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SPECT Imaging of Dopamine Transporter with $[^{123}I]{\beta}$-CIT: A Potential Clinical Tool in Parkinson's Disease (파킨슨병에서 $[^{123}I]{\beta}$-CIT SPECT를 이용한 도파민 운반체 영상)

  • Kim, Sang-Eun;Lee, Won-Yong;Chi, Dae-Yoon;Choe, Yearn-Seong;Lee, Kyung-Han;Choi, Yong;Oh, Seung-Jun;Kim, Byung-Tae
    • The Korean Journal of Nuclear Medicine
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    • v.30 no.1
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    • pp.19-34
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    • 1996
  • [ $[^{123}I]{\beta}$ ]-CIT [$2{\beta}$-carbomethoxy-$3{\beta}$-(4-iodophenyl)tropane]는 도파민 운반체 (dopamine transporter)에 특이결합하며 $[^{123}I]{\beta}$-CIT의 도파민 운반체 결합정도는 파킨슨병에서 도파민 뉴우런의 변성정도를 반영하는 것으로 제안되어 왔다. 이 연구의 주요 목적은 파킨슨병 환자에서 $[^{123}I]{\beta}$-CIT SPECT를 이용하여 측정된 $[^{123}I]{\beta}$-CIT의 선조체 결합지표들이 질병의 임상적 진행정도를 반영하는지를 검토하고, 간편화된 조직방사능비가 $[^{123}I]{\beta}$-CIT의 결합정도를 나타내는 정량적 지표로 이용될 수 있는지를 검증하는 것이었다. 파킨슨병 환자 30명($59{\pm}9$세, 평균${\pm}$표준편차: Hoehn-Yahr stage 1-3)과 정상인 6명 ($58{\pm}5$세)을 대상으로 $[^{123}I]{\beta}$-CIT SPECT 영상을 얻었다. $[^{123}I]{\beta}$-CIT 선조체 결합의 정량적 지표로서 (선조체 방사능-소뇌방사능)/소뇌방사능 비(specific binding ratio, SBR)와 추적자역학모델을 이용하여 측정한 선조체 결합능(binding potential)($k_3/k_4$)을 구하였다. 파킨슨병 환자에서 $[^{123}I]{\beta}$-CIT의 선조체 결합역학은 정상인에 비하여 현저하게 느렸으며 그 결합지표들은 정상인에 비하여 뚜렷하게 낮았다. 한편, 편측파킨슨병 환자에서 $[^{123}I]{\beta}$-CIT 결합은 증상 반대쪽 선조체 뿐만 아니라 같은 쪽 선조체에서도 정상인에 비해 유의하게 감소되어 있었다. 파킨슨병 환자에서 $[^{123}I]{\beta}$-CIT 투여 후 24시간의 선조체 SBR 및 최대 SBR, 선조체 결합능은 모두, 유병기간, Hoehn-Yahr stage, UPDRS(Unified Parkinson's Disease Rating Scale) 총점, UPDRS 운동점수, UPDRS 일상활동점수와 유의한 상관관계를 나타내었다. 24시간 선조체 SBR과 최대 SBR은 선조체 결합능과 우수한 상관관계를 보였다. 이상의 결과로부터 $[^{123}I]{\beta}$-CIT의 선조체 결합은 파킨슨병의 진행정도를 나타내는 지표로 이용될 수 있다. 또 $[^{123}I]{\beta}$-CIT 투여 후 24시간 영상으로부터 얻은 간편화된 조직방사능 비는 $[^{123}I]{\beta}$-CIT의 결합정도를 정량적으로 반영한다. $[^{123}I]{\beta}$-CIT SPECT는 파킨슨병의 조기진단 및 진행 추적에 임상적으로 유용할 것으로 판단된다.

