• Title/Summary/Keyword: 방사성동위원소 치료

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Quality Assurance of Brachytherapy System(Physical Aspects) (근접방사선치료 시스템의 QA(물리적 측면))

  • Ji, Young-Hoon
    • Progress in Medical Physics
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    • v.4 no.1
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    • pp.17-21
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    • 1993
  • 근접방사선치료는 방사성동위원소를 종양에 밀착시키거나 또는 종양내에 직접 삽입하여 치료하는 방법으로서 종양에는 일시에 많은 선량을 주는 반면 주위 정상조직에는 선량을 최소화시킬 수 있는 장점이 있다. 따라서 근래에 들어 종양치료에 있어서 외부방사선치료와 병행하여 근접방사선치료를 시행하는 병원이 증가하고 있다. 그러나 근접방사선치료는 방출 방사선의 에너지가 낮고, 대부분 짧은 반감기를 가지며, 소형의, 수 mCi에서 수Ci 정도의 방사능을 가진 방사성동위원소들을 인체에 직접 삽입하는 것으로 정확한 선량 분포를 위해서는 방사성동위원소의 방사능량, 위치, 분포 등의 정확성 확보가 절실히 요구된다. 따라서 이 논문은 근접방사선치료시스템의 QA프로그램 개발을 위하여 작성하였다.

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The Radiopharmaceutical Therapy for Multiple Bone Metastases of Cancer (암의 다발성 뼈 전이의 방사성동위원소 치료)

  • Choi, Sang Gyu
    • Journal of Hospice and Palliative Care
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    • v.17 no.4
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    • pp.207-215
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    • 2014
  • Multiple bone metastases are common manifestation of many malignant tumors such as lung cancer, breast cancer, prostate cancer and renal cell carcinoma. Bone metastasis is secondary cancer in the bone, and it can lead to bone pain, fracture, and instability of the weight bearing bones, all of which may profoundly reduce physical activity and life quality. Treatment for bone metastasis is determined by multiple factors including pathology, performance status, involved site, and neurologic status. Treatment strategies for bone metastasis are analgesics, surgery, chemotherapy and radiotherapy. External beam radiotherapy has traditionally been an effective palliative treatment for localized painful bone metastasis. However, in some cases such as multiple bone metastases, especially osteoblastic bone metastasis originated from breast or prostate cancer, the radiopharmaceutical therapy using $^{89}Sr$, $^{186}Re$, $^{188}Re$, $^{153}Sm$ and $^{117m}Sn$ are also useful treatment option because of administrative simplicity (injection), few side effects, low risk of radiation exposure and high response rate. This article offers a concise explanation of the radiopharmaceutical therapy for multiple bone metastases.

Measurement of Radioactive Surface Contamination of the Restroom in the Hospital (병원 내 화장실의 방사성 표면오염도 측정)

  • Han, Sang-Hyun
    • Journal of the Korea Convergence Society
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    • v.11 no.8
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    • pp.71-76
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    • 2020
  • This study measured radioactive surface contamination in general public restrooms in hospitals and in dedicated toilets for nuclear medicine. The measurement method was measured using Berthold (LB 124, Germany) at the entrance to the restroom, inside the restroom, around the restroom, in the urinal, and around the urinal. As a result of the use of the restroom, there was no dedicated place waiting for patients who received radioisotopes in one of the three hospitals. As a result of measuring the restroom for exclusive use of radioisotopes, all measurement sites in the radioiodine therapy room were the highest, and the results of measuring the public restrooms showed background level contamination at all hospitals except hospital B. However, it was measured as 8.073 Bq/㎠ and 6.426 Bq/㎠ in the urinals in the public restroom on the first floor of the B hospital. Therefore, it is recommended to explain the dangers of radiation exposure to patients and provide a place for patients to wait. In addition, a plan should be sought to prevent patients from receiving radioisotopes from using unnecessary movements and general public restrooms.

Analysis of Radiation Dose on Single Cells Using Therapeutic Radioisotopes Using the Monte Carlo Method (몬테카를로 방법을 이용한 치료용 방사성동위원소 사용 시 단일 세포에 대한 선량 분석)

  • Kim, Jung-Hoon;Kim, Yu-Soo
    • Journal of radiological science and technology
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    • v.45 no.5
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    • pp.433-438
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    • 2022
  • Targeted radionuclides treatment (TRT) requires the establishment of treatment plans that consider various factors, such as the type of radionuclides, target organs, and administration methods. For this reason, in this study, the absorption dose of a single cell was analyzed according to the type of radioisotope used to treat target radionuclides. In this study, a simulation was performed on beta rays used in the treatment of target radionuclides at the cell level using MCNPX (ver. 2.5.0). First, according to the calculation formula, the beam path according to the type of radioisotope for treatment was calculated. Second, the amount of self-radiation by beta rays emitted from cell diameters of 5 ㎛ and 10 ㎛ cell nuclei was evaluated. As a result, it showed a high range proportional to the maximum energy of the beta-ray, and the highest self-dose distribution from 177 Lu radiation sources among therapeutic radioisotopes. This was analyzed as a result that is inversely proportional to the maximum energy of the beta-ray, and it suggests that the selection of a nuclide considering the range of the beta-ray is necessary in the treatment of target radionuclides in the future.