• Title/Summary/Keyword: 박종

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Effect of anticancer drug methortrexate on the biliary excretion kinetics of the reudced folate derivatives in rats (항암제 methotrexate가 랫드 담즙중 환원형엽산유도체의 배설동태에 미치는 영향)

  • Shin, Ho-chul;Cha, Shin-woo;Bae, Ju-hyun;Kim, Hyun-ju;Jeong, Tae-cheon;Park, Jong-il;Yoon, Jong-man;Kim, Gye-woong;Kim, Jin-suk;Han, Sang-seop
    • Korean Journal of Veterinary Research
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    • v.36 no.1
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    • pp.57-63
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    • 1996
  • The biliary excretion kinetics of the active folate derivatives were examined after an intravenous injection of methotrexate at doses of 0.3 and 10mg/kg to clarify the mechanism of the acute decrease in the plasma folate by the dihydrofolate reductase inhibitors. Even at a higher dose than used in the clinical therapy, methotrexate did not cause any acute depletion of folate denvatives in the excreted bile. Therefore, the decrease in the plasma folate appeared not to be related with the biliary excretion process of folates. A factor responsible for the plasma folate depletion by DHFR inhibitors may be due to the malabsorption of folate derivatives excreted into the small intestine.

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Estimation of Genetic Parameters and Annual Trends for Racing Times of Thoroughbred Racehorses (더러브렛 경주마의 주파기록에 대한 유전모수 추정과 연도별 개량량 분석)

  • Oh, Seung-Yoon;Park, Jong-Eun;Lee, Jeong-Ran;Lee, Jin-Woo;Oh, Hee-Seok;Kim, Hee-Bal
    • Journal of Animal Science and Technology
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    • v.51 no.2
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    • pp.129-134
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    • 2009
  • The aim of this study was to estimate genetic parameters and annual trends on the racing performance of Thoroughbred horses by a statistical analysis of the resulting records. We used the racing results of 245,979 observations for 13,458 horses recorded in 19 years of race held at Seoul and Busan racing tracks, provided by Korea Racing Authority. After a careful adjustment of some variables such as racing times, jockey and trainer numbers and the average prize a horse won, we selected significant factors that explain the result of racing records of a horse by stepwise AIC and BIC methods. The estimated heritability and repeatability were 0.322 and 0.332, respectively. The average of annual phenotypic and genetic improvement was -0.166 seconds and -0.161 seconds, respectively. Based on the statistical approach, we established reasonable animal model of well-set variables, which is important in the study on estimating performance of racing horses.

The relationship between oral health behavior and dental services utilization in Korean adolescents (한국 청소년의 구강보건행태와 치과의료이용과의 연관성)

  • Choi, Moon-Sil;Park, Hyung-Su;Lee, Byung-Hoon;Jeong, Sang-Gil;Park, Jong
    • Journal of Korean society of Dental Hygiene
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    • v.10 no.5
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    • pp.851-860
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    • 2010
  • Objectives : This study examined the oral health behavior and dental services utilization of adolescents in order to provide information on how to disseminate the correct oral health behavior to the youth and develop programs for the approach. Methods : The raw data of 'The Third 2007 Youth Health Behavior Online Survey' carried out by the Korea Center for Disease Control and Prevention were analyzed. All survey data collected was processed using SPSS ver 17.0 for data analysis as Frequency analysis, chi-square and Logistic regression analysis. Results : 1.The adolescents who have parents with college degree are 70% higher of dental services utilization than the adolescents counterpart(whose parents don't have degrees). And also the adolescents living in cities are 1.3 times higher use of dental services than others living in countries. 2. In case of drinking soda, students having soda 4 days per week on average are 1.2 times higher use of dental services than who don't. 3.The students brushing teeth after lunch are 0.9 times lower use of dental service than who don't. And the students who have tooth ache whenever they have a meal are 1.6 times higher use of dental service than the students who don't have tooth ache. The students who had a dental health education are 1.4 times higher utilization of dental service than who don't. The difference of using dental service between the students who have gum disease and halitosis and the students who don't is almost none. 4. The students who drink alcohol and smoke 10 days more or less a month are 0.8 ~ 0.9 times lower use of dental service than who don't. Conclusions : The rate of utilizing dental service is higher at students who live with parents having college degrees and the more have oral health behavior, the less use of dental service for treatment. We concluded that more educational program should be developed and vitalized so that students can have oral health.

