• The Journal of Korean Society for Radiation Therapy
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• v.9 no.1
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• pp.106-112
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• 1997

The present study was undertaken to investigate the effects of cultured MDCK cell line on the cell viability and the activities of superoxide dismutase(SOD). catalase, change of FOX 1 with low dose radiation. When MDCK cells were irradiated low dose (less than 50 cGy), the cell viability remains high after 2 hrs, but few changes after 24 hrs. In the low dose irradiated MDCK cells, the activities of SOD and catalase were increased with compared to control group and high dose. But the content of $H_2O_2$(FOX 1) was decreased. These results suggest that the cultured MDCK cells probably were induced expression of defense mechanism.

• Proceedings of the Korea Contents Association Conference
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• 2011.05a
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• pp.187-188
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• 2011

저 에너지 방사선검사 시 부득이하게 방사선 노출을 받게 되는 방사선 작업종사자나 환자의 보호자가 위치와 거리에 따른 방사선 피폭 선량의 감소 방안을 알아보고자 한다. Ion chamber mode 2026c, Reader기 20X6-1800을 사용하여 구강내 검사와 구강외 검사의 각각 검사실과 조정실에서의 관전압의 변화, 관전류와 조사시간의 변화, 조사방향의 변화에 따라 선량을 측정하였다. 그 결과 검사실 안에서는 최고선량이 평균 $702.8{\mu}R$으로 측정 되었으며, 조정실 안에서 측정하였을 경우 $20{\mu}R$이하의 낮은 선량을 보였으며, 후방검사보다 측방검사가 낮은 선량으로 나타났다. 방사선검사 시 위치와 거리에 따른 조사선량을 비교 분석하여, 적절한 거리 확보와 조사되는 중심방사선을 기준으로 측방($90{\sim}135^{\circ}$)에 위치함으로써 방사선 방어에 도움을 줄 것이며, 차폐문을 이용하여 방사선 피폭으로부터 감소 효과를 볼 수 있을 것이다.

• Radiation Oncology Journal
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• v.18 no.1
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• pp.60-67
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• 2000

Purpose :To evaluate protective mechanism of melatonin against radiation damage and its relationship with apoptosis in mouse jejunum. Materials and Methods: 168 mice were divided into 28 groups according to radiation dose and matatonin treatment. To analysis crypt survival, microcolony survival assay was done according to Withers and Elkind's method. To analysis apoptosis, TUNEL assay was done according to Labet-Moleur's method. Results : Radiation protection effect of melatonin was demonstrated by crypt survival assay and its effect was stronger in high radiation dose area. Apoptosis index with 8 Gy irradiation was 18.4$\%$ in control group and 16.5$\%$ in melatonin treated group. After 18 Gy, apoptosis index was 17.2$\%$ in control group and 15.4$\%$ in melatonin treated group. Apoptosis index did not show statistically significant difference between melatonin treated group and control group. Conclusion : Melatonin shows clear protective effect in mouse jejunum against radiation damage but its protective effect seems not to be related with apoptosis protection effect.

• Journal of the Korean Society of Radiology
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• v.12 no.7
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• pp.909-917
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• 2018

3D printing technology is expected to be an innovative technology of the manufacturing industry during the 4th industrial revolution, and it is being used in various fields including biotechnology and medical field. In this study, we verified the printing materials through Monte Carlo simulation to evaluate the radiation shielding ability of the raw material using this 3D printing technology. In this paper, the printing materials were selected from the raw materials available in a general-purpose FDM-based 3D printer. Simulation of the ICRU phantom and the shielding system was carried out to evaluate the shielding effect by evaluating the particle fluence according to the type and energy of radiation. As a result, the shielding effect tended to decrease gradually with increasing energy in the case of photon beam, and the shielding effect of TPU, PLA, PVA, Nylon and ABS gradually decreased in order of materials. In the case of the neutron beam, the neutron intensity increases at a low thickness of 5 ~ 10 mm. However, the effective shielding effect is shown above a certain thickness. The shielding effect of printing material is gradually increased in the order of Nylon, PVA, ABS, PLA and TPU Respectively.

