• Title/Summary/Keyword: 변이 추정

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A Case of Wiskott-Aldrich Syndrome with Novel Mutation in Exon 2 of the WASP Gene (WASP 유전자의 Exon 2에서 새로운 돌연변이를 가진 Wiskott-Aldrich 증후군의 1례)

  • Lee, Hyuk;Park, Jung-In;Kim, Sun Young;Moon, Kyeung Hee;Yi, Ho Keun;Hwang, Pyeong Han
    • Clinical and Experimental Pediatrics
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    • v.48 no.5
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    • pp.551-556
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    • 2005
  • Wiskott-Aldrich syndrome(WAS) is an X-linked recessive immunodeficiency characterized by thrombocytopenia with small platelet volume, eczema, and recurrent infections, and is also characterized by increased incidence of auto immune diseases and malignancies. The phenotype observed in this syndrome is caused by mutation in the Wiskott-Aldrich syndrome protein(WASP) gene localized to the proximal short arm of the X chromosome and recently isolated through positional cloning. The gene encodes a 502 amino acid protein, which contains 12 exons and spans 9 kb of genomic DNA. The function of the encoded protein is not well understood. The clinical diagnosis of WAS can be difficult and is usually confirmed by the detection of WASP gene mutations and the expression of WSAP in patient blood sample using genetic analysis. We reported a case of a 13-month old boy with WAS who was identified with the novel mutation in exon 2 of WASP gene by direct sequencing and the complete absence of WASP expression by immunoblotting.

Varietal Classification by Multivariate Analysis in Job′s Tears (Coix lachryma-jobi L. var. mayuen STAPF) (다변량 해석법에 의한 율무의 품종군 분류)

  • 권병선;박희진
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.35 no.2
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    • pp.126-131
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    • 1990
  • Sixty two Job's Tear cultivars were largely classified into ten varietal groups and every varieties. except for Group V forming the Group by one variety. uniformly formed the Groups. From Group I to Group Ⅹ respectively contained three(5%), eighteen(29%), five(8%), thirteen(21%), one(2%), five(8%), seven(11%), four(7%), two(3%) and four(7%) varieties. Group II and Group IV showed considerably large variation whereas Group Ⅷ, IV and Ⅹ showed low variation and inferiority in vigorosity and yield components. Most of the varietal Group were not associated with their geographical origin. Days to flowering and plant height among the nine characters were the largest contributors to the D$^2$ in both inter- and inter groups.

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RMR Evaluation by Integration of Geophysical and Borehole Data using Non-linear Indicator Transform and 3D Kriging (암반등급 해석을 위한 비선형 지시자 변환과 3차원 크리깅 기술의 물리탐사 및 시추자료에 대한 적용)

  • Oh, Seo-Khoon
    • Journal of the Korean earth science society
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    • v.26 no.5
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    • pp.429-435
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    • 2005
  • 3D RMR (Rock Mass Rating) analysis has been performed by applying the Geostatistical integration technique for geophysical and borehole data. Of the various geostatistical techniques for the integrated data analysis, in this study, we applied the SKlvm (Simple Kriging with local varying means) method that substitutes the values of the interpreted geophysical result with the mean values of the RMR at the location to be inferred. The substitution is performed by the indicator transform between the result of geophysical interpretation and the observed RMR values at borehole sites. The used geophysical data are the electrical resistivity and MT result, and 10 borehole sites are investigated to obtain the RMR values. This integrated analysis makes the interpretation to be more practical for identifying the realistic RMR distribution that supports the regional geological situation.

Genetic Analysis of Caulobuter crescentus by Using Transposon Tn5 and Reverse Field Electrophoresis (Transposon Tn5 및 Reverse Field Electrophoresis를 이용한 Caulobuter crescentus의 유전자 분석 연구)

  • 구본성;버트일리
    • Microbiology and Biotechnology Letters
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    • v.17 no.3
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    • pp.183-187
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    • 1989
  • The bacteriophage Mu and transposon Tn5 containing plasmid pJB4JI-transferred transposon Tn5 to Caulobuter crescentus. When several thousand of transposon Tn5 insertion mutants were examined, we found auxotrophic and motility mutants at frequencies of 2% and 3%, respectively. Transposition of transposon Tn5 was analyzed by the reverse field electrophoresis and Southern hybridization. The results indicated that transposon Tn5 was randomly inserted to Caulobuter crescentus chromosome but the plasmid vector, pJB4JI, was not maintained.

