• Proceedings of the Korean Radioactive Waste Society Conference
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• 2004.06a
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• pp.52-57
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• 2004

In order to analyze key parameters of important radionuclides in dose evaluation model of decommissioning site, a sensitivity analysis was performed. This analysis assumed a resident farmer for an exposure scenario and 0.037Bq/g for the concentration of radionuclides. As a result of sensitivity analysis, the key parameters of radionuclides considered were the area of contaminated zone, external gamma shielding factor and indoor time fraction for Cs-137 and Co-60. The key parameters for C-14 were the environmental parameters and hydrological parameters of unsaturated zone. Also, the key parameter for Sr-90 was the density of contaminated zone.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.8
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• pp.75-83
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• 2005

A steady transonic dilute premixed combustion in a diverging channel is investigated by using asymptotic analysis. This model explores the nonlinear interactions between the near-sonic speed of the flow, the small changes in geometry from a straight channel, and the small heat release due to the one-step first-order Arrhenius chemical reaction. The reactive flow is described by a nonhomogeneous transonic small-disturbance (TSD) equation coupled with an ordinary differential equation for the calculation of the reactant mass fraction in the combustible gas. Also the asymptotic analysis reveals the similarity parameters that govern the reacting flow problem. The results show the complicated nonlinear interaction between the convection, reaction, and geometry effects and its effect on the flow behavior.

• Nuclear Engineering and Technology
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• v.22 no.2
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• pp.116-127
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• 1990

The fission gas release model used In the SPEAR-BETA fuel performance code was modified by use of effective thermal conductivity for cracked fuel and by laking Into account axial fission-gas mixing between the fuel-clad gap and the plenum. With use of this modified model the fission gas release was analyzed under various power ramping conditions of P$_{max}$ and $\Delta$.fP. Effective fuel thermal conductivity that accounts for the effect of fuel tracking was used in calculation of the fuel temperature distribution and the Internal gas pressure under power ramping conditions. Mixing and dilution effects due to axial gas flow were also considered in computing the width and the thermal conductivity of the gap. The effect of axial gas flow w3s solved by the Crank-Nicholson method. The finite difference method was used to save running time in the calculation. The present modified fission-gas release model was validated by comparing its predicted results with experimental data from various lamping tests In the literature and calculated results with use of the models used In the SPEAR-BETA and FEMAXI-IV codes. Results obtained with use of the present modified model showed better agreement with experimental data reported in the literature than those results with use of the latter codes. The fuel centerline temperature calculated with introduction of effective thermal conductivity for centerline temperature calculated with Introduction of effective thermal conductivity for cracked fuel was 200 higher fission gas release predicted with use of the modified model was nearly 6% larger on the average than that calculated by use of the unmodified model used in the SPEAR-BETA code.e SPEAR-BETA code.e.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.7
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• pp.721-727
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• 2010

The spontaneous ignition of coal stockpile causes serious safety and economic problems. Such spontaneous ignition occurs in coal stockpile when the rate of heat released by the oxidation of coal is greater than the rate of heat lost to the surroundings. In this study, a two-dimensional unsteady model is adopted for studying spontaneous ignition and the numerical results are compared with experimental results. The numerical results are in a good agreement with the experimental ones. Depending on the porosity, the internal maximum temperature, pressure, and oxygen mass fraction during spontaneous ignition are investigated. On the basis of the numerical results, the transient temperature variations for several shapes of coal stockpiles are analyzed. Further, the physical mechanisms of hot-spot formation and spontaneous ignition are analyzed.

• Journal of the Korean Ceramic Society
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• v.39 no.8
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• pp.801-806
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• 2002

The decomposition and/or conversion of carbon dioxide to carbon have been studied using oxygen-deficient ferrites for the reduction of $CO_2$ emission to the atmosphere. In this work, the homogeneous precipitation method using urea decomposition was employed to induce in situ precipitation of Ni ferrite($Ni_{0.4}Fe_{2.6}O_4$) on the porous ceramic fiber support (50 mm diameter${\times}$10 mm thickness). Effects of ferrite loading conditions on the CO2 decomposition efficiency were discussed in this paper. Removal of residual chloride ions and urea by solvent exchange from the porous media after ferrite deposition apparently helps to form spinel ferrite, but does not increase the efficiency of $CO_2$ decomposition. Porous ceramic fiber composites containing 20 wt% (1g) ferrite samples showed 100% efficiency for $CO_2$decomposition during the first three minutes, but the efficiency decreased rapidly after the elapsed time of ten minutes. The characteristic reduction time for the $CO_2$ decomposition efficiency was estimated as about 3∼7 min.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.215-222
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• 2020

