• Title/Summary/Keyword: 바이오 데이터

Search Result 1,364, Processing Time 0.028 seconds

Modified Pyramid Scene Parsing Network with Deep Learning based Multi Scale Attention (딥러닝 기반의 Multi Scale Attention을 적용한 개선된 Pyramid Scene Parsing Network)

  • Kim, Jun-Hyeok;Lee, Sang-Hun;Han, Hyun-Ho
    • Journal of the Korea Convergence Society
    • /
    • v.12 no.11
    • /
    • pp.45-51
    • /
    • 2021
  • With the development of deep learning, semantic segmentation methods are being studied in various fields. There is a problem that segmenation accuracy drops in fields that require accuracy such as medical image analysis. In this paper, we improved PSPNet, which is a deep learning based segmentation method to minimized the loss of features during semantic segmentation. Conventional deep learning based segmentation methods result in lower resolution and loss of object features during feature extraction and compression. Due to these losses, the edge and the internal information of the object are lost, and there is a problem that the accuracy at the time of object segmentation is lowered. To solve these problems, we improved PSPNet, which is a semantic segmentation model. The multi-scale attention proposed to the conventional PSPNet was added to prevent feature loss of objects. The feature purification process was performed by applying the attention method to the conventional PPM module. By suppressing unnecessary feature information, eadg and texture information was improved. The proposed method trained on the Cityscapes dataset and use the segmentation index MIoU for quantitative evaluation. As a result of the experiment, the segmentation accuracy was improved by about 1.5% compared to the conventional PSPNet.

Identification and Characterization of Secreted Phosphoprotein 2 as a Novel Bioactive Protein for Myocardial Differentiation (심근세포로의 분화에 관여하는 새로운 생리활성 단백질 SPP2의 발굴)

  • Sejin Jeon
    • Journal of Life Science
    • /
    • v.33 no.1
    • /
    • pp.64-72
    • /
    • 2023
  • Despite several advances in identification of cardiac transcription factors, there are still needs to find new bioactive molecules that promote cardiomyogenesis from stem cells to highly efficient myocardial differentiation. We analyzed Illumina expression microarray data of mouse embryonic stem cells (mESCs)-derived cardiomyocytes. 276 genes were upregulated (≥ 4fold) in mESCs-derived cardiomyocytes compared undifferentiated ESCs. Secreted phosphoprotein 2 (Spp2) is one of candidates and is known to inhibit bone morphogenetic protein 2 (BMP2) signal transduction as a pseudoreceptor for BMP2. However, its function in cardiomyogenesis is unknown. We confirmed that Spp2 expression increased during the differentiation into functional cardiomyocytes using mESCs, TC-1/Kh2 and E14. Interestingly, Spp2 secretion transiently increased 3 days after formation of embryoid bodies (EBs), indicating that the extracellular secretion of Spp2 is involved in the differentiation of ESCs into cardiomyocytes. To characterize Spp2, we performed experiments using the C2C12 mouse myoblast cell line, which has the property of shifting the differentiation pathway from myoblastic to osteoblastic by treatment with BMP2. Similar to the differentiation of ESCs, transcription of Spp2 increased as C2C12 myoblasts differentiated into myotubes. In particular, Spp2 secretion increased dramatically in the early stage of differentiation. Furthermore, treatment with Spp2-Flag recombinant protein promoted the differentiation of C2C12 myoblasts into myotubes. Taken together, we suggest a novel bioactive protein Spp2 that differentiates ESCs into cardiomyocytes. This may be useful for understanding the molecular pathways of cardiomyogenesis and for experimental or clinical promotion of stem cell therapy for ischemic heart diseases.

Serum Biomarkers for Cardiovascular Disease and Atrial Fibrillation in Ischemic Stroke: A Systematic Review and Meta-Analysis (허혈성 뇌졸중에서 심혈관 질환과 심방세동을 위한 혈청 바이오마커: 체계적 문헌 고찰과 메타분석)

  • Myoung Soo, Woo;Sora, Mun;Jiyeong, Lee
    • Korean Journal of Clinical Laboratory Science
    • /
    • v.54 no.4
    • /
    • pp.256-264
    • /
    • 2022
  • Ischemic stroke is caused by an occlusion by a thrombus or embolus in a cerebral artery, preventing oxygenated blood from reaching the brain and causing the necrosis of nerve cells. This paper summarizes the serum candidate markers associated with cardiovascular disease and atrial fibrillation (AF) disease that enable an early diagnosis of ischemic stroke studied thus far and compares the odds ratio (OR) of each marker. This study examined the effect size of these serum candidate markers using meta-analysis techniques. The academic database search screening for articles containing the keywords "cardiovascular disease," "atrial fibrillation," "ischemic stroke," and "serum marker" was limited to results for patients with ischemic stroke. The most derived markers in this study were N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), D-dimer, C-reactive protein (CRP), and glial fibrillary acidic protein (GFAP), the rest being investigated individually. In conclusion, NT-pro-BNP appears to be very useful for the early diagnosis of ischemic stroke. Primarily, it is a marker of AF, and more AF markers will be uncovered and studied in the future.

