Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Secondary Brain Tumor Caused by Infiltration of Nasal Neuroendocrine Carcinoma in a Chihuahua Dog: Clinical, Magnetic Resonance Imaging and Histopathological Findings

치와와견에서 발생한 비강 신경내분비암종의 침윤에 의한 이차적인 뇌종양 증례; 자기공명영상과 조직학적 특성

  • Jung, Dong-In (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kang, Byeong-Teck (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Ju-Won (Cell Therapy Center, Ajou University School of Medicine) ;
  • Kim, Ha-Jung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Accepted : 2010.04.12
  • Published : 2010.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

A 14-year-old neutered female Chihuahua was presented because of seizure episodes and circling to the left side. Based on neurological examination, the lesion was localized on left forebrain. The mass in the left nasal cavity and breaching of the nasal septum were seen magnetic resonance images. And there was a presence of contrast enhanced mass involving the rostral left brain. Based on diagnostic image analysis, this lesion strongly suggested secondary brain tumor infiltrated by nasal cavity. The patient's symptoms were well controlled by a combination therapy of prednisolone and lomustine (CCNU), and survived for two months after diagnosis. This case was definitively diagnosed as a nasal neuroendocrine carcinoma based on histopathological findings. This report describes the clinical findings, imaging characteristics, and pathologic features of secondary brain tumor which caused by infiltration of nasal neuroendocrine carcinoma in a dog.

14년 령의 암컷 치와와견이 발작증세 및 좌측으로의 선회운동 증상을 보여 내원하였다. 신경검사결과 좌측 대뇌 병변이 의심되어 자기공명영상 촬영을 실시하여 좌측 비강에서 좌측 대뇌로 파급된 병변을 확인하였다. 영상 분석 상에서 비강 내에서 유래된 2차적인 뇌종양이 강력하게 의심되었다. 환자의 증상은 프레드니솔론과 로무스틴의 혼합치료 후 상당히 개선되었고 진단 후 2개월간 생존하였다. 조직 검사 결과 비강에서 유래한 신경내분비암종으로 확진되었다. 본 증례보고는 개에서 발생한 비강유래 신경내분비암종의 침윤에 의한 2차적인 뇌종양의 임상적인 특징, 영상 진단 결과, 그리고 조직학적인 특성을 잘 보여주고 있다.

Keywords

References

  1. Dewey CW. Encephalopathies: Disorders of the brain. In: A practical guide to canine and feline neurology, 2nd ed. USA: Wiley-Blackwell. 2008: 168-172.
  2. Fenner WR. Metastatic neoplasms of the central nervous system. Semin Vet Med Surg 1990; 5: 253-261
  3. Patnaik AK, Ludwig LL, Erlandson RA. Neuroendocrine Carcinoma of the Nasopharynx in a dog. Vet Pathol 2002; 39: 496-500. https://doi.org/10.1354/vp.39-4-496
  4. Sako T, Shimoyama Y, Akihara Y, Ohmachi T, Yamashita K, Kadosawa T, Nakade T, Uchida E, Okamoto M, Hirayama K, Taniyama H. Neuroendocrine carcinoma in the nasal cavity of ten dogs. J Comp Path 2005; 133: 155-163. https://doi.org/10.1016/j.jcpa.2005.04.002
  5. Snyder JM, Lipitz L, Skorupski KA, Shofer FS, Van Winkle TJ. Secondary intracranial neoplasia in the dog: 177 cases (1986-2003). J Vet Intern Med 2008; 22: 172-177. https://doi.org/10.1111/j.1939-1676.2007.0002.x
  6. van Maanen C, Laein WR, Dik KJ, Ingh TS. Three cases of carcinoid in the equine nasal cavity and maxillary sinuses: histologic and immunohistochemical features. Vet Pathol 1996; 33: 92-95. https://doi.org/10.1177/030098589603300114
  7. Voges AK, Ackerman N. MR evaluation of intra and extracranial extension of nasal adenocarcinoma in a dog and cat. Vet Radiol Ultrasound 1995; 36: 196-200. https://doi.org/10.1111/j.1740-8261.1995.tb00246.x