• Applied Chemistry for Engineering
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• v.26 no.6
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• pp.719-724
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• 2015

Isoliquiritigenin (ILG) is a hydrophobic component in licorice and has a variety of pharmaceutical and biological activities. In this study, we prepared an isoliquiritigenin-hydroxypropyl-${\beta}$-cyclodextrin (ILG/HP-${\beta}$-CD) complex by freeze-drying method to enhance its water solubility. The complex was characterized by phase solubility studies, DSC, SEM, and 1H NMR. Antimicrobial activities against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were evaluated by broth dilution method. The results showed that the stoichiometry of ILG/HP-${\beta}$-CD complex was 1 : 1. The antimicrobial activity of ILG/HP-${\beta}$-CD complex was higher than that of using free ILG against S. aureus and E. coli. Therefore, we suggest that ILG/HP-${\beta}$-CD complex may be used as a natural antiseptic and could potentially replace synthetic preservatives in cosmetic and food industries.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.1661-1665
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• 2006

In a natural river, cross sections of a channel vary according to inner or outer parts of meandering. Generally, depth of outer parts is deeper than that of inner parts. This kind of cross section change by meandering can be demonstrated by Beta distribution. The objects of this research is a 3D simulation of primary and secondary flow in the meandering natural channel. FLOW-3D program, a numerical model using CFD technique, and LES method was used for this research. 3D simulations were conducted in the channels having Beta distribution cross sections which have beds of mortar, gravel and vegetation. Two types of water stages and discharge were applied to each channel. In this research, primary flows are located in the outer parts of a top of bend and secondary flows rotate in the bottom on outer parts.

• The Monthly Diabetes
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• s.240
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• pp.35-35
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• 2009

베타세포 손상 및 비만 등 제 2형 당뇨병의 근본적인 원인을 치료해 줄 인슐린 유사체가 개발됐다. 도마뱀의 타액성분을 합성시켜 만든 한국릴리의 '바이에타'는 엑세나타이드를 주성분으로, 인크레틴계열 호르몬인 GLP-1과 유사한 작용을 갖고 있다. 국내에서는 지난해 6월 식품의약품안전청으로부터 승인을 받고 같은 해 11월 출시됐다.

• The Korean Journal of Mycology
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• v.23 no.2 s.73
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• pp.129-138
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• 1995

DNA fragment being able to restore in vitro activity of ${\beta}-1,3-glucan$ synthase was cloned by transformation of the Saccharomyces cerevisiae LP353 mutant strain with genomic library constructed in the YCp50. For the selection of transformants which showed no detectable phenotype linked to recovery of the defect in ${\beta}-1,3-glucan$ synthase activity, the colony autoradiography was succesfully applied. The restriction map of the cloned DNA fragment, which is 8.5-kb in length, was constructed. Both the YEplac195 and the YCp50 carrying the 8.5-kb fragment increased ${\beta}-1,3-glucan$ synthase activity of LP353 by two fold. Neither the YEplac195 nor the YCp50 carrying the 8.5-kb DNA fragment, however, complemented the temperature-dependent osmotic sensitivity which is another distinctive phenotype of LP353. Subcloning experiments indicated that a functional region was located in 4.8-kb BglII-KpnI fragment. The 4.8-kb fragment was also able to increase the level of ${\beta}-1,3-glucan$ content in cell wall as well as the resistance of cells to cell wall lytic enzyme, ${\beta}-1,3-glucanase$. The growth rate of the LP353 with 4.8-kb fragment was almost same as that of wild type strain in liquid medium with 1.2 M sorbitol at nonpermissive temperature. Taken these results together, the 4.8-kb fragment seemed to contain the BGS2 gene for ${\beta}-1,3-glucan$ synthase activity in yeast S. cerevisiae.

• Proceedings of the Materials Research Society of Korea Conference
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• 2012.05a
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• pp.102.1-102.1
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• 2012

Ti 및 Ti 합금은 치과 및 정형외과 등의 분야에서 생체재료로써 다양한 용도로 적용되고 있으며, 보다 안전하고 우수한 특성의 Ti 합금 개발에 대한 관심이 높아지고 있다. 본 연구에서는 Ti-Nb-Ge 합금의 초탄성 특성에 미치는 집합조직의 영향에 대해 조사하였다. 집합조직 제어를 위해 등속 및 이주속 압연을 적용한 후 $850^{\circ}C$에서 30분~2시간까지 어닐링하였다. 광학현미경과 SEM-EBSD를 이용하여 미세조직 및 집합조직을 분석하고, 순환식 인장시험을 통해 시편의 초탄성 특성을 평가하였다. 등속압연 후 어닐링한 시료의 경우 alpha-fiber 집합조직이 발달하는 한편, 이속압연 후 어닐링한 시료는 {113}// 및 {331}의 집합조직이 발달하는 것으로 나타났다. 마르텐사이트 변태에 의한 변형회복능과 집합조직 성분별 강도의 관계를 비교한 결과, alpha-fiber 집합조직이 발달할수록 변형회복능이 증가하는 것으로 나타났다.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.3
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• pp.253-260
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• 2020