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Persuasion Effects of Imagery Information Processing caused by Brand in Advertisement Design (광고디자인에 있어서 브랜드명에 의해 유발된 심상정보처리의 설득효과에 관한 연구)

  • Lee Jin-Ryeol;You Si-Cheon
    • Science of Emotion and Sensibility
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    • v.8 no.3
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    • pp.177-187
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    • 2005
  • This article examined how the amount of information presented in ad design affect consumer's evaluation on the ad Existing researches have mainly considered external information presented in the ad from the resource principle perspective. This study investigated how internal information processing such as imagery information processing caused by brand names moderates persuasion effects according to the amount of external information through two experiments. The experiments leave us the conclusion that brand names presented in the ads stimulate imagery information processing when surplus cognitive resources do exist and they lead ad recipients' evaluation to positive direction in prestige brand condition and to the contrary to negative direction in non-prestige brand condition. The results contribute to the direction of ad design in that ad needs not contain as muck product-related information as needed in order to increase persuasion effects in prestige brand condition. Rather, it's necessary to leave the room for internal information processing such as imagery information processing by well structured brand equity. On the contrary, non-prestige brand needs to contain explicit product-relevant information to exert a potent influence on a4 persuasion. We hope this study result is helpful for design direction of advertisement in order to heighten persuasion effects toward ad recipients.

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Scientific Creativity and Visual Artistic Creativity: The Domain-universality and Domain-specificity on Creative Accomplishment (과학적 창의성과 시각예술적 창의성: 창의적 성취 사례의 영역보편성 및 영역특정성)

  • Kang, Jung-Ha;Choe, In-Soo
    • Journal of Gifted/Talented Education
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    • v.18 no.2
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    • pp.201-237
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    • 2008
  • The object of this research is to understand the domain-universality and domain-specificity of scientific domain and visual art domain from case studies on individuals who had made creative accomplishments in the domain of science and visual art. For case studies, 10 people who made creative accomplishments in the science and technology domain and 9 people who made creative accomplishments in the visual art domain were selected as the research participants. The conclusions for the case studies were made on the data obtained from interviewing the research participants using KES as an analytical frame. The findings of this study support as follows. Creativity on scientific domain and visual art domain is both the domain-universality and domain-Specificity. The domain-universality Of scientific domain and visual art domain is related to the nature of human beings, originality in creativity, and the natural selection. On the other hand, The domain-specificity of scientific domain and visual art domain is related to the type of knowledge and the context of applying the knowledge, will, thinking skill, direction, and social components.

Effectiveness of the Internet Real-Name Verification Law: Evidence from Self-censorship and Intention to Detour the Regulation (인터넷실명제와 우회로의 선택: 인터넷 공론장 참여자들의 자기검열과 우회로 선택의향을 중심으로)

  • Han, Hye-Kyung;Kim, Eu-Jong
    • Korean journal of communication and information
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    • v.55
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    • pp.50-73
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    • 2011
  • This paper investigates the effectiveness of Real-Name System on Internet, which has been applied to some Internet service provider bulletin boards in Korea. The goal of the Real-Name system on the Internet is controlling expression of slanderous or abusive language. The effectiveness of the regulation is dependent on the people's perceptions and attitude toward to the legislation. This empirical study examines the antecedents that affect the perceptions and attitude toward the regulation. Further, we investigate the relationships among variables such as internet public sphere participation, attitude to the regulations, and intention to choose detours. Results of regression analysis show that the younger and the more progressive individuals are, the more they oppose the implementation of the law. Also, it was found that people who have more political interest and participate more actively in public sphere via internet, tend to oppose the law. Structural equation models reveal that participation in online public sphere drives negative attitudes about the regulation. In addition, people with negative perceptions about the law tend to choose the detours such as 'cyber asylum' and 'service asylum'.

