• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.205-213
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• 2019

The protective effect of Agrimonia pilosa var. (AP) extract on potassium dichromate ($K_2Cr_2O_7$)-induced cytotoxicity in cultured NIH3T3 fibroblasts, was examined by performing an XTT assay for the cell viability and antioxidative effects, such as lactate dehydrogenase (LDH) activity and superoxide anion-radical (SAR) scavenging activity. In this study, $K_2Cr_2O_7$ decreased the cell viability significantly in a dose-dependent manner, and the $XTT_{50}$ value was determined to be $37.5{\mu}M$, which was highly-toxic according to the Borenfreund and Puerner' toxic criteria. The antioxidant, butylated hydroxytoluene (BHT), increased remarkably the cell viability damaged by $K_2Cr_2O_7$-induced cytotoxicity in these cultures. With regard to the protective effect of the AP extract on $K_2Cr_2O_7$-induced cytotoxicity, AP extract produced a significant increase in cell viability and antioxidative effects as the inhibitory ability LDH and SAR scavenging ability. These findings suggest that oxidative stress is involved in the cytotoxicity of $K_2Cr_2O_7$, and the AP extract effectively protected the cells from $K_2Cr_2O_7$-induced cytotoxicity by antioxidative effects. These results suggest that natural resources, such as AP extract, may be a putative therapeutic agent for the diminution or treatment of cytotoxicity induced by heavy metallic bases, such as $K_2Cr_2O_7$ correlated with oxidative stress.

• Parasites, Hosts and Diseases
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• v.23 no.1
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• pp.151-155
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• 1985

Female BALB/c mice weighing 18~20g were immunized by three injections of $1{\times}10^6$ Naegleria iowleri trophozoites intraperitoneally at the interval of one week 6 times for the pregnant mice and 3 times for the offspring mice. One week after immunization the mice were challenged intranasally with N. fcwleri trophozoites $5{\times}10^4$ under secobarbital anesthesia. Experimental primary amoebic meningoencephalitis developed between day 7 and 16 after infection. All mice were dead due to amoebic meningoencephalitis in all experimental groups except in the offspring born to non-immune mothers. Mean of survival time, which is the duration of survival of mice from infection to death, was delayed in the groups of mice born to immune mothers, immune mice born to immune mothers. Active or passive protective immunity against N. fowleri infection was demonstrated in the ismunized mice and mice born to immune mothers. But the effectiveness of immunization was greatly impaired in terms of mortality in the immune mice born to immune mothers when N. fowulsri was infected intranasally.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.23 no.1
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• pp.69-79
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• 2013

Recently, many enterprises are suffering from advanced types of malware and their variants including intelligent malware that can evade the current security systems. This addresses the fact that current security systems have limits on protecting advanced and intelligent security threats. To enhance the overall level of security, first of all, it needs to increase detection ratio of each security solution within a security system. In addition, it is also necessary to implement internetworking between multiple security solutions to increase detection ratio and response speed. In this paper, we suggest a collaborative security response method to overcome the limitations of the previous Internet service security solutions. The proposed method can show an enhanced result to respond to intelligent security threats.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.21 no.1
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• pp.30-34
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• 1988

In roastal fish farms the farmers, especialy engaging in dealing with the floating cage culture, going to know about relationships between holding capacity and water quality in cage. Some of water quality managers and specialists studing physiological ecology understand that the key of water quality management concerned fish farming is budget of dissolved oxygen. This paper deals with oxygen budget in floating cage of the yellow tail farms at southern coastal area in Korea. The sampling station is located at Konli-Do fish farm near Chungmu, and the data is collected for 24 hours from 3:00 p.m. 8th September 1987. In result, the needed oxygen coming after the consumption by the rearing fish had been supplied with the tide current exchange, the sum of oxygen produced by phytoplankton photosynthesis and diffused from atmosphere are no more that $43\%$ for the needs of sea water consumption included respiration of planktons and decomposition of organic matters. The optimum holding capacity of cage is possible to compute with the calculation of minimum diurnal water exchange rate $[Qin{\cdot}V^{-1}\;(C-\bar{c})]$ through net mesh of cage.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.37 no.3
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• pp.232-239
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• 2001

