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http://dx.doi.org/10.15188/kjopp.2019.10.33.5.275

Immune-Enhancing Effects of Phellinus linteus Fruit Body and Mycelium Cultured in Cudrania tricuspidata  

Hong, Da Hyun (Department of Pathology, College of Korean Medicine, Daejeon University)
Joo, In Hwan (Department of Pathology, College of Korean Medicine, Daejeon University)
Park, Jong Min (Department of Pathology, College of Korean Medicine, Daejeon University)
Han, Su Hyun (Department of Pathology, College of Korean Medicine, Daejeon University)
Lee, Su Bin (Department of Pathology, College of Korean Medicine, Daejeon University)
Gwak, Seong Geun (Hongik Herbal Farm Corporations)
Kim, Dong Hee (Department of Pathology, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.33, no.5, 2019 , pp. 275-281 More about this Journal
Abstract
Polysaccharides produced in microorganisms and plants are known to increase the immune response in the body. We proposed analysis of beta-glucan contents of phellinus linteus fruit body (FB) and mycelium (MC) cultured in cudrania tricuspidata. Also, we examined whether fruit body and mycelium can increase the immune response in cyclophosphamide-induced immunosuppression animal models. We injected cyclophosphamide (50 mg/kg) twice to produce immunosuppression mice. Then, FB (200 mg/kg) and MC (200 mg/kg) were oral administered for 14 days. In order to confirm the immune-enhancing effect of FB and MC, we analyzed spleen weight, the number of immune cells, cytokines, and immunoglobulins levels. Cyclophosphamide decreased the weight of spleen, the number of immune cells. However, FB and MC have significantly increased the weight of spleen, the number of white blood cell, lymphocyte and monocyte. In addition, they have significantly increased immune-related cytokines (IL-2 and IFN-${\gamma}$) and immunoglobulins (IgA, IgG, IgM) levels. As a results, phellinus linteus fruit body (FB) and mycelium (MC) cultured in cudrania tricuspidata can be used as effective natural materials for immune-enhancing.
Keywords
Cudrania tricuspidata; Phellinus linteus; Mycelium; Immunomodulatory; Cyclophosphamide;
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