• Journal of the Society of Cosmetic Scientists of Korea
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• v.37 no.1
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• pp.43-53
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• 2011

The conditions in fluid-bed processor for nanoencapsulation of azelaic acid-milk nano powder for acne nanocosmetics were optimized by response surface methodology (RSM). The maximum value of yield was 70.97 %. The yield was appreciably influenced by inlet air temperature, atomizing pressure, and feeding speed. The particle size increased with an increase in the feeding speed and a decrease in the atomizing pressure. The elution rate in saline solutions was appreciably influenced by inlet air temperature and atomizing pressure. The moisture content increased with higher atomizing pressure, which was demonstrated to be similar to the nanoencapsulation characteristics related to water activity. The Hunter's L and b values increased with an increase in the inlet air temperature. The optimum conditions estimated by RSM for the maximized values of yield, moisture content, particle size and elution rate in skin suitability were $67{\sim}73^{\circ}C$ of inlet air temperature, 0.6 ~ 0.8 mL/min feeding speed and 1.8 ~ 2.0 kg/$cm^2$ of atomizing pressure, respectively. These estimated values were in agreement with those measured by real experiments.

• Korean Journal of Food Science and Technology
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• v.45 no.2
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• pp.137-141
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• 2013

Flavonoids have various biological activities; however, their cellular uptake mechanism is beginning to be understood only recently. This review focuses on cellular flavonoids transport mechanisms in both plants and animals. In plants, flavonoids exist in various cellular compartments, providing a specialized transport system. Newly synthesized flavonoids can be transported from the endoplasmic reticulum to the vacuoles or extracellular space via cellular trafficking pathway. Among membrane transporters, ATP binding cassette, multidrug and toxic extrusion, bilitranslocase homologue transporters play roles in both the influx and efflux of cellular flavonoids across the cell membrane. In recent years, extensive researches have provided a better understanding on the cellular flavonoid transport in mammalian cells. Bilitranslocase transports flavonoids in various tissues, including the liver, intestine and kidneys. However, other transport mechanisms are largely unknown and thus, further investigation should provide detailed mechanisms, which can potentially lead to an improved bioavailability and cellular function of flavonoids in humans.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.52 no.6
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• pp.571-579
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• 2019

Surimi has been widely investigated for developing fish snacks; however, few studies have examined the optimal drying conditions of surimi for fish snacks. This study used a response surface methodology to optimize the drying conditions for the overall acceptance of fish snacks. The drying temperature (X₁, 51-65℃) and drying time (X₂, 1.5-2.5 h) were chosen as independent variables. The dependent variables were overall acceptance (Y₁, points), hardness (Y₂, N), moisture content of the dried intermediate product (Y₃, %), and volatile basic nitrogen of the fried final product (Y₄, mg/100 g). The estimated optimal conditions for overall acceptance (Y₁) were X₁=64℃ and X₂=2 h. The predicted values of the dependent variables at the optimal conditions were overall acceptance (Y₁)=8.60 points, hardness (Y₂)=10.07 N, and moisture content of the dried intermediate product (Y₃)=10.00% and were similar to the experimental values. Scanning electron microscopy images revealed that the drying conditions affected the microstructure of the fish snacks. Our results could be used to increase the productivity of fish snacks made by small- and mid-sized seafood companies.

• Korean Journal of Food Science and Technology
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• v.45 no.4
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• pp.441-450
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• 2013

The purpose of this study was optimization of the conditions for mixing different amounts of red radish (Raphanus sativus L.) sprout powder, butter, and sugar when baking domestic wheat cookies prepared using red radish sprout powder. Response surface methodology, with a central composite design comprising 5 levels and 3 variables, was used to identify the best possible combination of amounts of red radish sprout powder ($X_1$), butter ($X_2$), and sugar ($X_3$). The physical and mechanical properties of each of the 20 samples analyzed, including color L (p<0.001), color a (p<0.01), color b (p<0.001), spread ratio (p<0.001), and hardness (p<0.01), differed significantly. The results of sensory evaluations, including color (p<0.001), appearance (p<0.001), texture (p<0.001), flavor (p<0.01), taste (p<0.001), and overall quality (p<0.001) also differed significantly among the samples. The optimal compositional ratios were 5.15 g for the red radish sprout powder, 64.84 g for the butter, and 47.18 g for the sugar.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.3
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• pp.307-311
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• 2014