For the purpose of providing the basic data on the improved fishing gear and the man power saving, which contribute to enhance fishing efficiency of set net in the coast of Jeju Island, this study analyzed the catch of two fishing place for the past 3 years in order to compare the fishing efficiency between rectngular set net and pound net, which have been used for fishing with being attached to the set net fishing place in coast of Jeiu Island, Thereby the result is as follows ; 1. When using pound net, the total amount of catch during 1997 to 1999 was 2 times more than that of when using rectangular set net. 2. When using Pound net, the catch of squid, mackerel, rabbit fish and Yellow tail during 1997 to 1999 was 1.8 times more than that of when using rectangular set net.. 3. In case of rectangular set net, CPUE marked 10.1㎏ with horse amckerel, 20.5㎏ with squid, 18.0㎏ with rabbit fish and 2.2㎏ with Yellow tail, and in case of pound net, CPUE marked 57.5 ㎏ with horse mackerel, 30.0㎏ with squid, 25.0 with rabbit fish and 4.7㎏ with yellow tail, and on the whole CPUE of poind net marked higher. 4. In case of rectangular set net, the catch ratio for fishing operation marked 64% with horse mackerel, 79% with squid, 39% with rabbit fish and 14% with yellow tail, and in case of pound net, the catch ratio fishing operation marked 18% with horse mackerel, 85% with souid 40% with rabbit fish and 14% with yellow tail, and accordingly it showed the result that the catch ratio for fishing operation was higher with the case of rectangular set net, but higher with the case of pound net.

• Journal of Radiation Protection and Research
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• v.10 no.1
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• pp.41-49
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• 1985

Neutron Streaming analysis in 1300 MWe pressurized water reactor cavity was performed. In this calculation, the discrete ordinates transport codes, ANISN and DOT 3.5, and the Monte Carlo code, TRIPOLI-02 were used with the coupling code, DOTTRI. In this study IBM 3033 type computer was used. The calculated neutron fluxes and dose rates were compared with the measured data in a 900MWe pressurized water reactor cavity to show a good agreement, although some deviations in the results for each energy group were noticed. These results will be applied in the radiation shielding design of high capacity nuclear power reactors and, to the means of radiation protection in case of the reactor maintenance and the access of the reactor cavity.

• Journal of KIISE:Computing Practices and Letters
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• v.9 no.3
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• pp.311-321
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• 2003

A current firewall or IDS (intrusion detection system) of the network level suffers from many vulnerabilities in internal computing servers. For a secure Linux implementation using system call hooking, this paper defines two requirements such as the multi-level security function of TCSEC B1 and a prevention of hacking attacks. This paper evaluates the secure Linux implemented in terms of the mandatory access control, anti-hacking and performance overhead, and thus shows the security, stability and availability of the multi-level secure Linux. At the kernel level this system protects various hacking attacks such as using Setuid programs, inserting back-door and via-attacks. The performance degradation is an average 1.18% less than other secure OS product.

• Journal of the Korean Society of Radiology
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• v.17 no.4
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• pp.489-495
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• 2023

