• Korean Journal of Food Science and Technology
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• v.36 no.4
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• pp.531-536
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• 2004

Synthesis conditions were optimized using response surface methodology for producing structured lipids (SL) by interesterification of DHA-enriched algae oil derived from microalgae, Schizochytrium sp. and corn oil. Reaction was performed fer 24 hr at $55^{\circ}C$ catalyzed by immobilized lipase from Rhizomucor miehei (RM IM) in shaking water bath. Major fatty acids of SL were palmitic (21.70 mol%), oleic (20.20 mol%), and linoleic (27.34 mol%) acids, and DHA (15.06 mol%). To separate newly synthesized SL-triglycerides (TG) species, HPLC with evaporative light scatting detector (ELSD) was used. Production conditions were optimized using central composite design with reaction temperature $(35-75^{\circ}C,\;X_1)$, reaction time $(2-42\;hr,\;X_2)$, and enzyme concentration $(2-14%,\;X_3)$ as variables. When variables were $70.28^{\circ}C\;(X_1),\;28.74\;hr\;(X_2),\;and\;11.30%\;(X_3)$, maximum content of selected three peaks of synthesized SL-TG species was predicted as 6.97 area%.

• Korean Chemical Engineering Research
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• v.57 no.5
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• pp.743-748
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• 2019

This study focuses on the simulation of wet flue gas desulfurization process for improving the production of gypsum by the utilization of low-grade limestone. At present, high-grade limestone with a $CaCO_3$ content of 94% is used for producing merchantable gypsum. In modeling process, a lot of reactions are considered to develop model. First, the limestone dissolution is simulated by RSTOIC model. Second, SOx absorption and crystallization is used by RCSTR model. Finally the gypsum is separated by using SEPERATORS model. Modeling steps make it easy to reflect further side reactions and physical disturbances. In optimization condition, constraints are set to 93% purity of gypsum, 94% desulfurization efficiency, and total use of limestone at 3710 kg/hr. Under these constraints, the mass flow of low-grade limestone was maximized. As a result, the maximum blending quantity of low-grade limestone for 2,100 kg of high-grade limestone that satisfies constraints is about 1,610 kg.

• Journal of Korean Society for Quality Management
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• v.41 no.1
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• pp.109-118
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• 2013

Purpose: Given the several proper models for given mixture components-process variables experimental data, we propose a strategy to find the optimal condition in which the performance of the responses is well-behaved under those models. Methods: Given the mixture experimental data with process variables, first we choose the reasonable starting models among the class of admissible product models based on the model selection criteria and then, search for the candidate models that are the subset models of the starting model by the sequential variable selection method or all possible regressions procedure. Good candidate models are screened by the evaluation of model selection criteria and checking the residual plots for the validity of the model assumption. Results: We propose a strategy to find the optimal condition in which the performance of the responses is well-behaved under those good candidate models by adopting the optimization methods developed in multiple responses surface methodology. Conclusion: A strategy is proposed to find the optimal condition in which the performance of the responses is well-behaved under those proper combined models. This strategy to find the optimal condition is illustrated with the example in this paper.

• Korean Chemical Engineering Research
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• v.50 no.3
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• pp.545-550
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• 2012

A 17-run Box-Behnken design (BBD) was used to optimize the extraction conditions of astaxanthin from shrimp waste. Three factors such as ratio of ethanol to raw material, extraction temperature ($^{\circ}C$) and extraction time (min) were investigated. The adjusted coefficient of determination ($R^2{_{adj}}$) for the model was 0.9218, and the probability value (p=0.0003) demonstrated a high significance for the regression model. The optimum extraction conditions were found to be: optimized ratio of ethanol to raw material 29.7, extraction temperature $49.5^{\circ}C$ and extraction time 59.9 min. Under these conditions, the mean extraction yield of astaxanthin was $17.80{\mu}g/g$, which was in good agreement with the predicted model value. Under these conditions, validation experiments were done and the mean extraction yield of astaxanthin was $17.77{\mu}g/g$, which is in good agreement with the predicted model value.

• 한국신재생에너지학회:학술대회논문집
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• 2006.06a
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• pp.281-286
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• 2006

본 연구의 목적은 차세대 대체에너지로 각광받는 풍력발전 중에서 육상발전보다 여러 가지 이점이 있는 한국형 해상풍력터빈 블레이드의 최적형상설계를 위한 알고리즘을 구현하는 것이다. 블레이드 단면 익형의 양력과 항력 분포는 XFOIL을 이용하여 예측하였다. 첫 번째 수준의 설계변수인 각각의 블레이드 지름과 축 회전수에서 익형의 공력변수들과 최소에너지손실 조건을 이용하여 두 번째 설계변수인 각 블레이드 단면에서의 시위길이와 피치각 분포를 최적화하였다. 그리고 성능결과를 바탕으로 반응면을 구성하고, 확률적 방법을 이용하여 타당성 있는 설계공간까지 첫 번째 설계변수를 이동시키고 구배최적화 기법을 통해 각각의 제약함수를 만족하면서 목적함수를 죄대로 하는 최적블레이드 형상을 구현하였다. 설계된 최적형상에 대해 탈설계점 해석을 수행하여 성능을 구하였다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1992.10a
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• pp.145-150
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• 1992

화인세라믹의 우수한 공학적 특성으로 인한 최근의 이용가치 증대와 더불어 세라믹의 고정도 가공에 대한 관심이 높아지고 있다. 다이아몬드휠을 이용한 연삭이나 다이아몬드 공구를 이용한 선삭에 의해 세라믹의 고정도 표면생성을 실현시키고자 하는 연구가 활발히 진행되고는 있으나 아직 미흡한 상태에 있다. 따라서 전통적으로 고정도 표면생성에 널리 용되어 온 래핑에 의한 표면다듬질이 현재 행하여지고 있는 일반적인 방법이다. 본 연구에서는 화인세라믹의 고정도 표면생성을 위한 원통래핑 공정의 최적화 방법으로 실험계획법의 한 응용분야인 반응표면분석법을 이용하였으며 그 결과, 적은 재료와 시간으로 능률적이고 체계적인 실험 및 통계적인 분석을 통해서 원통세라믹의 고정도 표면생성을 위한 최적래핑조건을 찾아내었다.

