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http://dx.doi.org/10.17946/JRST.2017.40.1.19

Effect of Selenium on the Thyroid gland Antioxidative Metabolisms in Rat Model by Ionizing Radiation  

Choi, Hyung-Seok (Department of Emergency Management, Inje University)
Choi, Jun-Hyeok (Radiation Safety Research Center, Inje University)
Jung, Do-Young (Department of Emergency Management, Inje University)
Kim, Jang-Oh (Department of Emergency Management, Inje University)
Shin, Ji-Hye (Department of Emergency Management, Inje University)
Min, Byung-In (Department of Nuclear Applied Engineering, Inje University)
Publication Information
Journal of radiological science and technology / v.40, no.1, 2017 , pp. 135-142 More about this Journal
Abstract
Selenium (Se), which is natural materials existing was known as an important component of selenoprotein, one of the important proteins responsible for the redox pump of a living body. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the thyroid gland was used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium (Se) through changes of blood components, thyroid hormones (T3, T4), antioxidant enzyme (GPx) activity and thyroid tissue changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet)(p<0.05). The activity of Glutathione Peroxidase (GPx), the antioxidant enzyme, and the activity of the target organ, thyroid hormone (T3, T4), also showed significant activity changes (p<0.05). In the observation of tissue changes, it was confirmed that there was a protective effect of thyroid cell damage which caused the cell necrosis by radiation treatment. Therefore, it is considered that selenium(Se) can be utilized as a radiation defense agent by inducing immunogenic activity effect of a living body.
Keywords
Selenium; T3.T4; Thyroid gland; GPx; Radioprotector;
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Times Cited By KSCI : 1  (Citation Analysis)
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