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Effect of Sequence Variation in Mitochondrial DNA D-loop Region on Milk and Milk Fat Production in Holstein Cows  

Oh J. D. (Genomic Informatics Center, Hankyong National University)
Kong H. S. (Genomic Informatics Center, Hankyong National University)
Lee H. K. (Genomic Informatics Center, Hankyong National University)
Jeon G. J. (Genomic Informatics Center, Hankyong National University)
Publication Information
Reproductive and Developmental Biology / v.29, no.1, 2005 , pp. 9-13 More about this Journal
Abstract
This study was performed to analyze the sequence variation in mtDNA D-loop and their effects on milk and milk fat production in Holstein cows. The analyzed sequences were compared with previously published sequences from other cattle breeds (GenBank J01394). PCR was performed to amplify a total of 964 bp between nucleotide 15758 and 383 within D-loop region of mtDNA using specific primers. Thirty five polymorphic sites by nucleotide substitution were found in mtDNA. The frequencies of positions at 106, 169, 16057, 16231 and 16255 nt with high levels of sequence polymorphism were 0.090, 0.555, 0.055, 0.090 and 0.050, respectively. The substitution effect at 169 nt was found significant on milk production, and substitution effect at 16118, 16139 and 16302 nt was highly significant (p<0.1) on milk fat production. Polymorphism of mtDNA sequence in D-loop region might be useful for the analysis of cytoplasmic genetic variation and associations with the other economically important traits and maternal lineage analysis in Holstein cows.
Keywords
mtDNA; D-loop region; Sequence variation; Holstein;
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