• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.25 no.2
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• pp.70-78
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• 2013

Plants which are having conditions of high temperature and pressure always are exposed to danger. In order to prevent unexpected accidents, safety management that can effectively and appropriately examine facilities is required in plant operation. RBI(Risk-Based Inspection) technology in API 581 is one of standard management technique for evaluating risk on petroleum plants. There are qualitative and quantitative assessments in RBI methodology. Quantitative evaluation step is complex and required much information, so high-risk facilities in plant are selected firstly by qualitative method. Qualitative RBI is performed by choosing the answer in prepared questionnaire. However, it is difficult to believe thoroughly results from survey including ambiguous information. In this study, the procedure of qualitative RBI analysis with considering probability distribution concept were proposed by using Monte Carlo simulation method in order to increase reliability in spite of uncertain factors. In addition, qualitative risk of cooling system for LNG plant was evaluated using proposed procedure. Although 20 items of total 39 assessment items are applied to uncertain factors, risk section of high probability(89%) were verified. The detailed results were described in manuscript.

• The Korean Journal of Nuclear Medicine
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• v.31 no.4
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• pp.433-439
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• 1997

$^{166}Ho$-chitosan complex, or $^{166}Ho$-CHICO, is a candidate pharmaceutical for intracavitary radiation therapy of cystic brain tumors because of the desirable nuclear characteristics of $^{166}Ho$ for therapeutic use and the suitable biological and chemical characteristics of chitosan, not to mention its ready producibility The amount of $^{166}Ho$-CHICO to be administered to obtain the goal therapeutic effect can be suggested by predicting the dose to the cyst wall for a varying pharmaceutical dose. When $^{166}Ho$-CHICO is infused into the cyst, the major part of the energy delivery by beta particles emitted from $^{166}Ho$ occurs in the cyst wall within 4mm in depth from the cyst wall surface. Also, realizing the attachment of $^{166}Ho$-CHICO to the cyst wall surface would change the predictions of dose to the cyst wall.

• The Korean Journal of Applied Statistics
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• v.17 no.3
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• pp.489-498
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• 2004

In this paper, a new form of linear models referred to as generalized weighted linear models is proposed. The proposed models assume that the relationship between the response variable and explanatory variables can be modelled by a distribution function of the response mean and a weighted linear combination of distribution functions of covariates. This form addresses a structural problem of the link function in the generalized linear models in which the parameter space may not be consistent with the space derived from linear predictors. The maximum likelihood estimation with Lagrange's undetermined multipliers is used to estimate the parameters and resampling method is applied to compute confidence intervals and to test hypotheses.

• Communications for Statistical Applications and Methods
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• v.1 no.1
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• pp.157-164
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• 1994

본 연구에서는 확률화응답기법을 이용하여 모집단내의 민감집단의 비율을 추정함에 있어 조사의 효율성을 높이기 위한 층화표본의 최적할당방법을 제안한다. 확률화응답기법은 Warner(1965)에 의하여 제안된 방법으로 민감한 사안에 대한 조사시 무응답이나 거짓응답으로 인한 비표본오차를 줄일수 있는 기법으로 간접질문에 의한 조사방법이다. 여기에서 최적할당이란 베이즈위험을 최소로 하는 할당법을 의미하며, 이 과정에서 민감집단의 모비율에 대한 사전분포로는 베타분포를 취하였다.

• Journal of Life Science
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• v.21 no.3
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• pp.417-423
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• 2011

Thymosin ${\beta}4$ (TB-4) has been reported to play a key role in tumor growth, metastasis and angiogenesis. In addition, TB-4 induced the expression of vascular endothelial growth factor (VEGF) and stabilized the hypoxia-inducible factor (HIF)-$1{\alpha}$ in melanoma cells. Although the importance of thymosin ${\beta}4$ in angiogenesis and metastasis has been proven, there are few studies that show the expression patterns of TB-4, VEGF and HIF-$1{\alpha}$. This study was conducted to analyze the relationship among these proteins in various tumors. Using tissue microarray analysis, we investigated the expression patterns of TB-4, VEGF and HIF-$1{\alpha}$ in various tumors to identify the expression patterns and relationships of these proteins in certain tumors. TB-4 was highly expressed in osteosarcoma, colon adenocarcinoma, esophageal squamous cell carcinoma, kidney and urinary bladder transitional carcinoma, lung cancer, and liver cancer. HIF-$1{\alpha}$ was highly expressed in nasal cavity inverted papilloma, lung cancer, and esophageal squamous cell carcinoma. The expression patterns of TB-4 and HIF-$1{\alpha}$ were almost similar and co-localized. VEGF expression was high in the blood vessels in tumors, but usually not high in the tumors themselves. VEGF was moderately expressed in stomach cancer, liver angiosarcoma, gall bladder adenocarcinoma, and uterus endometrial adenocarcinoma. The expression patterns of VEGF shows similarities in certain tumors including stomach cancer, osteosarcoma, liposarcoma, lung cancer, liver cancer, gall bladder adenocarcinoma, esophageal squamous cell carcinoma, stomach cancer, colorectal carcinoma and renal cell carcinoma. These results suggest that the expression patterns of TB-4, HIF-$1{\alpha}$ and VEGF were co-localized and related to tumorigenesis and angiogenesis of certain tumors.