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A Study on the Warpage of Glass Fiber Reinforced Plastics for Part Design and Operation Condition: Part 1. Amorphous Plastics (유리섬유로 보강된 수지에서 제품설계 및 성형조건에 따른 휨의 연구: Part 1. 비결정성 수지)

  • Lee, Min;Kim, Hyeok;Lyu, Min-Young
    • Polymer(Korea)
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    • v.36 no.5
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    • pp.555-563
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    • 2012
  • Warpage of injection molded product is caused by non-uniform shrinkage during shaping operation and relaxation of residual stress. Robust part design and glass fiber reinforced reins have been adopted to prevent warpage of part. Warpages for part designs have been investigated in this study according to the injection molding conditions. Part design contains flat specimen and two different rib designs in the flat part. Resins used in this study were glass fiber reinforced amorphous plastics, PC and ABS. Different rib designs showed significant differences of warpages in the parts. Various warpages have been observed in the three regions of the part, near gate region, opposite region to the gate, and flow direction region. Results of computer simulation revealed that the warpages were strongly related to glass fiber orientation. Flat specimen showed the smallest warpage and the specimen with ribs to the flow direction showed a high resistance to warpage. Warpage highly depended upon part design rather than molding condition. It was concluded that the rib design and selection of gate location in injection molding would be the most important factors for the control of warpage since those are directly related to the fiber orientation during molding.

Study on the Coefficient of Thermal Expansion for Composites Containing 3-Dimensional Ellipsoidal Inclusions (3차원적 타원 형태의 충전제를 함유하는 복합체의 열팽창 계수 연구)

  • Lee, Kee-Yoon;Kim, Kyung-Hwan;Jeoung, Sun-Kyoung;Jeon, Hyoung-Jin;Joo, Sang-Il
    • Polymer(Korea)
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    • v.31 no.3
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    • pp.206-214
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    • 2007
  • The theoretical study is developed for predicting the thermal expansion changes of composites which include complex inclusion, which is used three-dimensional ellipsoid model ($a_1>a_2>a_3$), which has two aspect ratios (the primary aspect ratio, $\rho_{\alpha}=a_1/a_3$ and the secondary aspect ratio, $\rho_{\beta}=a_1/a_2$). We can predict the feature of general thermal expansion factors by theoretical approach of matrix with aligned ellipsoidal inclusion using the Eshelby's equivalent tensor. The coefficients of longitudinal linear thermal expansion ${\alpha}_{11}$ decrease to those of inclusions, ${\alpha}_f$, as both aspect ratios increase. The coefficients of transverse linear thermal expansion of composites ${\alpha}_{33}$ initially increase and show the parabolic corves with maximum values, as the concentrations of filler increase. The coefficient of thermal expansion, ${\alpha}_{22}$ in the transverse direction decreases, as $\rho_{\alpha}$ increases, however, ${\alpha}_{22}$ increases as $\rho_{\beta}$ increases. The coefficient of linear thermal expansion of composites, ${\alpha}_{33}$ in the normal direction increases, as $\rho_{\alpha}$ increases, while ${\alpha}_{33}$ decreases as $\rho_{\beta}$ increases.

Influence of Different Slope Analysis during Pitching Wedge Swing on Plantar Pressure Distribution Pattern (경사면에서 골프스윙 동작시 족저압력 분석)

  • Son, Dong-Ju;Yang, Jeong-Ok;Lee, Joong-Sook
    • Korean Journal of Applied Biomechanics
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    • v.19 no.2
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    • pp.297-309
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    • 2009
  • The study analyzed the mechanism of plantar foot pressure distribution during pitching wedge swinging on a flat, an up hill lie and a down hill lie to provide the fundamental information regarding biomechanical motion data by using plantar foot pressure measuring instrument. In the results, time factor spanning according to slope differences, plantar foot pressure factor and swing motion on the slope could have negative effect on the coiling of lower limbs during back swing, as well as the blocking of the lower limbs to minimize the dispersion of the weight and the release of the lower limbs after the impact during the down swing process. Moreover, since slope is one of many external factors affecting swing motion, address motion on an up hill lie limits the lower limbs movement, therefore, a relatively narrow stance is better on a down hill lie. It is estimated that a relatively wide stance would be better in order to limit the bigger activation of the lower limbs. Not only for the address motion but also during the down swing on an up hill lie it is concluded that the weight should be on the left foot in order to keep the body balance.