• Journal of the Korean Society of Radiology
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• v.15 no.3
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• pp.313-320
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• 2021

This study evaluates the radiation protection effects of Schizonepeta tenuifolia water extract on white rat by gender. Schizonepeta tenuifolia contains polyphenol and flavonoid, which are typical substances that remove free radical. Thus, to determine the effectiveness of radiation protection, the Schizonepeta tenuifolia water extract was administered to Sparaqu-Dawely (SD) rat males and females for two weeks, followed by hematological analysis, analysis of changes in the length of the small intestine villi length, and SOD activity evaluation. The male rat in ST+IR group showed a slightly greater recovery of platelets than the IR group. The ST+IR group also showed a higher platelet recovery capability than the IR group. lymphocyte showed that male and female rat ST+IR groups have higher resilience than IR groups likewise platelet. After irradiation, the villi length of the male rat and female rat decreased less in ST+IR group than in the IR group, indicating that the villi length of all genders was less damaged. This result confirmed that the Schizonepeta tenuifolia water extract had a radiation protection effect.

• Journal of the Korean Society of Radiology
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• v.14 no.6
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• pp.755-762
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• 2020

This study is desinged to examine the effects of Taheebo(Tabebuia avellanedae) extract on the prostate of male rats as a natural radiation protection agent. Taheebo extract is well known to inhibit cell growth for the cell lines of breast and prostate cancer. In this study, the X-ray 7 Gy was irradiated in the prostate of male rat to identify radiation protection effects by Taheebo Extracts, 1, 7, and 21 Days later, hematological changes, external toxicity assessments(LDH), antioxidant enzyme(SOD) activity changes and tissue change were observed. IR+TH group showed greater lymphocyte levels than the irradiation group, which is believed to affect the hematopoietic immune system's resilience. As a results of the external toxicity assessment, Taheebo extract's toxicity is maximum 18.128±5.16%, minimum 13.6945±4.43%. Taheebo is considered to be of little toxicity. The composition of prostate cell nuclei and cytoplasm in Control and TH group was honogeneous, whereas the cell nucleus cohesion in the prostate in irradiation group and inflammatory reactions in cytoplasm were shown. IR+TH group showed less inflammatory reactions of cytoplasm in the prostate than in the radiation irradiation group, but showed a cohesive phenomenon of cell nuclei. It is judged that Taheebo extract has radiation protection against prostate cells.

• Korean Journal of Food Science and Technology
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• v.30 no.4
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• pp.888-894
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• 1998

In order to investigate the radioprotective effect of Si-Wu-Tang (Korean name: Sa-Mul-Tang), a kind of traditional Oriental medicine as a blood-building decoction (Oriental medical concept: Bu-Xie), and Si-Jun-Zi-Tang (Korean name: Sa-Gun-Ja-Tang), one of the widely used Oriental herbal medicines as an energy tonic (Chinese medical concept: Bu-Qi). the jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were observed in irradiated mice. Jejunal crypts were protected by Si-Wu-Tang pretreated both per os (2 mg/mL of drinking water for 7 days, p<0.05) and intraperitoneally (1 mg/head, single injection at 24 hours before irradiation). Si-Wu-Tang adminstration before irradiation(1 mg/head, single injection at 24 hours before irradiation) resulted in an increase of the formation of endogenous spleen colony (p<0.005). The frequency of radiation-induced apoptosis in intestinal crypt cells was also reduced by pretreatment of Si-Wu-Tang (p<0.01). However, the radioprotective effect of Si-Jun-Zi-Tang was not as significant as that of Si-Wu-Tang. These results suggest that Si-Wu-Tang may be a useful radioprotective food, especially since it is a relatively nontoxic natural product.

