• Proceedings of the Korean Nuclear Society Conference
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• 1998.05b
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• pp.730-734
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• 1998

난포성숙호르몬(FSH)은 난소내 난포의 성장인자로 작용한다. 본 실험은 방사선 조사된 미성숙 생쥐의 난포 폐쇄가 ESH에 의해 억제되는지를 확인하는 한편 방사선어제 개발을 위한 실험모델로서의 가능성을 평가하기 위해 수행되었다. PCNA 에 의한 염색의 정도는 FSH군의 경우, 1이에 최저, 12시간과 8일에 가장 많이 염색되었으며, 방사선을 조사한 후 ESH를 주사한 경우, PCNA에 의한 염색용은 6시간 경과시어 제일 낮게 나타나고 이후 증가하는 경향성을 보였다. 즉, FSH는 방사선에 피폭된 난소내 난포외 apoptosis를 지연시키는 효과를 갖고 있음을 알 수 있었다. 본 연구의 결과, 특정물질의 방사선방어효능 평가를 위한 실험모델로서 난소내 난포를 활용할 수 있으며 특히 FSH가 나타내는 난포폐쇄 억제효과도 방사선방어제 개발을 위한 실험연구에 중요한 역할을 할 것으로 기대된다.

• The Journal of the Korea Contents Association
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• v.9 no.12
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• pp.376-384
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• 2009

This research has microstructure observation to find tissue damage mechanism and radio-protection effect on mouse kidney tissue. The result observation of a Light Microscope(LM); The kidney tissue after 5Gy irradiation observed a glomerulus atrophy, also crack distance to base membrane of a convoluted tubules. The kidney tissue after 10Gy irradiation observed out flow cytoplasm to membrane break of a convoluted tubules. The result observation of a Transmission Electron Microscope(TEM); The kidney tissue of after 5Gy irradiation has to breaking a inside cristae and membrane of mitochondria, also show definite damage of nucleus membrane. 10Gy irradiation has all the more damage a base membrane and thickness of lysosome. However, Propolis eating groups observed normal to nucleus membrane and small body of intracellular. therefore We considered "Propolis" as make radio protection function to kidney tissue of the greater part.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.3 no.1
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• pp.129-147
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• 1997

Radiotherapy is an irreplaceable method of cancer treatment. But it has several side effects, especially damages to the hemopoietic and Immune system. Therefore radioprotectors are required to treat cancer successfully. A lot of Herbs and Herbal prescriptions are reported to have radioprotective effects. Above all, those to support the healthy energy and strengthen the body resistance are found more effective. This study was performed to evaluate the radioprotective effects of prescription Shenrong Fuzheng Tang(S.F.T.), which consists of 16 kinds of herbs. We investigated proliferation of murine splenocytes, secretion of colony-stimulating-factors(CSFs), immunocompetence after irradiation in-vitro, and Endogenous spleen colony assay, survival assay in-vivo. When splenocytes were cultured with Shenrong Fuzheng $Tang(S.F.T.)(500{\mu}g/ml)$, proliferation was enhanced 5.7 times compared to control cultured with medium alone(p<0.05) and, showed highest proliferation at 4th day after incubation. In order to evaluate stimulation of hemopoiesis of Shenrong Fuzheng Tang(S.F.T.), the supernatant of splenocytes cultured with optimal concentration of Shenrong Fuzheng Tang(S.F.T.) was used to measure CSFs secretion. The result showed enhanced secretion of colony-stimulating-factors (CSFs) compared to control(p<0.05). To evaluate the protective effect of lymphocytes from irradiation, proliferation of splenocytes stimulated by LPS and ConA after incubation with Shenrong Fuzheng Tang(S.F.T.) for 24h Prior to Irradiation$(1{\sim}3\;Gy)$ was measured. The results showed higher proliferation of Shenrong Fuzheng Tang(S.F.T.) treated cells than that of non-treated cells. And percentage increases of irradiated splenocytes per non-irradiated splenocytes were also higher in Shenrong Fuzheng Tang (S.F.T.)-treated cells than control. Endogenous spleen colony assay. to evaluate the protection of hemopoietic cells from irradiation, showed increased number of colonies(p=0.03) in Shenrong Fuzheng Tang(S.F.T.) treated murine spleen$(10.3{\pm}1.9)$ compared to non-treated murine spleen$(3.4{\pm}0.8)$. Survival time of mice irradiated with lethal dose of ${\gamma}-ray(9Gy)$ was prolonged in Shenrong Fuzheng Tang(S.F.T.) treated group prior to irradiation as compared to non-treated group. According to these results we can suggest that prescription Shenrong Fuzheng Tang(S.F.T.) has radioprotective effects and can be used to protect the hemopoietic and immune system from damages of anti-cancer radiotherapy.