Determination of the effective components in the various parts of Luffa cylindrica (L.) Roemer and development to remove the flesh from its fruit : (II) -Removal of flesh on the net fiber In fruit of sponge-gourd and improvement of quality of the net fiber- (수세미외의 부위별(部位別) 유효성분(有效成分) 조사(調査) 및 사과락중(絲瓜絡中) 육질제거(肉質除去) 방법(方法) 개발(開發) 연구(硏究) : (II) -사과락 육질제거 및 섬유품질개선-)

  • Yoo, Tae-Bang;Chang, Ki-Woon;An, Byung-Chang;Shin, Jong-Sun;Park, Joung-Sang
    • Applied Biological Chemistry
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    • v.34 no.4
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    • pp.373-378
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    • 1991
  • The skin and fleshy substance on the net fiber of sponge-gourd fruit pressed mechanically was removed with 0.2% NaOH solution in $3{\sim}5$ hours. The treatment of 0.2% NaOH with 0.02% Monopol(non-ionogenic polyoxethylen derivative) as surfactnat and with 0.1% $Ca(OCl)_2$ as bleaching agent enhanced the effect to remove the fleshy substance and improve the quality of net fiber. Also, the wet hardness and tensile strength of net fiber were controlled by the crosslinkage of the fiber with glu tardialdehyde, glyoxal, and formalin, respectively. The net fiber was stable on the acid and alkaline solutions. Also the range of temperature to degradate the fiber was $338{\sim}385^{\circ}C$. These values indicated a fair stability. The improved net fiber can be used for raw material of bath, dish washing, oil and gas filter, and many kinds of decorations.

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PVD Image Steganography with Locally-fixed Number of Embedding Bits (지역적 삽입 비트를 고정시킨 PVD 영상 스테가노그래피)

  • Kim, Jaeyoung;Park, Hanhoon;Park, Jong-Il
    • Journal of Broadcast Engineering
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    • v.22 no.3
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    • pp.350-365
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    • 2017
  • Steganography is a technique for secret data communication, which is not perceived by third person between a receiver and a transmitter. It has been developed for thousands of years for the transmission of military, diplomatic or business information. The development of digital media and communication has led to the development of steganography techniques in modern times. Technic of image steganography include the LSB, which fixes the number of embedded bits into a pixel, and PVD, which exploits the difference value in the neighboring pixel pairs. In the case of PVD image steganography, a large amount of information is embedded fluidly by difference value in neighboring pixel pairs and the designed range table. However, since the secret information in order is embedded, if an error of the number of embedded bits occurs in a certain pixel pair, all subsequent information will be destroyed. In this paper, we proposes the method, which improve the vulnerability of PVD property about external attack or various noise and extract secret information. Experimental process is comparison analysis about stego-image, which embedded various noise. PVD shows that it is not possible to preserve secret information at all about noise, but it was possible to robustly extract secret information for partial noise of stego-image in case of the proposed PVD image steganography with locally-fixed number of embedding bits.