2,3,5-Triphenyltetrazolium chloride (TTC) is used as a redox indicator in culture media. It is colorless in the oxidized form and is reduced to formazan, an insoluble pigment, by dehydrogenases in actively growing microbial cells. The aim of this study was to assess by microbial test of the pathogenic microorganisms using TTC reduction. The pathogenic microorganisms were reduced in medium by dehydrogenase to produce insoluble red formazan. We observed that the optimization method of TTC allowed more than 12 h incubation in 0.04% concentration. Also, the growth of microorganisms with media was increased formazan production. We confirmed that microorganisms were quickly observed to grow colonies cultured red color without affecting the growth of microorganisms. It is suggested that the microbial test using TTC can provide better and quicker test method in cosmetics development.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.559-559
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• 2013

KSTAR (Korea Superconducting Tokamak Advanced Research) 장치는 차세대 에너지원 중의 하나인 핵융합로를 위한 과학기술 기반을 마련하기 위해 개발된 중형급 토카막 실험장치로서 토카막 운전 영역의 확장과 안정성 확보, 정상상태 운전 도달을 위한 방법 연구, 최적화된 플라즈마 상태와 연속 운전 실현 등을 주요 목표로 하고 있다. 이를 위해 핵융합 반응에 의한 점화조건과 가까운 상태로 플라즈마를 가열해주어야 하며, 토카막 장치의 저항가열 이외에도 외부에서 추가 가열이 반드시 필요하다. 중성 입자빔 입사 장치는 현재 토카막에서 사용되고 있는 가열장치 중 가장 신뢰성있는 추가 가열 장치라 할 수 있으며 한국 원자력연구원에서는 1997년부터 KSTAR 토카막 실험 장치에 사용될 중성 입자빔 입사 장치를 개발해왔었다. 중성빔 입사 장치는 크게 이온원, 진공함, 열량계, 진공 펌프, 중성화 장치, 이온덤프와 전자석으로 이루어져 있으며, 이중 이온원은 중성빔의 성능을 좌우하는 핵심적인 장치라 할 수 있다. 최근 한국원자력연구원에서는 2 MW 중성 입자빔 입사장치용 이온원 개발을 완료하여 KSTAR 토카막 장치에 설치하였으며, 2013년 현재 KSTAR에는 총 두 개의 이온원이 장착되어 최대 약 3 MW 이상의 중수소 중성 입자빔을 입사하여 KSTAR 토카막 실험의 H-mode 달성과 운전 시나리오 연구에 많은 기여를 하고 있다. 한국원자력연구원에서 최초로 개발된 이온원은 미국 TFTR 장치에서 사용되었던 US LPIS (Long Pulse Ion Source)를 기본으로 하여 국내 개발을 수행하였다. 이 온원은 크게 플라즈마를 발생시키는 플라즈마 발생부와 발생된 이온을 인출 및 가속시키는 가속부로 구성되는데, 개발과정에서 가장 먼저 KSTAR의 장주기 운전에 적합하도록 플라즈마 방전부와 가속부의 냉각회로를 요구되는 열부하에 맞게 설계 수정하였다. 그 후 플라즈마 방전부는 방전 시간과 안정성, 플라즈마 밀도의 균일도, 정격 운전, 방전 효율 등을 고려하여 수정 보완하며 개발을 진행하여왔다. 가속부의 경우 국내 제작기술의 한계를 극복하기 위해 빔 인출그리드를 TFTR의 US LPIS 모델의 슬릿형 그리드 타입에서 원형 인출구 타입으로 변경하였으며, 이후 가속 전극의 고전압 내전력 문제, 빔 인출 전류와 전력, 인출 빔의 광학적 질(quality), 빔 인출 시간 동안의 안정성 등을 위해 그리드의 크기와 간격, 모양 등을 변경하여 개발을 수 행하여 왔다. 이 논문은 한국원자력연구원에서 개발이 진행되어 왔던 이온원들을 시간적으로 되짚어 보면서 현재까지의 성과와 문제점, 그리고 앞으로의 개발 방향에 대해 논의하고자 한다.