Factors Influencing the Intention of Knowledge Sharing of Records Management Specialists in Government-affiliated Public Institutions (정부산하공공기관 기록물관리전문요원의 지식공유의도 영향요인에 관한 연구)

  • Kim, Youngeun;Park, Ji-Hong
    • Journal of the Korean BIBLIA Society for library and Information Science
    • /
    • v.33 no.1
    • /
    • pp.47-70
    • /
    • 2022
  • The purpose of this study is to empirically verify the factors(organization managerial factors, relational factors and personal factors) that affect the knowledge sharing intention of records management specialists. A total of 126 responses were used for the final analysis and the findings of this study are as follows: First, managers' interests and supports had a significant positive effect on tacit knowledge sharing intention, but evaluation and compensation system had a negative effect on tacit knowledge sharing intention. Second, job stress was found to have a significant positive effect on the intention of knowledge sharing(tacit, explicit). It is required to form an organizational culture where records management specialists can freely participate in knowledge sharing activities with the interest and support of managers. In addition, the process of continuously improving the causes of one of the causes of job stress, such as awareness improvement and deprivation, should be carried out through records management training for all employees. This study is meaningful in that it provides policy implications for promoting knowledge sharing as a solution to the managerial problems faced by records management specialists by utilizing the current staffing structure.

The Effects of Cadmium on Seed Germination and Growth of Sunflower and Rape (카드뮴이 해바라기와 유채 발아 및 성장에 미치는 영향)

  • Lee, Kwang Kun;Cho, Han Sang;Kim, Jae Young
    • KSCE Journal of Civil and Environmental Engineering Research
    • /
    • v.30 no.1B
    • /
    • pp.101-105
    • /
    • 2010
  • Sunflower (Sunking4505) and Rape (Sunmang) are oil-seeds containing high oleic acid, and these are used for the production materials of bio-diesel and applying for phytoremediation. The effect of cadmium on germination rate and the growth of the plants is evaluated. Object seeds were placed in Cd (0, 1.5, 4, 12, 30, 60, 100, 150, 300, 500 mg/L) solutions for seven days, and germination rate, root length, shoot length, seedling length, and dry weight were observed. $IC_{50}$, seedling vigor index, and tolerance indices were computed, and data were statistically analyzed by Analysis of Variance (ANOVA). Germination rate as well as root, shoot, and seedling length decreased as the cadmium concentration increased except dry weight. The $IC_{50}$ of sunflower and rape are 112 and 10 mg-Cd/L, respectively. Only one of the sunflower seeds is germinated at 500 mg-Cd/L whereas rape seeds are not germinated more than 150 mg-Cd/L solution. Root has higher cadmium sensitivity than shoot, and sunflower has higher germination rate, growth, and seedling vigor index than rape. In case of tolerance indices, sunflower has lower value than rape at relatively low concentration, but has higher value at high concentration.

A Study on customer experience centered innovation model for Funeral Mutual Enterprise - Centered on Funeral service - (상조기업의 고객경험 기반 혁신모델 연구 - 장례서비스 산업을 중심으로 -)

  • Ahn, Jinho;Lee, Jeungsun
    • Journal of Service Research and Studies
    • /
    • v.11 no.2
    • /
    • pp.67-77
    • /
    • 2021
  • This study is a study on the methodology of establishing an innovation strategy centering on the customer experience, which is essential in order to transform the existing collection and preservation-centered mutual aid company service into a visitor-centered service. To this end, we conducted literature research on environmental changes in the funeral industry from the perspective of service science and the significance and value of customer experiences within them, good customer experiences and bad customer experiences from the perspective of customer experience management. A study was conducted to present and prove a specific model. The customer experience-oriented innovation strategy of the funeral industry means to search for various alternatives that can reach the target state from the present state, focusing on the customer, and select the most appropriate transformation plan among them. As an effect of application, it was found that it is a source of differentiation by generating positive emotions to customers, and that customer experience data is highly helpful in making important decisions for the actual resource input of the parent company. This innovation model was presented, and its value was firstly proved by analyzing the difference from the existing evaluation method. Finally, as a result of analyzing the causal relationship through regression analysis using the customer experience measurement procedure, customer experience diagnosis/evaluation, customer experience innovation strategy, and cooperative company's performance as variables, the relationship proved to be significant.

