• Title/Summary/Keyword: 변이분석

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Secondary Brain Tumor Caused by Infiltration of Nasal Neuroendocrine Carcinoma in a Chihuahua Dog: Clinical, Magnetic Resonance Imaging and Histopathological Findings (치와와견에서 발생한 비강 신경내분비암종의 침윤에 의한 이차적인 뇌종양 증례; 자기공명영상과 조직학적 특성)

  • Jung, Dong-In;Kang, Byeong-Teck;Kim, Ju-Won;Kim, Ha-Jung;Park, Hee-Myung
    • Journal of Veterinary Clinics
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    • v.27 no.2
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    • pp.186-189
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    • 2010
  • A 14-year-old neutered female Chihuahua was presented because of seizure episodes and circling to the left side. Based on neurological examination, the lesion was localized on left forebrain. The mass in the left nasal cavity and breaching of the nasal septum were seen magnetic resonance images. And there was a presence of contrast enhanced mass involving the rostral left brain. Based on diagnostic image analysis, this lesion strongly suggested secondary brain tumor infiltrated by nasal cavity. The patient's symptoms were well controlled by a combination therapy of prednisolone and lomustine (CCNU), and survived for two months after diagnosis. This case was definitively diagnosed as a nasal neuroendocrine carcinoma based on histopathological findings. This report describes the clinical findings, imaging characteristics, and pathologic features of secondary brain tumor which caused by infiltration of nasal neuroendocrine carcinoma in a dog.

Application of Remote Sensing and Geographic Information System in Forest Sector (원격탐사와 지리정보시스템의 산림분야 활용)

  • Lee, Woo-Kyun;Kim, Moonil;Song, Cholho;Lee, Sle-gee;Cha, Sungeun;Kim, GangSun
    • Journal of Cadastre & Land InformatiX
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    • v.46 no.2
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    • pp.27-42
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    • 2016
  • Forest accounts for almost 64 percents of total land cover in South Korea. For inventorying, monitoring, and managing such large area of forest, application of remote sensing and geographic information system (RS/GIS) technology is essential. On the basis of spectral characteristics of satellite imagery, forest cover and tree species can be classified, and forest cover map can be prepared. Using three dimensional data of LiDAR(Light Detection and Ranging), tree location and tree height can be measured, and biomass and carbon stocks can be also estimated. In addition, many indices can be extracted using reflection characteristics of land cover. For example, the level of vegetation vitality and forest degradation can be analyzed with VI (vegetation Index) and TGSI (Top Grain Soil Index), respectively. Also, pine wilt disease and o ak w ilt d isease c an b e e arly detected and controled through understanding of change in vegetation indices. RS and GIS take an important role in assessing carbon storage in climate change related projects such as A/R CDM, REDD+ as well. In the field of climate change adaptation, impact and vulnerability can be spatio-temporally assessed for national and local level with the help of spatio-temporal data of GIS. Forest growth, tree mortality, land slide, forest fire can be spatio-temporally estimated using the models in which spatio-temporal data of GIS are added as influence variables.

In Vitro Construction and Characterization of the Bacteriophage P4 Derivative, P4 sid71 cosP2, Containing the Bacteriophage P2 cos Region (박테리오파지 P2의 cos 지역을 함유하는 박테리오파지 P4 유도체인 P4 sid71 cosP2의 In vitro 조성과 정성 연구)

  • Kim, Kyoung-Jin
    • Korean Journal of Microbiology
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    • v.49 no.1
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    • pp.99-104
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    • 2013
  • Bacteriophage P2 sir mutants are inefficient helpers for their satellite bacteriophage P4. The term, "P2 sir-associated helper inefficiency" has been used to define this phenomenon and it has been suggested that the DNA sequence difference between the cos region of P2 and that of P4 is responsible. To test this hypothesis, P4 derivative phage, P4 sid71 cosP2, containing the cos region of P2 and sid71 allele was constructed through several in vitro DNA manipulation steps. Its burst size was determined using a one-step growth experiment. The results showed that the substitution of the cos region of P2 for the cos region of P4 in P4 sid71 cosP2 overcame "P2 sir-associated helper inefficiency". P4 sid71 cosP2 stock phages prepared with P2 wild type helper and P2 sir helper were analyzed using a CsCl buoyant equilibrium density gradient experiment. The results revealed that the phage particles containing three copies of the P4 genome were the predominant particles in both cases.

