• Radiation Oncology Journal
• /
• v.4 no.1
• /
• pp.1-13
• /
• 1986

In order to clarify the effect of radiation on the mouse jejunal crypt cells by combined administration of administration and radiation and also to evaluate the enhancing effect of adriamycin, the authors performed this study by delivering single irradiation of 1,000 to 1,600 rad to the whole abdomen of mice by cobalt-60 teletherapy unit. In combination with adriyamycin treatment groups, the drug was administered as single dose of 10 mg/kg either 2 hours before or 4 hours after graded single dose,900 to 1,400 rad, of irradiation. The authors studied the quantitative changes of intestinal crypt cells by microcolony survival assay technique and the morphological changes of small intestinal villi by scanning electron microscope in mice following to combined therapy with adriamycin and irradiation, The average number of jejunal crypts per circumference was $130{\pm}16$ in control group. The mean lethal dose(Do) of each irradiation alone and combined therapy groups 2 hours before and 4 hours after irradiation, were 160, 170, and 170 rad in cell survival curves, respectively. The dose effect factor(DEF) of adriamycin in each groups of pre-irradiation and post-irradiation were 1.19 and 1.26, respectively. The conical shaped villi were noted on 1,200 rad in irradiation alone group and 1,000 rad in combined groups. For the proper clinical application we must be careful of the radiation injury to small bowel when the anticancer chemotherapy and radiation therapy to the abdomen and pelvic area are used as combined therapeutic modality.

• Journal of the Korean Society of Radiology
• /
• v.13 no.1
• /
• pp.87-93
• /
• 2019

Recently, the number of passengers using airplanes is rapidly increasing due to the increase of overseas travelers. Therefore, the probability of exposure to natural radiation due to altitude is increasing due to the increase in flight time. Cosmic-ray penetrates the Earth's magnetic field belt Van Allen, which is located at an altitude of 400 km to 1200 km. Most cosmic rays are blocked at Van Allen belt. However, cosmic-ray could be not completely blocked, and a small amount of cosmic-ray affects the earth. In general, if the altitude was increased by 100m, the natural exposure dose increased by 0.03 mSv on the Earth. In this study, I tried to minimize the exposure to natural radiation in airplanes when boarding airplanes. Especially, I was aimed to minimize radiation exposure by protecting the highly sensitive thyroid gland among human organs. According to the results of the study, the designed shielding handkerchief was able to shield cosmic natural radiation dose by more than 70%. In conclusion, the application of the shielding handkerchief made in this study can be effectively shield natural radiation.

• Nuclear industry
• /
• v.9 no.12 s.82
• /
• pp.50-54
• /
• 1989

• Radiation Oncology Journal
• /
• v.28 no.1
• /
• pp.16-22
• /
• 2010

Purpose: We analyzed the incidence and related factors of radiation dermatitis; at first, to recognize whether a decrease in radiation dermatitis is possible or not in breast cancer patients who received radiation therapy. Materials and Methods: Of 338 patients, 284 with invasive breast cancer who received breast conservation surgery with radiotherapy at Chonbuk National University Hospital from January 2007 to June 2009 were evaluated. Patients who also underwent bolus, previous contralateral breast irradiation and irradiation on both breasts were excluded. For patients who appeared to have greater than moderate radiation dermatitis, the incidence and relating factors for radiation dermatitis were analyzed retrospectively. Results: A total of 207 and 77 patients appeared to have RTOG grade 0/1 or above RTOG grade 2 radiation dermatitis, respectively. The factors found to be statistically significant for the 77 patients who appeared to have greater than moderate radiation dermatitis include the presence of lymphocele due to the stasis of lymph and lymph edema which affect the healing disturbance of radiation dermatitis (p=0.003, p=0.001). Moreover, an allergic reaction to plaster due to the immune cells of skin and the activation of cytokine and concomitant hormonal therapy were also statistically significant factors (p=0.001, p=0.025). Conclusion: Most of the breast cancer patients who received radiation therapy appeared to have a greater than mild case of radiation dermatitis. Lymphocele, lymphedema, an allergy to plaster and concomitant hormonal therapy which affect radiation dermatitis were found to be significant factors. Consequently, we should eliminate lymphocele prior to radiation treatment for patients who appear to have an allergic reaction to plaster. We should also instruct patients of methods to maintain skin moisture if they appear to have a greater than moderate case of radiation dermatitis.