THE STUDY OF FRACTURE STRENGTH OF PORCELAIN LAMINATE VENEER WITH VARIOUS LINGUAL EXTENTION LENGTH WHEN LNCISAL RESTORING (Porcelain Laminate veneer 절연 피복시 설측 연장 길이에 따른 파절강도의 연구)

  • Park, Johng-Han;Jo, Kwang-Hun
    • The Journal of Korean Academy of Prosthodontics
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    • v.34 no.4
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    • pp.746-754
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    • 1996
  • The purpose of this study was to evaluate the fracture strength of porcelain laminate veneer with various lingual extention length when incisal restoring. Sixty recently extracted, intact maxillary incisors were used and stored in a physiologic saline solution from the time of extraction. Seating form was preparation at the labial surface of each tooth with a water-cooled round diamond bur. Standard block was formed with 32 gauge and 24 gauge wax at tooth labial and lingual surface. Lingual extention length differed according to each group. (group I : 0.5mm, group II : 1 mm, group III : 2mm, group IV : 0mm) All tooth specimens were impressioned with examix(GC Inc., Japan). Refractory cast were maked with refractory die material(Ceramco Inc., U.S.A.) Laminate porcelain (Ceramco II Veneer porcelain, Ceramco Inc., U.S.A.) was condensed in refractory die cast and baked according to the manufacturer's recommendations. Each surface was contoured with low speed diamond bur according to guide block. All porcelain specimens were sandblasted and ultrasonically cleaned in distlled water for 3 minutes. Then, all porcelain specimen were etched with 8% hydrofluoric acid for 5 minutes. Sixty specimens were bonded with composite resin cement(Choice Porcelain Veneer System, Bisco Inc., U.S.A.) according to manufacture's directions. The fracture loads of the specimen were measured by Instron universal testing machine. The mean values of fracture loads for the groups were statistically compared by Duncan's multiful range test. The result were as follows : Mean fracture strengths of each group were 86.95Mpa in no lingual extention group, 44.98Mpa in 0.5mm lingual extention group, 27.47Mpa in 1mm lingual extention group, 19.61Mpa in 2mm lingual extention group. There was a statistically significant difference between all group(p<0.01).

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Electrical and Dielectric Properties of Zn-Pr-Co-Cr-Dy Oxides-based Varistors (Zn-Pr-Co-Cr-Dy 산화물계 바리스터의 전기적, 유전적 특성)

  • 남춘우;박종아;김명준;류정선
    • Journal of the Korean Ceramic Society
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    • v.40 no.10
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    • pp.943-948
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    • 2003
  • The microstructure and electrical characteristics of Zn-Pr-Co-Cr-Dy oxides-based varistors were investigated with Dy$_2$ $O_3$ content in the range of 0.0∼2.0 ㏖%. As Dy$_2$ $O_3$ content is increased, the average grain size was decreased in the range of 18.2∼4.6 $\mu\textrm{m}$ and the ceramic density was decreased in the range of 5.49∼4.64 g/㎤. The incorporation of Dy$_2$ $O_3$ markedly enhanced the nonlinear properties of varistors more than 9 times in nonlinear exponent, compared with the varistor without Dy$_2$ $O_3$ The varistor with 0.5∼1.0 ㏖% Dy$_2$ $O_3$ exhibited the high nonlinearity, in which the nonlinear exponent is above 55 and the leakage current is below 1.0 ${\mu}\textrm{A}$. The donor concentration and the density of interface states were decreased in the range of (4.66∼0.25)${\times}$10$\^$18//㎤ and (5.70∼1.39)${\times}$10$\^$12//$\textrm{cm}^2$, respectively, with increasing Dy$_2$ $O_3$ content. The minimum dielectric dissipation factor of 0.0023 was obtained for 0.5 ㏖% Dy$_2$ $O_3$, but further addition of Dy$_2$ $O_3$ increased it.

Curing Behavior and Interfacial Properties of Electrodeposited Carbon Fiber/Epoxy Composites by Electrical Resistivity Measurement under Tensile/Compressive Tests (전기증착된 탄소섬유/에폭시 복합재료의 인장/압축 하중하에서의 전기저항 측정법을 이용한 경화 및 계면특성)