Structure-activity Analysis of Benzylideneacetone for Effective Control of Plant Pests (벤질리덴아세톤 화학구조 변이에 따른 생리활성 변화 분석 및 식물 병해충 방제 효과)

  • Seo, Sam-Yeol;Jun, Mi-Hyun;Chun, Won-Su;Lee, Sung-Hong;Seo, Ji-Ae;Yi, Young-Keun;Hong, Yong-Pyo;Kim, Yong-Gyun
    • Korean journal of applied entomology
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    • v.50 no.2
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    • pp.107-113
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    • 2011
  • Benzylideneacetone (BZA) is a compound derived from culture broth of an entomopathogenic bacterium, Xenorhabdus nematophila (Xn). Its immunosuppressive activity is caused by its inhibitory activity against eicosanoid biosynthesis. This BZA is being developed as an additive to enhance control efficacy of other commercial microbial insecticides. This study was focused on the enhancement of the immunosuppressive activity of BZA by generating its chemical derivatives toward decrease of its hydrophobicity. Two hydroxylated BZA and one sugar-conjugated BZA were chemically synthesized. All derivatives had the inhibitory activities of BZA against phospholipase $A_2$ ($PLA_2$) and phenoloxidase (PO) of the diamondback moth, Plutella xylostella, but BZA was the most potent. Mixtures of any BZA derivative with Bacillus thuringiensis (Bt) significantly increased pathogenicity of Bt. BZA also inhibited colony growth of four plant pathogenic fungi. However, BZA derivatives (especially the sugar-conjugated BZA) lost the antifungal activity. These results indicated that BZA and its derivatives inhibited catalytic activities of two immune-associated enzymes ($PLA_2$ and PO) of P. xylostella and enhanced Bt pathogenicity. We suggest its use to control plant pathogenic fungi.

The Protective Effects of Kamdootang on Accumulation of Cadmium in Rats (랫트의 신장 내 카드뮴 축적에 대한 감두탕(甘豆湯)의 방어 효과)

  • Kim, Pom-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.5
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    • pp.2180-2186
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    • 2011
  • To find out the protective effects of Kamdootang against accumulation of cadmium in rats, the experimental rats were divided into 2 groups. One group was administered with cadmium alone and the other group administered with cadmium mixed with Kamdootang. Each group has been orally administered with different doses of cadmium such as 1.7 ${\mu}g/g/day$, 3.4 ${\mu}g/g/day$ and 6.8 ${\mu}g/g/day$, respectively, for 1 to 8 weeks. As a results, body weight gained has a tendency to decrease more in the Kamdootang treated groups and non-treated groups than in control group. Cadmium accumulation in kidney showed a significant difference between the Kamdootang treated group and Kamdootang non-treated group. As the experiment period is longer and longer, both groups have got more significantly cadmium accumulation amounts. The kidney system was researched through histopathological observation that Multiple foci of necrosis, hemorrhagic necrosis in glomeruli and cloudy swelling of tubules in kamdootang non-treated group. but tissue lesion of kidney was showed less kamdootang treated group than Kamdootang non-treated group. As remarked above results, when dose low concentrated Cd in rat, Kamdootang was reduced accumulation of Cd. in kidney.

Correlations Between Concentrations of Negative Ions and Forest Type, and Site Factors at National Forests in Yangyang-gun (양양군 국유림 지역의 음이온 농도와 임상, 숲 관련인자와의 상관)

  • Um, Tae-Won;Kim, Gab-Tae
    • Korean Journal of Environment and Ecology
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    • v.24 no.5
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    • pp.539-546
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    • 2010
  • To investigate the variation of anion concentrations in relation to forest type, forest-related factors, forest survey and anion concentrations measurement were carried out on the 52 quadrats located at the national forest areas in Yangyang-gun, Kangwon-do. The relationship between anion concentrations and forest-related factors were correlated. Total mean of anion concentration was 2,405 ea/$cm^3$, which was slightly higher than general figures 2,000ea/$cm^3$. Highly significant positive correlations were observed between anion concentrations and soil moisture contents, and also between anion concentrations and altitude. Significant positive correlations were observed between anion concentrations and topography. Anion concentrations were significantly different among soil moisture levels. Mean anion concentration were highest at 4,524.4ea/$cm^3$ in on wet sites, and followed slightly wet sites and moderate sites. Mean anion concentrations was highest on valley sites at 3,372.4ea/$cm^3$, followed by slope and ridge areas. Mean anion concentrations measured before noon was highest at 3,133.4ea/$cm^3$, and measurements during 12:00~15:00 and after 15:00, showed relatively low anion concentrations. Mean anion concentrations was highest at mixed deciduous forests at 3,503.9ea/$cm^3$, followed by oak forests, pine forests, and pine-oak forests. Results of this study are expected to be used in planning therapeutic forests.

The study on immaterial role of traditional furniture

  • Lee, Dae-Woo;Moon, Dae-Sung
    • Journal of the Korea Furniture Society
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    • v.21 no.6
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    • pp.439-448
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    • 2010
  • Furniture world which is closely associated with human life had been constantly developed, but traditional furniture disappeared after modernization almost. The reason lies rather in the importance of the diversity of Western-style furniture pursuing convenience and shapes, than in change of life style meanwhile. The diversity however reached the limit and it made a new advanced role of not only furniture, also design sector in general necessary, and as solution to solve this problem the immaterial value based on Eastern philosophy/mental was suggested in architecture and all around design sector overall as well. It means that the immaterial point which traditional furniture involved should be focused now and furthermore it's emotional and mental value which is more natural and has close relation with human being accordingly could be judged rightly. The reason why traditional furniture had been used since long time is the immaterial tendency which is well harmonized with the surrounding environment rather than the function. To verify this, the present study aimed to analyze not only the basic, also additional function of traditional furniture used in Hanok (traditional Koran-style house) by the inductive method for investigating the additional effects which users felt. Such immaterial role offers the user more convenience besides the original function of furniture and this made it available that furniture dominates the space. As good examples of such roles it was investigated that traditional furniture played meaningful roles like extensional serviceability, variable space, formation & movement of space, expression of grade of rank. That allowed that this study suggested the sustainable design and also the direction of development of interactive function of furniture through the expected effect having been showed in the modern space where the immaterial role of traditional furniture was applied to and the related cases.