• Progress in Medical Physics
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• v.5 no.1
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• pp.75-85
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• 1994

As we enter the 2000s, there are four nuclear power units of the pressurized heavy water reactor-type in the commercial operation at the Wolsung Nuclear Power Plant(NPP) site where a larger amount of tritium ($\^$3/H) is released inevitably to the site environment. This radioctive nuclide is easily distributed throghout our environment because of its ubiquitous form as tritiated water (HTO) and its persistence in the environment. Tritum has certain characterisitics that present unique challenges for beta radiation dosimety and health risk assesment. In this paper, therefore, a variety of matters on tritium are considered and reviewed in terms of its characteristics and sources, metabolism and dosimetry, microdosimetry, radiobiology, risk assessment, and transport and cycling in the environment, etc.

• Journal of Korean Society of Environmental Engineers
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• v.22 no.5
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• pp.939-947
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• 2000

Enhanced biological phosphorus removal (EBPR) was performed in an anaerobic/aerobic sequencing batch reactor (SBR). Influent was a synthetic wastewater based on acetate as a carbon source. The sludge age and hydraulic retention time were kept at 10 days and 16 hrs, respectively, Phosphate release during the anaerobic period and phosphate uptake in aerobic period were increased gradually with time. and after about 200 days, steady-state operation could be achieved with complete removal of influent phosphate. Number distribution of microbial community in the sludge performing EBPR was investigated during the steady state operation. 17 rRNA targeted oligonucleotide probes were designed and slot hybridization technique was used to determine the number distribution of each microorganism. In the acetate fed SBR, rRNA belonging to the beta subclass of proteobacteria was the most dominant in total rRNA and rRNA matching to CTE probe was the second, rRNAs of Acinetobacter, Aeromonas and Pseudomonas, which are usually thought as phosphorus accumulating organisms in EBPR processes, constituted less than 10% of total rRNA. From this community analysis, it was inferred that microorganisms belong to the beta subclass of proteobacteia (BET) and CTE such as Rhodocyclus group were important in biological phosphorus removal. Therefore, the role of Acinetobacter, Aeromonas and Pseudomonas in the EBPR might have been overestimated.

• The Korean Journal of Applied Statistics
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• v.6 no.1
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• pp.41-52
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• 1993

In this paper we study numerical behavior of the adjustments for the variances of the pearson and deviance type dispersion statistics in two overdispersed mixture models; negative binomial and beta-binomial distribution. They are important families of an extended quasi-likelihood model which is very useful for the joint modelling of mean and dispersion. Comparisons are done for two types of dispersion statistics for various mean and dispersion parameters by simulation studies.

• Progress in Medical Physics
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• v.13 no.4
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• pp.187-194
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• 2002

In this work we investigated through Monte Carlo calculations the physical characteristics of the absorbed dose from the Ir-192 source used in brachytherapy The Monte Carlo calculations were performed using the code EGS4, which was extensively modified in order to handle cylindrical sources, phantoms, and energy distributions to suit out own purpose. From the results of the calculations for the $\beta$ -rays, it was found that they contribute on the average 0.02% to The total absorbed dose in the distance range of 0.5-5.0 cm from the source. This is due to the face that, although most of the primary $\beta$ -rays are absorbed in the source and encapsulation material, the resulting low energy braking radiation from them contribute to such a distance. The absorbed dose in the encapsulation material varied on the average from 2.8% for platinum down to 1.1% for iron. The radial dose functions obtained by our Monte Carlo calculations were consistent within $\pm$3% with those of the TG-43 report for the radial distance interval 0.5-10.0 cm from the source. The user code we wrote in this work can be used for other sources of different sizes and so it can be very useful in designing and producing the sources for brachytherapy.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.1
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• pp.179-193
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• 1994

In the development of engineering designs, decisions are required irrespective of the state of completeness and quality of information, and are formulated under conditions of uncertainty. Furthermore, under conditions of uncertainty the design invokes risks. Thus, in the design of the structures, the currently used deterministic design method does not provide a realistic assessment of the actual safety or the reliability of the structures. It is desirable that decisions required in The process of the design invariably must be made based on the reliability analysis. Properties of soil material are subject to more uncertainty than those of other structural material. In the field of soil mechanics and foundation engineering, it needed to develop reliability-based design methods. In order to simplify the reliability analysis or the reliability-based design process of the structures associated with the active earth pressure, it is necessary to find the variation and the distribution type of the active earth pressure calculated from the basic properties of soils. Monte Carlo simulation is performed to obtain the relationship between the variation of the active earth pressure for cohessionless soils calculated by using Rankine formula and the basic soil properties and the distribution type of the earth pressure. A series of regression equations obtained by utilizing the multi-linear regression analysis is suggested in this paper and the sensitivity of the basic soil properties to the variation of The earth pressure is investigated. The type of distribution of the active earth pressure was found to be the beta distribution in most cases or to be very similar to the beta distribution, if the basic soil variables are normally distributed.