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The Algorithm of Efficient Core Selection Estimation for the Multicast Delay Variation Problem and Minimum Delay Variation (멀티캐스트 지연변이 문제에 대한 효율적인 코어 선택 추정 알고리즘)

  • Ahn, Youn-Gjin;Kim, Moon-Seong;Choo, Hyun-Seung
    • Journal of Internet Computing and Services
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    • v.8 no.2
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    • pp.33-41
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    • 2007
  • With the development of the multicast technology, the realtime strategy among the group applications using the multicast routing is getting more important. An essential factor of these real-time application is to optimize the Delay- and delay Variation-Bounded Multicast Tree(DVBMT) problem. This problem is to satisfy the minimum delay variation and the end-to-end delay within an upper bound. The DVBMT problem is known as NP-complete problem. The representative algorithms for the problem are DVMA, DDVCA, and so on. In this paper, we show that the proposed algorithm outperforms any other algorithm. The efficiency of our algorithm is verified through the prerformance evaluation and the enhancement is up to about 9% to 29% in terms of the multicast delay variation. The time complexity of our algorithm is $O(mn^2)$M.

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Genetic Variation in the Natural Populations of Abies holophylla Max. Based on RAPD Analysis (RAPD 분석(分析)에 의한 전나무 천연집단(天然集團)의 유전변이(遺傳變異))

  • Kim, In Sik;Hyun, Jung Oh
    • Journal of Korean Society of Forest Science
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    • v.88 no.3
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    • pp.408-418
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    • 1999
  • On the basin of RAPD analysis, genetic diversity and structure of the natural populations of Abies holophylla was estimated by AMOVA procedure. The average value of percent of polymorphic markers was 71.9%. Most variation existed among individuals within population(80.2%). Genetic differentiation among populations(${\Phi}_{ST}$) was 0.198. When the populations were grouped as two region(i.e., Taebaek and Sobaek Mountain Regions), 8.5% of the total genetic variation was explained as regional differences. The heterogeneity of molecular variance among populations was investigated with Bartlett's test, which revealed that populations of Mt. Taebaek and Mt. Gariwang were more heterogeneous. Generally, the populations of Taebaek Mountain Reion were more heterogeneous than those of Sobaek Mountain Reion. Finally, the applicability of AMOVA to the populations frenetic study was discussed in comparison with other measures of genetic differentiation which were widely used.

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Model Parameter-based Rate Control Algorithm for Constant Quality Real-Time Video Coding (실시간 부호화를 위한 모델 파라미터 기반 일정 화질 비트율 제어 기법)

  • Jeong, Jin-Woo;Cho, Kyung-Min;Choe, Yoon-Sik
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.45 no.3
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    • pp.93-102
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    • 2008
  • In this paper, we propose a rate control algorithm for constant quality real time video coding. To achieve constant quality, previous algorithm exploit mean absolute of difference(MAD) as measure of frame complexity. However, if scene is abruptly changed or if quantization parameter is not constant, encoder produces various output bits with same MAD. Therefore we know that MAD does not appropriately reflect characteristic of frame. To solve this problem, we exploit model parameter as measure of frame complexity. Because model parameter means slope between output bits and MAD, it reflects correctly complexity of frame. And because previous model, R-MAD model, is not considered quantization parameter, as quantization parameter increases or decreases, model parameter of frame also vary. So model parameter obtained using previous model cannot reflect internal characteristic of video. We solve this problem using proposed model, which is considered quantization parameter. Experiment results show that our algorithm provide better performance, in terms of quality smoothness than previous algorithm. Especially, when scene is abruptly changed, our algorithm alleviates quality drop.