Development and Applications of Pore-filled Ion-exchange Membranes (세공충진 이온교환막의 개발 및 응용)

  • Kim, Do-Hyeong;Kang, Moon-Sung
    • Membrane Journal
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    • v.28 no.5
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    • pp.307-319
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    • 2018
  • Ion-exchange membrane (IEM) has fixed charge groups and is a separation membrane which is capable of selectively transporting ions of the opposite polarity. Recently, the interest in IEMs has been increasing as the importance of the desalination and energy conversion processes using them as the key components has increased. Since the IEMs determine the efficiency of the above process, it is necessary to improve the separation performance and durability of them and also to lower the expensive membrane price, which is a hindrance to the widening application of the IEM process. Therefore, it is urgent to develop high-performance and low-cost IEMs. Among various types of IEMs, pore-filled membranes prepared by filling ionomer into a porous polymer substrate are intermediate forms of homogeneous membranes and heterogeneous membranes. The production cost would be cheap like the case of heterogeneous membranes because of the use of inexpensive supports and the reduction of the amount used of raw materials, and at the same time, they exhibit excellent electrochemical characteristics close to homogeneous membranes. In this review, major research and development trends of pore-filled IEMs, which are attracting attention as high-performance and low-cost IEMs, have been summarized and reported according to the application fields.

An Analysis of Various Types of Social Movement Through the New Media -Focusing on the 2008 Candle Rally- (뉴미디어를 활용한 다양한 사회운동방식에 대한 고찰 -2008년 촛불집회를 중심으로-)

  • Lee, Chang-Ho;Bae, Ae-Jin
    • Korean journal of communication and information
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    • v.44
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    • pp.44-75
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    • 2008
  • The candle rally against the import of American beef which lasted for a long time was full of various types of social movement. That is, new media including mobile phone, Internet, Internet cafes played an important role in mobilizing people around the rally. Thus, this research focuses on the meaning and effect of these kinds of movement. In particular, it analyzed the possibility of real time broadcasting through the Internet as civic journalism, which received much attention in the rally. For this, this research used case study and interview as main research method. Case study focused on Internet cafes based on the media coverage of the rally. Interviews were conducted with workers at OhmyTV, Color TV, and 615TV. These workers at progressive media emphasized on the scene coverage as the advantage of real time delivery. Transmitting many citizens' voices was another advantage. It is expected that personal media and progressive media which try to show the scent as it is will play an important role in the future journalism with the expansion of Wibro.

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A Comparison of shear Bonding Strength with Polyacrylic acid and Phosphoric acid Enamel Surface Conditioning (폴리아크릴산과 인산으로 법랑질표면 처리후 전단결합강도의 비교)

  • Roh, Joung-Sub;Kim, Sang-Cheol
    • The korean journal of orthodontics
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    • v.32 no.1 s.90
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    • pp.51-57
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    • 2002
  • The purpose of this study was to compare in vitro shear bonding strength with three different enamel surface preparations (1) 30% sulfated polyacrylic acid with 0.3M lithium sulfate (2) 40% sulfated polyacrylic acid with 0.3M lithium sulfate (3) 37% phosphoric acid. 105 extracted human premolar teeth were divided into each three groups of 35. Metal brackets were bonded to teeth in the three groups. The same self curing resin was used for all groups. A shearing force was applied to the teeth. After debonding, bases of bracket and enamel surfaces were examined under steroscopic microscope to determine the failure modes. Statistical analysis of the data was carried out with one way ANOVA and Student t- test. The results were as follows. 1. Shear bond strength values for the 30% polyacrylic acid and 40% polyacrylic acid group were approximately two thirds of the phosphoric acid group. It maintains clinically acceptable but not enough bond strength. 2. There was no statistically significant difference in shear bond strengths between 30% and 40% polyacrylic acid group. 3. The failure modes of brackets had some differences. In polyacrylic acid groups, the percentage of adhesive/enamel failure was higher than that of adhesive/ bracket interface failure. On the contrary in phosphoric acid groups, the results were reversed. Further study of bond strength could be required. If polyacrylic acid enamel conditioning is used clinically.