Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Antioxidant and Hangover Cure Effects of Compound Prescription Containing Phyllanthus emblica and Azadirachta Indica Leaf Extract

인디언구스베리와 님잎 추출물을 함유한 복합 처방의 항산화 및 숙취해소 효과

  • Lee, Su-Bin (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Joo, In-Hwan (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Park, Jong-Min (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Han, Su-Hyun (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Wi, Young-Joon (Hanul, Private Company) ;
  • Kim, Dong-Hee (Department of Pathology, College of Korean Medicine, Daejeon University)
  • 이수빈 (대전대학교 한의과대학 병리학교실) ;
  • 주인환 (대전대학교 한의과대학 병리학교실) ;
  • 박종민 (대전대학교 한의과대학 병리학교실) ;
  • 한수현 (대전대학교 한의과대학 병리학교실) ;
  • 위영준 (유한회사 한얼) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Received : 2020.05.27
  • Accepted : 2020.09.04
  • Published : 2020.10.25
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Abstract

The purpose of this study was to investigate the antioxidant and hangover cure effects of compound prescription containing Phyllanthus emblica and Azadirachta Indica leaf extract (CP). In vitro experiments, HepG2 cells were induced oxidative stress by hydrogen peroxide (H2O2) and treated with CP at 50, 100, 200 ㎍/㎖ concentration. Antioxidant enzyme (superoxide dismutase (SOD), catalse (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) activity and glutathione (GSH) content were decreased by hydrogen peroxide-induced oxidative stress, but CP was increased that. In vivo experiments, experiment rats were orally administered alcohol 3 g/kg and, after 30 min administered CP 200 mg/kg. After 1 and 3 h of alcohol administration, blood was collected from the tail vein, while after 5 h, blood was collected from the heart. CP modulates alcohol dehydrogenase (ADH) and acetaldehyde level, thereby decreased alcohol level in serum. Also, CP decreased the levels of aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These results suggest that CP has antioxidant effects and alleviates alcohol hangover symptoms.

Keywords

References

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