• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.3
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• pp.506-512
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• 2000

건조 농산물을 비롯한 식품에 대한 방사선 조사가 허가, 시행되고 있으며, 그 적용 범위도 확대되고 있다. 이에 따라 건조 생약재의 위생화의 대체방법으로 방사선 조사 기술의 적용이 산업계로부터 요구되고 있다. 본 연구는 감마선 조사 생약재의 효능 변화 유무를 확인하기 위한 일환으로 수행되었다. 저자 등은 사물탕, 보중익기탕 및 삼령백출산 등이 방사선 방호 효과를 보이는 것으로 이미 보고한 바 있다. 본 실험에서는 감마선 조사(10 kGy)한 이들 한약제 각각의 방사선 방호 효과를 비조사 시료와 비교 평가하였다. 효과평가를 위하여 방사선 조사 마우스에서 소장움 생존시험, 내재성 비장집락 형성시험 및 apoptosis 측정을 시행하였다. 각 한약제의 감마선 조사 시료는 3가지 시험 모두에서 비조사 시료와 유사한 효과를 나타내었으며(p<0.05), 생체내 독성도 나타내지 않았다. 이는 생약재의 여러 가지 고유 효능 중 일부의 안정성으르 확인한 것으로 생각되며, 이 결과로 미루어 보아 감마선 조사 생약재의 효능 안정성은 한의학적 고유의 효능 비교 평가를 통하여 확인될 수 있을 것으로 사료된다. 한편, 저자 등은 감마선 조사 생약재의 유효성분 안정성 및 유전 독성학적 안전성을 확인하여 보고한 바 있다. 이들 결과를 토대로 향후 감마선 조사 행약재의 고유 효능의 안정성에 관한 체계적인 연구결과를 얻는다면 생약재의 위생화 수단으로 감마선 조사기술의 이용이 실용화될 수 있을 것으로 사료된다.

• Journal of the Korean Society of Radiology
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• v.15 no.2
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• pp.247-255
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• 2021

The purpose of this study was to examine the radiation protection effect of protaetia brevitarsis larvae extracts known as antioxidant food. In this study 90 female rats were clssified in to 5 groups: NC Group, PBE Group, IR Group, PBE+IR Group and IR+PBE Group. In IR Group, 7 Gy of Co-60 gamma ray was irradiated to SD rat and protaetia brevitarsis larvae extracts were administered orally at 200 mg/kg once a day for 14 days. And then on the 1 day, 7 days, 21 days later after irradiation, changes in blood cell component, superoxide dismutase(SOD) activity, spleen index, histopathological evaluation of the ovary and uterus were observed. As a result, the PBE+IR Group (p<0.01, p<0.05) and IR+PBE Group (p<0.01, p<0.01) showed a significantly radiation protection than the IR Group in lymphocyte and red blood cell on the 21 days. It was also confirmed that SOD activity of PBE+IR Group (p<0.01) and IR+PBE Group (p<0.01) was significantly increased than the IR Group. In spleen index, PBE+IR Group (p<0.05) and IR+PBE Group (p<0.01) showed a significantly recovery than the IR Group. In histopathological observation, PBE+IR Group in the ovary and PBE+IR, IR+PBE Group in the uterus showed less inflammatory reactions of cystoplasm than the IR Group. Based on These results, It is judged that protaetia brevitarsis larvae Extracts have radiation protection effect against blood and reproductive. It is expected to be useful for research of radiation protection agent.

• Journal of Radiation Protection and Research
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• v.38 no.4
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• pp.237-241
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• 2013

The gamma energy distributions at the major working places during refueling outage of Korean PWR nuclear power plants were measured. In order to estimate the dose reduction effect of a lead vest, Monte Carlo calculation method was used. For the simulations, the MIRD-V phantom with a lead vest was formed and exposed to the measured radiation field. The average measured gamma energy is lower than that of standard which is generally applied to radiation protection procedures. For the efficient use of a lead vest and achievement of radiation protection purpose, it is necessary to estimate the energy distribution of radiation field at working places.

• Journal of the Korean Society of Radiology
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• v.14 no.2
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• pp.97-104
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• 2020

This aimed at figuring out if there were the radioprotection effects of aronia on livers of laboratory rats radiated through serum test. For the objects of animal testing, one group consists of five male laboratory rats (weight 200~250 g), and the groups were set as follows: Group 1, normal; Group 2, 5 Gy radiated control group; and Group 3, 5 Gy radiated experiment group with aronia. Group 1(A) was prescribed with ordinary meal without radiation while the control group, Group 2(B) was prescribed with ordinary meal and radiation, and the experiment group, Group 3(C) was orally prescribed with aronia (daily oral dosage: 100 mg/kg/day) diluted with distilled water at the amount of 50 mg/kg/day twice a week, using oral zonde needle for rats for 14 days before being radiated, and then, radiation were made on them. For the study, using Linac (Linear Accelerator) 6 MV X-ray therapy device, rats were irradiated on their whole bodies once, and their blood was sampled for conducting five blood serum tests with regard to liver. For statistical analysis, ANOVA test was conducted. In conclusion, as a result of the analysis, it seemed that there were no the radioprotection effects of aronia on liver. However, it was confirmed statistically that ALB (P>0.05) showed no significance and that TP (P<0.05) showed significant differences. It is expected that there should be more tests in future.

• Journal of the Korean Society of Radiology
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• v.13 no.3
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• pp.439-444
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• 2019

In this study, the radiation protection effects of selenium, known as a powerful antioxidant, were studied. After 14 days of oral injection of selenium into the rat, a full body irradiation of 10 Gy was carried out. And after 1 day, 3.5 day, 7 day and 21 day, we observed blood cell components and superoxide dismutase(SOD) and small intestine changes. Compared to irradiation groups, there was a significant protection effect of reducing the hematopoietic immune system damage in the irradiated group after selenium administration(p<0.05). Then, selenium is a valid ingredient that increases the activity of the superoxide Dismutase(SOD), and it is confirmed that it has an effect of inhibiting apoptosis expression of small intestinal cells by irradiation. Based on these results, selenium is considered to be an essential ingredient for protecting living things from radiation.

• Journal of Radiation Protection and Research
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• v.1 no.1
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• pp.31-36
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• 1976

• Nuclear industry
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• v.24 no.10 s.260
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• pp.58-67
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• 2004

• Radioisotope journal
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• v.14 no.4
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• pp.47-50
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• 1999

• Radioisotope journal
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• v.14 no.2
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• pp.37-40
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• 1999

• Radioisotope journal
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• v.21 no.3
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• pp.24-29
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• 2006