• 대한방사선방어학회:학술대회논문집
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• 2011.04a
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• pp.58-59
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• 2011

• Proceedings of the Korean Nuclear Society Conference
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• 1999.05a
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• pp.388-388
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• 1999

• Journal of Radiation Protection and Research
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• v.33 no.3
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• pp.99-104
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• 2008

According to the increase in the use of radiotherapy to cancer patients, many approaches have been tried to develop new agents for the protection of surrounding normal tissues. However, it is still few applied in the clinic as a radioprotector. We aim to find a representative parameter for radioprotection to easily predict the activity of in vivo experiment from the results of in vitro screening. The polysaccharide extracted from Panax ginseng was used in this study because the immunostimulator has been regarded as one of the radioprotective agent category and was already reported having a promising radioprotective activity through the increase of hematopoietic cells and the production of several cytokines. Mitogenic activity, AK cells activity and nitric oxide production were monitored for the in vitro immunological assay, and endogenous colony-forming unit (e-CFU) was measured as in vivo radioprotective parameter. The immunological activity was increased by the galactose contents of ginseng polysaccharide dependently. The result of this study suggests that mitogenic activity of splenocytes demonstrated a good correlation with in vivo radioprotective effect, and may be used as a representative parameter to screen the candidates for radioprotector.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2579-2586
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• 2014

It is crucial to set up early the required performance of surface ship for preventing the risk factors such as an excess of performance, cost and period in development stage. In this study, MOP and MOE are proposed to establish the method for deriving alternatives, MOP represents the defensive effect for anti ship missiles and MOE is the ratio of cost and performance. The 16 engagement scenarios which selectively install RF decoy, RF jammer, CIWS and anti air missile are suggested. The simulation results by using NORAM tool operated by ROK Navy show that the ship survivability is 0.605~0.975 and MOP is 0.301~0.887. The analyzed results represent the operating scenario with RF decoy, RF jammer and short range anti air missile is the best cost and effectiveness measure.

• Journal of Radiation Protection and Research
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• v.22 no.3
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• pp.195-205
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• 1997

This paper is to assess the effect of Adaptagen as a radioprotector in which main component is alkaloid fraction of ginseng. Evaluation was made in vitro and in vivo study with NIGP(S) mouse by the measurement of regeneration of jejunal crypt cell and micronucleus assay to analyze radioprotective effect of ginseng alkaloid fraction in comparison with that of water fraction after whole body irradiation. The results were as follows, 1. The degree of radiation damage of mouse jejunal crypt cell was diminished in both of alkaloid and water fraction groups compared to control group but more in alkaloid fraction group than water fraction group. Regeneration of mouse jejunal crypt cell was higher both in alkaloid and water fraction groups than control group. 3. In vitro study, frequency of micronucleus was diminished in tendency for the treated groups than control group but statistically insignificant. 4. In vitro study, frequency of micronucleus was diminished in both alkaloid and water fraction groups compared to control group but more in alkaloid fraction group than water fraction group.

• The Journal of the Korea Contents Association
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• v.20 no.9
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• pp.558-576
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• 2020

The purpose of the research was to verify the mediating effect of social support and cognitive emotional regulation strategy when office worker's emotional expressive ambivalence influences on interpersonal stress. A survey was conducted with 422 office workers from August to September of 2018. SPSS, AMOS and Mplus were used for descriptive statistics, correlation analysis, verification of structural equation modeling and mediated effect. There was a partial mediating effect in emotional expressive ambivalence of self-defense model, a complete mediating effect in relational emotional expressive ambivalence model. In both self-defense and relational emotional expressive ambivalence model, double mediation effect of passing through support and cognitive emotional regulation strategy in the relationship between emotional expressive ambivalence and interpersonal stress was significant. This study sought ways to reduce interpersonal stress by increasing the level of perception of social support and using adaptive cognitive emotional control strategies for office workers.