  • Park, Joung-Man;Lee, Sang-Il;Kim, Jin-Won
    • Journal of Adhesion and Interface
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    • v.2 no.1
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    • pp.9-17
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    • 2001
  • Curing behavior and interfacial properties were evaluated using electrical resistance measurement and tensile/compressive fragmentation test. Electrical resistivity difference (${\Delta}R$) during curing process was not observed in a bare carbon fiber. On the other hand, ${\Delta}R$ appeared due to the matrix contraction in single-carbon fiber/epoxy composite. Logarithmic electrical resistivity of the untreated single-carbon fiber composite increased suddenly to the infinity when the fiber fracture occurred under tensile loading, whereas that of the ED composite reached relatively broadly up to the infinity. Comparing to the untreated case, interfacial shear strength (IFSS) of the ED treated composite increased significantly in both tensile fragmentation and compressive Broutman test. Microfailure modes of the untreated and the ED treated fiber composite showed the debonding and the cone shapes in tensile test, respectively. For compressive test, fractures of diagonal slippage were observed in both untreated and the ED treated composite. Sharp-end shape fractures exhibited in the untreated composite, whereas relatively dull fractures showed in the ED Heated composite. It is proved that ED treatments affected differently on the interfacial adhesion and microfailure mechanism under tensile/compressive tests.

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Interfacial and Mechanical properties of Different Heat Treated Wood and Evaluation of Bonding Property between Stone and Wood for Rock Bed (열처리 조건에 따른 목재의 계면과 기계적 물성 및 돌침대용 석재/목재간 접착제에 따른 접착력 평가)

  • Kwon, Dong-Jun;Shin, Pyeong-Su;Choi, Jin-Yeong;Moon, Sun-Ok;Park, Joung-Man
    • Journal of Adhesion and Interface
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    • v.16 no.2
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    • pp.69-75
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    • 2015
  • Stone board for the rock bed was needed to reduce weight using thin thickness and reinforced materials. In this work, stone/wood board for rock bed was studied. Stone and wood were attached to reduce total weight of stone for rock bed. For reinforcing wood heat treatment method was used to change surface and mechanical properties. Mechanical strength of heat treated wood increased more than neat condition. The optimum heat treatment condition was set on $100^{\circ}C$ under tensile, flexural loads whereas surface energy was also obtained by contact angle measurement. Optimum adhesive condition was to get the maximum adhesion between stone and wood. Lap shear test was performed for stone/wood board with different adhesives such as amine type epoxy, polyurethane, chloro-rubber and vinyl chloride acetate type. Fracture surface of lap shear test was shown at wood fracture part on stone using amine type epoxy adhesive. It was found that for high adhesion between stone and wood the optimum adhesive was epoxy type for the rock bed.

A Study on the Inhibition of Skin Pigmentation by Lobaric Acid as Protease Activated Receptor-2 Antagonist (Protease Activated Receptor-2의 길항제로서 Lobaric Acid의 피부 색소침착 억제 효능 연구)

  • Goo, Jung Hyun;Lee, Ji Eun;Myung, Cheol Hwan;Park, Jong Il;Hwang, Jae Sung
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.41 no.3
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    • pp.243-252
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    • 2015
  • Melanosome, the pigment granule in melanocyte, determines the color of skin when it moves into the keratinocyte. Inhibition of melanosome transfer from melanocyte to keratinocyte results in skin depigmentation. Protease activated receptor-2 (PAR-2) is involved in signal transduction systems via cell membrane and increases the melasome transfer when it is activated by cleavage of their extracellular amino acid sequence by trypsin or by a peptide such as SLIGKV. Here, we showed that lobaric acid inhibited PAR-2 activation and affected the mobilization of $Ca2^+$. The uptake of fluorescent microspheres and isolated melanosomes from melan-a melanocytes to keratinocytes induced by SLIGKV were inhibited by lobaric acid. Also, confocal microscopy studies illustrated a decreased melanosome transfer to keratinocytes in melanocyte-keratinocyte co-culture system by lobaric acid. In addition, lobaric acid induced visible skin lightening effect in human skin tissue culture model, melanoderm$^{(R)}$. Our data suggest that lobaric acid could be an effective skin lightening agent that works via regulation of phagocytic activity of keratinocytes.