Browse > Article
http://dx.doi.org/10.3857/jkstro.2010.28.1.16

An Analysis of the Incidence and Related Factors for Radiation Dermatitis in Breast Cancer Patients Who Received Radiation Therapy  

Lee, Sun-Young (Department of Radiation Oncology, Chonbuk National University Hospital)
Kwon, Hyoung-Cheol (Department of Radiation Oncology, Chonbuk National University Hospital)
Kim, Jung-Soo (Department of Radiation Oncology, Chonbuk National University Hospital)
Lee, Heui-Kwan (Department of Radiation Oncology, Prebyterian Medical Center)
Publication Information
Radiation Oncology Journal / v.28, no.1, 2010 , pp. 16-22 More about this Journal
Abstract
Purpose: We analyzed the incidence and related factors of radiation dermatitis; at first, to recognize whether a decrease in radiation dermatitis is possible or not in breast cancer patients who received radiation therapy. Materials and Methods: Of 338 patients, 284 with invasive breast cancer who received breast conservation surgery with radiotherapy at Chonbuk National University Hospital from January 2007 to June 2009 were evaluated. Patients who also underwent bolus, previous contralateral breast irradiation and irradiation on both breasts were excluded. For patients who appeared to have greater than moderate radiation dermatitis, the incidence and relating factors for radiation dermatitis were analyzed retrospectively. Results: A total of 207 and 77 patients appeared to have RTOG grade 0/1 or above RTOG grade 2 radiation dermatitis, respectively. The factors found to be statistically significant for the 77 patients who appeared to have greater than moderate radiation dermatitis include the presence of lymphocele due to the stasis of lymph and lymph edema which affect the healing disturbance of radiation dermatitis (p=0.003, p=0.001). Moreover, an allergic reaction to plaster due to the immune cells of skin and the activation of cytokine and concomitant hormonal therapy were also statistically significant factors (p=0.001, p=0.025). Conclusion: Most of the breast cancer patients who received radiation therapy appeared to have a greater than mild case of radiation dermatitis. Lymphocele, lymphedema, an allergy to plaster and concomitant hormonal therapy which affect radiation dermatitis were found to be significant factors. Consequently, we should eliminate lymphocele prior to radiation treatment for patients who appear to have an allergic reaction to plaster. We should also instruct patients of methods to maintain skin moisture if they appear to have a greater than moderate case of radiation dermatitis.
Keywords
Breast Neoplams; Radiation therapy; Radiation dermatitis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Ha CC, Lee MZ. Radiation therapy for operable breast cancer after conservative surgery. J Korean Soc Ther Radiol Oncol 2002;20:309-315   과학기술학회마을
2 Pignol JP, Olivotto I, Rakovitch E, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008;26:2085-2092   DOI   ScienceOn
3 Isomura M, Oya N, Tachiiri S, et al. IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis. Clin Cancer Res 2008;14:6683-6689   DOI   ScienceOn
4 Central Cancer Registry Center. Annual Report of the Central Cancer in Korea: 2005.01-2007.12. Seoul; Ministry for Health, Welfare and Family Affairs, 2010
5 Primavera G, Carrera M, Berardesca E, et al. A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis. Cutan Ocul Toxicol 2006;25:165-171   DOI   ScienceOn
6 Meeren AV, Bertho JM, Vandamme M, Gaugler MH. Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells. Mediators Inflamm 1997;6:185-193   DOI   ScienceOn
7 Merchant TE, Bosley C, Smith J, et al. A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients. Radiat Oncol 2007;2:45   DOI   ScienceOn
8 Muller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells. Exp Hematol 2007;35:96-104
9 Dooms-Goossens A, Boden G, Aupaix F, Bruze M. Allergic contact dermatitis from adhesive plaster due to colophony and epoxy resin. Contact Dermatitis 1993;28:120-121   DOI   ScienceOn
10 Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 2008;453:314-321   DOI   ScienceOn
11 Turesson I, Nyman J, Holmberg E, Oden A. Prognostic factors for acute and late skin reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 1996;36:1065-1075   DOI   ScienceOn
12 Fisher J, Scott C, Stevens R, et al. Randomized phase III study comparing Best Supportive Care to Biafine asa prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13. Int J Radiat Oncol Biol Phys 2000;48: 1307-1310   DOI   ScienceOn
13 Wickline MM. Prevention and treatment of acute radiation dermatitis: a literature review. Oncol Nurs Forum 2004;31:237-247   DOI   ScienceOn
14 Walker VA. Skin care during radiotherapy. Nurs Times 1982;78:2068-2070
15 Jill Stein. Postmastectomy radiation may cause skin toxicity and pain. In: 13th Annual Meeting of the European Cancer conference; 2005 Oct 31; Paris, France
16 Andreassen CN, Alsner J, Overgaard M, Overgaard J. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol 2003;69:127-135   DOI   ScienceOn
17 Fujishiro S, Mitsumori M, Kokubo M, et al. Cosmetic results and complications after breast conserving therapy for early breast cancer. Breast Cancer 2000;7:57-63   DOI   ScienceOn
18 Rosen EM, Fan S, Rockwell S, Goldberg ID. The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Invest 1999;17:56-72   DOI
19 Harper JL, Franklin LE, Jenrette JM, Aguero EG. Skin toxicity during breast irradiation: pathophysiology and management. South Med J 2004;97:989-993   DOI   ScienceOn
20 Lopez E, Nunez MI, Guerrero MR, et al. Breast cancer acute radiotherapy morbidity evaluated by different scoring systems. Breast Cancer Res Treat 2002;73:127-134   DOI   ScienceOn
21 Collen EB, Mayer MN. Acute effects of radiation treatment: skin reactions. Can Vet J 2006;47:931-935
22 Haffty BG, Buchholz TA, Perez CA. Early stage breast cancer. In: Halperin EC, Perez CA, Brady LW, eds. Principles and Practice of Radiation Oncology. 5th ed. Philadelphia, Lippincott Williams & Wilkins. 2007:1175-1291
23 Hiraoka M, Mitsumori M, Kokubo M. The Roles and Controversies of Radiation Therapy in Breast Conserving Therapy for Breast Cancer. Breast Cancer 1997;4:127-133   DOI   ScienceOn