• Herbal Formula Science
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• v.7 no.1
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• pp.143-151
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• 1999

To evaluate the neurotoxic effect of oxygen radicals in cultured mouse spinal dorsal root ganglion(DRG) neurons, cytotoxicity was determined by MTT assay after cultured DRG neurons were grown in the media containing various concentrations of glucose oxidase(GO). In addition, neuroprotective effect of herb extract, Epimedium Koreanum Nakai was examined by MTT assay in cultured DRG neurons. Cell viability of cultured DRG neurons was remarkably decreased by GO in dose- and time-dependent manner, and Epimedium Koreanum Nakai protected remarkably GO-induced neurotoxicity in these cultures. From the above results, it is suggested that oxygen radicals is toxic in cultured mouse DRG neurons, and herb extracts such as Epimedium Koreanum Nakai are effective in prevention of the neurotoxicity induced by oxygen radicals in cultured mouse DRG neurons.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.1
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• pp.1-7
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• 2016

The aim of this study was to evaluate the cytotoxicity of cadmium chloride ($CdCl_2$), toxicant, and the protective effect of Chelidonium majus (CM) extract on $CdCl_2$-induced cytotoxicity in cultured NIH3T3 fibroblasts. Cell viability, the effect of butylated hydroxytoluene (BHT) against $CdCl_2$, and the antioxidative effects including DPPH-free radical scavenging activity, superoxide anion-radical scavenging activity (SSA), and lactate dehydrogenase (LDH) activity were assessed. $CdCl_2$ caused a significant dose-dependent decrease in cell viability, and $XTT_{50}$ value was determined at 38.7uM of $CdCl_2$. It was determined as highly-toxic by Borenfreund and Puerner' toxic criteria. BHT of antioxidant significantly increased cell viability severely damaged by $CdCl_2$-induced cytotoxicity in these cultures. In the protective effect of CM extract on $CdCl_2$-induced cytotoxicity, CM extract significantly increased cell viability, DPPH-free radical scavenging activity, SSA and inhibitory activity of LDH. From these results, it is suggested that oxidative stress is involved in the cytotoxicity of $CdCl_2$, and CM extract showed protective efficacy on $CdCl_2$-induced cytotoxicity via antioxidative effects. Conclusively, natural resources like CM extract may be a putative antioxidative agent for the detoxification or diminution of toxicity correlated with oxidative stress.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.11a
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• pp.1456-1459
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• 2012

사설서버는 개발사의 동의 없이 게임 서버를 제작 및 운영 하여 게임에 대한 저작권 침해와 서비스의 권리 없이 영리나 비영리 목적으로 단체 또는 개인이 온라인 게임을 즐길 수 있도록 서비스 하는 행위 또는 서버 자체를 뜻한다. 본 논문에서는 이러한 사설서버에 대한 기술적인 대응 방법인 사설서버 방어코드에 대해서 제안 한다. 본 연구는 사설서버로 인한 게임 개발사의 피해와 사설서버에 대한 방어 방법, 그리고 실제 온라인 게임에 사설서버 방어 기술을 도입한 후 사설서버 방어의 효과에 대해서 조사를 한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2013.05a
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• pp.917-920
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• 2013

사설서버는 개발사의 동의 없이 게임 서버를 제작 및 운영 하여 게임에 대한 저작권 침해와 서비스의 권리 없이 영리나 비영리 목적으로 단체 또는 개인이 온라인 게임을 즐길 수 있도록 서비스 하는 행위 또는 서버 자체를 뜻한다. 본 논문에서는 이러한 사설서버에 대한 기술적인 대응 방법인 사설서버 방어코드에 대해서 제안 한다. 본 연구는 사설서버로 인한 게임 개발사의 피해와 사설서버에 대한 방어 방법, 그리고 실제 온라인 게임에 사설서버 방어 기술을 도입한 후 사설서버 방어의 효과에 대해서 조사를 한다.