• Proceedings of the Korea Society for Energy Engineering kosee Conference
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• 1993.11a
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• pp.82-87
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• 1993

산업폐기물 소각시스템으로 현재 널리 이용되고 있는 대형 로타리 킬른형 소각로를 모델로 선정하여 소각로 설계에 필요한 제반변수에 대한 영향을 슈퍼컴퓨터를 이용하여 분석하였다. 화염억제 작용이 있으며 소각처리시 유독물질을 배출하는 $CCl_4$를 폐기물로 주입하는 경우 비평형 난류반응모델을 도입하여 반응장 해석을 한 결과 실험결과와 정성적으로 일치된 결과를 얻을 수 있었다.

• Proceedings of the KAIS Fall Conference
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• 2000.10a
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• pp.178-180
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• 2000

제올라이트의 결정성장은 유도기와 결정성장기 안정화기의 3단계로 진행한다 이러한 제올라이트의 결정성장 기구를 이해하고 결정의 성장기를 계속적으로 연장함으로서 조대한 NaX 제올라이트 결정의 성장을 유도하였으며, 선형결정성장속도에 대하여 고찰하였다. NaX 제올라이트의 수열합성 과정 중 결정성장기에 일정하게 3일 간격으로 반응용액내의 액상을 분리하고 반응겔을 보충하여 제올라이트의 합성 반응이 안정화기로 진행하는 것을 억제하고 결정 성장기를 연장하여 30㎛ 이상의 NaX 제올라이트 결정을 얻었다.

• Journal of Life Science
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• v.21 no.7
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• pp.969-975
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• 2011

We focused on relationship between phytohormones and AtEXPA3 gene in gravitropic response of A. thaliana. RT-PCR analysis shows that AtEXPA3 was highly expressed in actively developing tissues such as leaf, rosette, root and flower tissues. AtEXPA3 gene expression was enhanced by gravistimulation, BR and IAA. Furthermore, decreased gravitropism was observed when treatment of AVG, an ethylene biosynthetic inhibitor, suggesting that ethylene has a gravistimulating effect itself as well as BRs and IAA. Inhibition of gravitropism in AtEXPA3 RNAi mutant suggests that BR, auxin and ethylene are playing roles as regulators of AtEXPA3. In addition, altered gravitropism in BRs signaling mutant (decreased in bri1-301, bak1, and increased BRI-GFP) indicated that BRs signaling mediated the gravitropism. In conclusion, gravitropic responses of Arabidopsis root resulting from root growth were mediated by increased expression of AtEXPA3 gene, which is stimulated by phytohormones.

• Korean Journal of Cognitive Science
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• v.20 no.1
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• pp.29-49
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• 2009

The purpose of the present research was to examine whether the parietal pathway and the temporal pathway were responsible for the phenomena of the inhibition of return and the facilitation of return respectively and at what stage of the information processing they occurred. The response time and the ERPs(event-related potentials) were examined in the two conditions(the valid condition and the invalid condition) while subjects were doing detection task, location discrimination task, color discrimination task and orientation discrimination task in separate sessions. No significant response time difference was found between the valid and the invalid conditions when subjects did the detection task as well as the location discrimination task. However, significant response time difference was found when they did the color discrimination as well as the orientation discrimination task. Futhermore, there was a significant difference of ERP difference between the two conditions in the Pz area when subjects were doing location discrimination task and significant difference was found in the T7 area when they were doing color discrimination task and marginal difference was found in T7/T8 area when they were doing orientation discrimination task just before they responded. These results imply the possibility that both the inhibition of return and the facilitation of return occur in the parietal and in the temporal pathway respectively in the late stage of information processing.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.9
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• pp.1226-1234
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• 2012