Variation of Soil Characteristics for Soil Color Groups in Jeju-Do (토색분류(土色分類)에 의(依)한 제주도(濟州道) 토양(土壤)의 변이분석(變異分析))

  • Park, Chang-Seo;Um, Ki-Tae;Kim, Lee-Yul
    • Korean Journal of Soil Science and Fertilizer
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    • v.17 no.2
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    • pp.141-146
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    • 1984
  • Variation of soil characteristics and purity were examined within mapping unit and estimates were given for the number of samples required to reach predetermined levels of accuracy for black soil, VDBr. soil, DBr. soil, and brown soil in Jeju. Variation of chemical properties except pH and CEC was higher than that of physical properties. Brown soil showed the lowest variation and hence required the smallest sample size. The soils examined were correctly classified with regard to brown soil at purity 74.1, to DBr. soil 60.8, to black soil 55.6, and to VDBr. soil 46.9%. Sample calculation was presented which showed approximate sample sizes required to detect the difference of 10 and 20% of the mean with 0.95 confidence level.

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A study on frequency gain control of frequency shift keying signals using the preamble error rate for underwater acoustic communications (수중 음향 통신에서 주파수 편이 변조 신호의 프리엠블 오류율을 이용한 주파수 이득 조절 연구)

  • Jeong, Hyun-Woo;Jung, Ji-Won;Kim, Wan-Jin
    • The Journal of the Acoustical Society of Korea
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    • v.41 no.2
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    • pp.218-226
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    • 2022
  • The main characteristics of the underwater acoustic channel have varying multipath and fast fading. Especially, Frequency Shift Keying (FSK) signals with multiple frequency bands caused loss of information bits allocated on the specific frequencies due to selective fading phenomenon. Therefore, this paper proposes frequency gain control algorithm based on preamble error rates. The proposed algorithm estimates optimal gain value in the range of preamble error rate with less than 10 % for specific faded frequency. By employing turbo equalized FSK signals with rate of 1/3, the experiment was conducted on a lake in Munkyeong city with distance of 300 m to 500 m. The result confirms that packets are decoded successfully by applying proposed algorithm as increasing number of iterations.

A Basic Study of Roughness coefficient of Domestic Rivers (국내 하천 조도계수 산정을 위한 기초연구)

  • Yoo, Dong-Hoon;Lee, Tae-Hee
    • Proceedings of the Korea Water Resources Association Conference
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    • 2009.05a
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    • pp.1775-1780
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    • 2009
  • 개수로 마찰흐름 특성에 관한 연구로서 유량조사사업단(2006)의 우리나라 3대강 유역 하천 관측자료와 Jarrett(1984)의 미국 Colorado지역 하천의 관측자료로 부터 흐름특성을 구분하여 개수로 흐름의 마찰특성 또는 조도계수의 변이특성을 분석하였다. 기존 지수형 완난류 마찰계수 산정식(유동훈과 이민호,1997)의 비례상수 $\alpha$에 조도계수 n을 도입하여 실무에서 보다 편하게 적용할 수 있는 새로운 산정식을 개발하였다. 유량조사사업단의 관측자료 분석에 있어서 유량 관측시 관측지점의 수면경사 및 하상경사의 미관측으로 하천정비기본계획상에 제시된 지형으로부터 관측지점의 하상경사를 추정하였으며 1차적으로 에너지경사는 하상경사와 동일하다고 가정하였다. 이러한 가정하에 하천정비기본계획상에 제시된 Manning의 조도계수를 인용하여 관측유속과 계산유속을 비교8 분석하였다. 또한 전통적 산정식인 Ganguillet & Kutter(1869)식과 Manning(1889)식으로 부터 산정된 유속과의 비교를 통하여 조도계수 n을 추정하였고 추정된n을 도입하여 새로 개발된 지수형 마찰계수 산정식의 적용성을 입증하였을 뿐만 아니라 기존 조도계수 산정의 문제점을 제시하였다.

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