• Proceedings of the KAIS Fall Conference
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• 2011.05b
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• pp.1052-1056
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• 2011

이 연구는 동위원소실에 근무하는 임상병리사들의 방사선 방어에 대한 지식, 태도 및 행위수준을 조사하여 상관관계를 파악하고 방사선 안전관리에 대한 행위에 영향을 미치는 요인을 분석하기 위해 시행하였다. 설문지는 2010년 10월부터 11월까지 대전 충청권 및 서울 경기권 동위원소실 임상병리사를 연구 대상자로 하여 연구자자 임의로 선정 직접설문, 또는 우편방식으로 조사하였고, 수집된 자료는 SPSS12.0 프로그램을 이용하여 빈도와 백분율, T-검정, ANOVA, 다중회귀분석법을 이용하여 분석하였다. 방사선 안전관리에 대한 지식 점수는 평균은 11.5점이었으며 표준편차는 ${\pm}$1.9 분포를 보였다. 방사선 안전관리에 대한 태도 점수는 평균 69.0점, 표준편차는 ${\pm}$5.4이었다. 방사선 방어에 대한 행위점수는 평균은 57.1점, 표준편차 ${\pm}$3.5이었다. 방사선 안전관리 행위에 있어 이론적으로 알고 있는 내용에 비해 수행이 현저히 떨어진 결과가 나왔으며, 방사선 안전관리에 대한 지식, 태도, 행위와의 상관성은 통계적으로 유의한 상관관계를 보였다(p<0.01). 행위점수에 영향을 미치는 요인으로는 종사자법정교육, RI 면허취득, 지식, 태도로 나타났다. 결론적으로 동위원소실에 근무하는 임상병리사의 방사성동위원소 안전관리 행위는 태도에 비하여 수행이 현저히 떨어진 결과가 나왔고, 안전관리 행위에 영향을 주는 인자로 종사자법정교육, RI 면허취득, 지식점수, 태도점수를 알 수 있었다. 업무 진행에 있어 잘못된 지식의 습득 및 태도를 취할 수 있는 가능성이 충분히 있으며 이를 바로 잡을 수 있도록 안전관리에 대한 지속적인 교육을 실시함과 더불어 RI면허 취득, 방사선 종사자에게 교육의 효과를 더욱 높이기 위한 적절한 교육 자료의 개발이 필요하다고 할 수 있다.

• Journal of the Korean Society of Radiology
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• v.5 no.5
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• pp.303-308
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• 2011

Background/Aims : The increasing use of diagnostic and therapeutic interventional radiology calls for greater consideration of radiation exposure risk to radiologist and radiological technician, and emphasizes the proper system of radiation protection. This study was designed to assess the effect of a protective grass shield. Methods : A protective grass was following data depth, 0.8 cm; width, 100 cm; length, 100 cm, lead equivalent, 1.6 mmPb. The protective shield was located between the patient and the radiologist. Thirty patients (13 male and 17 female) undergoing interventional radiology between September 2010 and December 2010 were selected for this study. The dose of radiation exposure was recorded with or without the protective grass shield at the level of the head, chest, and pelvis. The measurement was made at 50 cm and 150 cm from the radiation source. Results : The mean patient age was 69 years. The mean patient height and weight was $159.7{\pm}6.7$ cm and $60.3{\pm}5.9$ kg, respectively. The mean body mass index (BMI) was $20.5{\pm}3.0$ kg/m2. radiologists received $1530.2{\pm}550.0$ mR/hr without the protective lead shield. At the same distance, radiation exposure was significantly reduced to $50.3{\pm}85.2$ mR/hr with the protective lead shield (p-value<0.0001). The radiation exposure to radiologist and radiological technician was significantly reduced by the use of a protective lead shield (p value <0.0001). The amount of radiation exposure during interventional radiology was related to the patient' BMI (r=0.749, p=0.001). Conclusions : This protective shield grass is effective in protecting radiologist and radiological technician from radiation exposure.