Metformin is a recommended first-line therapy drug for type 2 diabetes patients. However, compared to other oral antidiabetic drugs (OAD), metformin has a large unit dosage, with bioavailability of 40-60%. This limiting bioavailability is because metformin is absorbed only in the upper gastrointestinal tract as a BCS class 3 drug. Hence, we propose that applying the Gastroretentive Drug Delivery System (GRDDS) and extending drug release time in the stomach will result in improved bioavailability. We selected the swelling type delivery system, as it is considered the most stable gastroretention technology compared to other GRDDSs. We modified the swelling excipient by using a natural swelling excipient to form a swelling tablet made of carrageenan and hydroxypropyl methylcellulose (HPMC). Our results indicate that the swelling complex tablet made of carrageenan and HPMC has a good swelling ability and shows required sustained release in a dissolution pattern. In addition, the carrageenan complex has a better swelling ability than the marketed metformin tablet, as determined by the ratio, (swelling ability)/(excipient weight). Taken together, our results indicate that the carrageenan complex can be developed as a good swelling excipient. Further optimizations are required for the commercialization of the carrageenan complex.

• Journal of Energy Engineering
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• v.27 no.4
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• pp.27-35
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• 2018

The passive containment cooling system (PCCS) has been designed to remove the released decay heat during the accident by means of the condensation heat transfer phenomenon to guarantee the safety of the nuclear power plant. The heat removal performance of the PCCS is mainly governed by the condensation heat transfer of the steam-air mixture. In this study, the heat removal performance of the PCCS was evaluated by using the MARS-KS code with a new empirical correlation for steam condensation in the presence of a noncondensable gas. A new empirical correlation implemented into the MARS-KS code was developed as a function of parameters that affect the condensation heat transfer coefficient, such as the pressure, the wall subcooling, the noncondensable gas mass fraction and the aspect ratio of the condenser tube. The empirical correlation was applied to the MARS-KS code to replace the default Colburn-Hougen model. The various thermal-hydraulic parameters during the operation of the PCCS follonwing a large-break loss-of-coolant-accident were analyzed. The transient pressure behavior inside the containment from the MARS-KS with the empirical correlation was compared with calculated with the Colburn-Hougen model.

• Radiation Oncology Journal
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• v.22 no.2
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• pp.145-154
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• 2004

Purpose : To examine whether a synthetic bile acid derivatives (HS-1200) sensitizes the radiation-induced apoptosis in human breast cancer cells (MCF-7) and to investigate the underlying mechanism. Materials and Methods : Human breast cancer cells (MCF-7) in exponential growth phase were treated with HS-1200 for 24 hours at 37$^{\circ}C$ with 5$\%$ CO$_{2}$ in air atmosphere. After removal of HS-1200, cells were irradiated with 2$\~$8 Gy X-ray, and then cultured Ii drug-free media for 24-96 hours. The effect of radiation on the clonogenicity of MCF-7 cells was determined with clonogenic cell survival assay with 16$\mu$M of HS-1200. The induction of apoptosis was determined using agarose gel electrophoresis and Hoechst staining. The expression level of apoptosis-related molecules, such as PARP, Bax, Bcl-2, Bak and AIF, were assayed by Western blotting analysis with 40$\mu$M of HS-1200 combined with 8 Gy irradiation. To examine the cellular location of cytochrome c, bax and AIF immunofluorescent stainings were undertaken. Results : Treatment of MCF-7 cells with 40$\mu$M of HS-1200 combined with 8 Gy irradiation showed several changes associated with enhanced apoptosis by agarose gel electrophoresis and Hoechst staining. HS-1200 combined with 8 Gy irradiation treatment also enhanced production of PARP cleavage products and increased Bax/Bcl-2 ratio by Western blotting. Loss of mitochondrial membrane potential ($\Delta$$\psi$$_{m}$) and increased cytochrome c staining indicated that cytochrome c had been released from the mitochondria in HS-1200 treated cells. Conclusion : We demonstrated that combination treatment with a synthetic chenodeoxycholic acid derivative HS-1200 and irradiation enhanced radiation-induced apoptosis of human breast cancer cells (MCF-7). We suggest that the increased Bax/Bcl-2 ratio In HS-1200 co-treatment group underlies the increased radio sensitivity of MCF-7 cells. Further futures studies are remained elusive.