• Title/Summary/Keyword: 변이

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Effect of Sequence Variation in Mitochondrial DNA D-loop Region on Milk and Milk Fat Production in Holstein Cows (Holstein의 유량과 유지방 생산에 미치는 Mitochondrial DNA D-loop 영역의 염기 서열 변이 효과)

  • Oh J. D.;Kong H. S.;Lee H. K.;Jeon G. J.
    • Reproductive and Developmental Biology
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    • v.29 no.1
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    • pp.9-13
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    • 2005
  • This study was performed to analyze the sequence variation in mtDNA D-loop and their effects on milk and milk fat production in Holstein cows. The analyzed sequences were compared with previously published sequences from other cattle breeds (GenBank J01394). PCR was performed to amplify a total of 964 bp between nucleotide 15758 and 383 within D-loop region of mtDNA using specific primers. Thirty five polymorphic sites by nucleotide substitution were found in mtDNA. The frequencies of positions at 106, 169, 16057, 16231 and 16255 nt with high levels of sequence polymorphism were 0.090, 0.555, 0.055, 0.090 and 0.050, respectively. The substitution effect at 169 nt was found significant on milk production, and substitution effect at 16118, 16139 and 16302 nt was highly significant (p<0.1) on milk fat production. Polymorphism of mtDNA sequence in D-loop region might be useful for the analysis of cytoplasmic genetic variation and associations with the other economically important traits and maternal lineage analysis in Holstein cows.

First Report on External Quality Assurance Study of Radioassay of Thyroid Related Hormones - First One Year of Operation From 1989. 9 To 1990. 8- (갑상선 호르몬의 외부정도 관리 분석 -1989년 9월부터 1990년 8월까지 첫해 시행 결과-)

  • Lee, Dong-Soo;Cho, Bo-Youn;Kwark, Cheol-Eun;Seo, Il-Taek;Chung, June-Key;Lee, Myung-Chul;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.25 no.2
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    • pp.266-279
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    • 1991
  • 1989년 9월부터 1990년 8월까지 국제 원자력기구의 지역 계획에 의해 국내 26개 (후반부 31개)의 기관이 참가하여 T3, T4, TSH를 측정하여 결과를 모으고, 외부정도관적를 시행한 결과가 다음과 같다. 1) 외부정도관리를 위한 컴퓨터 소프트웨어를 작성하였다. 데이타의 입력, 정도 분석, 월별 보고, 분기별 보고 및 수행 분석 프로그램을 만들되 전체 검사실결과에서 추린 평균값(all laboratories trimmed mean: ALTM)으로 모집단평균을 삼아 편차, 편이, 편이평균 그리고 이들의 경시적 변화를 분석하도록 하였다. 2) 전후반 2회에 나누어 만든 및치 사이의 편차는 유의하지 않았다. T3값의 변이계수는 7.2%이하(정상 T3 값) 또는 9.2%와 13.4%사이 (높은 T3 값), 74 값의 변이계수는 4.6%이하(정상 또는 높은 T4값), 5.4%와 9.5%사이(낮은 T4값)이었다. TSH는 정상범위 값에서 21.7%이하의 변이 계수를 보였고 정상보다 낮거나 높은 TSH의 풀은 8 7%와 21.2%사이의 변이제수를 보였다. 3) 전체 검사실 추린 평균값(ALTM)에 따른 변이계수의 변동은, ALTM이 정상 T4값범위일 때 변이계수는 15%이하이었고, 낮은 T4값일 때는 중간값이 15%이고 분포범위는 50%까지이었다. T3값의 변이계수는 대체로 20%이하이었다. TSH의 변이계수는 1mU/L를 전후로 급격히 상승하여 200%에 달하였다. 4) 3표준편차보다 높거나 낮은 값을 보인 검사실들의 분포는 전체 검사실결과에서 추린 평균값(ALTM)과 상관없었다. 5) 첨가한 T3, T4, TSH에 대한 회수율은 T4는 104, 106%, T3는 67%, 74%, TSH는 87%, 86%이었다. 이상과 같이, 저자들이 만든 소프트웨어 프로그램으로 외부정도관리를 위하여 쉽게 데이터를 분석하고 보고서를 작성하여 갑상선호르몬의 경사신뢰도를 평가할 수 있게 되었으며, 위에 요약한 첫 해의 외부정도관리 결과를 바탕으로 참가기관의 동의하에, 앞으로 정도관리 항목의 확대와 외부정도관리의 지속적인 시행이 바람직하다고 생각하였다.