• Journal of Radiation Protection and Research
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• v.15 no.1
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• pp.9-13
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• 1990

1959년 한국원자력연구소가 창립됨과 동시에 &Health Physics&, 즉 보건물리라고 하는 명칭과 조직이 탄생되어, 방사선안전관리의 실무와 보건물리의 연구가 시작되었다. 최초 10년간은 선진제국의 보건물리분야의 연구와 기술을 추적하여 우리나라의 방사선안전관리 기술의 기초를 다지는 시기로서 개인방사선모니터링기술, 환경방사선(능) 모니터링기술 및 방사선방어용계측기기의 교정기술 개발에 중점을 두고 연구개발이 추진되었으며, TRIGA Mark-II 연구용원자로의 가동에 따라 원자로 생체차폐체의 건전성 검증에 관한 유익한 방사선량 측정자료도 얻게 되었다. 즉 이 기간은 방사선안전관리의 체제정비 및 기초기술 확립에 노력한 기간이었다. 1970년대는 원자력 연구개발에 대한 기본방향과 정책의 변경등으로 보건물리 연구조직은 방사선안전관리, 환경연구 그리고 방사화학분야로 분산되었으며, 그로인하여 연구개발활동은 거의 정체되어 겨우 방사선안전관리 실무만이 그 명맥을 유지하였다. 그 결과 우리나라 방사선안전관리 및 그와 관련된 연구개발의 기반이 흔들리게 되었으나, 그러한 환경하에서도 방사선량측정평가기술, 방사선차폐설계기술 및 원자로사고시 피폭선량평가기술의 선진화에 필요한 지식을 얻었으며, 방사선 안전관리에 유익한 실무경험도 축적하게 되었다. 1980년대는 통합된 원자력 연구개발체제의 구축으로 방사선작업종사자 및 일반공중의 피폭저감화 기술개발에 필요한 각종 최신기술을 도입하였고, 관리업무에 있어서도 측정의 정확도와 신뢰성향상 및 새로운 관리기술의 개발에 많은 노력을 한 결과, 유익한성과를 얻게된 기간이다. 특히, 이 기간은 방사선안전관리기술의 선진화를 위한 지식이 축적되어 90년대의 방사선안전관리기술자립화를 위한 전환기로서, 이와같이 축적된 기술은 원자력의 평화적 이용에 크게 기여할 것으로 기대된다.서 dithiothreitol를 투여한 군에서는 우라늄단독투여군에 비해 cretinine의 배설이 상당히 증가하였다(P<0.05). 6. 우라늄오염에 의한 신장의 소견에 있어 우라늄단독투여군은 근위곡세뇨관상피의 공포화 및 종창, microvilli와 brush border의 손실, 세뇨관 상피의 괴사가 관찰되었으며, 간장의 충혈, 중심성 괴사 및 모세관 확장증도 관찰되었다. 그리고 sodium bicarbonate와 생리적 식염수를 병행투여한 군과 우라늄을 투여하고 30분이 지나서 dithiothreitol를 투여한 군에서는 우라늄 단독투여군에 비해 높은 방호효과가 관찰되었으나 다른 실험군에서는 큰 효과가 없는 것으로 나타났다. 결론적으로 우라늄의 체내오염시에는 sodium bicarbonate와 생리적 식염수를 가능한 빨리 병행투여하거나 dithiothreitol을 체내오염후 30분이 지나서 투여하는 방법이 우라늄오염에 대한 제염에 매우 유효할 것으로 생각되며, 특히 우라늄에 의한 인체장해를 유의하게 경감시켜줄 것으로 사료되었다.내의 어떤 부위와도 관계가 되는 것으로 간주되는데 이것이 $(^3H)$ QNB가 $(^3H)$ NMS보다 높은 최대 결합능력 $(B_{max})$을 나타낼 이유이다. (b) 두 종류의 다른 제제에서 우리는 같은 양상의 결과를 관찰하었기에 결점이 많은 homogenates 제제보다는 intact cell aggregates 제제를 수용체 연구에 대한 새로운 실험모형(experiment model)으로 사용할 수 있는 가능성을 제시하고자 한다.$가 38.8%로 가장 많고, 그 다음이 ${\ulcorner}$l9세(歲)이후${\lrcorner}$가 25.2%로서 전체