• Journal of the East Asian Society of Dietary Life
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• v.21 no.5
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• pp.713-722
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• 2011

This study was conducted to monitor the quality characteristics of Acai (Euterpe oleracea Mart.) ethanolic extracts by a response surface methodology. The independent variables in the extraction experiments were ethanol concentration (0~100%), extraction temperature ($35{\sim}95^{\circ}C$), and ratio of solvent to sample (10~30 mL/g). The coefficients of determinations ($R^2$) were 0.9596 (p<0.01), 0.9356 (p<0.01), and 0.8842 (p<0.05) for total polyphenol, total flavonoid, and electron donating ability, respectively. The electron donating ability and nitrite scavenging effect improved with an increase in ethanol concentration as opposed to extraction temperature. Anthocyanin content with extraction conditions was 74.421~291.841 mg/L and the coefficient of determinations ($R^2$) was 0.9792 (p<0.01). ORAC (oxygen radical absorbance capacity) with extraction conditions was 137.73~562.94 ${\mu}moles$ TE/g and increased with an increase in ethanol concentration and a decrease in the ratio of solvent to sample content. Estimated conditions for maximum extraction including yield, total polyphenol, total flavonoid, electron donating ability, anthocyanin content, and ORAC were 28~58% for ethanol concentration, $60{\sim}68^{\circ}C$ for extraction temperature, and 10~12 mL/g for ratio of solvent to sample.

• 수도
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• v.24 no.4 s.85
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• pp.39-46
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• 1997

실험실 규모의 연구를 확대한 Pilot-Plant연구는 Bromate 감소에 대한 다양한 수질 문제에 대응할 수 있었다. 이러한 연구를 통해 산성하에서 $Fe^{2+}$을 주입시 Bromate가 감소됨을 확인하였다. 그러나 이러한 반응은 느린 반응이었으며, 온도에 의존하는 반응이었다. 단독응집제로서 $Fe^{2+}$은 탁도를 증가시켰다. 따라서 탁도를 제어하기 위해 $Fe^{2+}$를 주입하였다. $Fe^{2+}$/$Fe^{3+}$응집제의 조합으로 TOC를 제거할 수 있었다. 초기 결과를 통해 이러한 공정은 매우 면밀히 추진되어야 하며, 모든 온도에서 적용될 수 없었다. 현재까지 얻어진 결과에 의하면 오존처리함으로서 발생되는 Bromate를 최소화하는 방안은 낮은 pH조건과 $Fe^{2+}$의 주입이다. 최종 처리수에서 입자상물질과 철을 최소화하기 위해서는 pH 등과 같은 조건들을 변화시켜 여과공정 이전에 잔류 $Fe^{2+}$를 산화시킬 수 있도록 초기에 최적화가 이루어 져야 한다.

• Korean Journal of Food Science and Technology
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• v.32 no.1
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• pp.117-124
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• 2000

Considering the thermal unstableness of ginseng components, microwave-assisted extraction(MAE) was performed under the atmospheric pressure condition. The monitoring of extraction characteristics and the optimization of extraction conditions were made by response surface methodology. The extraction efficiency of soluble ginseng components was high at lower ethanol concentration and at higher microwave power, while crude saponin content was easily extracted at higher ethanol concentration. Estimated conditions for the maximized extraction of soluble components including crude saponin, total phenolics and electron donating ability were $54{\sim}60%$ in ethanol concentration, $41{\sim}90$ W in microwave power, and within 4 min in extraction time. Predicted values at the optimum condition(60% ethanol, 80 W microwave power and 4 min extraction time) were in good agreement with observed values.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.8
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• pp.986-996
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• 2017

In this study, we optimized fermentation conditions for burdock vinegar by response surface methodology. We confirmed the fermentation characteristics and major components of burdock vinegar. Alcohol fermentation of burdock extract added with 15% apple concentrates for vinegar production was performed. Consequently, 6.4% alcohol was produced after 5 days of fermentation. Central composite design was applied to investigate the effects of two independent variables, fermentation time (5~17 days; X1) and fermentation temperature ($26{\sim}34^{\circ}C$; X2), on fermentation of burdock vinegar. Fermentation conditions were optimized using characteristics of fermentation broth as a dependent variable. Acetic acid contents of dependent variables were 3.85~4.73% during acetic acid fermentation. The correlation coefficient ($R^2$) of the derived equation from the response surface regression for acetic acid contents was 0.9850 with significance level of 1%. Arctiin contents of all fermentation samples were 0.37~0.50 mg/100 mL, with an $R^2$ value of 0.8380 and significance level of 5%. We elicited a regression equation for each variable and superimposed the optimum area of fermentation conditions for characteristics and effective constituent contents of the fermentation broth. The predicted values for the optimum fermentation conditions for burdock vinegar were at $31^{\circ}C$ and 16 days.