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QTL for Quality Properties in the Milyang23 $\times$ Gyhobyeo Recombinant Inbred Lines by Different Locations (벼 밀양 23호 $\times$ 기호벼 재조합 자식계통의 지역에 따른 품질 특성 관련 QTL 분석)

  • Kwak Tae-Soon;Yeo Jun-Hwan;Eun Moo-Young;Cha Young-Soon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.49 no.6
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    • pp.539-545
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    • 2004
  • The purpose of this study was to locate the quantitative trait loci (QTL) associated with quality properties in the recombinant inbred lines derived from the 'Milyang 23' and 'Gihobyeo' cross. Four quality-related traits; protein content, amylose content, fat acid content and sensory value were measured. Eight QTLs for protein content were detected on chromosomes 1 (two loci), 3, 6, 7 and 8 (three loci), each accounting for $6.0\%\~15.2\%$ of the phenotypic variation. Three QTLs for amylose content were detected on chromosomes 6 and 7 (two loci), each explaining from $7.3\%\;to\;24.4\%$ of the phenotypic variation. Six QTLs for fat acid content were detected on chromosomes 2 (two loci), 3, 6 (two loci) and 7, each explaining form $5.5\%\;to\;14.0\%$ of the phenotypic variation. Six QTLs for sensory value were detected on chromosomes 2, 6, 7(two loci) and 8 (two loci), each accounting for $5.5\%\~10.3\%$ of the phenotypic variation.

A Study on Variation and Application of Metabolic Syndrome Prevalence using Geographically Weighted Regression (지리적 가중 회귀를 이용한 대사증후군 유병률의 지역별 변이에 관한 연구 및 적용 방안)

  • Suhn, Mi Ohk;Kang, Sung Hong;Chun, Jin-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.2
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    • pp.561-574
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    • 2018
  • In this study, regional variations and factors associated with prevalence of metabolic syndrome were grasped using GWR (geographically weighted regression) and methodologies for the efficient management of metabolic syndrome were then set up to resolve health inequalities. Based on the National Health Screening Statistical Yearbook published by the National Health Insurance Service (NHIS), community health survey (KCDC) and other governmental institutions, indicators of social structural and mediation factors related to the regional prevalence of metabolic syndrome were collected. First, the existence of indicators to measure variations in metabolic syndrome were confirmed with the collected data by calculating the EQ (extremal quotient) and CV (coefficient of variations). The GWR, which is able to take spatial variations into consideration, was then adopted to analyze the factors of regional variations in metabolic syndrome. The GWR analysis revealed that severity and management of the main causes need to be prioritized in accordance with the prevalence of metabolic syndrome. Consequently, the order of priority in management of regional prevalence of metabolic syndrome was established, and plans that can increase the effectiveness of management of metabolic syndrome were confirmed to be feasible.

The Environmental Pollution and Geochemical Behavior of Heavy Metals in Roadside Soil and Settling Particles from Retention Pond on A-71 Motorway, France (프랑스 A-71 고속도로변 토양과 부유퇴적물의 중금속 거동 및 오염에 관한 연구)

  • 이평구
    • Journal of Korea Soil Environment Society
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    • v.2 no.1
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    • pp.21-34
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    • 1997
  • Retention ponds have been dug along some of the motorways in France to minimize environmental pollution by preventing pollutants from spreading over the surrounding area. A series of studies have been conducted to determine the physicochemical characteristics of the particles settling down in such a pond to evaluate the effectiveness of the pond as a trap for heavy metals such as Pb, Zn and Cd. The highly contaminated roadside soil and the uncontaminated background soil were also studied for comparison. The settling particles exhibited heavy metal concentrations of 2 to 8 times as much as the background Sologne soil, depending on the metal species. However, the heavy metal concentrations in the roadside soil were 7 to 26 times higher than those in the· settling particles. Sequential extraction experiments illustrated that the highly contaminated roadside soil consisted mainly of the readily soluble fractions (FII, FIII and FIV) for all three heavy metals, but little W which is hardly soluble. The proportion of W considerably increased up to one third of the total in the settling particles for Pb and Zn. This result as well as the large concentration differences between the roadside soil and the settling particles indicates that most of the heavy metals were lost to the surroundings even before reaching the retention pond. Cd exhibited somewhat different behavior in that the most soluble FI, which is negligible for Pb and Zn, occupied as much as one fourth of the total in the roadside soil. In addition, FV for Cd did not increase in the settling particles.

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