• Radiation Oncology Journal
• /
• v.17 no.3
• /
• pp.238-248
• /
• 1999

Purpose : To assess the histomorphologic changes in the rat lung injury induced by radiation, to determine whether captopril reduces the rat lung injury and to evaluate change in TNF-${\alpha}$ and TGF-${\beta}$ in rat lung damage by radiation and captopril Methods and material : Right lungs in male Sprague-Dawley rats were divided irradiation alone (10, 20, 30 Gy) or radiation (same dose with radiation alone group) with captopril (500 mg/L). Radiation alone group were sacrificed at twelve hours and eleven weeks after radiation and radiation with captopril group (captopril group) were sacrificed at eleven weeks after radiation with captopril. We examined the light microscope and electron microscopic features in the groups. Results : In radiation alone group, there were patch parenchymal collapse and consolidation at twelve hours after radiation. The increase of radiation dose shows more prominent the severity and broader the affected areas. Eleven weeks after radiation, the severity and areas of fibrosis had increased in proportion to radiation dose given in the radiation alone group. There was notable decrease of lung fibrosis in captopril group than in radiation alone group. The number of mast cells rapidly increased with increase of radiation dose in radiation alone group and the degree of increase of mast cell number and severity of collagen accumulation more decreased in captopril group than in radiation alone group. In radiation alone group, expression of TNF-${\alpha}$ and TGF-${\beta}$ increased according to increase of radiation dose at twelve hours after radiation in both group. At eleven weeks after radiation, expression of TGF-${\beta}$ increased according to increase of radiation dose in radiation group but somewhat decreased in captopril group. In the captopril group the collagen deposition increased but less dense than those of radiation alone group. The severity of perivascular thickening, capillary change, the number and degranulation of mast cells more decreased in the captopril group than in the radiation alone group. Conclusion : It is concluded that the effect of captopril in the rat lungs after radiation was considered to be due to its effect on inhibition of mast cells and reduction of collagen deposition, and captopril may be protect in lung damage after radiation. We observed expression of TNF-${\alpha}$ and TGF-${\beta}$ increased at the early phase after radiation and expression of TGF-${\beta}$ increased in proportion to increase of radiation dose at the chronic phase after radiation. This results will contribute to future investigation in reduction mechanism of captopril in lung damage after radiation.

• Journal of radiological science and technology
• /
• v.40 no.1
• /
• pp.71-78
• /
• 2017

Scattered radiation is inherent phenomenon of x-ray, which occurs to the subject (or patient). Therefore it cannot be avoidable but also interacts as serious noise factor because the only meaningful information on x-ray radiography is primary x-ray photons. The purpose of this study was to quantify scattered radiation for various shooting parameters and to verify the effect of anti-scatter grid. We employed beam stopper method to characterize scatter to primary ratio. To evaluate effect on the projection images calculated contrast to noise ratio of given shooting parameters. From the experiments, we identified the scattered radiation increases in thicker patient and smaller air gap. Moreover, scattered radiation degraded contrast to noise ratio of the projection images. We find out that the anti-scatter grid rejected scattered radiation effectively, however there were not fewer than 100% of scatter to primary ratio in some shooting parameters. The results demonstrate that the scattered radiation was serious problem of medical x-ray system, we confirmed that the scattered radiation was not considerable factor of dig ital radiog raphy.