Classification of Social Welfare Organizations' Innovations (사회복지조직의 혁신유형화에 관한 시론적 연구 - 혁신의 내용적 측면을 중심으로 -)

  • Jeong, Eun-Ha
    • Korean Journal of Social Welfare Studies
    • /
    • v.42 no.2
    • /
    • pp.123-153
    • /
    • 2011
  • This study tries to categorize innovation types for social welfare organizations and investigate the level of innovation in each type in practical field. Firstly, this study scrutinizes the concept and classification's criterias of innovation. Secondly, this study reviews not only classification of innovation in profit organization but also several researches of innovation in service industry and public sectors, and finally, this study makes a suggestion of innovations' classification that is applicable for social welfare organizations. Based on this suggestion, fifteen questions are designed to ask the innovative activities in the organizations. And total 496 respondents from 116 organizations answered these questionnaire. The outcomes of this survey were substantiated by second data through converted procedures to mean value of organizations. Consquently, service innovation, administrative innovation and human resource innovation, proposed based on theoretical review, were subdivided into six categories such as service innovation, structural innovation, internal and efficiency innovation, marketing and communication innovation, external and employment innovation and evalution and mission innovation. The mean value of service(mean=14.7) and marketing innovation(mean=13.3) are higher than other type of innovations, which shows the aspect of innovative activities in social welfare organizations. Based on this result, we can get the directions of following study in investigating innovation of social welfare organization.

The Estimation on the Optimal Size of Self-employed in Korea using OECD Data: Focusing on the Sectors of Wholesale/Retail & Hotel/Restaurant (OECD 회원국 자료를 활용한 한국의 자영업 적정규모 추정에 관한 실증연구: 도소매업 및 음식숙박업을 중심으로)

  • Moon, Sunung;Jun, In Woo
    • International Area Studies Review
    • /
    • v.15 no.1
    • /
    • pp.241-266
    • /
    • 2011
  • This study examines the determinants of proportion of self-employed and their policy implications focusing hotel/restaurant and wholesale/retail sectors in Korea. In this study, we estimate the optimal size of self-employed in Korea using OECD data. Several hypothesis are tested by use of the regression analysis on the panel data of OECD economies during 2000-2007 period. Using the panel data of per capita GNI, unemployment level, income tax burden, we found that the excess supply level of self-employed was about 8.0%~9.5% overall. We also found that the excess supply level of self-employed was 13.7~14.1% for hotel and restaurant sector, and 10.4~11.1% for wholesale and retail sector. This results imply that strategically coordinated programs for noncompetitive sectors are more effectively implemented. Furthermore, more aggressive entry and exit policies are needed to solve the over-supply problem of self-employed in Korea.

Comparison of digitalized fabrication method for interim removable partial denture: case reports (두 가지 프린팅 방식으로 제작한 임시 가철성 의치의 비교: 증례 보고)

  • Yoon-Jeong Shin;Cheong-Hee Lee;Du-Hyeong Lee
    • The Journal of Korean Academy of Prosthodontics
    • /
    • v.61 no.4
    • /
    • pp.379-385
    • /
    • 2023
  • With the recent development of digital dentistry, fully digitalized methods for fabricating dentures, using intraoral scans and computer-aided design/computer-aided manufacturing (CAD-CAM), are getting popular. Digital methods have the advantage of simplifying the fabrication process in the clinic and laboratory, supplementing digital data. This case report shows a fully digital fabrication method for interim removable dentures in a patient with anterior tooth loss in which implant placement is impossible or delayed. Interim removable dentures were fabricated using two methods. One method is printing tooth and base parts separately and combining, and the other method is printing the whole denture at one time and coloring on the base part. Afterward, dentures were delivered and adaptation was evaluated using the triple scan technique. The extracted site was scanned intraorally (first scan) and the interim removable denture was digitally scanned both intraorally (second scan) and, after removal extraorally (Third scan). In both method, denture adaptation was shown favorable. We report this case report as both the patient and the operator were satisfied with a simplified process using a fully digital method in the clinic.

Understanding and Trends of Roll-to-Roll Operation (롤투롤 공정의 이해 및 동향)

  • Yeong-Woo Ha;Gi-Hwan Kim;Dong-Chan Lim
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
    • /
    • v.37 no.1
    • /
    • pp.36-42
    • /
    • 2024
  • Roll-to-roll processing holds an integral position within the manufacturing landscape, and its significance reverberates across numerous industries. This versatile technology platform encompasses a diverse array of process methods and accommodates a wide spectrum of material categories, making it a cornerstone of modern production. Within this expansive domain, two commonly employed coating techniques, namely the slot die and gravure coating methods, have earned their prominence for their precision and efficiency in delivering flawless coatings. Additionally, the realm of drying processes relies heavily on thermal drying, infrared (IR) drying, and ultraviolet (UV) drying methods to expedite the transformation of materials from their liquid or semi-liquid states to solid, ready-to-use products. The undeniable importance of roll-to-roll processing lies in its ability to streamline manufacturing processes, reduce costs, and enhance product quality. This article embarks on a comprehensive journey to fathom the depth of this importance by delving into the intricacies of these common roll-to-roll process methods. Through rigorous research and meticulous data collection, we aim to shed light on the pivotal role these techniques play in shaping various industries and advancing the world of manufacturing. By understanding their significance, we can harness the full potential of roll-to-roll processing and pave the way for innovation and excellence in production.