3,4,3',5'-Tetrahydroxy-trans-stilbene (piceatannol) is a derivative of resveratrol with a variety of biological activities, including anti-inflammatory, anti-proliferative, and anti-cancer activities. We assessed the mechanisms by which piceatannol inhibits inflammatory responses using lipopolysaccharide (LPS)-treated Raw264.7 murine macrophages. Piceatannol (0~10 ${\mu}mol/L$) decreased LPS-induced release of nitric oxide, tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6, IL-$1{\beta}$, and inhibited LPS-induced protein expression of inducible nitric oxide synthase (iNOS). Activation of nuclear factor-kappaB (NF-${\kappa}B$), activator protein (AP)-1, and signal transducer and activator of transcription 3 (STAT3) are crucial steps during an inflammatory response. Piceatannol prevented LPS-induced degradation of inhibitor of ${\kappa}B$ ($I{\kappa}B$), translocation of p65 to the nucleus, and phosphorylation of stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK). Additionally, piceatannol inhibited LPS-induced phosphorylation of STAT3 and IL-6-induced translocation of STAT3 to the nucleus. Furthermore, piceatannol increased the protein and mRNA levels of hemeoxygenase (HO)-1, the rate-limiting enzyme of heme catabolism that plays a critical role in mediating antioxidant and anti-inflammatory effects. Piceatannol further induced antioxidant response elements (ARE)-driven luciferase activity in Raw264.7 cells transfected with an ARE-luciferase reporter construct containing the enhancer 2 and minimal promoter region of HO-1. These results suggest that piceatannol exerts anti-inflammatory effects via the down-regulation of iNOS expression and up-regulation of HO-1 expression.

• Korean Journal of Food Science and Technology
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• v.21 no.3
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• pp.435-440
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• 1989

The present study was attempted to investigate the mutagenicities of carbonyl compounds(methyl glyoxal, glyoxal, diacetyl, dihydroxyacetone, glycolaldehyde, glyceraldehyde and furfural) derived from Maillard reaction toward Salmonella typhimurium TA 100(base-substitution mutant) without metabolic activation . And for further Investigation of mutagenicity mechanism including desmutagenicity, active oxygen scavengers (cysteine, ${\alpha}-tocopherol$, tris (hydroxymethyl) aminomethane, catalase, ascorbic acid) and reducing agents (glutathione, sodium bisulfite) were also used. Among carbonyl compounds tested, methyl glyoxal, glyoxal, dihydroxyacetone, glycolaldehyde and glyceraldehyde exhibited mutagenicities, and methyl glyoxal showed the strongest mutagenic activity. On the other hand , the mutagenicities of carbonyl compounds were significantly suppressed by cysteine, tris (hydroxymethyl) aminomethane, glutathione and sodium bisulfite. Also, these active oxygen scavengers and reducing agents alone did not show mutagenicity in the present study.

• Journal of Nutrition and Health
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• v.50 no.1
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• pp.25-31
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• 2017

Purpose: Neuroinflammation is mediated by activation of microglia implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Inhibition of neuroinflammation may be an effective solution to treat these brain disorders. Petalonia binghamiae is known as a traditional food, based on multiple biological activities such as anti-oxidant and anti-obesity. In present study, the anti-neuroinflammatory potential of Petalonia binghamiae was investigated in LPS-stimulated BV2 microglial cells. Methods: Cell viability was measured by MTT assay. Production of nitric oxide (NO) was examined using Griess reagent. Expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) was detected by Western blot analysis. Activation of nuclear factor ${\kappa}B$ ($NF-{\kappa}B$) signaling was examined by nuclear translocation of $NF-{\kappa}B$ p65 subunit and phosphorylation of $I{\kappa}B$. Results: Extract of Petalonia binghamiae significantly inhibited LPS-stimulated NO production and iNOS/COX-2 protein expression in a dose-dependent manner without cytotoxicity. Pretreatment with Petalonia binghamiae suppressed LPS-induced $NF-{\kappa}B$ p65 nuclear translocation and phosphorylation of $I{\kappa}B$. Co-treatment with Petalonia binghamiae and pyrrolidine duthiocarbamate (PDTC), an $NF-{\kappa}B$ inhibitor, reduced LPS-stimulated NO release compared to that in PB-treated or PDTC-treated cells. Conclusion: The present results indicate that extract of Petalonia binghamiae exerts anti-neuroinflammation activities, partly through inhibition of $NF-{\kappa}B$ signaling. These findings suggest that Petalonia binghamiae might have therapeutic potential in relation to neuroinflammation and neurodegenerative diseases.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.1
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• pp.45-55
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• 2015