• Journal of radiological science and technology
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• v.41 no.5
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• pp.471-478
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• 2018

Oogenesis process of ovary produces a lot of undifferentiated cells. Especially, the radiation exposure of early immature cells in the process of growth to oocyte causes serious disabilities. This study examined the radiation damage mechanism of undifferentiated cells and organelles in oogenesis process, and the radioprotection after injection of alliin. The ultrastructure after 7Gy X-ray irradiation on the white rat was observed in the experiment. The results is as follows. It was observed that the nucleus membrane of an oogonium was damaged and vacuolated in the several parts after 15 days of irradiation. The damage of mitochondria membrane and flow in cytoplasm after 20 and 30 days was found in the oogonium. After 40 days observation, peroxidation of fat droplets was found and organelles were tangled each other in ovary tissue. The partial damage of nuclear membrane in oogonium past 15 days after injection of alliin was found, but decreased remarkably. Mitochondria, Golgi body, and rough endoplasmic reticulum were also clearly observed, therefore, radioprotection effects in alliin was confirmed partially.

• Korean Journal of Food Science and Technology
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• v.10 no.1
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• pp.88-91
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• 1978

When the food poisoning bacteria Salmonella enteritidis and S. typhimurium were treated with radiation (cobalt-60 r-rays) and heat (10 minutes at $45^{\circ}C\;or\;50^{\circ}C$), their sterilizing effect was revealed differently depending on the order of treatments. Post-irradiation heating showed a synergistic effect whereas pre-irradiation heating revealed the opposite effect and the effects differed slightly with heating temperature.

• Radiation Oncology Journal
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• v.17 no.3
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• pp.238-248
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• 1999

Purpose : To assess the histomorphologic changes in the rat lung injury induced by radiation, to determine whether captopril reduces the rat lung injury and to evaluate change in TNF-${\alpha}$ and TGF-${\beta}$ in rat lung damage by radiation and captopril Methods and material : Right lungs in male Sprague-Dawley rats were divided irradiation alone (10, 20, 30 Gy) or radiation (same dose with radiation alone group) with captopril (500 mg/L). Radiation alone group were sacrificed at twelve hours and eleven weeks after radiation and radiation with captopril group (captopril group) were sacrificed at eleven weeks after radiation with captopril. We examined the light microscope and electron microscopic features in the groups. Results : In radiation alone group, there were patch parenchymal collapse and consolidation at twelve hours after radiation. The increase of radiation dose shows more prominent the severity and broader the affected areas. Eleven weeks after radiation, the severity and areas of fibrosis had increased in proportion to radiation dose given in the radiation alone group. There was notable decrease of lung fibrosis in captopril group than in radiation alone group. The number of mast cells rapidly increased with increase of radiation dose in radiation alone group and the degree of increase of mast cell number and severity of collagen accumulation more decreased in captopril group than in radiation alone group. In radiation alone group, expression of TNF-${\alpha}$ and TGF-${\beta}$ increased according to increase of radiation dose at twelve hours after radiation in both group. At eleven weeks after radiation, expression of TGF-${\beta}$ increased according to increase of radiation dose in radiation group but somewhat decreased in captopril group. In the captopril group the collagen deposition increased but less dense than those of radiation alone group. The severity of perivascular thickening, capillary change, the number and degranulation of mast cells more decreased in the captopril group than in the radiation alone group. Conclusion : It is concluded that the effect of captopril in the rat lungs after radiation was considered to be due to its effect on inhibition of mast cells and reduction of collagen deposition, and captopril may be protect in lung damage after radiation. We observed expression of TNF-${\alpha}$ and TGF-${\beta}$ increased at the early phase after radiation and expression of TGF-${\beta}$ increased in proportion to increase of radiation dose at the chronic phase after radiation. This results will contribute to future investigation in reduction mechanism of captopril in lung damage after radiation.