• KSBB Journal
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• v.11 no.6
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• pp.663-668
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• 1996

In the production of recombinant protein using E. coli, phage lysogen system can be usefully applied for simultaneously achieving protein production at high cell concentration and recovery by cell disruption in the same bioreactor. A major drawback of this system is that the intracellular product and complex broth components are mixed together in culture broth and hence purification efficiency is reduced. With the E. coli double-lysogen system, the expanded bed adsorption is very useful because the pretreatment processes in a routine bioseparation process can be done in a single column operation, and therefore may contribute towards lowering the operating cost of overall recovery/purification process. In the operation of EBA, it has been observed that the change in broth feed volume does not influence much the protein recovery in a tested range. The amount of protein adsorption per mL of resin was increased from $3.44{\times}106unit to 5.28{\times}106unit$ by doubling the column length. By two-fold increase of the column diameter, the ratio of protein concentration in eluent to that in feed was increased from 0.8 to 2.1. It is concluded from the present investigation that the increase of column length and diameter is necessary to enhance the protein adsorption amount per volume of resin and protein concentration in the eluent. The development of resins with various physical properties will be necessary for more extensive application of EBA.

• Korean Chemical Engineering Research
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• v.46 no.5
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• pp.880-885
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• 2008

Spray pyrolysis was applied to prepare spherical silica particles with mesopores of a regular structure. The physical properties such as surface area, pore size, pore structure, particle size, and morphology were studied by BET, SEM, SAXS, and DLS analysis. At a fixed gas flow rate, the BET surface area changed from 200 to $1,290m^2/g$ as changing the CTAB/TEOS molar ratio from 0.05 to 0.3. At a fixed CTAB/TEOS ratio, the surface area of silica particles was varied from 1,062 to $1,305m^2/g$ with changing the gas flow rate from 10 to 40 l/min. The average pore size measured by BJH desorption was about $21{\sim}23{\AA}$ and not significantly influenced by the CTAB/TEOS ratio and the gas flow rate. Finally, the highest surface area which was $1,305m^2/g$ were obtained when the CTAB/TEOS ratio and the gas flow rate were 0.2 and 20 l/min, respectively. According to SAXS analysis, the prepared silica particles showed a strong peak at $2{\theta}=2.6^{\circ}$ and two minor peaks around $2{\theta}=4.4^{\circ}$ and $5.1^{\circ}$, which are due to regular mesopores of hexagonal structure. The morphology of silica particles prepared were spherical shape and the average particle size was $1.0{\mu}m$.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2003.05a
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• pp.55-55
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• 2003