• Korean Journal of Environmental Biology
• /
• v.20 no.4
• /
• pp.355-359
• /
• 2002

This study was carried out to investigate the combined effect of cold storage with irradiation on rooting of chrysanthemum cuttings. Each cutting was six cm in length with three real leaves. A set of Groups of the cuttings was irradiated with 0 to 70Gy of gamma-ray after four weeks of cold storage, while another groups were irradiated with the same doses and then stored at $4^\circ{C}$ for four weeks. Root and shoot growth were observed at 15 and 20 days after planting of the cuttings in a Plug tray. Accelerated root formation was observed in 30 Gy irradiated group, and root growth was also enhanced in 20 and 30 Gy irradiated groups 20 days after planting. In case of irradiation combined with pre-treatment of cold storage, survival rate of cuttings was the highest (80%) in 30 Gy irradiated group. The groups treated with irradiation first before cold storage were apparently better in root formation, among which 50 Gy irradiated group showed the highest rate of root growth.

• Journal of the Korean Society of Radiology
• /
• v.16 no.4
• /
• pp.395-403
• /
• 2022

Flat-panel detector (FPD) used in digital radiographic imaging systems was used to perform a quantitative power spectrum evaluation as a result of the thickness change of polymethyl methacrylate (PMMA), a tissue equivalent. As the PMMA thickness increases with the resolution-chart phantom image, the effect of the scattering line increases, indicating that the modulation characteristics decrease, and the image is bright. The results show that the noise of the image increases, and noise-power spectral images are obtained by Fourier transform to confirm by spatial frequency. Thus, it can be verified that the PMMA thickness and noise are proportional through the result of evaluating the change of resolution characteristics and representing the 2D noise-power spectrum as one-dimensional values by evaluating the change of scattering line with MTF as the PMMA thickness increases in the image.

• Journal of Radiation Industry
• /
• v.5 no.1
• /
• pp.69-73
• /
• 2011

Polyamide 66 (PA66) nanofibers with Triallyl cyanurate (TAC) were obtained by electrospinning of formic acid and chloroform solution. Electron beam irradiation of PA66 nanofiber with and without TAC was carried out over a range of absorbed doses (20~100 kGy) in nitrogen. The characterization of the irradiated PA66 nanofibers and PA66 nanofibers with TAC was done by scanning electron microscopy (SEM), nuclear magnetic resonance (NMR), thermogravimetric analysis (TGA) and universal testing machine (UTM). The results of the SEM image analysis confirmed that the morphology of PA66 nanofibers was not altered by electron beam. The amount of TAC in PA66 nanofiber with TAC was identified by $^1H-NMR$ analysis. The degradation temperature of PA66 nanofibers with TAC at an absorbed dose of 20~100 kGy was higher than the irradiated PA66 nanofiber without TAC. On the other hand, the decreasing rate of modulus of irradiated PA66 nanofibers with TAC was less than PA66 nanofibers.

• Radiation Oncology Journal
• /
• v.16 no.2
• /
• pp.107-114
• /
• 1998

Purpose : Ginkgo biloba extract(GBE) is known to increase the peripheral blood circulation. This study was designed to evaluate the effect of GBE on the acute normal tissue radiation reaction. Materials and Methods : mice were divided into two groups, radiation alone and two doses GBE plus radiation, for both acute skin reaction and jejunal crypt assay. GBE was given i.p. one hour before irradiation with priming dose given one day earlier. Thirty to Fifty Gy for acute skin reaction and 11 to 14 Gy for jejunal crypt were irradiated to right hind leg and whole body, respectively. Results : Radiation doses($RD_{50}$) for Peak skin score of 2.0 were 44.2Gy (40.6-48.2Gy) for radiation alone and 44.4Gy(41.6-47.4Gy) for two doses GBE plus radiation, showing no effect of GBE on acute radiation skin damage. The numbers of regenerating jejunal crypts per circumference were also almost the same for each radiation dose level(p=0.57-0.94), and the mean lethal doses($D_o$) were 1.800y(1.57-2.09Gy) for radiation alone and 1.88Gy(1.65-2.18Gy) for two doses GBE plus radiation, indicating no effect of GBE on jejunal crypt cell survival after radiation. Conclusion : GBE doesn't increase acute normal tissue radiation reaction in this model system. As GBE was verified to enhance radiation effect on tumor, high therapeutic gain is expected when GBE is combined with radiation therapy.