Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Effect of Selenium on the Thyroid gland Antioxidative Metabolisms in Rat Model by Ionizing Radiation

셀레늄이 전리방사선에 의한 힌쥐 모델에서의 갑상선 항산화계에 미치는 영향

  • Choi, Hyung-Seok (Department of Emergency Management, Inje University) ;
  • Choi, Jun-Hyeok (Radiation Safety Research Center, Inje University) ;
  • Jung, Do-Young (Department of Emergency Management, Inje University) ;
  • Kim, Jang-Oh (Department of Emergency Management, Inje University) ;
  • Shin, Ji-Hye (Department of Emergency Management, Inje University) ;
  • Min, Byung-In (Department of Nuclear Applied Engineering, Inje University)
  • 최형석 (인제대학교 재난관리학과) ;
  • 최준혁 (인제대학교 방사선방재센터) ;
  • 정도영 (인제대학교 재난관리학과) ;
  • 김장오 (인제대학교 재난관리학과) ;
  • 신지혜 (인제대학교 재난관리학과) ;
  • 민병인 (인제대학교 원자력응용공학부)
  • Received : 2017.02.09
  • Accepted : 2017.03.14
  • Published : 2017.03.31
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Abstract

Selenium (Se), which is natural materials existing was known as an important component of selenoprotein, one of the important proteins responsible for the redox pump of a living body. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the thyroid gland was used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium (Se) through changes of blood components, thyroid hormones (T3, T4), antioxidant enzyme (GPx) activity and thyroid tissue changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet)(p<0.05). The activity of Glutathione Peroxidase (GPx), the antioxidant enzyme, and the activity of the target organ, thyroid hormone (T3, T4), also showed significant activity changes (p<0.05). In the observation of tissue changes, it was confirmed that there was a protective effect of thyroid cell damage which caused the cell necrosis by radiation treatment. Therefore, it is considered that selenium(Se) can be utilized as a radiation defense agent by inducing immunogenic activity effect of a living body.

천연물에 존재하는 셀레늄(Se)은 생체의 산화환원작용을 주관하는 중요한 단백질의 하나인 셀레늄함유단백질(selenoprotein)의 중요한 요소로 알려져 있다. 셀레늄(Se)을 Rat에 경구 투여하여 10 Gy의 방사선을 조사 시킨 후 갑상선을 표적 장기로 삼고 1일, 7일, 21일 기간에 따른 혈구성분의 변화, 갑상선호르몬(T3, T4)의 변화, 항산화효소((Glutathione Peroxidase, GPx)의 활성 변화, 갑상선 조직 변화 관찰을 통하여 셀레늄(Se)의 방사선 방호 작용을 알아보고자 하였다. 실험결과 조혈 면역계(혈색소농도, 호중구, 혈소판)에서 회복을 보이는 유의한 방호 효과가 있었다(p<0.05). 항산화효소인 Glutathione Peroxidase(GPx) 활성과 표적 장기인 갑상선 호르몬(T3, T4)의 활성 변화 결과에서도 유의성 있는 활성 변화를 보였으며(p<0.05), 조직 변화 관찰에서는 방사선 처리에 의한 세포 괴사를 일으킨 갑상선 세포 손상 보호 효과가 있음을 확인하였다. 따라서, 셀레늄(Se)은 떨어진 생체의 면역 활성 효과를 유도함으로써 방사선 방어제로 활용될 수 있을 것이라 판단된다.

Keywords

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