• Journal of the Korean Society of Radiology
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• v.8 no.1
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• pp.1-10
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• 2014

The bi-plane cerebrovascular angiography radiation is done the radiation exposure at the forward and lateral direction as opposed to the one of the source. So, the exposure dose of radiation workers increases further. Therefore, the medical diagnostic radiation workers as well as patients is interested to ways to reduce the dose. The exposure dose of cerebral angiography and interventional radiology must be considered the primary radiation of X-ray tube directly, scattered primary radiation between lateral tube and lateral detector and relatively small secondary scatter radiation in the walls of room. The aim of study is that the exposure dose of primary and scatter radiation reduce as much as possible to install protection device of lateral protection than common shielding of table and ceiling. As a result, the dose of fluoroscopy was reduced approximately 3.64 times the gonads, thyroid approximately 3.13 times, 4.42 times around eyes. And the dose of DSA was reduced approximately 4.98 times the gonads, thyroid approximately 3.00 times, 1.67 times around eyes. Consequently, medical practitioners can be helpful for radiation dose-exposure for the lateral protection of bi-plane cerebrovascular angiography more than the common shield method in cerebrovascular angiography and interventional radiological procedures.

• Journal of radiological science and technology
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• v.34 no.2
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• pp.141-147
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• 2011

We developed an alternative radiation shielding material which is economical and has high protection efficiency. We validated the material in the form of sheet to make an apron. We increased the rate of barium and mixed tourmaline into silicon to improve the flexibility and protection rate of the sheet. The results showed that the shielding effect at low radiation energy is good enough with both 5 mm and 7 mm thickness. In the future, we will perform a quantitative evaluation of the reproducibility, volumetric efficiency, and porosity in mixing the ingredients.

• Journal of radiological science and technology
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• v.40 no.1
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• pp.135-142
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• 2017

Selenium (Se), which is natural materials existing was known as an important component of selenoprotein, one of the important proteins responsible for the redox pump of a living body. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the thyroid gland was used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium (Se) through changes of blood components, thyroid hormones (T3, T4), antioxidant enzyme (GPx) activity and thyroid tissue changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet)(p<0.05). The activity of Glutathione Peroxidase (GPx), the antioxidant enzyme, and the activity of the target organ, thyroid hormone (T3, T4), also showed significant activity changes (p<0.05). In the observation of tissue changes, it was confirmed that there was a protective effect of thyroid cell damage which caused the cell necrosis by radiation treatment. Therefore, it is considered that selenium(Se) can be utilized as a radiation defense agent by inducing immunogenic activity effect of a living body.

• Journal of the Korean Society of Radiology
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• v.15 no.2
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• pp.191-199
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• 2021

The purpose of this research is to analyze the radiation shielding effect of soft magnetic material to confirm the applicability to the military facilities. The soft magnetic material is known to be effective in shielding EMP. If this material is also effective in radiation shielding, it is expected that it has a lot of applicability in military protection. In particular, this material contains boron, so it will be effective in shielding neutrons. In this research, experiments were conducted using Cs-137 and Co-60 sources to check the gamma ray shielding effect. In addition, the Monte Carlo N-Particle(MCNP) modeling was applied to evaluate the gamma ray and neutron shielding effect of a military command tent. As a result, as the soft magnetic thickness increased, the shielding performance improved according the linear attenuation law of gamma ray and neutron. Therefore, this research verified that the application of soft magnetic material for military purposes in radiation shielding would be effective.