Radiation shielding facilities are constructed in locations where diagnostic radiation generators are installed, with the aim of preventing exposure for patients and radiation workers. The purpose of this study is seek to compare and validate the trend of attenuation thickness of lead, the primary material in these radiation shielding facilities, at different maximum tube voltages by Monte Carlo simulations and measurement. We employed the Monte Carlo N-Particle 6 simulation code. Within this simulation, we set a lead shielding arrangement, where the distance between the source and the lead sheet was set at 100 cm and the field of view was set at 10 × 10 cm². Additionally, we varied the tube voltages to encompass 80, 100, 120, and 140 kVp. We calculated energy spectra for each respective tube voltage and applied them in the simulations. Lead thicknesses corresponding to attenuation rates of 50, 70, 90, and 95% were determined for tube voltages of 80, 100, 120, and 140 kVp. For 80 kVp, the calculated thicknesses for these attenuation rates were 0.03, 0.08, 0.21, and 0.33 mm, respectively. For 100 kVp, the values were 0.05, 0.12, 0.30, and 0.50 mm. Similarly, for 120 kVp, they were 0.06, 0.14, 0.38, and 0.56 mm. Lastly, at 140 kVp, the corresponding thicknesses were 0.08, 0.16, 0.42, and 0.61 mm. Measurements were conducted to validate the calculated lead thicknesses. The radiation generator employed was the GE Healthcare Discovery XR 656, and the dosimeter used was the IBA MagicMax. The experimental results showed that at 80 kVp, the attenuation rates for different thicknesses were 43.56, 70.33, 89.85, and 93.05%, respectively. Similarly, at 100 kVp, the rates were 52.49, 72.26, 86.31, and 92.17%. For 120 kVp, the attenuation rates were 48.26, 71.18, 87.30, and 91.56%. Lastly, at 140 kVp, they were measured 50.45, 68.75, 89.95, and 91.65%. Upon comparing the simulation and experimental results, it was confirmed that the differences between the two values were within an average of approximately 3%. These research findings serve to validate the reliability of Monte Carlo simulations and could be employed as fundamental data for future radiation shielding facility construction.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.2
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• pp.150-157
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• 2020

The protective effects of a Celastrus orbiculatus Thunb (CO) extract against manganese dioxide (MnO₂)-induced cytotoxicity in cultured C6 glioma cells were examined. This study assessed the antioxidative effects, including the suppressive ability of lipid peroxidation (LP), the inhibitory ability of xanthine oxidase (XO), and the cell viability. MnO₂ decreased the cell viability remarkably in a dose-dependent manner. The XTT₅₀ value was determined to be 146.7 μM in these cultures. The cytotoxicity of MnO₂ was calculated to be mid-toxic using Borenfreund and Puerner's toxic criteria. Kaempferol (KAE) increased the cell viability damaged by MnO₂-induced cytotoxicity significantly. Regarding the protective effects of the CO extract on MnO₂-induced cytotoxicity, the CO extract increased cell viability significantly compared to the MnO₂-treated group. The CO extract also had inhibitory abilities against lipid peroxidation (LP) and xanthine oxidase (XO). From these findings, oxidative stress is involved in the cytotoxicity of MnO₂. The CO extract effectively blocked the cytotoxicity induced by MnO₂ via its antioxidative effects. Conclusively, natural resources, such as the CO extract, might be a useful agent for the diminution or improvement of the heavy metal cytotoxicity correlated with disease through oxidative stress, such as MnO₂, a Parkinsonism inducer.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.1
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• pp.1-7
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• 2016

The aim of this study was to evaluate the cytotoxicity of cadmium chloride ($CdCl_2$), toxicant, and the protective effect of Chelidonium majus (CM) extract on $CdCl_2$-induced cytotoxicity in cultured NIH3T3 fibroblasts. Cell viability, the effect of butylated hydroxytoluene (BHT) against $CdCl_2$, and the antioxidative effects including DPPH-free radical scavenging activity, superoxide anion-radical scavenging activity (SSA), and lactate dehydrogenase (LDH) activity were assessed. $CdCl_2$ caused a significant dose-dependent decrease in cell viability, and $XTT_{50}$ value was determined at 38.7uM of $CdCl_2$. It was determined as highly-toxic by Borenfreund and Puerner' toxic criteria. BHT of antioxidant significantly increased cell viability severely damaged by $CdCl_2$-induced cytotoxicity in these cultures. In the protective effect of CM extract on $CdCl_2$-induced cytotoxicity, CM extract significantly increased cell viability, DPPH-free radical scavenging activity, SSA and inhibitory activity of LDH. From these results, it is suggested that oxidative stress is involved in the cytotoxicity of $CdCl_2$, and CM extract showed protective efficacy on $CdCl_2$-induced cytotoxicity via antioxidative effects. Conclusively, natural resources like CM extract may be a putative antioxidative agent for the detoxification or diminution of toxicity correlated with oxidative stress.