최근 높은 해상도의 평판 디스플레이 장치 특히 차세대 TFT-LCD를 개발하기 위해서는 건식식각공정의 개발이 필수 불가결하며 이는 플라즈마 공정장치의 대면적화가 가능해야 한다. 따라서 산업계는 이러한 제조 조건에 알맞는 대면적 플라즈마 반응기 개발을 추구하고 있다. 이를 위해서는 건식식각공정의 개발이 필수 불가결하며 이를 위해선 플라즈마 공정장 치의 대면적화가 가능해야 한다. 이러한 대면적 공정을 위해서는 낮은 공정압력, 고밀도, 높은 플라즈마 균일도가 요구된다. 또한 이러한 대면적 고밀도 플라즈마에의 적용을 위하여 새로운 유도결합형 플라즈마 소오스의 개발이 진행되고 있으며, 안정적인 300mm웨이퍼 공정을 위하여 여러 형태의 안테나가 연구되어지고 있다. 그러나 차세대 TFT-LCD에 적용 가 능하게끔 기존의 ICP 소오스를 직접적으로 대면적화 하는데 있어서는 안테나의 인덕턴스의 값이 키지며, 유전물질의 두께 증가 및 그에 따른 재료비의 상슴에 의해 그 한계점을 나타 내었다. 본 연구에서는 차세대 TFT-LCD 및 POP 대면적 공정에 적용 가능한 고밀도 플라즈마를 발생시키기 위해서 내장형 유도결합형 선형 안테나를 사용하였다. 내장형 유도결합형 선형 안테나가 가지고 있는 고유의 정전기적 결합효과를 최소화시키기 위해 직사각형모양의 플라즈마 챔버(830mm*1,020mm)에서 영구자석을 사용하였다. 영구자석을 사용하여 외부자 장을 인가하였을 때가, 그럴지 않은 때보다 RF 안테나에 걸리는 코일의 전압을 낮춰주었으며, 영구자석의 배열에 따라 코일의 인덕턴스의 값이 크게 변함을 알 수 있었다. 그리고, 최적화된 자장의 배열은 플라즈마의 이온밀도를 증가시켰으며, 플라즈마 균일도 또한 10% 이 내로 유지됨을 알 수 있었다. 따른 식각 메커니즘에 대하여 알아보고자 하였다. $CF_4/Cl_2$ gas chemistry 에 첨 가 가스로 $N_2$와 Ar을 첨 가할 경 우 텅 스텐 박막과 하부 layer 간의 etch selectivity 증가는 관찰되지 않았으며, 반면에 첨가 가스로 $O_2$를 사용할 경우, $O_2$의 첨가량이 증가함에 따라 etch s selectivity 는 계속적으로 증가렴을 관찰할 수 있었다. 이는 $O_2$ 첨가에 따라 형성되는 WOF4 에 의한 텅스텐의 etch rates 의 감소에 비하여, $Si0_2$ 등의 형성에 의한 poly-Si etch rates 이 더욱 크게 감소하였기 때문으로 사료된다. W 과 poly-Si 의 식각 특성을 이해하기 위하여 X -ray photoelectron spectroscopy (XPS)를 사용하였으며, 식각 전후의 etch depth 를 측정하기 위하여 stylus p pmfilometeT 를 이용하였다.X> 피막이 열처리 전후에 보아는 기계적 특성의 변화 양상은 열역학적으로 안정한 Wurzite-AlN의 석출에 따른 것으로 AlN 석출상의 크기에 의존하며, 또한 이러한 영향은 $(Ti_{1-x}AI_{x})N$ 피막에 존재하는 AI의 함량이 높고, 초기에 증착된 막의 업자 크기가 작을 수록 클 것으로 여겨진다. 그리고 환경의 의미의 차이에 따라 경관의 미학적 평가가 달라진 것으로 나타났다.corner$적 의도에 의한 경관구성의 일면을 확인할수 있지만 엄밀히 생각하여 보면 이러한 예의 경우도 최락의 총체적인 외형은 마찬가지로

• Journal of the Korean Society for Railway
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• v.18 no.6
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• pp.543-551
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• 2015

Quick-hardening track (QHT) is a construction method which is used to change from old ballast track to concrete track. Sufficient time for construction is important, as the construction should be done during operational breaks at night. Most of the time is spent on exchanging the ballast layer. If it is possible to apply the ballast non-exchange type of quick-hardening track, it would be more effective to reduce the construction time and costs. In this paper, pouring materials with high permeability are suggested and a construction method involving a layer separation pouring process considering the void condition is introduced in order to develop ballast non-exchange type of QHT. The separate pouring method can secure the required strength because optimized materials are poured into the upper layer and the lower layer for each void ratio condition. To ensure this process, a rheology analysis was conducted on the design of the pouring materials according to aggregate size, the aggregate distribution, the void ratio, the void size, the tortuosity and the permeability. A polymer series was used as the pouring material of the lower layer to secure the void filling capacity and for adhesion to the fine-grained layer. In addition, magnesium-phosphate ceramic (MPC) was used as the pouring material of the upper layer to secure the void-filling capacity and for adhesion of the coarse-grained layer. As a result of a mechanics test of the materials, satisfactory performance corresponding to existing quick-hardening track was noted.