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Arthroscopic Meniscal Repair with Rapid Loc Device (Rapid Loc 기기를 이용한 관절경적 반월상 연골판 봉합술)

  • Kwon, Duck-Joo;Lee, Kee-Byung;Joeng, Woong-Kyo;Lee, Byung-Taek;Park, Sang-Wook
    • Journal of the Korean Arthroscopy Society
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    • v.9 no.2
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    • pp.180-185
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    • 2005
  • Purpose: To purpose of this study is to evaluate the clinical and radiological results of arthroscopic meniscus repair using Rapid Loc device. Materials and Methods: A retrospective study was performed on 44 cases which had been turned out longitudinal tear without degeneration. We repaired all cases with Rapid Loc device. Patients were evaluated using clinical examination, Orthopaedische Arbeitsgemeinschaft Knie (OAK) scheme, and MRI. We regarded patients with joint line tenderness, swelling or McMurray positive test as clinical failure. Results: A mean age was 33.3 years and follow-up period was average 15 months. Clinical results were excellent 15 cases(34.1%), good 20 cases(45.5%), fair 7 cases(15.9%), poor 2 cases(4.5%). MRI showed grade 115 cases(33.3%), grade II 22 cases(50%), grade III 7 cases(16.7%). Clinical failures were 8 cases and only one complication was developed. Conclusion: Rapid Loc device showed the excellent results in meniscus repair. We regard it has a lot of advantages in safety, softness, ease, ability to control tension at repair site.

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THE EFFECT OF GENETIC VARIATION IN THE DNA BASE REPAIR GENES ON THE RISK OF HEAD AND NECK CANCER (DNA 염기손상 치유유전자의 변이와 두경부암 발생 위험성)

  • Oh, Jung-Hwan;Yoon, Byung-Wook;Choi, Byung-Jun
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.34 no.5
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    • pp.509-517
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    • 2008
  • DNA damage accumulates in cells as a result of exposure to exogenous agents such as benzopyrene, cigarette smoke, ultraviolet light, X-ray, and endogenous chemicals including reactive oxygen species produced from normal metabolic byproducts. DNA damage can also occur during aberrant DNA processing reactions such as DNA replication, recombination, and repair. The major of DNA damage affects the primary structure of the double helix; that is, the bases are chemically modified. These modification can disrupt the molecules'regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. DNA repair genes and proteins scan the global genome to detect and remove DNA damage and damage to single nucleotides. Direct reversal of DNA damage, base excision repair, double strand break. DNA repair are known relevant DNA repair mechanisms. Four different mechanisms are distinguished within excision repair: direct reversal, base excision repair, nucleotide excision repair, and mismatch repair. Genetic variation in DNA repair genes can modulate DNA repair capacity and alter cancer risk. The instability of a cell to properly regulate its proliferation in the presence of DNA damage increase risk of gene mutation and carcinogenesis. This article aimed to review mechanism of excision repair and to understand the relationship between genetic variation of excision repair genes and head and neck cancer.

The Distribution and Habitation Characteristics of Zostera marina L. along the Southern Coast of Korea (남해안에서 자생하는 거머리말(Zostera marina L.)식물의 분포와 생육지 환경)

  • Lee, Sang-Yong;Lee, Sung-Mi;Jee, Hae-Geun;Choi, Chung-Il
    • Korean Journal of Environmental Biology
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    • v.19 no.4
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    • pp.313-320
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    • 2001
  • An ecological study was conducted to determine the geographic distribution, community structure, and habitat characteristics of eelgrass, Zostera marina L. beds along the southern coast of Korea. Plants and sediment samples were collected during June 2000 and December 2000 on twenty-eight locations, including two Cheju Island stations, which were used to compare morphological characteristics with habitat types. Z. marina populations existed from the intertidal to subtidal zone, mainly in the bays along the coast and the island, the barrier reef, and the estuary where the water depth was 0.5${\sim}$8.0m. Salinity range in Z. marina beds ranged 18.2 to 34.5%$_o$. Sediments of Z. marina beds contained 49.7${\sim}$99.1% of sand and were classified into sand, muddy sand, and sandy mud. Mean grain size varied from 1.5 to 4.4 phi. Height of vegetation shoots varied from 54.7 to 171.4 cm, depending on water depth, location, substrata and habitat types. quantitative morphological features that enabled recognition of the two phonetic groups were short-narrow leaf type and long-broad leaf type. Statistical analysis indicated that biomass of individual plants and their quantitative morphological characteristics were significantly correlated.

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