health sciences. The names of 'medical technology·medical technologist' can be replaced by 'biomedical laboratory science·biomedical laboratory technologist' or 'clinical laboratory analysis·clinical laboratory analyst'. In this study, it is proposed to change the name of academic and occupation to 'medical biology·medical biology technologist' that combines the term biomedical.

• Proceedings of the Korea Information Processing Society Conference
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• 2016.10a
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• pp.663-664
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• 2016

다양한 분야에서 특정 이미지와 유사한 내용의 이미지를 찾기 위해서 이미지 유사도 기법을 지원하는 웹 또는 프로그램이 많이 사용되고 있다. 본 논문에서는 이미지 유사도 기법을 병리학 이미지에 적용하여 특정 세포를 찾는데 사용함으로써 사용자에게 정확하고 신뢰성 있는 정보를 전달하려 한다. 실제로 병리학에서 특정 세포를 찾기에는 세포의 크기가 너무 작고 모양이 일정하지 않는다는 점 때문에 유사한 세포를 찾기가 힘들다. 이를 해결하기 위해 Leveling과 Tiling 방식을 적용하여 데이터를 추출하고 이미지 동기화를 통해 유사도 비교 시 정확도를 높이도록 한다. 다양한 병리학 이미지 포맷을 지원하는 OpenSlide 기반의 대용량 이미지에 제안하는 방식을 적용하여 특정 세포와 유사한 부분을 찾아내는 실험을 통하여 제안하는 방식이 효율적임을 보인다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.5
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• pp.229-237
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• 2020

The purpose of this study was to investigate the antioxidant and hangover cure effects of compound prescription containing Phyllanthus emblica and Azadirachta Indica leaf extract (CP). In vitro experiments, HepG2 cells were induced oxidative stress by hydrogen peroxide (H2O2) and treated with CP at 50, 100, 200 ㎍/㎖ concentration. Antioxidant enzyme (superoxide dismutase (SOD), catalse (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) activity and glutathione (GSH) content were decreased by hydrogen peroxide-induced oxidative stress, but CP was increased that. In vivo experiments, experiment rats were orally administered alcohol 3 g/kg and, after 30 min administered CP 200 mg/kg. After 1 and 3 h of alcohol administration, blood was collected from the tail vein, while after 5 h, blood was collected from the heart. CP modulates alcohol dehydrogenase (ADH) and acetaldehyde level, thereby decreased alcohol level in serum. Also, CP decreased the levels of aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These results suggest that CP has antioxidant effects and alleviates alcohol hangover symptoms.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.5
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• pp.245-254
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• 2020

The purpose of this study was to investigate the effects of natural herb mixture containing Laminaria japonica Areschoung (LAM) on fine dust-induced bronchitis in mice. Laminaria japonica Areschoung is main content of LAM, which is including fucoidan. Fucoidan extracted from phaophyta is known to prevent bronchitis and to defend against bacteria and virus infection. In this study, we experienced the effect of LAM on bronchitis and investigated gene expressions (e.g ; IL-8, COX-2, MCP-1) and bio-markers (e.g ; IL-8, PGE2, MUC5AC) associated with bronchitis by using A549 cells. Also, we investigated whether LAM can suppress the bronchitis in fine dust-induced animal models. We injected fine dust (50 ㎕) twice as INT (Intra-Nasal-Trachea) method. Then LAM (200 mg/kg and 400 mg/kg) were oral administered for 14 days. We analyzed the number of immune cells, immunoglobulin E, bio-markers level associated with bronchitis. LAM significantly decreased bio-marker (IL-1β, IL-6, IL-8, TNF-α, Histamine, PGE2), immune cells (white blood cell, neutrophil, lymphocyte, monocyte), and immunoglobulin E, that are increased by fine dust. Taken together, this study suggest that LAM can be used as effective herbal extract for bronchitis.

• The Science & Technology
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• v.30 no.3 s.334
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• pp.70-71
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• 1997

해방 이듬해인 1946년 10월 당시 조선의학회 회장이던 윤일선씨를 중심으로 창립되어 지난 반세기동안 우리나라 병리학의 발전을 주도해 온 대한병리학회. 초창기 30여명으로 발족된 이 학회는 현재 회원이 5백50여명으로 늘어났으며 지난해 10월에는 "한민족 병리학발전 50주년"을 캐치프레이즈로 한 창립 50주년 학술대회를 성황리에 개최했다.

• The Science & Technology
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• v.30 no.8 s.339
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• pp.82-83
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• 1997

위암 파라핀조직을 이용하여 세포배양없이 염색체변이를 규명하는 연구로 인정을 받고 있는 카톨릭의대 임상병리학교실 한경자교수. 염색체 연구는 살아있는 세포를 이용해왔으나 한교수는 수술을 통해 얻은 죽은 조직으로 연구해 이 분야의 연구 활성화에 전기를 마련해 학계의 기대를 모으고 있다.