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease that can be described by the occurrence of dementia due to a decline in cognitive function. The disease is characterized by the formation of extracellular and intracellular amyloid plaques. Amyloid beta (Aβ) is a hallmark of AD, and microglia can be activated in the presence of Aβ. Activated microglia secrete pro-inflammatory cytokines. Furthermore, S100A9 is an important innate immunity pro-inflammatory contributor in inflammation and a potential contributor to AD. This study examined the effects of metformin and α-LA on the inflammatory response and NLRP3 inflammasome activation in Aβ- and S100A9-induced BV-2 microglial cells. Metformin and α-LA attenuated inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). In addition, metformin and α-LA inhibited the phosphorylation of JNK, ERK, and p38. They activated the nuclear factor kappa B (NF-κB) pathway and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Moreover, metformin and α-LA reduced the marker levels of the M1 phenotype, ICAM1, whereas the M2 phenotype, ARG1, was increased. These findings suggest that metformin and α-LA are therapeutic agents against the Aβ- and S100A9-induced neuroinflammatory responses.

• Education of Primary School Mathematics
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• v.27 no.3
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• pp.303-320
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• 2024

This study presents the development and performance evaluation of a custom GPT-based chatbot tailored to provide solutions following Polya's problem-solving stages. A beta version of the chatbot was initially deployed to assess its mathematical capabilities, followed by iterative error identification and correction, leading to the final version. The completed chatbot demonstrated an accuracy rate of approximately 89.0%, correctly solving an average of 57.8 out of 65 image-based problems from a 6th-grade elementary mathematics textbook, reflecting a 4 percentage point improvement over the beta version. For a subset of 50 problems, where images were not critical for problem resolution, the chatbot achieved an accuracy rate of approximately 91.0%, solving an average of 45.5 problems correctly. Predominant errors included problem recognition issues, particularly with complex or poorly recognizable images, along with concept confusion and comprehension errors. The custom chatbot exhibited superior mathematical performance compared to the general-purpose ChatGPT. Additionally, its solution process can be adapted to various grade levels, facilitating personalized student instruction. The ease of chatbot creation and customization underscores its potential for diverse applications in mathematics education, such as individualized teacher support and personalized student guidance.

• KLA journal
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• v.31 no.2 s.261
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• pp.24-47
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• 1990

CO-ROM에 의한 데이터베이스의 제작이 큰 관심의 표적으로 되어있다. 그러나 대부분은 아직도 베타테스트의 단계이다. 먼저 CD-ROM의 개요와 현황을 설명하고 다음은 CD-ROM의 대표적 제품인 Dissertation Abstracts Ondisc에 대해 설명한 다음 Ondisc 검색과 Online 검색의 기능을 비교하였다. Ondisc, Online 양검색법의 장점과 단점을 서로 보완하기 위해 개발된 DIALOG Ondisc ERIC을 설명하고 Ondisc, Online의 상호검색에 대해 간단히 설명하였으며 더욱이 CD-ROM이 가지고 있는 문제점에 대해서도 일반에게 널리 알리고, 이것이 해결되면 Ondisc를 중심으로 분산형 Online시대가 될 것으로 예상하였다.

• Journal of the Korean Data and Information Science Society
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• v.15 no.4
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• pp.825-835
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• 2004

In this paper, we investigate the estimation of the value at risk(VaR) when stock prices are subjected to price limits. The mixture of probability mass functions and beta density functions is proposed to derive the distribution of asset returns. The analyses of real data show that the proposed distribution is appropriate to explain the VaR when the price limits exist in the data.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2001.05a
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• pp.156-161
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• 2001

본 연구에서는 45명의 가상현실 사용자들의 가상현실 전, 중, 후의 생리신호의 변화를 관찰하였고 성격, 능력 특성 설문지, 가상현실 평가 설문지를 이용하여 심리적 영향을 알아보았다. 체온의 변화 양상을 기준으로 하여 가상현실 사용자의 심리생리학적 유형을 나누고 유형별 심리적인 반응 특성을 살펴보았다. 1) A 유형: 가상현실 유행동안 체온이 연속적으로 감소하는 유형. 2) B 유형: 가상현실 윤행초기에 체온이 급격히 증가해서 운행동안 서서히 체온이 상승하는 유형. A 유형에 속하는 사용자들의 성격적 특성은 Holland의 성격 유형이론에 근거하여 실제형의 사람들이 많은 것으로 나타났으며 B 유형은 탐구형, 사회형의 사람들이 많은 경향으로 나타났다. 멀미민감도는 A 유형이 B 유형보다 더 크게 나타났다. A, B 유형의 뇌파분석 결과 정중 전두부 (Fz), 정중 중심부 (Cz)에서 베타파, 감마파 상대파워가 유의미한 차이가 있는 것으로 나타났다. 체온의 변화 양상에 따라 나눈 A, B 유형은 성격 및 능력 특성, 멀미민감도에 있어서 유형간 차이가 있는 것으로 나타났다.