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http://dx.doi.org/10.9721/KJFST.2013.45.2.137

Cellular Flavonoid Transport Mechanisms in Animal and Plant Cells  

Han, Yoo-Li (Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology)
Lee, So-Young (Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology)
Lee, Ji Hae (Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology)
Lee, Sung-Joon (Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology)
Publication Information
Korean Journal of Food Science and Technology / v.45, no.2, 2013 , pp. 137-141 More about this Journal
Abstract
Flavonoids have various biological activities; however, their cellular uptake mechanism is beginning to be understood only recently. This review focuses on cellular flavonoids transport mechanisms in both plants and animals. In plants, flavonoids exist in various cellular compartments, providing a specialized transport system. Newly synthesized flavonoids can be transported from the endoplasmic reticulum to the vacuoles or extracellular space via cellular trafficking pathway. Among membrane transporters, ATP binding cassette, multidrug and toxic extrusion, bilitranslocase homologue transporters play roles in both the influx and efflux of cellular flavonoids across the cell membrane. In recent years, extensive researches have provided a better understanding on the cellular flavonoid transport in mammalian cells. Bilitranslocase transports flavonoids in various tissues, including the liver, intestine and kidneys. However, other transport mechanisms are largely unknown and thus, further investigation should provide detailed mechanisms, which can potentially lead to an improved bioavailability and cellular function of flavonoids in humans.
Keywords
flavonoid; transport; animal cell; plant cell; transporter;
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