Ultraviolet B (UVB) irradiation induces both production of reactive oxygen species (ROS) and glucocorticoids (GCs)-mediated stress responses such as an increase of $11{\beta}$-hydroxysteroid dehydrogenase type 1 ($11{\beta}$-HSD1) activity in skin. In addition, ROS-induced inflammatory mediators and proinflammatory cytokines trigger skin inflammation. In this study, as $11{\beta}$-HSD1 inhibitor recovered a decrease of catalase expression, we investigated whether Trapa japonica (TJ) extract and its fractions could inhibit $11{\beta}$-HSD1/ROS-induced skin inflammation in HaCaT keratinocytes. TJ extract and its fractions inhibited expressions of $11{\beta}$-HSD1 as well as the increase of ROS in UVB-exposed HaCaT keratinocytes. Moreover, proinflammatory cytokines such as interleukin (IL)- ${\alpha}$, - ${\beta}$ and tumor necrosis factor (TNF)-${\alpha}$, and cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) as inflammatory mediators were also inhibited in both mRNA and protein levels. Finally, prostaglandin $E_2$ ($PGE_2$) produced by COX-2 was inhibited effectively by TJ extract and its fractions. Taken together, these results suggest that TJ extract could be a potential anti-inflammatory ingredient to inhibit UVB-induced inflammation in skin.

• Anatomy & Biological Anthropology
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• v.31 no.4
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• pp.143-149
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• 2018

Leucocyte extravasation has been known to play an important role in inflammatory reactions including contact dermatitis. Previous studies suggested that CD99 regulates ${\beta}1$ integrin activity and may be a novel therapeutic target molecule for inflammatory diseases. In this study, the effects of CD99-derived peptide, CD99CRIII3, on inflammatory reactions in contact dermatitis mouse model were investigated. CD99CRIII3 decreased ${\beta}1$-integrin activity in human monocytic U937 cells. CD99CRIII3 inhibited the adhesion of U937 monocytes to human umbilical vein endothelial cells and their extravasation through human umbilical vein endothelial cells. CD99CRIII3 reduced inflammation in the phorbol myristate acetate-induced contact dermatitis mice in a dose-dependent manner. These results indicate that CD99CRIII3 suppresses the extravasation of monocytes and inflammatory reactions in the animal model of the contact dermatitis, suggesting that CD99CRIII3 could be a new drug candidate against inflammatory skin diseases.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.77.2-77.2
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• 2010

일산화탄소를 수소로 변환하는 수성가스전환반응(WGSR)은 수소 생산, 연료개질 시스템뿐만 아니라 암모니아 제조, 제철소 제련과정등 일선 산업현장에서 널리 활용되고 있다. 상용공정에서의 WGS반응은 두 단계의 반응기(HTS/LTS)에서 각각 Fe/Cr, Cu/Zn기반 촉매를 사용하여 이루어진다. 하지만 이러한 촉매들은 공기중 자연발화성이 있고 사용전 환원과정이 필요하다. 또한 최근에 많은 연구가 진행되고 있는 귀금속 담지 촉매는 기존 촉매의 단점을 극복하고 활성이 높은 장점이 있다. 이에 본 연구에서 제시한 페로브스카이트 촉매는 상용 촉매, 귀금속 담지촉매 시스템과의 비교를 위하여 제작된 촉매를 사용한 반응시스템과 기존 상용촉매를 사용한 반응시스템을 비교하여 개발 촉매의 성능 수준을 검토하였다. 이러한 결과 페로브스카이트 구조 촉매는 상용촉매의 공정상의 단점과 귀금속 담지촉매의 가격적인 측면에서의 단점을 동시에 극복한 촉매로서 성능 및 메탄화반응 억제 측면에서 우수성을 보유하고 있다는 것을 증명하였다. 이러한 페로브스카이트 구조 촉매의 반응특성을 규명하기 위해 문헌조사해본 결과 기존 수성가스전환반응에서 쓰이는 촉매들의 반응매카니즘은 대표적으로 formate와 redox 반응 두가지가 있었다. 페로스브스카이트 구조 촉매는 그 구조와 귀금속 함량, 활성 등 성능측면에서 귀금속 촉매와 상당히 유사한 측면이 있기 때문에 귀금속 담지 촉매의 반응속도식을 기본으로 하여 실험결과와 일치시켜 페로브스카이트구조 촉매에 맞는 반응속도식을 제시하고 이를 통한 반응파라미터 값을 도출하였다.